WO2016055483A1 - Wound care product comprising a nano non-woven fabric - Google Patents

Wound care product comprising a nano non-woven fabric Download PDF

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Publication number
WO2016055483A1
WO2016055483A1 PCT/EP2015/073059 EP2015073059W WO2016055483A1 WO 2016055483 A1 WO2016055483 A1 WO 2016055483A1 EP 2015073059 W EP2015073059 W EP 2015073059W WO 2016055483 A1 WO2016055483 A1 WO 2016055483A1
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WO
WIPO (PCT)
Prior art keywords
wound
care product
product according
wound care
preceding
Prior art date
Application number
PCT/EP2015/073059
Other languages
German (de)
French (fr)
Inventor
Birgit Riesinger
Original Assignee
Bsn Medical Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to DE102014114461 priority Critical
Priority to DE102014114461.9 priority
Application filed by Bsn Medical Gmbh filed Critical Bsn Medical Gmbh
Publication of WO2016055483A1 publication Critical patent/WO2016055483A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/58Adhesives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/60Liquid-swellable gel-forming materials, e.g. super-absorbents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/12Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

Abstract

The invention relates to a wound care product comprising at least one flat layer comprising a nano nonwoven fabric.

Description

Wound care product, a nanofiber nonwoven comprising

The present invention relates to a wound care product comprising a nanofiber nonwoven according to the preamble of claim 1.

From the prior art, various types of wound care products are known, some of which have also absorbing properties, for example by being provided with superabsorbent polymers.

Much of this wound care products based on cellulose and is possibly supplemented with other materials.

Although cellulose has proved extraordinarily in wound care, it has in certain circumstances on properties that can adversely affect the wound healing process, where appropriate.

Thus, cellulose only bad so-called "wicking" - behavior that is also only poorly influenced Therefore, wound care products tend to fix absorbed moisture in place, which in turn can lead to maceration of the wound edges..

Furthermore cellulose in the wet state may represent, in certain circumstances a favorable environment for the growth of bacteria. Furthermore, cellulose fiber has a certain level of hardness, which can be perceived by patients as unpleasant.

Existing dressings based on plastics often have several disadvantages. Thus known foam dressings, the foamed usually based on

Of polyurethane, often soft and cushioning, but still stiff and rigid. Take only relatively little liquid and often leave these to external pressures again free. This leads to a high exchange rate, which in turn high

bring treatment costs.

The composition of such foam dressings usually consists of materials that absorb only liquids and cushion lacking jecoh to further functional properties.

SUMMARY OF THE INVENTION

Object of the present invention is therefore to provide a wound care product which does not have said disadvantages of the products of the prior art, and having the enhanced functional properties. This object is achieved with a wound dressing according to the present main claim; the dependent claims specify preferred embodiments. Here, by numerical values ​​limited value ranges are always to be understood including the stated values.

AUSFÜRHLI CHE DESCRIPTION OF THE INVENTION

According to the invention, a wound care product comprising at least one flat layer comprising providing a nanofiber nonwoven,

The term "nanofibers", as used herein, fine fibers are understood polyurethanes μιη a diameter of less than 10, often less than 1 have μιη.

Such nanofiber webs are described in US Patent No. described 4,043,331 and WO 01/27365. They have a great deal of flexibility, adaptability and softness and are also effectively dissipate able fluids. Preferably is provided that it is comprising at the nanofibers are fibers polyurethane.

This may preferably be aromatic or aliphatic, polyester or polyether-based polyurethane. Alternatively, the fibers and cellulose or derivatives thereof, polyamides, polyesters, polyacrylonitriles, polyvinyl alcohols, polyvinyl pyrrolidones, polyethylene oxides, cellulose acetates, polyethylene imines, polycaprolactone, or poly-2 may have hydroxy methacrylates, or mixtures or copolymers deeselben

Particularly preferably, it is provided that at least one of the flat layers comprises a nanofiber nonwoven comprising a hydrophilic TPU nanofiber matrix.

The term "TPU", as used herein, Thermoplastic elastomers are understood urethane. These have a foam-like consistency, similar to a very fine polyurethane foam, and are respectively, for example by the company SNS Nano Fiber technology, Hudson, OH, under the term Nanosan ® . Nanosan - Sorb sold.

Compared to cellulose, this material readily controllable "wicking" - Behavior In this way, for example, maceration can be prevented Also, this material offers other than cellulose bacteria only an unfavorable environment for growth...

Moreover, this material has a great softness which is perceived by patients as unpleasant. This is accompanied by a particularly high flexibility and / or a particularly low stiffness, which allows the wound care product to adapt well to the wound outline.

Opposite foam dressings, the material has a lower casting Today and rigidity. Furthermore, the material can be functionalized differently than foams in many different ways.

Further, it is preferably provided that at least one of the planar layers in addition superabsorbent polymer has. Superabsorbent polymers (SAP) are plastics that are able to absorb many times their own weight - up to 1000-fold - to soak up liquids. Chemically it is a copolymer of acrylic acid (propenoic acid, C3H4O2) and sodium (sodium salt of acrylic acid, NaCsFbC), wherein the ratio of the two monomers may vary from each other. In addition, a so-called Kernvernetzer (Core Cross-linker CXL) is added to the monomer solution, which connects the long-chain polymer molecules formed in places with one another by chemical bonds (they are "linked"). By these bridges, the polymer is water-insoluble. The penetration of water or aqueous salt solutions into the polymer particles it swells up and tightens at the molecular level this network, so that the water without assistance can no longer escape. The superabsorbent polymers may be of a fiber woven fabric, or -geleges -vlieses and / or a fiber wadding in the inventive wound care product in the form of granules, a powder, a bulk, a pellet, a foam, in the form of fibers.

Alternatively, the superabsorbent to, methyl acrylic acid-based, polyvinyl alcohol-maleic anhydride copolymers, polysaccharide maleic anhydride copolymers, maleic acid, acrylamidopropanesulfonic acid copolymers, starch acrylonitrile graft polymers, gelantinisierte starch derivatives, alkyl- or hydroxyalkylcellulose, carboxymethylcellulose, starch-acrylic acid graft polymers, vinyl acetate-acrylate can - copolymers, acrylonitrile or acrylamide copolymers chosen to be.

The superabsorbent particles may be μιη in an average particle size between 10 and 2000 in powder or granular form. You may also be present in fiber form. Mixtures of these embodiments are conceivable.

Superabsorbent polymers, in particular based on polyacrylates, have germ-binding properties, and are also able to deactivate microorganisms by ional interactions, dehydration, and other, not yet clarified in detail effects.

Without being bound by theory, there is evidence that such effects are due to the built up by the superabsorbent polymers osmotic pressure which is higher than the osmotolerance of various pathogens, such as Pseudomonas aeruginosa, and Staphylococcus aureus (particularly multidrug-resistant variant MRSA), and / or Candida albicans.

An appropriately equipped inventive wound care product can therefore also without delivering pharmaceutical substances to bring about a reduction in the number of bacteria in the wound. The patent applicant has carried out extensive experiments on this first time.

Moreover, having superabsorbent polymers, in particular based on polyacrylate, protein-binding properties, and therefore can accomplish as interleukins or Tumornekrosefaktroen such, the inclusion of bacterial endotoxins, sore damaging proteases such as MMPs and cytokines.

These features go far beyond the well-known cellulosic or polyurethane foams and actively contribute to improved wound healing. Here, too, the patent applicant has carried out extensive experiments for the first time.

Unlike foams large quantities of liquid can be added in addition so that can not be released on outside pressure again. This leads to a lower exchange rate, which in turn leads to a reduction in treatment costs.

Preferably, it is provided that the superabsorbent polymers

• are scattered and mechanically incorporated into the nanofiber structure in particle, fiber or granulate form to a location of a nanofiber nonwoven, or

• which is then subjected to a process Elektospinning be homogeneously dispersed in a polymer solution, where the superabsorbent polymers are homogeneously embedded in the nanofiber matrix.

controllable "wicking" a product manufactured in this way material has properties, ie it can be precisely how strong the material is derived liquids. In this way, for example, can be prevented from healthy skin parts are permanently wetted by exudate fibers in contact , which would lead to a maceration of these lots.

In this way it can be ensured that a low lateral fluid discharge takes place when wetted, so that with selective liquid receiving a local liquid acquisition and storage takes place, which remains small and limited in the top view, but increases in the amount of volume, so that a narrow but high "mountain" is created.

It is particularly preferred that the wound care product comprises a nanofiber nonwoven comprising two or more planar layers, wherein at least two of which have a different grammage and / or a different SAP content.

The term "basis weight", as used herein, the mass per unit area is understood. She is presently expressed in g / m 2.

It is preferably provided that at least one of the planar layers m has a grammage in the range of> 150 g / 2 and <500 g / m 2.

Preferably, the grammage is in this case 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370 , 380, 390, 400, 410, 420, 430, 440, 450, 460, 470, 480, 490 or 500 g / m 2 +/- 5 g / m 2.

It is also preferably provided that at least one of the planar layers m has a grammage in the range of> 30 g / 2 and <250 g / m 2.

Preferably, the grammage is in this case 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, or 250 g / m 2 +/- 5 g / m 2.

It is also preferably provided that at least one of the flat layers comprises an SAP content of from> 30 wt and <95 wt.

Preferably, the SAP content amounts to 30, 32.5, 35, 37.5, 40, 42.5, 45, 47.5, 50, 52.5, 55, 57.5, 60, 62.5, 65, 67.5, 70, 72.5, 75, 77.5, 80, 82.5 , 85, 87.5, 90, 92.5, 95, 97.5, or 100 +/- 2.5 wt Likewise, it is preferably provided that at least one of the flat layers comprises an SAP content of between> 0 by weight and <40 wt ,

Preferably, the SAP content is from 0, 2.5, 5, 7.5, 10, 12.5, 15, 17.5, 20, 22.5, 25, 27.5, 30, 32.5, 35, 37.5, or 40 wt .-% +/- 2.5

It is also preferably provided that the wound care product comprises a sandwich-like arrangement of the at least two flat layers, and a wound facing away from, and a wound-facing surface side, wherein the layer with the lower grammage and / or the lower SAP content at the wound-facing side is arranged.

This ensures that liquid is always transported from the wound-facing side of the behind it location and so can not come to wet congestion on the wound-facing side can be ensured.

Furthermore, it is preferably provided that the wound care product comprises a sandwich-like arrangement with at least three sheet-like layers, with an inner layer having a relatively higher grammage and / or a relatively higher level of SAP and two respective outer layers of a relatively lower basis weight and / or a relatively lower have up missing SAP content.

Furthermore, it is preferably provided that the wound care product further comprises a wound facing away from, and a wound-facing surface side, wherein the side facing away from the wound with a liquid and / or elastic backsheet

is provided.

Said backsheet can be configured in particular color. It can have a rough or smooth surface further to either possess an attractive handle to be worn under a garment without further complications. The backsheet may further be configured preferably germ-tight, to prevent leakage of germs. For this purpose, a maximum pore size of about 0.2 μιη - μιη be provided. 1

The backsheet can be present as non-woven fabric, film, or nonwoven. Said backsheet can be, in particular vapor permeable designed. It can be provided that the Water Vapor Transmission Rate (WVTR) is in the range> 4000 g / m 2 day and <15,000 g / m 2 day. In this way it is ensured that under said backsheet no accumulation of humidity or sweating occurs during a wet exit continues to be prevented.

It is particularly provided that the backsheet comprising a nanofiber nonwoven protrudes beyond the edges of the sheet-like position. In this way, a so-called border-or Iceland dressing may be realized by means of an adhesive layer described below.

Furthermore, it is preferably provided that the wound care product comprises an adhesive layer disposed at least in sections against the wound-facing surface side.

Particularly preferred is also provided that the edge of at least one of the flat layers having enclosed a nanofiber web and / or is sealed. This may focus particularly be useful for SAP-containing materials to prevent leakage swollen SAP material. Although this is for the wound non-toxic, and otherwise inert and harmless, but it can be as an increased cleaning effort and possibly also environmental contamination can be prevented with pathogenic bacteria.

Preference is given to the enclosure from the material of the back sheet and / or is formed from the material of the adhesive layer, such as in the form of a piping, which is formed mainly from the material of the back sheet and partly from the material of the adhesive layer.

Likewise preferred are the sealing by thermal sealing, gluing, inductive bonding, stitching or ultrasonic sealing is produced.

Furthermore, it is preferred that the adhesive layer comprises at least a physiologically acceptable adhesive selected from the group consisting of silicone, HydrokoUoid, or acrylate having. Preferably is provided that the adhesive layer comprises an adhesive laminate comprising a first, distal to the skin adhesive layer located on an acrylate, a backing layer, and a second, proximal to the skin underlying continuous layer of adhesive based on silicone.

The adhesive layer may be arranged as a frame only in the region of the periphery of the wind-care product, one or even entirely inferior this on the wound-facing side more or less. In the latter case it may be preferred that the adhesive layer has pores or punching at least in the central area that facilitate Exsudatdurchtritt.

Preferably, the adhesive layer wiest a larger area than the underlying absorbent layer.

Preferably it is further provided that the backsheet and / or at least one layer of a nanofiber nonwoven is designed elastically deformable comprising.

In this way it is ensured that the wound care product is able to realize its full absorbency and can also adapt to complicated wound geometry and / or contours.

Preferably it is further provided that the wound care product contains at least one additive wundheilungsfördemdes. This may be for example, a material selected from the group DHMB, heavy metal or heavy metal ions (silver, copper, Zionk), honey or honey extracts, detergent, disinfectant such as octenidine, antibiotics, polyhexanide, antibacterial peptides and / or acting antibiotics.

Further, it is preferably provided that the wound care product of the invention wound-facing surface having a micro abrasive to promote the removal of wound covering. Such a surface is formed so that the wound care product is suitable, during relative movement thereof to a wound a) in the wound biofilms arranged to break, and / or

b) stimulate the wound exudate. Such micro abrasive surface, for example

comprising a material substantially oblique or perpendicular to the wound surface is arranged or arrangeable fibers

a plaster body comprising an emulsion, a gel, a suspension, a paste or a dry product.

a material, particularly a sheet comprising a three-dimensional

Pore ​​structure,

arranged substantially or oblique or perpendicular to the wound surface

arrangement capable of bristles, and / or

a pile exhibiting or velvet-like material. respectively. Such surfaces are described in detail in the published patent application WO2013113906 of the Applicant, whose contents are fully referenced here is

Further, it is preferably provided that the wound care product of the invention wound facing a wound spacer grid, preferably a three-dimensional wound spacer grid, comprising.

Such a wound spacer grids are described in detail in the published patent applications WO2007118652, WO2013121006 and WO2014108476 of the applicant, is on the content of which fully referenced here

Preferably it is further provided that the wound care product has no envelope.

In another embodiment, it is provided that the wound care product comprises a shell that - defines an inner surface which is 3% to 80% larger in plan view than the area disposed therein absorbent layer - for example meadow by sutures or folding edges.

In this way, the inner absorbent layer in their absorption capacity is not limited by a constricting sheath is ensured. said inner surface 3 is preferred; 4; 5; 6; 7; 8th; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23; 24; 25; 26; 27; 28; 29; 30; 31; 32; 33; 34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79 or 80% greater than the surface of an absorbent layer disposed therein.

It is particularly preferred that the sheath consists of two connected at the edges of sheet-like layers.

The sheath may be identical on both sides configured thereby, but also so that the materials of the two flat sheets are different

It is also preferably provided that the wound care product is moistened with an Elektolyt or impregnated. Also, a kit of parts may be provided a wound care product comprising according to any one of the preceding claims and a Elektolyt for moistening or impregnation thereof

In this way, a cleaning and flushing system is realized, which, applied to the wound, exudate pathological and opposite electrolyte such as physiological saline or Ringer solution, the Windabgibt. In this way, coverings, such as biofilms or fibrin can be softened and removed.

Further, the use of nanofibers for the preparation of a wound care product for use as described above - or the use of the wound care product itself - of one of the following purposes provided:

• treatment of a chronic wound

• Treatment of postoperative wound or seam

• treatment which has previously been subjected to debridement of a wound,

• Filling of substance defects in deep wounds

• covering a highly confluent wound

• filling of wound pockets, wound tunnels or fistulas

• as a wound pad, that is in the wound and without contact with the surrounding skin ■ for attachment to traumatic, iatrogenic or diabetic wounds as a dispenser for previously entered liquid for external humidification of the wound region

support of wound bed preparation

to reduce the number of bacteria in the wound

to reduce the surface moisture of the wound

for Ödementlastung in wounds, and / or

for the reduction of biofilms in wounds.

Further, the use of nanofibers for the preparation of a wound care product for use as described above - or the use of the wound care product itself - of one of the following purposes provided:

as a primary dressing that directly as the first bandage on the wound surface

can be arranged, or

as a secondary dressing, which can be arranged as a second bandage over a primary dressing such as a spacer grid, or a wound gel

Further, the use of a wound care product according to the above description provided, this wetted or impregnated with electrolyte disposed in the wound region.

The following table provides some critical parameters of preferred embodiments of the invention at PHYSICAL TEST TYPICAL UNITS Type I Type 2 Type 3 PROPERTY VALUES

Mass Per Unit Area WSP g / m2 50-200 50-200 50-200 50-400

130.1 (5)

Breaking Force WSP 110.4 MPa 1.5 - 2.0 0.2 0.2-0.6 4

(05)

Elongation (Strip) WSP 110.4% 400 - 500380300-400600

(05)

ABSORBENCY (@RT)

In saline (0.9% WSP g / g 6.0 - 9.0 30-35 28-30 0.1 NaCl in water) - 30 240.2 (05)

min

In saline (0.9% WSP% in 1400 from 1100 to 1300 100 NaCl in water) - 10.1 (05) 150 10s

RETENTION CAPACITY (@RT)

In saline (0.9% WSP g / g 4.0 - 6.0 14.0-15.0

NaCl in water) - 30 241.2 (05)

min

pictures

The present invention is more specifically illustrated by the steps shown in and discussed below. It should be noted that the figures are only descriptive and are not intended to limit the invention in any form.

Fig. 1 shows a wound care product comprising a flat base 1 comprising a nanofiber nonwoven fabric made of a hydrophilic TPU nanofiber matrix. In said flat layer 1 2 superabsorbent polymers are additionally introduced. The wound care product further comprises a wound-remote side, which is provided with a liquid-impermeable, elastic backsheet. 3 The wound care product further comprises an adhesive layer 4 which is disposed on the wound-facing surface side of the wound care product. The backsheet 3 projects beyond the edges of the flat base 1 comprising a nanofiber web on. The adhesive layer 4 is arranged like a frame only in the region of the periphery of the wind care product.

To manufacture Superabsorbent polymers were homogeneously dispersed in a polymer solution, which is then subjected to a Elektospinning process, where the superabsorbent polymers are homogeneously embedded in the nanofiber matrix.

Fig. 2 shows a similar wound care product, comprising, however, three flat layers 5, 6 and 7 comprising a nanofiber web. The two layers have a different outer grammage and another SAP content than the inner layer.

This ensures that liquid is always transported from the wound-facing side of the behind it location and so can not come to wet congestion on the wound-facing side can be ensured.

Fig. 3 shows a similar wound care product, comprising, however, disposed on the wound-facing surface side of the wound care product-adhesive layer 4, which covers the entire wound-facing side, and which has 8 pores or punched in the central area that facilitate Exsudatdurchtritt.

Fig. 4 shows a similar wound care product in which the edge of the sheet-like layers comprising a nanofiber nonwoven is enclosed. The enclosure is formed from the material of the back sheet and the adhesive layer. In addition, the edge area with an adhesive is filled in 9 so as to fix the enclosure.

Fig. 5 shows a micrograph of a nanofiber nonwoven fabric comprising superabsorbent polymers.

Other embodiments

Further embodiments are described in the following: Wound care product according to the invention, or parts thereof preferably has a higher affinity for protein-containing solutions but to salt-containing solutions.

Preferably, the fiction, modern wound care product is a location on which zeigt- a significant stretchability in at least one direction

Preferably, the fiction, modern wound care product on a location with a non-cellular polyurethane.

Preferably, the wound care product of the invention has a layer containing between 3 and 95, including SAP Vol .-%, preferably 3; 4; 5; 6; 7; 8th; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23; 24; 25; 26; 27; 28; 29; 30; 31; 32; 33; 34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82; 83; 84; 85; 86; 87; 88; 89; 90; 91; 92; 93; 94 or 95%.

Preferably, the wound care product of the invention has a layer containing between 3 and 95 wt .-%, including SAP, preferably 3; 4; 5; 6; 7; 8th; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23; 24; 25; 26; 27; 28; 29; 30; 31; 32; 33; 34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82; 83; 84; 85; 86; 87; 88; 89; 90; 91; 92; 93; 94 or 95%.

Preferably, the fiction, modern wound care product is a location having between 3 and 95 wt .-%, including polyurethane, preferably 3; 4; 5; 6; 7; 8th; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23; 24; 25; 26; 27; 28; 29; 30; 31; 32; 33; 34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82; 83; 84; 85; 86; 87; 88; 89; 90; 91; 92; 93; 94 or 95% as a mass fraction of the polyurethane.

Preferably, the fiction, modern wound care product is a location having between 3 and including 95 vol .-% of polyurethane, preferably 3; 4; 5; 6; 7; 8th; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23; 24; 25; 26; 27; 28; 29; 30; 31; 32; 33; 34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82; 83; 84; 85; 86; 87; 88; 89; 90; 91; 92; 93; 94 or 95% on a volume basis of the polyurethane.

Preferably, the wound care product of the invention has a multilayer structure composed of at least two layers, wherein the first layer is free of SAP, and the second layer contains at least 5 wt .-% SAP.

Preferably, the fiction, modern wound care product to a thickness (height) of between 1 and 10 mm inclusive, preferably 1; 2; 3; 4; 5; 6; 7; 8th; 9; 10 mm; particularly preferably between 2 and including 4 mm, preferably 2.0; 2.1; 2.2; 2.3; 2.4; 2.4; 2.5 2.6; 2.7; 2.8; 2.9; 3.0; 3.1; 3.2; 3.3; 3.4; 3.5 3.6; 3.7; 3.8; 3.9 or 4.0 mm.

Preferably, the fiction, modern wound care product a particularly high flexibility and / or a particularly low stiffness.

Preferably has wound care product of the invention dialkylcarbamoyl chloride or similar non-polar materials.

Preferably, the fiction, modern designed wound care product so that an inner layer has a greater affinity to liquid than the recorded remote from a wound position, so that the liquids absorbed pass through until saturation of the inner sheet in the wound-remote location.

Preferably, the wound care product of the invention is designed so that at least one layer of the wound care product upon wetting and / or saturation expands laterally and possibly wrinkled.

Claims

claims
1. Wound care product, comprising at least one flat layer comprising a nanofiber web.
2. Wound care product according to one of the preceding claims, wherein there are fibers comprising polyurethane with the nanofibers.
3. Wound care product a nanofiber nonwoven fabric having a hydrophilic TPU nanofiber matrix according to one of the preceding claims, wherein at least one of the planar sheets comprising
4. Wound care product according to one of the preceding claims, wherein at least one of the planar layers in addition superabsorbent polymer has.
5. Wound care product according to any preceding claim, wherein the superabsorbent polymers
• are scattered and mechanically incorporated into the nanofiber structure in particle, fiber or granulate form to a location of a nanofiber nonwoven fabric, or the like.
• which is then subjected to a process Elektospinning be homogeneously dispersed in a polymer solution, where the superabsorbent polymers are homogeneously embedded in the nanofiber matrix.
6. Wound care product according to one of the preceding claims, comprising two or more surface layers comprising a nanofiber nonwoven, wherein at least two of which have a different grammage and / or a different SAP content.
7. Wound care product according to one of the preceding claims, wherein at least one of the planar layers m has a grammage in the range of> 150 g / 2 and <500 g / m 2.
8. Wound care product according to one of the preceding claims, wherein at least one of the planar layers m has a grammage in the range of> 30 g / 2 and <250 g / m 2.
9. Wound care product according to one of the preceding claims, wherein at least one of the flat layers comprises an SAP content of from> 30 wt and <95 wt.
10. Wound care product according to one of the preceding claims, wherein at least one of the flat layers comprises an SAP content of between> 0 by weight and <40 wt.
11. Wound care product according to one of the preceding claims, comprising a sandwich-like arrangement of the at least two flat layers, and a wound facing away from, and a wound-facing surface side, wherein the layer with the lower grammage and / or the lower to lack of SAP content at the wound-facing side arranged is.
12. Wound care product according to one of the preceding claims, comprising a sandwich-like arrangement with at least three sheet-like layers, with an inner layer having a relatively higher grammage and / or a relatively higher level of SAP and two respective outer layers of a relatively lower basis weight and / or relatively lower have up missing SAP content.
13. Wound care product according to one of the preceding claims, comprising further a wound facing away from, and a wound-facing surface side, wherein the wound-remote side is provided with a liquid and / or elastic backsheet.
14. Wound care product according to claim 13, wherein the back sheet comprising a nanofiber web protrudes beyond the edges of the sheet-like position.
15. Wound care product according to claim 13 and / or 14, further comprising an adhesive layer disposed at least in sections against the wound-facing surface side.
16. Wound care product wherein the edge of at least one of the flat sheets is enclosed comprising a nanofiber web and / or sealed in accordance with one of the preceding claims.
17. Wound care product according to claim 16, wherein the enclosure is formed from the material of the back sheet and / or from the material of the adhesive layer.
18. Wound care product according to claim 16, wherein the seal is produced by heat-sealing, gluing, inductive bonding, stitching or ultrasonic sealing.
having 18, wherein the adhesive layer comprises at least a physiologically acceptable adhesive selected from the group consisting of silicone, hydrocolloid or acrylate - 19. Wound care product according to any one of claims 15 °.
20. Wound care product according to one of the preceding claims, wherein said backsheet and / or at least one layer of a nanofiber nonwoven fabric is configured comprising elastically deformable.
21. Wound care product according to one he preceding claims, further comprising at least one wound healing-promoting additive.
22. Wound care product according to one of the preceding claims, wherein it
sore face having a micro abrasive surface to promote the removal of wound covering.
23. Wound care product according to one of the preceding claims, wherein it
wound facing a wound spacer grid, preferably a three-dimensional
has wound spacer grids,
24. Wound care product according to any one of the preceding claims, wherein this no cover.
25. Wound care product according to one of the preceding claims, wherein it comprises a sheath that - defines an inner surface which is 3% to 80% larger in plan view than the area disposed therein absorbent layer - for example meadow by sutures or folding edges.
26. Wound care product according to one of the preceding claims, wherein the shell consists of two connected at the edges of sheet-like layers.
27. Wound care product according to one of the preceding claims, wherein it is moistened with a Elektolyt or impregnated.
28 kit of parts comprising a wound care product according to one of the previous
of the same claims and a Elektolyt for humidifying or soaking
29. The use of nano fibers for producing a wound care product according to
one of the preceding claims for use as one of the following purposes:
• treatment of a chronic wound
• Treatment of postoperative wound or seam
• treatment which has previously been subjected to debridement of a wound,
• Filling of substance defects in deep wounds
• covering a highly confluent wound
• filling of wound pockets, wound tunnels or fistulas
• as a wound amount, namely in the wound and without contact with the surrounding skin
for mounting to traumatic, iatrogenic or diabetic wounds
as a dispenser for liquid previously entered for external humidification of the wound region
support of wound bed preparation
to reduce the number of bacteria in the wound
to reduce the surface moisture of the wound
for Ödementlastung in wounds, and / or
for the reduction of biofilms in wounds.
30. The use of a wound care product according to one of the preceding claims
as a primary dressing that directly as the first bandage on the wound surface
can be arranged, or
as a secondary dressing, which can be arranged as a second bandage over a primary dressing such as a spacer grid, or a wound gel
31. The use of a wound care product according to one of the preceding claims, wherein said wetted or impregnated with electrolyte is placed in the wound region.
PCT/EP2015/073059 2014-10-06 2015-10-06 Wound care product comprising a nano non-woven fabric WO2016055483A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE102014114461 2014-10-06
DE102014114461.9 2014-10-06

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Publication Number Publication Date
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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4043331A (en) 1974-08-05 1977-08-23 Imperial Chemical Industries Limited Fibrillar product of electrostatically spun organic material
EP0341870A2 (en) * 1988-05-13 1989-11-15 Minnesota Mining And Manufacturing Company Absorbent elastomeric wound dressing
WO2001027365A1 (en) 1999-10-08 2001-04-19 The University Of Akron Electrospun fibers and an apparatus therefor
WO2007118652A1 (en) 2006-04-12 2007-10-25 Birgit Riesinger Primary dressing
US20080255492A1 (en) * 2004-08-19 2008-10-16 Jens Hoeg Truelsen Absorbent Fiber Material and Use Thereof in Wound Dressings
EP2335743A2 (en) * 2005-08-05 2011-06-22 Schill + Seilacher GmbH Nanofibrous fleece containing superabsorbent powder
EP2359784A1 (en) * 2005-11-02 2011-08-24 Birgit Riesinger Absorption body for attachment to human or animal skin surfaces
US20120070485A1 (en) * 2009-05-26 2012-03-22 Giorgio Soldani method for producing a device applicable to biological tissues, particularly a patch for treating damaged tissues, and a device obtained by said method
WO2013113906A1 (en) 2012-02-01 2013-08-08 Birgit Riesinger Wound care article comprising at least one surface having abrasive properties
WO2013121006A1 (en) 2012-02-17 2013-08-22 Birgit Riesinger Liquid-permeable primary dressing having a fraction of heavy metal
WO2014108476A1 (en) 2013-01-09 2014-07-17 Birgit Riesinger Liquid-permeable primary dressing with a silicone coating

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4043331A (en) 1974-08-05 1977-08-23 Imperial Chemical Industries Limited Fibrillar product of electrostatically spun organic material
EP0341870A2 (en) * 1988-05-13 1989-11-15 Minnesota Mining And Manufacturing Company Absorbent elastomeric wound dressing
WO2001027365A1 (en) 1999-10-08 2001-04-19 The University Of Akron Electrospun fibers and an apparatus therefor
US20080255492A1 (en) * 2004-08-19 2008-10-16 Jens Hoeg Truelsen Absorbent Fiber Material and Use Thereof in Wound Dressings
EP2335743A2 (en) * 2005-08-05 2011-06-22 Schill + Seilacher GmbH Nanofibrous fleece containing superabsorbent powder
EP2359784A1 (en) * 2005-11-02 2011-08-24 Birgit Riesinger Absorption body for attachment to human or animal skin surfaces
WO2007118652A1 (en) 2006-04-12 2007-10-25 Birgit Riesinger Primary dressing
US20120070485A1 (en) * 2009-05-26 2012-03-22 Giorgio Soldani method for producing a device applicable to biological tissues, particularly a patch for treating damaged tissues, and a device obtained by said method
WO2013113906A1 (en) 2012-02-01 2013-08-08 Birgit Riesinger Wound care article comprising at least one surface having abrasive properties
WO2013121006A1 (en) 2012-02-17 2013-08-22 Birgit Riesinger Liquid-permeable primary dressing having a fraction of heavy metal
WO2014108476A1 (en) 2013-01-09 2014-07-17 Birgit Riesinger Liquid-permeable primary dressing with a silicone coating

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