DE10344799A1 - Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie - Google Patents

Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie Download PDF

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Publication number
DE10344799A1
DE10344799A1 DE10344799A DE10344799A DE10344799A1 DE 10344799 A1 DE10344799 A1 DE 10344799A1 DE 10344799 A DE10344799 A DE 10344799A DE 10344799 A DE10344799 A DE 10344799A DE 10344799 A1 DE10344799 A1 DE 10344799A1
Authority
DE
Germany
Prior art keywords
nucleic acid
tumor
associated antigen
sequence
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10344799A
Other languages
German (de)
English (en)
Inventor
Özlem TÜRECI
Ugur Sahin
Gerd Helftenbein
Volker SCHLÜTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ganymed Pharmaceuticals GmbH
Original Assignee
Ganymed Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ganymed Pharmaceuticals GmbH filed Critical Ganymed Pharmaceuticals GmbH
Priority to DE10344799A priority Critical patent/DE10344799A1/de
Priority to EP10009751.8A priority patent/EP2266613B1/de
Priority to EP10009748A priority patent/EP2332979A3/de
Priority to EP10009757A priority patent/EP2266615A3/de
Priority to EP10009745A priority patent/EP2266610A3/de
Priority to EP10009763A priority patent/EP2272534A3/de
Priority to AU2004275500A priority patent/AU2004275500B2/en
Priority to EP10009743.5A priority patent/EP2266608B1/de
Priority to EP10009762A priority patent/EP2332983A3/de
Priority to EP10009759A priority patent/EP2266617A3/de
Priority to ES10009753.4T priority patent/ES2634705T3/es
Priority to CA2984653A priority patent/CA2984653C/en
Priority to EP10009758A priority patent/EP2266616A3/de
Priority to EP10009752A priority patent/EP2266614A3/de
Priority to CA3096188A priority patent/CA3096188C/en
Priority to EP10009747A priority patent/EP2295077A3/de
Priority to EP10009750.0A priority patent/EP2266612B1/de
Priority to JP2006527354A priority patent/JP5144933B2/ja
Priority to PCT/EP2004/010697 priority patent/WO2005030250A2/de
Priority to EP10009755A priority patent/EP2332981A3/de
Priority to EP10009744A priority patent/EP2266609A3/de
Priority to EP10009746A priority patent/EP2267011A3/de
Priority to EP10009753.4A priority patent/EP2267012B1/de
Priority to EP10009754.2A priority patent/EP2267013B1/de
Priority to EP10009761A priority patent/EP2266618A3/de
Priority to CA2814269A priority patent/CA2814269C/en
Priority to US10/573,229 priority patent/US7875424B2/en
Priority to EP10009749A priority patent/EP2266611A3/de
Priority to EP04786996.1A priority patent/EP1664113B1/de
Priority to CA2539837A priority patent/CA2539837C/en
Priority to EP10009756A priority patent/EP2332980A3/de
Priority to EP10009760A priority patent/EP2267014A3/de
Publication of DE10344799A1 publication Critical patent/DE10344799A1/de
Priority to US12/969,754 priority patent/US20110135640A1/en
Priority to JP2011253535A priority patent/JP5639989B2/ja
Priority to JP2012223869A priority patent/JP5804519B2/ja
Priority to US13/863,780 priority patent/US9139880B2/en
Priority to JP2014113690A priority patent/JP5969538B2/ja
Priority to US14/830,506 priority patent/US9267177B2/en
Priority to US14/849,052 priority patent/US9733251B2/en
Priority to US15/046,700 priority patent/US9910043B2/en
Priority to JP2016094337A priority patent/JP6196350B2/ja
Withdrawn legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
DE10344799A 2003-09-26 2003-09-26 Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie Withdrawn DE10344799A1 (de)

Priority Applications (41)

Application Number Priority Date Filing Date Title
DE10344799A DE10344799A1 (de) 2003-09-26 2003-09-26 Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
EP10009753.4A EP2267012B1 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009746A EP2267011A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009754.2A EP2267013B1 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009745A EP2266610A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009763A EP2272534A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
AU2004275500A AU2004275500B2 (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
EP10009743.5A EP2266608B1 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009762A EP2332983A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009759A EP2266617A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
ES10009753.4T ES2634705T3 (es) 2003-09-26 2004-09-23 Identificación de antígenos de superficie celular, asociados a tumor para diagnóstico y terapia
CA2984653A CA2984653C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
EP10009758A EP2266616A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009752A EP2266614A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
CA3096188A CA3096188C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
EP10009747A EP2295077A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009750.0A EP2266612B1 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
JP2006527354A JP5144933B2 (ja) 2003-09-26 2004-09-23 診断および治療のための腫瘍関連細胞表面抗原の同定
PCT/EP2004/010697 WO2005030250A2 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten zelloberflächen-antigenen für die diagnose und therapie
EP10009755A EP2332981A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009744A EP2266609A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009751.8A EP2266613B1 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten zelloberflächen-antigenen für die diagnose und therapie
EP10009748A EP2332979A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009757A EP2266615A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009761A EP2266618A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
CA2814269A CA2814269C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
US10/573,229 US7875424B2 (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
EP10009749A EP2266611A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP04786996.1A EP1664113B1 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten zelloberflächen-antigenen für die diagnose und therapie
CA2539837A CA2539837C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
EP10009756A EP2332980A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
EP10009760A EP2267014A3 (de) 2003-09-26 2004-09-23 Identifizierung von tumorassoziierten Zelloberflächen-Antigenen für die Diagnose und Therapie
US12/969,754 US20110135640A1 (en) 2003-09-26 2010-12-16 Identification of tumour-associated cell surface antigens for diagnosis and therapy
JP2011253535A JP5639989B2 (ja) 2003-09-26 2011-11-21 診断および治療のための腫瘍関連細胞表面抗原の同定
JP2012223869A JP5804519B2 (ja) 2003-09-26 2012-10-09 診断および治療のための腫瘍関連細胞表面抗原の同定
US13/863,780 US9139880B2 (en) 2003-09-26 2013-04-16 Identification of tumor-associated cell surface antigens for diagnosis and therapy
JP2014113690A JP5969538B2 (ja) 2003-09-26 2014-06-02 診断および治療のための腫瘍関連細胞表面抗原の同定
US14/830,506 US9267177B2 (en) 2003-09-26 2015-08-19 Identification of tumor-associated cell surface antigens for diagnosis and therapy
US14/849,052 US9733251B2 (en) 2003-09-26 2015-09-09 Identification of tumour-associated cell surface antigens for diagnosis and therapy
US15/046,700 US9910043B2 (en) 2003-09-26 2016-02-18 Identification of tumor-associated cell surface antigens for diagnosis and therapy
JP2016094337A JP6196350B2 (ja) 2003-09-26 2016-05-10 診断および治療のための腫瘍関連細胞表面抗原の同定

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10344799A DE10344799A1 (de) 2003-09-26 2003-09-26 Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie

Publications (1)

Publication Number Publication Date
DE10344799A1 true DE10344799A1 (de) 2005-04-14

Family

ID=34306102

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10344799A Withdrawn DE10344799A1 (de) 2003-09-26 2003-09-26 Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie

Country Status (8)

Country Link
US (6) US7875424B2 (https=)
EP (22) EP2266615A3 (https=)
JP (5) JP5144933B2 (https=)
AU (1) AU2004275500B2 (https=)
CA (4) CA2539837C (https=)
DE (1) DE10344799A1 (https=)
ES (1) ES2634705T3 (https=)
WO (1) WO2005030250A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006100089A3 (de) * 2005-03-24 2007-01-11 Ganymed Pharmaceuticals Ag Identifizierung von oberflächen-assoziierten antigenen für die tumordiagnose und -therapie

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10344799A1 (de) 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
WO2005030955A1 (ja) * 2003-09-29 2005-04-07 Chugai Seiyaku Kabushiki Kaisha Nk細胞に発現するタンパク質
DE10347710B4 (de) 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Rekombinante Impfstoffe und deren Verwendung
WO2007013575A2 (en) * 2005-07-28 2007-02-01 Oncotherapy Science, Inc. Method for diagnosing and treating renal cell carcinoma
DE102005046490A1 (de) 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
US8404810B2 (en) * 2006-02-17 2013-03-26 Five Prime Therapeutics, Inc. Compositions and methods of use for modulators of polypeptides and polynucleotides in treating breast cancer and melanoma
EP2060583A1 (en) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identification of tumor-associated markers for diagnosis and therapy
EP3118326B1 (en) 2008-10-27 2020-04-29 Sapporo Medical University Molecular marker for cancer stem cell
WO2011051277A1 (en) 2009-10-26 2011-05-05 Externautics S.P.A. Breast tumor markers and methods of use thereof
US10288617B2 (en) * 2009-10-26 2019-05-14 Externautics Spa Ovary tumor markers and methods of use thereof
EP2494351B1 (en) 2009-10-26 2016-06-08 Externautics S.p.A. Colon and rectal tumor markers and methods of use thereof
US8921058B2 (en) 2009-10-26 2014-12-30 Externautics Spa Prostate tumor markers and methods of use thereof
WO2011051278A1 (en) 2009-10-26 2011-05-05 Externautics S.P.A. Lung tumor markers and methods of use thereof
FR2973380B1 (fr) * 2011-04-01 2018-02-09 C.Ris Pharma Peptides isoles et purifies a partir de testicules de roussette
PL3892295T3 (pl) 2011-05-24 2023-07-24 BioNTech SE Zindywidualizowane szczepionki przeciwnowotworowe
TW201302800A (zh) * 2011-06-10 2013-01-16 腫瘤療法 科學股份有限公司 Ｓｅｍａ５ｂ胜肽及含其之疫苗
WO2013143555A1 (en) 2012-03-26 2013-10-03 Biontech Ag Rna formulation for immunotherapy
EP3417874B1 (en) 2012-11-28 2024-09-11 BioNTech SE Individualized vaccines for cancer
BR112015012234A2 (pt) * 2012-12-04 2017-08-15 Oncotherapy Science Inc Peptídios sema5b e vacinas contendo os mesmos
WO2014180490A1 (en) 2013-05-10 2014-11-13 Biontech Ag Predicting immunogenicity of t cell epitopes
CN113791220A (zh) 2014-09-10 2021-12-14 豪夫迈·罗氏有限公司 免疫原性突变体肽筛选平台
WO2016045732A1 (en) 2014-09-25 2016-03-31 Biontech Rna Pharmaceuticals Gmbh Stable formulations of lipids and liposomes
WO2016128060A1 (en) 2015-02-12 2016-08-18 Biontech Ag Predicting t cell epitopes useful for vaccination
WO2017059902A1 (en) 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna
GB201520564D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
ES2970865T3 (es) 2015-12-16 2024-05-31 Gritstone Bio Inc Identificación, fabricación y uso de neoantígenos
WO2018224166A1 (en) 2017-06-09 2018-12-13 Biontech Rna Pharmaceuticals Gmbh Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
US20200040103A1 (en) * 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
CA3242459A1 (en) * 2021-12-27 2023-07-06 Memorial Sloan-Kettering Cancer Center Tumor mhc class i expression is associated with interleukin-2 response in melanoma

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9019812D0 (en) 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
WO1995004068A1 (en) * 1993-07-29 1995-02-09 Isis Pharmaceuticals, Inc. Oligomers for modulating human immunodeficiency virus
US5677139A (en) 1995-04-21 1997-10-14 President And Fellows Of Harvard College In vitro differentiation of CD34+ progenitor cells into T lymphocytes
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
CA2243235C (en) 1996-01-17 2010-08-10 Imperial College Innovations Limited Immunotherapy using cytotoxic t lymphocytes (ctl)
SE508004C2 (sv) 1996-08-07 1998-08-10 Intermec Ptc Ab Arrangemang för automatisk inställning av printrar samt material därtill
WO1998037094A2 (en) * 1997-02-24 1998-08-27 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
AU7549498A (en) * 1997-06-03 1998-12-21 Protegene Inc. Human proteins having transmembrane domains and dnas encoding these prot eins
AU764441B2 (en) * 1998-02-09 2003-08-21 Genset S.A. cDNAs encoding secreted proteins
EP1144444A3 (en) * 1998-12-22 2002-01-02 Genset Dnas encoding proteins with signal sequences
WO2001000661A2 (en) * 1999-06-25 2001-01-04 Genset Carnitine carrier related protein-1
WO2001054472A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001060860A2 (en) * 2000-02-17 2001-08-23 Millennium Predictive Medicine, Inc. Genes differentially expressed in human prostate cancer and their use
WO2001077292A2 (en) * 2000-04-07 2001-10-18 Senomyx, Inc. Novel signal transduction molecules
WO2001087937A2 (en) * 2000-05-18 2001-11-22 Incyte Genomics, Inc. G-protein coupled receptors
JP2002112793A (ja) * 2000-08-04 2002-04-16 Japan Science & Technology Corp 新規ｇ蛋白質共役受容体
WO2002012343A2 (en) * 2000-08-07 2002-02-14 Curagen Corporation Proteins and nucleic acids encoding g-protein coupled receptors
AU2001293854A1 (en) * 2000-10-04 2002-04-15 Bayer Aktiengesellschaft Regulation of human gpcr-like protein
AU2002255478A1 (en) 2001-01-10 2002-09-12 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
US7171311B2 (en) * 2001-06-18 2007-01-30 Rosetta Inpharmatics Llc Methods of assigning treatment to breast cancer patients
CA2460621A1 (en) * 2001-09-19 2003-03-27 Nuvelo, Inc. Novel nucleic acids and polypeptides
JP2005514051A (ja) * 2001-12-21 2005-05-19 ジーン ロジック インコーポレイテッド 胃癌における遺伝子発現プロファイル
GB0203419D0 (en) * 2002-02-13 2002-04-03 Oxford Biomedica Ltd Peptide
US20030170639A1 (en) * 2002-03-11 2003-09-11 Youmin Shu Liver transmembrane protein gene
DE10211088A1 (de) * 2002-03-13 2003-09-25 Ugur Sahin Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
ES2374311T3 (es) * 2002-03-13 2012-02-15 Genomic Health, Inc. Obtención de perfil de expresión génica en tejidos tumorales biopsiados.
DE10254601A1 (de) * 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
WO2005021793A1 (en) * 2003-08-29 2005-03-10 Pantarhei Bioscience B.V. Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood
DE10344799A1 (de) 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006100089A3 (de) * 2005-03-24 2007-01-11 Ganymed Pharmaceuticals Ag Identifizierung von oberflächen-assoziierten antigenen für die tumordiagnose und -therapie
US9090940B2 (en) 2005-03-24 2015-07-28 Ganymed Pharmaceuticals Ag Identification of surface-associated antigens for tumor diagnosis and therapy
US9194004B2 (en) 2005-03-24 2015-11-24 Biontech Ag Identification of surface-associated antigens for tumor diagnosis and therapy
US10036753B2 (en) 2005-03-24 2018-07-31 Ganymed Pharmaceuticals Ag Identification of surface-associated antigens for tumor diagnosis and therapy
US10302647B2 (en) 2005-03-24 2019-05-28 Biontech Ag Identification of surface-associated antigens for tumor diagnosis and therapy

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