DE10344229A1 - Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit - Google Patents

Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit Download PDF

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Publication number
DE10344229A1
DE10344229A1 DE10344229A DE10344229A DE10344229A1 DE 10344229 A1 DE10344229 A1 DE 10344229A1 DE 10344229 A DE10344229 A DE 10344229A DE 10344229 A DE10344229 A DE 10344229A DE 10344229 A1 DE10344229 A1 DE 10344229A1
Authority
DE
Germany
Prior art keywords
cavity
blocking element
liquid
carrier
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE10344229A
Other languages
German (de)
English (en)
Inventor
Klaus Dr. Kadel
Gert Dr. Blankenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Steag Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steag Microparts GmbH filed Critical Steag Microparts GmbH
Priority to DE10344229A priority Critical patent/DE10344229A1/de
Priority to EP04021864.6A priority patent/EP1518604B1/de
Priority to US10/948,792 priority patent/US20050093087A1/en
Priority to JP2004278569A priority patent/JP2005096866A/ja
Priority to CN200410011713.4A priority patent/CN100467128C/zh
Publication of DE10344229A1 publication Critical patent/DE10344229A1/de
Priority to US12/292,029 priority patent/US7964161B2/en
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/003—Valves for single use only
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Closures For Containers (AREA)
DE10344229A 2003-09-24 2003-09-24 Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit Ceased DE10344229A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE10344229A DE10344229A1 (de) 2003-09-24 2003-09-24 Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit
EP04021864.6A EP1518604B1 (de) 2003-09-24 2004-09-15 Mikrostrukturierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit
US10/948,792 US20050093087A1 (en) 2003-09-24 2004-09-24 Microstructured device for removable storage of small amounts of liquid and a process for removal of the liquid stored in this device
JP2004278569A JP2005096866A (ja) 2003-09-24 2004-09-24 少量の液体を取出し可能に貯留するための微細構造装置および該装置に貯留された液体の取出し方法
CN200410011713.4A CN100467128C (zh) 2003-09-24 2004-09-24 用于可取出地存储微量液体的微结构装置和用于取出存储在该装置中的液体的方法
US12/292,029 US7964161B2 (en) 2003-09-24 2008-11-10 Microstructured device for removable storage of small amounts of liquid and a process for removal of liquid stored in this device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10344229A DE10344229A1 (de) 2003-09-24 2003-09-24 Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit

Publications (1)

Publication Number Publication Date
DE10344229A1 true DE10344229A1 (de) 2005-05-19

Family

ID=34177921

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10344229A Ceased DE10344229A1 (de) 2003-09-24 2003-09-24 Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit

Country Status (5)

Country Link
US (2) US20050093087A1 (cg-RX-API-DMAC7.html)
EP (1) EP1518604B1 (cg-RX-API-DMAC7.html)
JP (1) JP2005096866A (cg-RX-API-DMAC7.html)
CN (1) CN100467128C (cg-RX-API-DMAC7.html)
DE (1) DE10344229A1 (cg-RX-API-DMAC7.html)

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DE102008005686A1 (de) * 2008-01-23 2009-07-30 Epcos Ag MEMS-Bauelement, Verfahren zur Herstellung eines MEMS-Bauelements und Verfahren zur Handhabung eines MEMS-Bauelements
US9562540B2 (en) 2011-09-29 2017-02-07 Protectlife International Biomedical Inc. Centrifugal rotor

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CN101458249B (zh) * 2007-12-14 2013-09-11 东莞博识生物科技有限公司 一种具有溶液储室兼泵体结构的微流体样品舟
DE102008042196A1 (de) * 2008-09-18 2010-03-25 Robert Bosch Gmbh Verfahren zum Herstellen eines mikrofluidischen Bauelementes sowie mikrofluidisches Bauelement
ATE546226T1 (de) * 2009-11-04 2012-03-15 Boehringer Ingelheim Micropart Verfahren zur aushärtung eines klebstoffs
EP4124856A1 (en) * 2010-03-09 2023-02-01 ANDE Corporation Biochip with valve
US8720036B2 (en) 2010-03-09 2014-05-13 Netbio, Inc. Unitary biochip providing sample-in to results-out processing and methods of manufacture
DE102011004125A1 (de) * 2011-02-15 2012-08-16 Robert Bosch Gmbh Vorrichtung zur hermetisch abgeschlossenen Bevorratung von Flüssigkeiten für ein mikrofluidisches System
EP2683483B1 (en) 2011-03-09 2021-08-18 Pixcell Medical Technologies Ltd. Disposable cartridge for preparing a sample fluid containing cells for analysis
WO2012174204A2 (en) 2011-06-17 2012-12-20 Fiberweb, Inc. Vapor permeable, substantially water impermeable multilayer article
US10369769B2 (en) 2011-06-23 2019-08-06 Fiberweb, Inc. Vapor-permeable, substantially water-impermeable multilayer article
EP2723568B1 (en) 2011-06-23 2017-09-27 Fiberweb, LLC Vapor permeable, substantially water impermeable multilayer article
US9765459B2 (en) 2011-06-24 2017-09-19 Fiberweb, Llc Vapor-permeable, substantially water-impermeable multilayer article
US8470153B2 (en) * 2011-07-22 2013-06-25 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
US9435765B2 (en) 2011-07-22 2016-09-06 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
US9857332B2 (en) 2011-07-22 2018-01-02 Tecan Trading Ag System for manipulating samples in liquid droplets
US9221053B2 (en) * 2011-09-20 2015-12-29 Fujibo Holdings, Inc. Reagent container
CN104994955B (zh) * 2013-01-09 2017-09-26 泰肯贸易股份公司 用于操纵液滴中的样品的系统
WO2014108184A1 (en) * 2013-01-09 2014-07-17 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
CN105992648B (zh) * 2013-05-31 2019-04-26 彼克斯赛尔医疗科技有限公司 用于制备含有用于分析的细胞的样品流体的盒
DE102013106353B4 (de) * 2013-06-18 2018-06-28 Tdk Corporation Verfahren zum Aufbringen einer strukturierten Beschichtung auf ein Bauelement
JP6192731B2 (ja) * 2013-09-30 2017-09-06 株式会社日立製作所 試薬保持容器、送液装置
US9795968B2 (en) * 2014-04-21 2017-10-24 Lawrence Livermore National Security, LLCq Multi-chamber nucleic acid amplification and detection device
JP5788562B1 (ja) * 2014-05-01 2015-09-30 株式会社タスコ 宝石
EP4115978A1 (en) 2015-01-14 2023-01-11 Pixcell Medical Technologies Ltd. Disposable cartridge for sample fluid analysis
JP6937686B2 (ja) * 2015-04-30 2021-09-22 シスメックス株式会社 液体封止カートリッジ、検体分析装置、および、検体分析方法
US20190240655A1 (en) * 2016-09-14 2019-08-08 Sekisui Chemical Co., Ltd. Microchip
JP6421159B2 (ja) 2016-10-28 2018-11-07 シスメックス株式会社 液体封止カートリッジおよび送液方法
DE102017210459B4 (de) * 2017-06-22 2026-07-30 Robert Bosch Gmbh Mikromechanische Vorrichtung mit einer ersten Kaverne und einer zweiten Kaverne
US11975321B2 (en) 2018-03-27 2024-05-07 Lawrence Livermore National Security, Llc Multi-channel optical detection system and method for multi-chamber assays
WO2020053111A1 (en) 2018-09-11 2020-03-19 F. Hoffmann-La Roche Ag Cartridge with liquid pack
JP2020125915A (ja) * 2019-02-01 2020-08-20 株式会社エンプラス 流体取扱システムおよびカートリッジ
JP7445403B2 (ja) * 2019-09-27 2024-03-07 シスメックス株式会社 液体封止カートリッジおよび送液方法

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US3825410A (en) * 1970-05-13 1974-07-23 K Bagshawe Performance of routine chemical reactions in compartmentalized containers
US3704206A (en) * 1971-02-25 1972-11-28 Miles Lab Device for the detection of bacteria in aqueous fluids
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DE10137561A1 (de) 2001-08-01 2003-02-13 Christian Hoernicke Gelenkstreifen zur Verbindung zweier schrittweise gegeneinander zu verdrehenden Gegenstände

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008005686A1 (de) * 2008-01-23 2009-07-30 Epcos Ag MEMS-Bauelement, Verfahren zur Herstellung eines MEMS-Bauelements und Verfahren zur Handhabung eines MEMS-Bauelements
US8674464B2 (en) 2008-01-23 2014-03-18 Epcos Ag MEMS component, method for producing a MEMS component, and method for handling a MEMS component
DE102008005686B4 (de) * 2008-01-23 2019-01-31 Tdk Corporation MEMS-Bauelement und Verfahren zur Herstellung eines MEMS-Bauelements
DE102008005686B9 (de) * 2008-01-23 2019-06-27 Tdk Corporation MEMS-Bauelement und Verfahren zur Herstellung eines MEMS-Bauelements
US9562540B2 (en) 2011-09-29 2017-02-07 Protectlife International Biomedical Inc. Centrifugal rotor
DE112011105686B4 (de) * 2011-09-29 2017-05-11 Protectlife International Biomedical Inc. Zentrifugenrotor

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US7964161B2 (en) 2011-06-21
US20090074626A1 (en) 2009-03-19
CN100467128C (zh) 2009-03-11
EP1518604A3 (de) 2009-07-01
US20050093087A1 (en) 2005-05-05
EP1518604B1 (de) 2018-06-13
EP1518604A2 (de) 2005-03-30
CN1608735A (zh) 2005-04-27

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