DE102010004478A1 - New technologies for use in wound dressings with superabsorbent polymers - Google Patents

Abstract

The present invention relates to a wound dressing, the use of such a dressing and a manufacturing method for such a dressing

Description

The present patent application relates to new technologies for use in wound dressings with superabsorbent polymers

1. Use of new materials and material mixtures

1.1. Superabsorbent fibers

Superabsorbent fibers are fibers made of superabsorbent polymers, for example polyarcylates. Particular preference is given to using fibers or fiber composites from the company Technical Absorbents Ltd, which are marketed under the brand name OASIS SAF.

SAF are white, odorless, have the look and characteristics of a textile fiber, and can be made in the form of various fabrics and nonwovens / veins. As a fibrous superabsorbent, SAF are easy to use and allow uniform distribution profiles within a fabric. It can be produced in different degrees of absorption and subtleties. Compared to conventional superabsorbent fibers of polyacrylates, SAF are less brittle and brittle, and are therefore ideal for forming fabrics and nonwovens.

Preference is given to the use of a nonwoven fabric from said SAF. In turn, it is preferably provided that the SAFs are not present in a three-dimensional random array (as is generally the case with nonwovens), but are oriented two-dimensionally (ie distributed only in one plane) or completely one-dimensionally aligned (i.e. all fibers point in the same direction).

Basically, techniques for using superabsorbent fibers are also in the art DE 10 2007 049 429 the assignee of the present application. The content of this document is added by reference to the disclosure of the present specification. In this case, it may be necessary for the edges of a suitably equipped wound dressing to be laminated in order to prevent the fibers from escaping (see 2 ). Wounds with said SAF preferably have an SAF content of about 25% by weight.

1.2. Mixtures of superabsorbent polymers

Preferably, it should be provided to use specific mixtures of superabsorbent polymers. The aim here is to provide for each type of exudate and / or wound the exactly matching type of superabsorbent.

In the various types of exudates, especially blood, exudate, plasma, lymph and pus are intended. For the various types of wounds, burn wounds, leg ulcers, bedsores, chronically inflamed wounds, etc. are especially important. Polyacrylates are polymeric esters of acrylic acid and of acrylic acid derivatives with alcohols. The preparation takes place via free-radical polymerization in aqueous solutions, emulsions (emulsion polymerization) or by bulk polymerization

The variation of the polyacrylates can be carried out in particular by controlling the degree of polymerization and by targeted control of the neutralization (pre- or post-neutralized, fully or partially neutralized). In this way, on the one hand, the absorption capacity of the SAP particles as a whole can be influenced, or it is achieved a layering of different absorption capabilities.

Furthermore, it may be provided here that the wound dressing in question or the at least one absorbent inner layer has a weight per unit area of between 500 and 6000 g / m ² , wherein the proportion of superabsorbent polymers may be between 30 and 90% by weight. thickness grammage 2 mm 500g / m ² 5 mm 480 g / m ² 5 mm 800 g / m ²

In particular, mixtures of superabsorbent fibers and granules may be provided. It can be z. B. be provided that the latter are less absorbent and the latter equipped more absorbent.

1.3. Luquafleece

The term Luquafleece hides a superabsorbent nonwoven material consisting of a superabsorbent polymers treated polyester nonwoven, which can be used for active moisture regulation. Above all, Luquafleece is characterized by an outstanding absorption capacity of aqueous solutions and water vapor.

Luquafleece consists of a polyester nonwoven treated with polyacrylic acid superabsorbents. The Luquafleece technology is characterized by a strong immobilization of the superabsorbent on the fiber, whereby high loadings of superabsorbent polymers and good abrasion properties can be achieved.

The mode of action of Luquafleece is based on a reversible mechanism. Thus, the performance is also fully maintained over a longer period of use. Therefore, Luquafleece is also suitable for multiple use.

For use in wound dressings Luquafleece has a number of excellent properties that have been recognized by the inventors here for the first time.

1.4. aerogels

Aerogels are highly porous solids in which up to 95% of the volume consists of pores. There are several types of aerogels, with silicate-based ones being the most common. Other forms, such as plastic or carbon based, may be of importance for specialty applications. In principle, one can use any metal oxide, polymer and various other substances as a starting point for the airgel synthesis by means of a sol-gel process.

Especially due to their low specific gravity aerogels are interesting for wound dressings. The inventors have recognized this advantage for the first time.

1.5. Intra-crosslinked cellulose fibers

Crosslinked cellulose fibers prove particularly bulky in the wetted state; they retain a large pore volume required for rapid uptake of fluid and are not prone to "wet collapse", therefore they are often used as body-facing fluid containment and distribution layers in sanitary article absorbent structures.

1.6. Industrial superabsorbents

For the wound and hygiene industry, very few superabsorbent types have been used so far, namely predominantly sodium polyacrylates. But there are a variety of other superabsorbents, which are hitherto used only for industrial applications, such. For example, from BASF the products LUQUASORB (for example types 1161, 1280, B1110, FP 800, P 1480) and Medi-Gel, or from Stockhausen the products STOCKOSORB, CABLOC, FAVOR-PAC and Firesorb / Firecape.

The following table gives documents describing industrial superabsorbers; its content should be considered as belonging to the disclosure content of the present patent application. document number Subject DE 10 2006 019 400 A1 Colored superabsorbents DE 10 2005 021 221 A1 Superabsorber with inorganic and organic ballast and additives DE 10 2005 010 198 A1 Hydrolysis stable, post-crosslinked superabsorbent DE 694 24 947 T2 Absorbent structure of superabsorbent, staple and binding fibers DE 199 14 067 C1 Oxidized starch, production, use, in particular as a superabsorbent DE 196 46 856 A1 Preformed superabsorbents with high swelling capacity DE 199 05 947 B4 Production of superabsorbents, superabsorbents and their use DE 198 05 447 A1 Modified superabsorbents based on polyacrylonitrile emulsions DE 197 16 657 A1 Superabsorber with controlled absorption speed DE 42 07 465 A1 Superabsorbent (SAP superabsorbent polymer) with significantly improved biodegradability over the prior art DE 10 2006 019 157 Highly permeable superabsorbers DE 101 25 599 A1 Superabsorbents, process for their preparation and their use DE 100 19 757 Production of SAP by alkaline hydrolysis DE 60 2004 005 830 Production of SAP, which has a high capillary suction and at the same time a high liquid permeability DE 60 2004 009 484 Production of SAP using intermittent light irradiation US 7615579 Superabsorbent polymer having increased rate of water absorption (by Evonik Stockhausen, Inc., Greensboro, NC) US 7588777 Surface cross-linked superabsorbent polymer particles and methods of making them US 7579402 Superabsorbent polymer having delayed free water absorption US 7588822 Absorbent articles surface cross-linked superabsorbent polymer particles made by a method of using ultraviolet radiation and bronsted acids DE 20 2005 020 566 Superabsorbents, nanofiber nonwovens and their use DE 101 60 097 New modified poly-2-oxazolines, their preparation and their use DE 40 20 780 C1 DE 26 12 846 DE 28 40 010 DE 27 06 135 EP 205674 A1 US 4340706 US 4286082 DE 202 21 830 U1 Geohumus (use: as a soil conditioner DE 10 2005 021 221 A1 Geohumus

2. New types of connection for vertical bonding

In order to reliably connect the various layers of an airlaid, a nonwoven or a wound dressing containing an airlaid or a nonwoven, various bonding techniques can be used.

2.1. Latex bonded airlaid (LBAL / BBAL)

Here, an adhesive adhesive is used, preferably a latex dispersion, to ensure the vertical cohesion. It is important in this case that said adhesion adhesive is physiologically acceptable, d. H. he must have a low allergenicity or toxicity. Alternatives to latex are z. As a hydrocolloid adhesive, a starch or protein adhesive or the like. Likewise suitable are EVA or PVC-based adhesives. These variants continue to fall under the term "LBAL".

Examples of suitable hydrocolloid adhesives include carboxyalkylated celluloses (for example carboxymethylcellulose), pectins or gelatin, but also mixtures comprising butyl esters of PVM / MA copolymer, ethyl alcohol, gelatin, pectin, polyacrylamides, polysorbates 20, silica, n-butyl alcohol, Allantoin, Butylparaben, Methylparaben, as z. B. be used in the product Adapt by Hollister. It is important that said hydrocolloids in themselves already have wound-healing properties and therefore can play a dual role.

When spraying the said dispersion adhesive and other agents can be introduced, for. B. nutritive, disinfecting or decontaminating and / or proteases inhibitory agents and / or active ingredient complexes. Such compositions are for example in the WO 2009003991 described as belonging to the disclosure of the present application as belonging.

2.2. Thermal bonded airlaid (TBAL)

This is a nonwoven consisting of natural and often synthetic fibers (such as PE or PP), which are thermally bonded together (hotmelt principle).

2.3. Multi-bonded grades (MBAL)

This is a hybrid system consisting of a mixture of synthetic fibers and cellulose fluff-pule.

2.4. Hydrogen bonded airlaid or x-bonded airlaid (HBAL / XBAL)

In this variant, the vertical cohesion is formed by hydrogen bonds formed between the individual cellulose fibers of the airlaid / nonwoven. For this purpose, for example, with a calender, which has an embossing, embossed under high pressure and possibly temperature and / or Wasserdampfbeaufschlagung embossed pattern in a web consisting of an airlaid / nonwoven.

2.5. Textile process

Furthermore, it can be provided that the various layers of the wound care article are connected to each other by a textile connection method using at least one yarn or thread. In the textile connection method, it may zs. B. stitching or quilting, missed, point sewing, plugs, tufts, and / or hole embroidery act. Basically, techniques for the textile processing of wound dressings are also in the DE 10 2009 038 388 the assignee of the present application. The content of this document is added by reference to the disclosure of the present specification.

2.6. new arrangement of the bonding points

It can be provided that the bonding points are arranged predominantly in the periphery of the wound dressing, specifically in such a way that they primarily serve to immobilize the SAP particles. It is sufficient that they are produced with relatively low pressure (> 200 mPa). Also possible are perforation points (small openings whose edges are compressed by applying pressure and temperature are). Moreover, a few bonding points and / or linear or wave-shaped embossings can be arranged in the interior region of the wound dressing. Likewise, punching, ie material interruptions, are possible, preferably those whose edges are compacted.

The calender rolls used to make these mats can be designed to have multiple raster patterns lying side-by-side across the roll width that are the same (eg for uniformly sized wound dressings) or different (for different sized dressings). The web leaving the calender roll pair then enters a roll cutting and winding machine where it is cut into individual strips. Each strip can therefore only have a specific, repeating pattern. The bobbins (with the strip of material) are removed from the machine by means of a lifting device and fed to a known cutting or punching device. For example, only one calender roller pair could be sufficient for the entire mat program, unless the production capacity is to be increased.

3. New fleeces and intermediate layers

3.1. Spunlace (hydro entanglement)

Spunlaces are also referred to as "hydroentangled webs" ("waterjet needling"). This process has recently gained significantly in importance, since the developments in the field of water jet needling also benefit the airlaid products. Reduced energy consumption per kg of raw material used, reduction of material losses, reduction of the amount of water consumed by optimized filter systems and the reliability as well as minimal maintenance of the systems are decisive for the application of water needling for Airlaid products.

Particularly noteworthy is the almost ideal possibility to produce products from different raw materials to so-called composites with the water needling. The individual layers are assigned certain properties such as moisture absorption, moisture barrier, strength or softness. Nonwovens, which are produced by the spunlace process, offer, as already mentioned, compared to pure airlaid nonwovens an optimally matched to the required properties product at the same time low raw material costs.

3.2. Airlace

This is a combination of airlaid and spunlace process. Other such combinations include spunlaid, spun jet, jet las and airjet techniques.

3.3. Luquafleece

This material is already described above.

4. Novel layer structures

4.1. distribution layers

It can be provided that the wound dressing according to the invention has specific distribution layers. These have the task of distributing liquid, which contacts the wound dressing in a locally limited area, vertically and / or horizontally over the wound dressing.

Such distribution layers preferably contain highly conductive fibers, such as. B. mercerized cotton fibers, which are also preferably arranged directionally to specify a direction of conduction. On the one hand, it can be provided that the preferred direction of conduction is in the horizontal plane (that is to say the fastest possible distribution of absorbed liquid conduction in the surface) or in the vertical direction (ie the fastest possible transfer of absorbed liquid to deeper layers).

Basically, techniques for using distribution layers are also in the DE 10 2008 045 833 the assignee of the present application. The content of this document is added by reference to the disclosure of the present specification.

Preferred materials are for. For example, the materials Luna Wave and Luna Core from SCA, which have particularly good liquid-conducting properties.

Furthermore, the liquid inlet and thus the distribution of the liquid can be considerably facilitated by vertical perforations. See also 6 , The said perforations can z. B. be carried out with the aid of a thermal punch, so that the surface of the respective layer in the region of the perforations is smooth. Moreover, in the area around the perforations, a lower SAP content may be provided than elsewhere (for example, only 4-8% by weight) in order to accelerate the initial fluid intake.

In principle, different layers of the wound dressing can also be slit.

4.2. network layers

Furthermore, it can be provided that mesh layers which are similar, for example, to the known wound spacer meshes are provided. Such nets may for example serve as stabilizing backbones, but also be impregnated with certain substances or contain them in microencapsulated form.

4.3. Layers with microencapsulated fabrics

It may be provided to provide layers with Mikroenkapuliserungen. These microencapsulations consist for example of thermo-enzyme-or moisture-degradable materials, such as. As wax, starch, cellulose or the like, and release their contents after a certain action (body heat, Exsudateinwirkung) (release processes). Ingredients can z. B. compositions containing at least one nutritive, at least one disinfecting or decontaminating and / or at least one protease inhibiting active ingredient and / or active ingredient complex. Such compositions are for example in the WO 2009003991 whose content is to be added to the content of this application in full.

On the one hand, it may be provided that said ingredients are mobilized so that they can be delivered to the wound, but on the other hand it can also be provided that they remain in the wound dressing.

4.4. Layer structure of different materials

• • Airlace
• • Airlaid
• • Schichten enthaltend Superabsorbierende Fasern, und/oder
• • Luquafleece

sein. Ferner ist vorgesehen, eine Trennung von Zellulose- und SAP-haltigen Schichten vorzunehmen. So können die Superabsorbierenden Polymere in hoher Dichte auf eine Trägermembran, beispielsweise aus einem sehr dünnen Vlies, aufgebracht sein, wobei dann diese Schicht von einer oder mehreren zellstoffhaltigen Schichten (beispielsweise Airlaid oder Airlace) unter- und/oder überlegt ist. Die besagte Trägermembran kann beispielsweise aus einem Zellulosevlies, einem Polypropylenvlies oder aus einem Hydrokolloid (siehe Punkt 2.1) bestehen (siehe 5) Auf diese Weise wird das Problem der Immobilisierung von superabsorbierenden Polymeren in einer Zellstofflage vermieden, und es kann eine stets trockene Oberfläche erzeugt werden.It is further provided that the wound dressing have novel, previously not described layer structures. This can, for example, layer combinations

• • Airlace
• • Airlaid
• Layers containing superabsorbent fibers, and / or
• • Luquafleece

be. Furthermore, it is provided to carry out a separation of cellulose and SAP-containing layers. Thus, the superabsorbent polymers can be applied in high density to a support membrane, for example of a very thin fleece, in which case this layer is underlaid and / or superimposed by one or more cellulose-containing layers (for example airlaid or Airlace). The said support membrane can for example consist of a cellulose fleece, a polypropylene fleece or a hydrocolloid (see point 2.1) (see 5 In this way, the problem of immobilization of superabsorbent polymers in a pulp layer is avoided, and an always dry surface can be produced.

4.5. New layer combinations

In principle, new layer combinations are conceivable, as shown in the following table: Airlaid mat with SAP Polypropylene sleeve (PP); loose arrangement liner Airlaid mat with SAP topcoat Airlaid mat with SAP Polypropylene sleeve A sleeve wall can be glued or welded to the laundry protection section (laminate) liner Airlaid mat with SAP laundry protection Airlaid mat with SAP Polypropylene sheath; loose arrangement topcoat topcoat Polypropylene sheath; loose arrangement Airlaid mat with SAP topcoat topcoat Cover layer is glued to shell wall Airlaid mat little SAP liner Airlaid mat much SAP Airlaid mat little SAP loose arrangement liner Airlaid mat much SAP Airlaid mat little SAP cascading suction capacity; loose arrangement liner Airlaid mat slightly more SAP liner Airlaid mat much SAP topcoat same suction capacity, but reinforced overall Airlaid mat with little SAP Airlaid mat with little SAP topcoat topcoat loose arrangement Airlaid mat much SAP Airlaid mat little SAP topcoat A shell wall (PP) glued, with the cover layer; others stretchy and waterproof, not glued Airlaid mat with SAP topcoat Airlaid mat little SAP A shell wall (PP) glued to the foam Airlaid mat much SAP Foam layer closed pore

4.6. Layers with punches

It can also be provided that one or more layers have punched holes or other material recesses. On the one hand, they enable rapid absorption of fluid into the absorbent material and, on the other hand, make room available for increasing volume after fluid absorption. In this way, a void at the edges of the liquid-absorbing layer in relation to the shell can be avoided, as it is for example in the WO 03094813 is described. Such an embodiment is in 7 shown; Here, only a very small distance is provided between the shell and the liquid-absorbing mat, which is less than, for example, in the in the WO 03094813 shown absorption body. Therein, the area provided by the shell has 3-75 greater than the area occupied by the liquid-absorbing layer. On the other hand, in the present embodiment, the space required for increasing the volume after taking up liquid is provided by the circular punches.

5. Use of new ingredients

5.1. Heat generating ingredients

The use of heat-generating ingredients, such. B. Combination of iron powder and activated carbon (controlled oxidation process), regenerable gel pad containing sodium acetate (trihydrate) and a metal plate (heat of crystallization) and the like.

Active heat delivery may promote wound healing in many types of wounds, especially chronic non-inflammatory wounds. So far, as far as this problem was even recognized, set only on a thermal insulation. The inventors have now recognized for the first time that an active heat supply here holds a further optimization potential.

5.2. Materials used in chromatography

Here, in particular thought of cation exchanger and / or anion exchanger; but also thought of other selectively binding materials. With the help of these materials, certain components of the exudate can be selectively bound in the wound dressing. For example, viruses, pathogens, pyrogens, endotoxins, certain proteins such as matrix metalloproteases, nucleic acids, inflammatory factors (cytokines) or the like are intended here. The prerequisite for selective bonding is that the constituents in question have a charge.

5.3. Materials for generating a pH gradient

Such materials are particularly useful in connection with the aforementioned chromatography materials. Certain substances change their surface charge depending on the pH. When they undergo a pH gradient in a cation or anion exchanger, they are fixed when a certain pH is reached.

However, such a pH gradient may also have immediate clinical relevance. So it may be useful to present the wound a surface with a certain pH (for example, an acidic pH) to z. For example, to inactivate matrix metalloproteases or to inhibit bacterial growth while in the wound dressing an alkaline pH may be desired for other reasons.

In addition, in this way the absorption capacity of the superabsorbent polymers can be influenced. The latter steadily decreases from pH 8 to pH 13. This is due to the decreasing degree of protonation at high pH values.

5.4. filtration materials

Furthermore, known from laboratory technology filtration materials such. As nitrocellulose can be used. These are capable of retaining certain components of the exudate, either by selective binding or by size exclusion.

5.5. detergents

The use of detergents, such as. SDS or Pluronic can serve different purposes. Thus, detergents have an antiviral effect as they denature viral nucleocapsids. In addition, detergents help immediately in wound cleansing, and also indirectly support the latter by stimulating exudation.

5.6. cobalamins

Further materials are, for example, cobalamins, such as. B. Vitamin B12, optionally in conjunction with at least one oil, such as. Almond oil, peanut oil, sesame oil, olive oil, wheat germ oil, corn oil, diest oil, Soybean oil, sunflower oil, coconut oil, palm kernel oil, cocoa butter, or preferably avocado oil. This combination has a soothing effect on conditions such as atopic dermatitis and psoriasis.

5.7. vitamins

Likewise, the use of other vitamins is provided, such. B. Vitamin C. The latter has an antioxidant effect and thus also serve as a radical scavenger. Other vitamins have comparable effects.

5.8. collagen powder

To support wound granulation and healing, the use of collagen, preferably in the form of powder, can furthermore be provided. In this case, collagen can serve, in particular, as a sacrificial substrate for per se interfering matrix metalloproteases. Said collagen may be of animal or vegetable origin or produced by recombinant means.

5.9. Carboxyalkyl cellulose powder

Carboxyalkylcelluloses, such as. As carboxymethylcellulose (CMC), have gel-forming properties and can therefore bind exudates. They can therefore assist in their action suoperabsorbierende polymers, especially when they are used in powder form.

5.10. betaglucans

Betaglucans, such as. B. (1,3) - (1,6) -β-D-glucan, have wound-healing properties especially in the context of diabetes or Saccharomyces-infected wounds.

11.5. Materials that selectively bind pathogens

Furthermore, the use of materials may be provided which selectively bind pathogens. This is z. B. thought of bacteria, viruses, fungi or protozoa. The purpose of the whole is to enable bioburden management. For this purpose, z. B. inflowing pathogens are immobilized. Possible materials are for this purpose z. B. correspondingly affine antibodies, lectins and / or other suitable materials.

6. softness

Furthermore, it is an important goal to increase the softness of a wound dressing. By "softness" is meant on the one hand the conformability or flexibility of the wound dressing as a whole, and on the other hand the tactile softness of the surface. Softness can be achieved on the one hand by using certain materials, on the other hand by certain processing techniques. On the one hand, it is important to ensure that healthy tissue is spared, but slough and necrosis are removed.

6.1. Materials to increase the softness

The following materials are conceivable here:

LIST OF REFERENCE NUMBERS

1

Superabsorbent fibers (in particular the already discussed SAF by Technical Absorbents)

2

Pulp fluff

3

Foam, preferably PU foam, EVA foam and / or cellulose foam

4

Microfibres and microfiber nonwovens, such as Alcantara

5

Curled Fibers

6

Plastic films with air cushions or bubbles

7

Hollow fibers ("hollow fibers")

8th

fleeces

9

Wool

Furthermore, the use of suitable plasticizers may be provided as z. B. from textile technology are known. Here, for example, thought of triacetin, cationic surfactants or DMP. The said materials can also be used in particular in the abovementioned layer structures.

Another measure to increase the softness is the reduction of specific gravity. Thus, a product with a basis weight of 500 g / m ² with a product thickness of 5 mm has a higher softness (since lower specific gravity) than with a product thickness of 2 mm (since higher specific gravity).

6.2. Processing techniques to increase the softness

Simply dispensing with the frequently used bonding points in the field of airlaids, or even a wider-meshed grid of bonding points, can considerably increase the conformability of a wound dressing.

Furthermore, it can be provided that the various layers of the wound care article are connected to each other by a textile connection method using at least one yarn or thread. In the textile connection method, it may, for. B. stitching or quilting, missed, point sewing, plugs, tufts, and / or hole embroidery act. Basically, techniques for the textile processing of wound dressings are also in the DE 10 2009 038 388 the assignee of the present application. In this way, on the one hand waiving the said bonding points allows, on the other hand can be such. B. produce surfaces with a velvet or a pile. The content of this document is added by reference to the disclosure of the present specification.

7. Dead space technology

• a) Verwendung eines Wundfüllers unter der Wundauflage
• b) konvexe Ausgestaltung der Wundauflage (wie beschrieben in der Patentanmeldung DE 10 2009 038 387 , deren Offenbarungsgehalt der vorliegenden Erfindung vollumfänglich zugeordnet werden soll;
• c) plastische Verformbarkeit der Wundauflage (wie beschrieben in der Patentanmeldung DE 10 2009 038 389 , deren Offenbarungsgehalt der vorliegenden Erfindung vollumfänglich zugeordnet werden soll;
• d) Anschmiegsamkeit der Wundauflage dergestalt, dass sie sich eng an den Wundboden anschmiegen läßt und dabei das Wundrelief abbildet.

Said term describes the approach that a wound dressing should be as close as possible to the wound floor. This can be done by

• a) Use of a wound filler under the wound dressing
• b) convex configuration of the wound dressing (as described in the patent application DE 10 2009 038 387 whose disclosure content is to be fully assigned to the present invention;
• c) plastic deformability of the wound dressing (as described in the patent application DE 10 2009 038 389 whose disclosure content is to be fully assigned to the present invention;
• d) conformability of the wound dressing such that it can be snugly nestled against the wound floor, thereby imaging the wound relief.

8. Condition of the shell or surface

8.1. Wettability or lotus effect

It is preferably provided that the wound dressing is provided with a shell which has a low wettability, so that liquids and their ingredients do not or hardly adhere to it. This can be achieved, for example, by providing the shell with a lotus effect. Here, microfine elevations are applied to the shell. These can be z. B. 10 to 20 microns high and 10 to 15 microns apart.

Likewise, the wettability can also be reduced by using hydrophobic shell materials. Here, for example, strongly halogenated hydrocarbons are used, such as. B polytetrafluoroethylene (PTFE or Teflon). Other materials are for. B. silanized materials, ie materials that are provided with a silane coating. These are z. Aminosilanes such as APTES ((3-aminopropyl) triethoxysilane), APDEMS ((3-aminopropyl) diethoxymethylsilane), APMES ((3-aminopropyl) -dimethyl-ethoxysilane) or APTMS ((3-aminopropyl) -trimethoxysilane) ), Glycidoxysilanes such as GPMES ((3-glycidoxypropyl) -dimethylethoxysilane), or mercaptosilanes such as MPTS ((3-mercaptopropyl) -trimethoxysilane) or MPDMS (3-mercaptopropyl) -methyl-dimethoxysilane).

8.2. surface scaling

The surface of the wound dressing can also be equipped with a one- or two-dimensional scale, for example in the form of a printed or imprinted scale or a two-dimensional network. The scale or the network can z. B. consist of at a regular distance (for example, every 5 or 10 mm) applied points (the latter may ideally be the bonding points already mentioned). Likewise, a box pattern may be provided, or a combination of dots and dashes, which may be printed and / or embossed.

Since wetting of the wound dressing with exudates indicates the shape of the wound on the wound dressing - which may be the responsibility of the superabsorbent polymers used in particular - the size or surface area of the wound can be quickly estimated by means of the said scaling, which results in control of the wound Wound progression or wound healing significantly easier. See also 3 ,

8.3. Shell with gel-forming properties

Unlike z. As carboxymethyl cellulose must be avoided in the conventional superabsorbent polymers direct contact with the wound, since the polymers are not biodegradable. As a rule, it can not be ruled out that polymer granules will remain in the wound upon direct contact with the wound.

If, however, superabsorbent polymers are initially introduced in bound form-for example, in the manner of the "Luquavleece" product already described above-there can be a danger that polymer components will remain in the wound when the wound is in contact with the wound. This opens up the possibility of providing a shell or a wound contact layer with gel-forming properties-for example, from the said Luquavleece-which in turn makes the wound dressing very pleasant to use and makes the latter in particular atraumatic.

In this case, provision may in particular be made for the sheath or wound contact layer so equipped to have a more absorbent layer, for example an airlaid heavily coated with superabsorbent polymers, to continuously remove moisture from the wetted sheath or wound contact layer so as to increase the moisture content of the wetted sheath or wound contact layer to keep within certain limits. This in turn can unwanted phenomena such. B. Wundrandmazeration, help avoid.

8.4. Measures for creating a close-fitting envelope

In many cases, it may be desirable for the sheath to be very close to the inner absorbent body. For this purpose, it can be provided that, the envelope is elastic or set by means of an elastic system (for example, a pleat, or a elastic seam) under train. In 1 some of the possible possibilities are shown.

8.5. Laminated case

To reduce the thickness of the wound dressing, z. B. laminated from a PP fleece shell directly on an underlying Airlaidmatte or sealed. In this way, the liquid entry into the wound dressing can be facilitated.

This approach is closely related to the lamination of a shell consisting of a three-dimensional wound spacer grid on the actual shell of a PP fleece, as in the DE 10 2009 021 701 is described, the content of which should be considered as belonging to the present application, and can also be combined with the latter.

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

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• DE 102008045833 [0036]
• WO 03094813 [0045, 0045]
• DE 102009038387 [0066]
• DE 102009038389 [0066]
• DE 102009021701 [0076]

Claims (1)

Wound dressing, use of such and manufacturing process for such.

Images