DE102006051020A1 - Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung - Google Patents

Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung Download PDF

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Publication number
DE102006051020A1
DE102006051020A1 DE200610051020 DE102006051020A DE102006051020A1 DE 102006051020 A1 DE102006051020 A1 DE 102006051020A1 DE 200610051020 DE200610051020 DE 200610051020 DE 102006051020 A DE102006051020 A DE 102006051020A DE 102006051020 A1 DE102006051020 A1 DE 102006051020A1
Authority
DE
Germany
Prior art keywords
meth
ethanol
acrylate
release
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE200610051020
Other languages
German (de)
English (en)
Inventor
Hans-Ulrich Petereit
Brigitte Dr. Skalsky
Diego Gallardo
Manfred Assmus
Andreas Gryczke
Wolfgang Weisbrod
Felix Hofmann
Hans BÄR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Roehm GmbH
Original Assignee
Evonik Roehm GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm GmbH filed Critical Evonik Roehm GmbH
Priority to DE200610051020 priority Critical patent/DE102006051020A1/de
Priority to PCT/EP2007/058100 priority patent/WO2008049657A2/fr
Priority to TW96139674A priority patent/TW200833372A/zh
Publication of DE102006051020A1 publication Critical patent/DE102006051020A1/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
DE200610051020 2006-10-26 2006-10-26 Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung Withdrawn DE102006051020A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE200610051020 DE102006051020A1 (de) 2006-10-26 2006-10-26 Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung
PCT/EP2007/058100 WO2008049657A2 (fr) 2006-10-26 2007-08-06 Utilisation de copolymères de (méth)acrylate dans des formes de médicaments à délivrance retardée pour diminuer les effets de l'éthanol sur la libération de la subtance active
TW96139674A TW200833372A (en) 2006-10-26 2007-10-23 Use of (meth)acrylate copolymers in delayed-release pharmaceutical forms for decreasing the influence of ethanol on the release of active compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE200610051020 DE102006051020A1 (de) 2006-10-26 2006-10-26 Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung

Publications (1)

Publication Number Publication Date
DE102006051020A1 true DE102006051020A1 (de) 2008-04-30

Family

ID=38521102

Family Applications (1)

Application Number Title Priority Date Filing Date
DE200610051020 Withdrawn DE102006051020A1 (de) 2006-10-26 2006-10-26 Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung

Country Status (3)

Country Link
DE (1) DE102006051020A1 (fr)
TW (1) TW200833372A (fr)
WO (1) WO2008049657A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150044282A1 (en) * 2007-08-13 2015-02-12 Inspirion Delivery Technologies, Llc Abuse resistant forms of immediate release oxycodone, method of use and method of making
US10420726B2 (en) 2013-03-15 2019-09-24 Inspirion Delivery Sciences, Llc Abuse deterrent compositions and methods of use
US10729685B2 (en) 2014-09-15 2020-08-04 Ohemo Life Sciences Inc. Orally administrable compositions and methods of deterring abuse by intranasal administration

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* Cited by examiner, † Cited by third party
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CA2738197C (fr) 2008-09-24 2016-01-05 Evonik Roehm Gmbh Composition pharmaceutique a liberation controlee dependant des variations du ph renfermant des substances autres que des opioides et se montrant resistante aux effets de l'ethanol
CN104984343B (zh) * 2008-09-24 2019-04-02 赢创罗姆有限公司 耐受乙醇影响的非阿片类药物的pH依赖性受控释放的药物组合物
PL2341899T3 (pl) * 2008-09-24 2015-05-29 Evonik Roehm Gmbh Opioidowa kompozycja farmaceutyczna o zależnym od pH kontrolowanym uwalnianiu z odpornością na działanie etanolu
CN102365083A (zh) * 2009-03-18 2012-02-29 赢创罗姆有限公司 采用包含聚合物混合物和赋形剂的包衣的具有耐乙醇影响的控释药物组合物
CN105287434A (zh) * 2009-03-18 2016-02-03 赢创罗姆有限公司 采用含有中性乙烯基聚合物和赋形剂的包衣的具有耐乙醇影响的控释药物组合物
WO2010105672A1 (fr) 2009-03-18 2010-09-23 Evonik Röhm Gmbh Composition pharmaceutique à libération controlée avec résistance contre l'influence de l'éthanol au moyen d'un enrobage comportant des polymères vinyliques et excipients neutres
CN103002882B (zh) * 2010-05-10 2016-03-02 欧洲凯尔特公司 不含活性剂之颗粒及包含其之片剂的制备
US9901540B2 (en) 2010-05-10 2018-02-27 Euro-Celtique S.A. Combination of active loaded granules with additional actives
EA201291211A1 (ru) 2010-05-10 2013-05-30 Эро-Селтик С.А. Фармацевтические композиции, содержащие гидроморфон и налоксон
RU2649806C2 (ru) 2011-06-17 2018-04-04 Эвоник Рем ГмбХ Желудочно-резистентная фармацевтическая или нутрицевтическая композиция с устойчивостью к воздействию этанола
SI2720681T1 (sl) 2011-06-17 2017-03-31 Evonik Roehm Gmbh Sestavek za oplaščenje primeren za farmacevtske ali nutracevtske dozirne oblike
SI2720682T1 (sl) 2011-06-17 2017-05-31 Evonik Roehm Gmbh Sestavek za oplaščenje primeren za farmacevtske ali nutracevtske dozirne oblike
KR102194174B1 (ko) 2013-11-13 2020-12-23 유로-셀티큐 에스.에이. 통증 및 오피오이드 장 기능장애 증후군의 치료를 위한 히드로모르폰 및 날록손
CA3129758A1 (fr) 2019-03-11 2020-09-17 Evonik Operations Gmbh Forme posologique comprenant une matrice polymere

Citations (7)

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US4152414A (en) * 1978-08-18 1979-05-01 Iowa State University Research Foundation, Inc. Combination vaccine for swine dysentery and method of use
GB2178313A (en) * 1985-07-31 1987-02-11 Zyma Sa A granular delayed-release forms
US6391338B1 (en) * 1995-09-07 2002-05-21 Biovail Technologies Ltd. System for rendering substantially non-dissoluble bio-affecting agents bio-available
WO2002041873A1 (fr) * 2000-11-27 2002-05-30 Dr. Falk Pharma Gmbh Procede de coacervation destine a la fabrication d'agents pharmaceutiques a liberation retardee
US20020106412A1 (en) * 2000-07-10 2002-08-08 Therics, Inc Method and materials for controlling migration of binder liquid in a powder
US20030118641A1 (en) * 2000-07-27 2003-06-26 Roxane Laboratories, Inc. Abuse-resistant sustained-release opioid formulation
WO2006002884A1 (fr) * 2004-07-01 2006-01-12 Grünenthal GmbH Forme posologique anti-abus pour administration par voie orale

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HRP20020124A2 (en) * 2002-02-11 2003-10-31 Pliva D D Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping
AU2006208627B8 (en) * 2005-01-28 2009-08-13 Mundipharma Pty Limited Alcohol resistant dosage forms
US20060228413A1 (en) * 2005-02-28 2006-10-12 Penwest Pharmaceuticals Co. Controlled release venlafaxine formulations
PL116330U1 (en) * 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
CA2637755A1 (fr) * 2006-01-21 2007-07-26 Abbott Gmbh & Co. Kg Forme dosifiee et methode d'administration de drogues toxicomanogenes
EP2068840A2 (fr) * 2006-07-21 2009-06-17 LAB International SRL Système de délivrance hydrophobe empêchant les utilisations abusives

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4152414A (en) * 1978-08-18 1979-05-01 Iowa State University Research Foundation, Inc. Combination vaccine for swine dysentery and method of use
GB2178313A (en) * 1985-07-31 1987-02-11 Zyma Sa A granular delayed-release forms
US6391338B1 (en) * 1995-09-07 2002-05-21 Biovail Technologies Ltd. System for rendering substantially non-dissoluble bio-affecting agents bio-available
US20050163856A1 (en) * 1999-07-29 2005-07-28 Roxane Laboratories, Inc. Abuse-resistant sustained-release opioid formulation
US20020106412A1 (en) * 2000-07-10 2002-08-08 Therics, Inc Method and materials for controlling migration of binder liquid in a powder
US20030118641A1 (en) * 2000-07-27 2003-06-26 Roxane Laboratories, Inc. Abuse-resistant sustained-release opioid formulation
WO2002041873A1 (fr) * 2000-11-27 2002-05-30 Dr. Falk Pharma Gmbh Procede de coacervation destine a la fabrication d'agents pharmaceutiques a liberation retardee
WO2006002884A1 (fr) * 2004-07-01 2006-01-12 Grünenthal GmbH Forme posologique anti-abus pour administration par voie orale

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11045422B2 (en) 2007-08-13 2021-06-29 Oheno Life Sciences, Inc. Abuse resistant drugs, method of use and method of making
US10688053B2 (en) 2007-08-13 2020-06-23 Inspirion Delivery Sciences, Llc Abuse resistant forms of extended release hydrocodone, method of use and method of making
US11291634B2 (en) 2007-08-13 2022-04-05 OHEMO Life Sciences, Inc. Abuse resistant forms of extended release oxymorphone, method of use and method of making
US10736850B2 (en) 2007-08-13 2020-08-11 Ohemo Life Sciences Inc. Abuse resistant oral opioid formulations
US10729656B2 (en) 2007-08-13 2020-08-04 Ohemo Life Sciences Inc. Abuse resistant forms of immediate release oxycodone, method of use and method of making
US10688054B2 (en) 2007-08-13 2020-06-23 Inspirion Delivery Sciences Llc Abuse resistant forms of extended release morphine, method of use and method of making
US10688051B2 (en) 2007-08-13 2020-06-23 Inspirion Delivery Sciences Llc Abuse resistant forms of extended release oxycodone, method of use, and method of making
US10695298B2 (en) 2007-08-13 2020-06-30 Inspirion Delivery Sciences, Llc Abuse resistant forms of extended release hydromorphone, method of use and method of making
US10702480B2 (en) 2007-08-13 2020-07-07 OHEMO Life Sciences, Inc. Abuse resistant forms of extended release morphine, method of use and method of making
US10729657B2 (en) 2007-08-13 2020-08-04 Ohemo Life Sciences Inc. Abuse resistant forms of extended release morphine, method of use and method of making
US10688052B2 (en) 2007-08-13 2020-06-23 Inspirion Delivery Sciences Llc Abuse resistant forms of extended release oxymorphone, method of use and method of making
US11285112B2 (en) 2007-08-13 2022-03-29 Oheno Life Sciences, Inc Abuse resistant forms of immediate release oxymorphone, method of use and method of making
US10688055B2 (en) 2007-08-13 2020-06-23 Inspirion Delivery Sciences, Llc Abuse resistant forms of extended release morphine, method of use and method of making
US10736852B2 (en) 2007-08-13 2020-08-11 OHEMO Life Sciences, Inc. Abuse resistant oral opioid formulations
US10736851B2 (en) 2007-08-13 2020-08-11 Ohemo Life Sciences Inc. Abuse resistant forms of extended release morphine with oxycodone, method of use and method of making
US20150044282A1 (en) * 2007-08-13 2015-02-12 Inspirion Delivery Technologies, Llc Abuse resistant forms of immediate release oxycodone, method of use and method of making
US11191730B2 (en) 2007-08-13 2021-12-07 Ohemo Life Sciences Inc. Abuse resistant forms of immediate release hydromorphone, method of use and method of making
US11278500B2 (en) 2007-08-13 2022-03-22 OHEMO Life Sciences, Inc. Abuse resistant forms of extended release hydrocodone, method of use and method of making
US10420726B2 (en) 2013-03-15 2019-09-24 Inspirion Delivery Sciences, Llc Abuse deterrent compositions and methods of use
US11571390B2 (en) 2013-03-15 2023-02-07 Othemo Life Sciences, Inc. Abuse deterrent compositions and methods of use
US10729685B2 (en) 2014-09-15 2020-08-04 Ohemo Life Sciences Inc. Orally administrable compositions and methods of deterring abuse by intranasal administration

Also Published As

Publication number Publication date
WO2008049657A2 (fr) 2008-05-02
WO2008049657A3 (fr) 2008-10-30
TW200833372A (en) 2008-08-16

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Legal Events

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OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8139 Disposal/non-payment of the annual fee