DE10333935A1 - Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel - Google Patents

Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel Download PDF

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Publication number
DE10333935A1
DE10333935A1 DE10333935A DE10333935A DE10333935A1 DE 10333935 A1 DE10333935 A1 DE 10333935A1 DE 10333935 A DE10333935 A DE 10333935A DE 10333935 A DE10333935 A DE 10333935A DE 10333935 A1 DE10333935 A1 DE 10333935A1
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DE
Germany
Prior art keywords
alkyl
aryl
alkylene
heterocycle
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10333935A
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German (de)
English (en)
Inventor
Holger Wagner
Karl Dr. Schoenafinger
Gerhard Dr. Jaehne
Holger Gaul
Christian Dr. Buning
Georg Dr. Tschank
Ulrich Dr. Werner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE10333935A priority Critical patent/DE10333935A1/de
Priority to PE2004000665A priority patent/PE20050249A1/es
Priority to EP04740985A priority patent/EP1651653B1/de
Priority to CA002534267A priority patent/CA2534267A1/en
Priority to JP2006520735A priority patent/JP4711959B2/ja
Priority to BRPI0412900-8A priority patent/BRPI0412900A/pt
Priority to MXPA06000634A priority patent/MXPA06000634A/es
Priority to CA002533672A priority patent/CA2533672A1/en
Priority to BRPI0412920-2A priority patent/BRPI0412920A/pt
Priority to JP2006520734A priority patent/JP2006528601A/ja
Priority to AU2004261366A priority patent/AU2004261366A1/en
Priority to AU2004261364A priority patent/AU2004261364A1/en
Priority to PCT/EP2004/007761 priority patent/WO2005012308A1/de
Priority to AT04740985T priority patent/ATE534650T1/de
Priority to EP04740981A priority patent/EP1651649B1/de
Priority to PCT/EP2004/007767 priority patent/WO2005012312A1/de
Priority to AT04740981T priority patent/ATE490256T1/de
Priority to DE502004011957T priority patent/DE502004011957D1/de
Priority to MXPA06000635A priority patent/MXPA06000635A/es
Priority to TW093121831A priority patent/TW200524944A/zh
Priority to TW093121832A priority patent/TW200524936A/zh
Priority to ARP040102609A priority patent/AR045080A1/es
Priority to PE2004000714A priority patent/PE20050255A1/es
Priority to US10/898,752 priority patent/US7094800B2/en
Priority to US10/898,751 priority patent/US7008957B2/en
Publication of DE10333935A1 publication Critical patent/DE10333935A1/de
Priority to IL173204A priority patent/IL173204A0/en
Priority to IL173203A priority patent/IL173203A0/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE10333935A 2003-07-25 2003-07-25 Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel Withdrawn DE10333935A1 (de)

Priority Applications (27)

Application Number Priority Date Filing Date Title
DE10333935A DE10333935A1 (de) 2003-07-25 2003-07-25 Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PE2004000665A PE20050249A1 (es) 2003-07-25 2004-07-13 Nuevas cianopirrolididas y procedimiento para su preparacion como medicamentos
AT04740985T ATE534650T1 (de) 2003-07-25 2004-07-14 Neue cyanothiazolide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
PCT/EP2004/007767 WO2005012312A1 (de) 2003-07-25 2004-07-14 Neue cyanothiazolide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2006520735A JP4711959B2 (ja) 2003-07-25 2004-07-14 新規なシアノチアゾリド、その製造方法、及びその薬剤としての使用
BRPI0412900-8A BRPI0412900A (pt) 2003-07-25 2004-07-14 cianopirrolididas, processo para a sua preparação e seu emprego como medicamento
MXPA06000634A MXPA06000634A (es) 2003-07-25 2004-07-14 Nuevas cianopirrolididas, metodos para su produccion y uso de las mismas como medicamentos.
CA002533672A CA2533672A1 (en) 2003-07-25 2004-07-14 Novel cyano thiazolides, methods for the production thereof, and use thereof as a medicament
BRPI0412920-2A BRPI0412920A (pt) 2003-07-25 2004-07-14 novas cianotiazolidas, processo para a sua preparação e seu emprego como medicamento
JP2006520734A JP2006528601A (ja) 2003-07-25 2004-07-14 新規なシアノピロリジド、その製造方法および薬剤としてのその使用
AU2004261366A AU2004261366A1 (en) 2003-07-25 2004-07-14 Novel cyano thiazolides, methods for the production thereof, and use thereof as a medicament
AU2004261364A AU2004261364A1 (en) 2003-07-25 2004-07-14 Novel cyanopyrrolidides, methods for the production thereof, and use of the same as medicaments
PCT/EP2004/007761 WO2005012308A1 (de) 2003-07-25 2004-07-14 Neue cyanopyrrolidide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP04740985A EP1651653B1 (de) 2003-07-25 2004-07-14 Neue cyanothiazolide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP04740981A EP1651649B1 (de) 2003-07-25 2004-07-14 Neue cyanopyrrolidide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA002534267A CA2534267A1 (en) 2003-07-25 2004-07-14 Novel cyanopyrrolidides, methods for the production thereof, and use of the same as medicaments
AT04740981T ATE490256T1 (de) 2003-07-25 2004-07-14 Neue cyanopyrrolidide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE502004011957T DE502004011957D1 (de) 2003-07-25 2004-07-14 Neue cyanopyrrolidide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
MXPA06000635A MXPA06000635A (es) 2003-07-25 2004-07-14 Nuevas cianotiazolidas, metodos para su produccion y uso de las mismas como un medicamento.
TW093121831A TW200524944A (en) 2003-07-25 2004-07-22 Novel cyanothiazolides, process for their preparation and their use as medicaments
TW093121832A TW200524936A (en) 2003-07-25 2004-07-22 Novel cyanopyrrolidides, process for their preparation and their use as medicaments
ARP040102609A AR045080A1 (es) 2003-07-25 2004-07-22 Compuestos de cianopirrolididas, procedimiento para su preparacion y su uso como medicamentos
PE2004000714A PE20050255A1 (es) 2003-07-25 2004-07-23 Nuevas cianotiazolidas y procedimiento para su preparacion como medicamentos
US10/898,752 US7094800B2 (en) 2003-07-25 2004-07-26 Cyanopyrrolidides, process for their preparation and their use as medicaments
US10/898,751 US7008957B2 (en) 2003-07-25 2004-07-26 Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments
IL173204A IL173204A0 (en) 2003-07-25 2006-01-17 Novel cyanopyrrolidides, methods for the production thereof, and use of the same as medicaments
IL173203A IL173203A0 (en) 2003-07-25 2006-01-17 Novel cyano thiazolides, methods for the production thereof, and use thereof as a medicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10333935A DE10333935A1 (de) 2003-07-25 2003-07-25 Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
DE10333935A1 true DE10333935A1 (de) 2005-02-24

Family

ID=34088830

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10333935A Withdrawn DE10333935A1 (de) 2003-07-25 2003-07-25 Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Country Status (12)

Country Link
EP (1) EP1651653B1 (https=)
JP (1) JP4711959B2 (https=)
AT (1) ATE534650T1 (https=)
AU (1) AU2004261366A1 (https=)
BR (1) BRPI0412920A (https=)
CA (1) CA2533672A1 (https=)
DE (1) DE10333935A1 (https=)
IL (1) IL173203A0 (https=)
MX (1) MXPA06000635A (https=)
PE (1) PE20050255A1 (https=)
TW (1) TW200524944A (https=)
WO (1) WO2005012312A1 (https=)

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EP2116235A1 (en) 2005-01-10 2009-11-11 Arena Pharmaceuticals, Inc. Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
US7816364B2 (en) 2006-04-11 2010-10-19 Arena Pharmaceuticals, Inc. GRP119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto
US7833730B2 (en) 2006-04-11 2010-11-16 Arena Pharmaceuticals, Inc. Methods of using GPR119 to identify compounds useful for increasing bone mass in an individual
US7838254B2 (en) 2008-04-07 2010-11-23 Arena Pharmaceuticals, Inc. Methods of using GPR119 to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
WO2011005929A1 (en) 2009-07-09 2011-01-13 Arena Pharmaceuticals, Inc. Piperidine derivative and its use for the treatment of diabets and obesity
WO2011127051A1 (en) 2010-04-06 2011-10-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012040279A1 (en) 2010-09-22 2012-03-29 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012135570A1 (en) 2011-04-01 2012-10-04 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145361A1 (en) 2011-04-19 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
US10555929B2 (en) 2015-03-09 2020-02-11 Coherus Biosciences, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
US11253508B2 (en) 2017-04-03 2022-02-22 Coherus Biosciences, Inc. PPARy agonist for treatment of progressive supranuclear palsy

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GB0526291D0 (en) 2005-12-23 2006-02-01 Prosidion Ltd Therapeutic method
EP2061767B1 (de) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
DE102007005045B4 (de) 2007-01-26 2008-12-18 Sanofi-Aventis Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
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WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
KR20120060207A (ko) 2009-08-26 2012-06-11 사노피 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
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US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
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IL173203A0 (en) 2006-06-11
JP2006528602A (ja) 2006-12-21
WO2005012312A1 (de) 2005-02-10
BRPI0412920A (pt) 2006-09-26
JP4711959B2 (ja) 2011-06-29
AU2004261366A1 (en) 2005-02-10
EP1651653A1 (de) 2006-05-03
EP1651653B1 (de) 2011-11-23
CA2533672A1 (en) 2005-02-10

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