DE102008063592A1 - Multifunktionaler Laborprozessbeutel für die Reinherstellung von Biomolekülen - Google Patents

Multifunktionaler Laborprozessbeutel für die Reinherstellung von Biomolekülen Download PDF

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Publication number
DE102008063592A1
DE102008063592A1 DE200810063592 DE102008063592A DE102008063592A1 DE 102008063592 A1 DE102008063592 A1 DE 102008063592A1 DE 200810063592 DE200810063592 DE 200810063592 DE 102008063592 A DE102008063592 A DE 102008063592A DE 102008063592 A1 DE102008063592 A1 DE 102008063592A1
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Prior art keywords
bag
buffer
dna
gene
molecules
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DE200810063592
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DE102008063592B4 (de
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Dirk Schindelhauer
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
DE200810063592 2008-12-18 2008-12-18 Multifunktionaler Laborprozessbeutel für die Reinherstellung von Biomolekülen Expired - Fee Related DE102008063592B4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE200810063592 DE102008063592B4 (de) 2008-12-18 2008-12-18 Multifunktionaler Laborprozessbeutel für die Reinherstellung von Biomolekülen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE200810063592 DE102008063592B4 (de) 2008-12-18 2008-12-18 Multifunktionaler Laborprozessbeutel für die Reinherstellung von Biomolekülen

Publications (2)

Publication Number Publication Date
DE102008063592A1 true DE102008063592A1 (de) 2010-06-24
DE102008063592B4 DE102008063592B4 (de) 2012-01-12

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ID=42194104

Family Applications (1)

Application Number Title Priority Date Filing Date
DE200810063592 Expired - Fee Related DE102008063592B4 (de) 2008-12-18 2008-12-18 Multifunktionaler Laborprozessbeutel für die Reinherstellung von Biomolekülen

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DE (1) DE102008063592B4 (ar)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016101350B3 (de) * 2016-01-26 2017-02-09 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zum Verbinden einer Einweg-Prozess-Ausrüstung mit einer in-situ sterilisierbaren Bioprozess-Ausrüstung
EP3182136A1 (de) * 2015-12-18 2017-06-21 Robert Bosch Gmbh Folienbeutel für ein mikrofluidisches analysesystem, mikrofluidisches analysesystem, verfahren zum herstellen und verfahren zum betreiben eines mikrofluidischen analysesystems
CN111751176A (zh) * 2019-03-26 2020-10-09 中国石油化工股份有限公司 一种岩石包裹体薄片移片装置

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US4425114A (en) 1981-04-23 1984-01-10 Haemonetics Corporation Blood donation unit
DE3238649A1 (de) 1982-10-19 1984-04-19 Hagen Dr. 8520 Erlangen Theuer Mehrkompartimentbeutel fuer mischinfusionsloesungen
US4637813A (en) 1979-12-06 1987-01-20 Baxter Travenol Laboratories, Inc. Blood processing assembly including a prepackaged fluid circuit module
US4915847A (en) 1987-08-04 1990-04-10 Baxter International Inc. Cryoglobulin separation
US4997083A (en) 1987-05-29 1991-03-05 Vifor S.A. Container intended for the separate storage of active compositions and for their subsequent mixing
US5176634A (en) 1990-08-02 1993-01-05 Mcgaw, Inc. Flexible multiple compartment drug container
DE9401288U1 (de) 1994-01-26 1994-03-17 Fresenius Ag Mehrkammerbeutel
US5296242A (en) 1991-08-03 1994-03-22 Rolf Zander Aqueous solution and the use thereof
US5308334A (en) 1990-12-27 1994-05-03 Block Medical, Inc. Closed system for iv site flush
US5382526A (en) 1980-10-31 1995-01-17 Baxter International Inc. Blood storage container and material
US5560403A (en) 1993-01-19 1996-10-01 Baxter International Inc. Multiple chamber container
EP0776649A2 (en) 1995-11-28 1997-06-04 Material Engineering Technology Laboratory, Inc. Medical container with electrolyte solution stored therein
EP0790051A2 (de) 1996-02-14 1997-08-20 B. Braun Melsungen Ag Flexibler Kunststoffbehälter
EP0875231A2 (en) 1997-05-02 1998-11-04 B. Braun Melsungen Ag Impermeable flexible multicompartment bag
US6231559B1 (en) 1996-10-11 2001-05-15 B. Braun Melsungen Ag Flexible plastic container with three chambers
US6331397B1 (en) 1997-05-17 2001-12-18 Dirk Schindelhauer Method for producing long DNA constructs in agarose
DE10041295A1 (de) 2000-08-23 2002-03-14 Fresenius Kabi De Gmbh Verfahren zur Herstellung einer Zweikammer-Anordnung und Zweikammer-Anordnung
DE69525902T2 (de) 1994-11-17 2002-07-18 Gerflor Villeurbanne Aus thermoplastischem Granulat erhaltene, elektrisch leitfähige Folie
DE102004025650A1 (de) 2004-05-26 2006-06-08 Schindelhauer, D., Dr. Verfahren für den quantitativen Ausschluß genickter (ssb) und gebrochener (dsb) Template-DNA aus Zellpräparationen in sehr langen Polymerase Reaktionen
DE69736909T2 (de) 1996-04-10 2007-05-24 Fresenius Kabi Ab Behälter für parenterale Flüssigkeiten
DE60030682T2 (de) 1999-09-10 2007-09-06 Baxter International Inc., Deerfield Zweiteilige bicarbonatlösung für die peritonealdialyse oder als substitutionslösung für die kontinuierliche nierensubstitutionstherapie
DE102006026179A1 (de) 2006-05-29 2007-12-06 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zur in vitro Präparation von lebenden Zellen und/oder Zellansammlungen aus einem Gewebe
WO2009033653A1 (en) 2007-09-11 2009-03-19 Minitüb Abfüll- und Labortechnik GmbH & Co. KG De novo formation of artificial chromosomes in primary cells and their uses in xenotransplantation, cell and gene therapy

Patent Citations (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098456A (en) 1977-03-29 1978-07-04 Baxter Travenol Laboratories, Inc. Centrifuge system having collapsible centrifuge bags
US4637813A (en) 1979-12-06 1987-01-20 Baxter Travenol Laboratories, Inc. Blood processing assembly including a prepackaged fluid circuit module
US5382526A (en) 1980-10-31 1995-01-17 Baxter International Inc. Blood storage container and material
US4425114A (en) 1981-04-23 1984-01-10 Haemonetics Corporation Blood donation unit
DE3238649A1 (de) 1982-10-19 1984-04-19 Hagen Dr. 8520 Erlangen Theuer Mehrkompartimentbeutel fuer mischinfusionsloesungen
US4997083A (en) 1987-05-29 1991-03-05 Vifor S.A. Container intended for the separate storage of active compositions and for their subsequent mixing
US4915847A (en) 1987-08-04 1990-04-10 Baxter International Inc. Cryoglobulin separation
US5176634A (en) 1990-08-02 1993-01-05 Mcgaw, Inc. Flexible multiple compartment drug container
US5308334A (en) 1990-12-27 1994-05-03 Block Medical, Inc. Closed system for iv site flush
US5296242A (en) 1991-08-03 1994-03-22 Rolf Zander Aqueous solution and the use thereof
US5560403A (en) 1993-01-19 1996-10-01 Baxter International Inc. Multiple chamber container
DE9401288U1 (de) 1994-01-26 1994-03-17 Fresenius Ag Mehrkammerbeutel
DE69525902T2 (de) 1994-11-17 2002-07-18 Gerflor Villeurbanne Aus thermoplastischem Granulat erhaltene, elektrisch leitfähige Folie
EP0776649A2 (en) 1995-11-28 1997-06-04 Material Engineering Technology Laboratory, Inc. Medical container with electrolyte solution stored therein
EP0790051A2 (de) 1996-02-14 1997-08-20 B. Braun Melsungen Ag Flexibler Kunststoffbehälter
DE69736909T2 (de) 1996-04-10 2007-05-24 Fresenius Kabi Ab Behälter für parenterale Flüssigkeiten
US6231559B1 (en) 1996-10-11 2001-05-15 B. Braun Melsungen Ag Flexible plastic container with three chambers
US6468259B1 (en) 1997-05-02 2002-10-22 B. Braun Melsungen Ag Impermeable flexible multicompartment bag
EP0875231A2 (en) 1997-05-02 1998-11-04 B. Braun Melsungen Ag Impermeable flexible multicompartment bag
US6331397B1 (en) 1997-05-17 2001-12-18 Dirk Schindelhauer Method for producing long DNA constructs in agarose
DE19720839B4 (de) 1997-05-17 2007-08-16 Dirk Dr. Schindelhauer Baukastenprinzip-Technologie zur Herstellung von langen, exakten DNA-Konstrukten in vitro, insbesondere für die Herstellung von Konstrukten zur Erzeugung von künstlichen Chromosomen (MAC, mammalian artificial chromosome) aus zwei stabil klonierten DNA-Komponenten und der ditelomerische Vektor-Prototyp PTAT
DE60030682T2 (de) 1999-09-10 2007-09-06 Baxter International Inc., Deerfield Zweiteilige bicarbonatlösung für die peritonealdialyse oder als substitutionslösung für die kontinuierliche nierensubstitutionstherapie
DE10041295A1 (de) 2000-08-23 2002-03-14 Fresenius Kabi De Gmbh Verfahren zur Herstellung einer Zweikammer-Anordnung und Zweikammer-Anordnung
DE102004025650A1 (de) 2004-05-26 2006-06-08 Schindelhauer, D., Dr. Verfahren für den quantitativen Ausschluß genickter (ssb) und gebrochener (dsb) Template-DNA aus Zellpräparationen in sehr langen Polymerase Reaktionen
DE102006026179A1 (de) 2006-05-29 2007-12-06 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zur in vitro Präparation von lebenden Zellen und/oder Zellansammlungen aus einem Gewebe
WO2009033653A1 (en) 2007-09-11 2009-03-19 Minitüb Abfüll- und Labortechnik GmbH & Co. KG De novo formation of artificial chromosomes in primary cells and their uses in xenotransplantation, cell and gene therapy

Non-Patent Citations (15)

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K. Inoue et al. 2005 Clin Chem Acta 358: 159-166
Kraner S., Christan S., Zoller M., Jung C., Schindelhauer D. (2007) Reconstructing functional gene loci using PCR. Eur J Hum Gen 15 suppl.1/C19:20
Laner A. Entwicklung von DNA- und Expressions-Markern zum Nachweis von menschlichen künstlichen Chromosomen und in vivo Transfektionsanalyse verbesserter HAC Vektoren. Doctoral thesis, Ludwigs-Maximilians Universität Munich (2004) (http://edoc.ub.unimuenchen.de/4286/)
Laner A., Goussard S., Ramalho A. S., Schwarz T., Amaral M. D., Courvalin P., Schindelhauer D., Grillot-Courvalin C. (2005) Bacterial Transfer of large functional genomic DNA into human cells. Gene Ther. 12, 1559-1572
Laner A., Schwarz T., Christan S., Schindelhauer D. (2004) Suitability of a CMV/EGFP cassette to monitor stable expression from human artificial chromosomes but not transient tansfer in the cells forming viable clones. Cytogenet Genome Res. 107, 9-13
MANIATIS,T., FRITSCH,E.F. und SAMBROOK,J.: Molecular Cloning, Cold Spring Harbor Laboratory (1982), S.164-165 *
Noerenberg M. Investigations an various aspects of intactness of long DNA molecules for the construction of human artificial chromosomes. Diploms thesis, Life Sciences Center Weihenstephan, Technical University Munich (2006)
Ref. Scientific Commettees 2008, SCENIHR Opinion, http://ec.europa.eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_014.pdf
Schindelhauer D., Cooke H. J. (1997) Efficient combination of large DNA in vitro: in gel site specific recombination (IGSSR) of PAC fragments containing alpha satellite DNA and the human HPRT gene locus. Nucleic Acids Res. 25(11): 2241-2243
SCHINDELHAUER,D. & LANER,A.: Visible transient expression of EGFP requires intranuclear injection of large copy numbers. Gene Ther. (2002) 9 (11) 727-30 *
SCHINDELHAUER,D. & LANER,A.: Visible transient expression of EGFP requires intranuclear injection of large copy numbers. Gene Ther. (2002) 9 (11) 727-30 MANIATIS,T., FRITSCH,E.F. und SAMBROOK,J.: Molecular Cloning, Cold Spring Harbor Laboratory (1982), S.164-165
Scientific Commettees 2008, SCENIHR Opinion, http://ec.europa.eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_014.pdf DINCH, Technisches Merkblatt Januar 2008 M6168d, BASF Chromosome Medicine Procurement Dr. Dirk Schindelhauer Anmeldung DPMA, Schin-Prozessbeutel Multifunktionaler Laborprozessbeutel für die Reinherstellung von Biomolekülen
Technisches Merkblatt Januar 2008 M6168d, BASF
Welle et al. (2005) Migration von Weichmachern aus PVC Schläuchen in enterale Nahrungslösungen. Pharma International 3/2005: 17-21

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3182136A1 (de) * 2015-12-18 2017-06-21 Robert Bosch Gmbh Folienbeutel für ein mikrofluidisches analysesystem, mikrofluidisches analysesystem, verfahren zum herstellen und verfahren zum betreiben eines mikrofluidischen analysesystems
US11027276B2 (en) 2015-12-18 2021-06-08 Robert Bosch Gmbh Film bag for a microfluidic analysis system, microfluidic analysis system, method for producing and method for operating a microfluidic analysis system
DE102016101350B3 (de) * 2016-01-26 2017-02-09 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zum Verbinden einer Einweg-Prozess-Ausrüstung mit einer in-situ sterilisierbaren Bioprozess-Ausrüstung
CN111751176A (zh) * 2019-03-26 2020-10-09 中国石油化工股份有限公司 一种岩石包裹体薄片移片装置
CN111751176B (zh) * 2019-03-26 2024-02-23 中国石油化工股份有限公司 一种岩石包裹体薄片移片装置

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