DE102006024355B4 - Mikrofluidische Anordnung zur Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln - Google Patents

Mikrofluidische Anordnung zur Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln Download PDF

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Publication number
DE102006024355B4
DE102006024355B4 DE102006024355A DE102006024355A DE102006024355B4 DE 102006024355 B4 DE102006024355 B4 DE 102006024355B4 DE 102006024355 A DE102006024355 A DE 102006024355A DE 102006024355 A DE102006024355 A DE 102006024355A DE 102006024355 B4 DE102006024355 B4 DE 102006024355B4
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DE
Germany
Prior art keywords
measuring channel
barrier elements
liquid sample
arrangement according
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE102006024355A
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German (de)
English (en)
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DE102006024355A1 (de
Inventor
Frank Dipl.-Ing. Sonntag
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
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Priority to DE102006024355A priority Critical patent/DE102006024355B4/de
Priority to PCT/DE2007/000926 priority patent/WO2007134593A1/fr
Publication of DE102006024355A1 publication Critical patent/DE102006024355A1/de
Application granted granted Critical
Publication of DE102006024355B4 publication Critical patent/DE102006024355B4/de
Expired - Fee Related legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/421—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4316—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor the baffles being flat pieces of material, e.g. intermeshing, fixed to the wall or fixed on a central rod
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/43197—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor characterised by the mounting of the baffles or obstructions
    • B01F25/431971—Mounted on the wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
DE102006024355A 2006-05-19 2006-05-19 Mikrofluidische Anordnung zur Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln Expired - Fee Related DE102006024355B4 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE102006024355A DE102006024355B4 (de) 2006-05-19 2006-05-19 Mikrofluidische Anordnung zur Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln
PCT/DE2007/000926 WO2007134593A1 (fr) 2006-05-19 2007-05-15 Système microfluidique de détection de molécules et/ou de particules chimiques/biochimiques contenues dans des échantillons

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006024355A DE102006024355B4 (de) 2006-05-19 2006-05-19 Mikrofluidische Anordnung zur Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln

Publications (2)

Publication Number Publication Date
DE102006024355A1 DE102006024355A1 (de) 2007-11-22
DE102006024355B4 true DE102006024355B4 (de) 2008-04-03

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DE102006024355A Expired - Fee Related DE102006024355B4 (de) 2006-05-19 2006-05-19 Mikrofluidische Anordnung zur Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln

Country Status (2)

Country Link
DE (1) DE102006024355B4 (fr)
WO (1) WO2007134593A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011004805A1 (de) * 2011-02-28 2012-08-30 Siemens Aktiengesellschaft Miniaturisierte magnetische Durchflusszytometrie

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009046598B4 (de) * 2009-11-11 2024-06-13 Robert Bosch Gmbh Vorrichtung zur Durchführung von Tests, insbesondere von molekularbiologischen Tests
DE102015204728B8 (de) * 2015-03-16 2021-08-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Messvorrichtung, Mikrofluidikvorrichtung und Zellinkubationssystem zum Bestimmen einer Anzahl biologischer Zellen

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618476A (en) * 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US6271040B1 (en) * 1992-05-21 2001-08-07 Biosite Diagnostics Incorporated Diagnostic devices method and apparatus for the controlled movement of reagents without membranes
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
US20030178641A1 (en) * 2002-01-23 2003-09-25 Blair Steven M. Microfluidic platforms for use with specific binding assays, specific binding assays that employ microfluidics, and methods
EP0981408B1 (fr) * 1997-05-16 2004-04-21 Alberta Research Council Systeme microfluidique et ses utilisations
EP1418243A2 (fr) * 2002-10-31 2004-05-12 Hewlett-Packard Development Company, L.P. Système microfluidique d analyse d acides nucléiques
DE10324973A1 (de) * 2003-05-27 2004-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln
EP1198294B1 (fr) * 1999-08-01 2005-11-09 febit biotech GmbH Support de reaction microfluide presentant trois niveaux d'ecoulement

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4797196B2 (ja) * 2001-02-14 2011-10-19 株式会社 フューエンス マイクロチップ
WO2004008142A1 (fr) * 2002-07-12 2004-01-22 Mitsubishi Chemical Corporation Puce d'analyse, unite de puce d'analyse, appareil d'analyse, methode d'analyse effectuee avec l'appareil et procede de production de la puce d'analyse
WO2005086703A2 (fr) * 2004-03-05 2005-09-22 Creatv Microtech, Inc. Detecteur chimique et biologique a flux continu

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618476A (en) * 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US6271040B1 (en) * 1992-05-21 2001-08-07 Biosite Diagnostics Incorporated Diagnostic devices method and apparatus for the controlled movement of reagents without membranes
EP0981408B1 (fr) * 1997-05-16 2004-04-21 Alberta Research Council Systeme microfluidique et ses utilisations
EP1198294B1 (fr) * 1999-08-01 2005-11-09 febit biotech GmbH Support de reaction microfluide presentant trois niveaux d'ecoulement
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
US20030178641A1 (en) * 2002-01-23 2003-09-25 Blair Steven M. Microfluidic platforms for use with specific binding assays, specific binding assays that employ microfluidics, and methods
EP1418243A2 (fr) * 2002-10-31 2004-05-12 Hewlett-Packard Development Company, L.P. Système microfluidique d analyse d acides nucléiques
DE10324973A1 (de) * 2003-05-27 2004-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011004805A1 (de) * 2011-02-28 2012-08-30 Siemens Aktiengesellschaft Miniaturisierte magnetische Durchflusszytometrie

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Publication number Publication date
WO2007134593A1 (fr) 2007-11-29
DE102006024355A1 (de) 2007-11-22

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