DE102012024435A1 - Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren - Google Patents

Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren Download PDF

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DE102012024435A1
DE102012024435A1 DE102012024435.5A DE102012024435A DE102012024435A1 DE 102012024435 A1 DE102012024435 A1 DE 102012024435A1 DE 102012024435 A DE102012024435 A DE 102012024435A DE 102012024435 A1 DE102012024435 A1 DE 102012024435A1
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cell
metabolite
dna
seq
gene
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Stephan Binder
Lothar Eggeling
Michael Bott
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Forschungszentrum Juelich GmbH
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Forschungszentrum Juelich GmbH
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Priority to DE102012024435.5A priority Critical patent/DE102012024435A1/de
Priority to JP2015546847A priority patent/JP6609475B2/ja
Priority to HUE13821429A priority patent/HUE037001T2/hu
Priority to US14/651,502 priority patent/US20160298094A1/en
Priority to DK13821429.1T priority patent/DK2931918T5/en
Priority to EP13821429.1A priority patent/EP2931918B1/fr
Priority to CN201380065322.8A priority patent/CN104838016B/zh
Priority to PCT/DE2013/000683 priority patent/WO2014090208A2/fr
Priority to ES13821429.1T priority patent/ES2643014T3/es
Publication of DE102012024435A1 publication Critical patent/DE102012024435A1/de
Priority to JP2019142159A priority patent/JP2019205460A/ja
Withdrawn legal-status Critical Current

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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DE102012024435.5A 2012-12-14 2012-12-14 Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren Withdrawn DE102012024435A1 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DE102012024435.5A DE102012024435A1 (de) 2012-12-14 2012-12-14 Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren
EP13821429.1A EP2931918B1 (fr) 2012-12-14 2013-11-15 Procédé d'identification d'une cellule présentant, comparativement à son type sauvage, une concentration intracellulaire augmentée d'un métabolite déterminé, la modification de la cellule s'effectuant par recombinaison, un procédé pour produire une cellule de production d'un métabolite déterminé, génétiquement modifiée comparativement à son type sauvage, ladite cellule étant à production optimisée, un procédé pour produire ledit métabolite ainsi que des acides nucléiques requis à cet effet
HUE13821429A HUE037001T2 (hu) 2012-12-14 2013-11-15 Eljárás egy adott metabolitot a megfelelõ vad típushoz képest megnövelt koncentrációban tartalmazó sejt azonosítására, ahol a sejt rekombináns mérnökség (rekombineering) révén van módosítva; eljárás egy adott metabolit optimális termelésével bíró, genetikailag módosított sejt elõállítására; eljárás az említett metabolit és a megfelelõ nukleinsavak elõállítására
US14/651,502 US20160298094A1 (en) 2012-12-14 2013-11-15 Method of identifying a cell with an intracellular concentration of a specific metabolite, which intracellular concentration is increased in comparison with the cell's wildtype, where the modification of the cell is achieved by recombineering
DK13821429.1T DK2931918T5 (en) 2012-12-14 2013-11-15 PROCEDURE FOR IDENTIFYING A CELL WITH INCREASED CONCENTRATION OF A PARTICULAR METABOLIT COMPARED TO THE SIMILAR WILD TYPE CELL .....
JP2015546847A JP6609475B2 (ja) 2012-12-14 2013-11-15 特定の代謝物の細胞内濃度がその野生型に比べて増加した細胞の同定方法であって、細胞の改変が組み換え操作によって達成される同定方法、ならびに特定の代謝物を最適に産生する、その野生型に比べて遺伝的に改変された産生細胞の製造方法、この代謝物の製造方法、およびそれに適した核酸
CN201380065322.8A CN104838016B (zh) 2012-12-14 2013-11-15 用于识别相对于其野生型具有提高的特定代谢物细胞内浓度的细胞的方法
PCT/DE2013/000683 WO2014090208A2 (fr) 2012-12-14 2013-11-15 Procédé d'identification d'une cellule présentant, comparativement à son type sauvage, une concentration intracellulaire augmentée d'un métabolite déterminé, la modification de la cellule s'effectuant par recombinaison, un procédé pour produire une cellule de production d'un métabolite déterminé, génétiquement modifiée comparativement à son type sauvage, ladite cellule étant à production optimisée, un procédé pour produire ledit métabolite ainsi que des acides nucléiques requis à cet effet
ES13821429.1T ES2643014T3 (es) 2012-12-14 2013-11-15 Procedimiento para la identificación de una célula con una concentración intracelular, aumentada en comparación con la de su tipo salvaje, de un determinado metabolito, consiguiéndose por recombinación la modificación de la célula, así como un procedimiento para la producción de una célula productora modificada genéticamente con respecto a su tipo salvaje, con producción optimizada de un determinado metabolito, un procedimiento para la preparación de este metabolito, así como ácidos nucleicos apropiados para ello
JP2019142159A JP2019205460A (ja) 2012-12-14 2019-08-01 特定の代謝物の細胞内濃度がその野生型に比べて増加した細胞の同定方法であって、細胞の改変が組み換え操作によって達成される同定方法、ならびに特定の代謝物を最適に産生する、その野生型に比べて遺伝的に改変された産生細胞の製造方法、この代謝物の製造方法、およびそれに適した核酸

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102012024435.5A DE102012024435A1 (de) 2012-12-14 2012-12-14 Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren

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DE102012024435.5A Withdrawn DE102012024435A1 (de) 2012-12-14 2012-12-14 Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren

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US (1) US20160298094A1 (fr)
EP (1) EP2931918B1 (fr)
JP (2) JP6609475B2 (fr)
CN (1) CN104838016B (fr)
DE (1) DE102012024435A1 (fr)
DK (1) DK2931918T5 (fr)
ES (1) ES2643014T3 (fr)
HU (1) HUE037001T2 (fr)
WO (1) WO2014090208A2 (fr)

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KR102175608B1 (ko) 2016-04-20 2020-11-06 콘비다 와이어리스, 엘엘씨 구성가능한 기준 신호들
JP6837492B2 (ja) 2016-04-20 2021-03-03 コンヴィーダ ワイヤレス， エルエルシー 新しい無線における物理チャネル
KR102106581B1 (ko) 2016-04-20 2020-05-04 콘비다 와이어리스, 엘엘씨 시스템 정보 프로비저닝 및 경량 접속 시그널링
US10524244B2 (en) 2016-05-11 2019-12-31 Convida Wireless, Llc Radio PDCCH to facilitate numerology operations
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JP6703145B2 (ja) 2016-06-15 2020-06-03 コンヴィーダ ワイヤレス， エルエルシー 許可不要動作
CN109644089B (zh) 2016-06-15 2022-04-26 康维达无线有限责任公司 用于新无线电的无许可上行链路传输
KR20240006080A (ko) 2016-08-11 2024-01-12 인터디지탈 패튼 홀딩스, 인크 뉴 라디오를 위한 유연한 프레임 구조에서의 빔포밍 스위핑 및 트레이닝
CN109891772B (zh) 2016-11-03 2022-10-04 康维达无线有限责任公司 Nr中的帧结构
KR20210066856A (ko) 2018-09-27 2021-06-07 콘비다 와이어리스, 엘엘씨 새로운 라디오의 비허가 스펙트럼들에서의 부대역 동작들

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