DE102005033902B3 - Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel - Google Patents
Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel Download PDFInfo
- Publication number
- DE102005033902B3 DE102005033902B3 DE102005033902A DE102005033902A DE102005033902B3 DE 102005033902 B3 DE102005033902 B3 DE 102005033902B3 DE 102005033902 A DE102005033902 A DE 102005033902A DE 102005033902 A DE102005033902 A DE 102005033902A DE 102005033902 B3 DE102005033902 B3 DE 102005033902B3
- Authority
- DE
- Germany
- Prior art keywords
- groups
- mmol
- general formula
- metal complexes
- och
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*CN(C*C)CC(C[U]I=C1OC1*1CCC1)N(C*)C*C Chemical compound C*CN(C*C)CC(C[U]I=C1OC1*1CCC1)N(C*)C*C 0.000 description 7
- XAZKFISIRYLAEE-UHFFFAOYSA-N CC1CC(C)CC1 Chemical compound CC1CC(C)CC1 XAZKFISIRYLAEE-UHFFFAOYSA-N 0.000 description 1
- YJFKBMPSUBWINR-UHFFFAOYSA-N CC1[U]C=[O]C1 Chemical compound CC1[U]C=[O]C1 YJFKBMPSUBWINR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005033902A DE102005033902B3 (de) | 2005-07-15 | 2005-07-15 | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
JP2008520780A JP2009501174A (ja) | 2005-07-15 | 2006-07-11 | ペルフルオロアルキル含有錯体、製造方法およびその使用 |
CNA2006800258905A CN101223148A (zh) | 2005-07-15 | 2006-07-11 | 含全氟烷基络合物、其制备方法及其应用 |
UY29664A UY29664A1 (es) | 2005-07-15 | 2006-07-11 | Complejos metalicos con contenido de prfluoroalquilo procedimientos para su preparacion, a´si como su uso |
CA002615443A CA2615443A1 (en) | 2005-07-15 | 2006-07-11 | Perfluoroalkyl-containing complexes, process for their production as well as their use |
EP06791535A EP1904463A2 (de) | 2005-07-15 | 2006-07-11 | Perfluoralkylhaltige komplexe, verfahren zu deren herstellung sowie deren verwendung |
AU2006272025A AU2006272025A1 (en) | 2005-07-15 | 2006-07-11 | Complexes containing perfluoroalkyl, method for the production and use thereof |
KR1020087001084A KR20080043762A (ko) | 2005-07-15 | 2006-07-11 | 퍼플루오로알킬 함유 착물, 그의 제조 방법 및 용도 |
PCT/EP2006/006777 WO2007009638A2 (de) | 2005-07-15 | 2006-07-11 | Perfluoralkylhaltige komplexe, verfahren zu deren herstellung sowie deren verwendung |
BRPI0613407-6A BRPI0613407A2 (pt) | 2005-07-15 | 2006-07-11 | Complexos contendo perfluoralquila, bem como composição farmacêutica, uso e processos de preparação dos mesmos |
RU2008105356/04A RU2008105356A (ru) | 2005-07-15 | 2006-07-11 | Перфторалкилсодержащие комплексы, способ их получения и их применение |
DO2006000167A DOP2006000167A (es) | 2005-07-15 | 2006-07-13 | Complejos metálicos con contenido de perfluoroalquilo, procedimientos para su preparación, así como su uso |
ARP060103020A AR054865A1 (es) | 2005-07-15 | 2006-07-14 | Complejos metalicos con contenido de perfluoroalquilo, procedimientos para su preparacion, asi como su uso |
PE2006000844A PE20070376A1 (es) | 2005-07-15 | 2006-07-14 | Complejos metalicos con contenido de perfluoroalquilo y procedimientos para su preparacion |
TW095125755A TW200706538A (en) | 2005-07-15 | 2006-07-14 | Perfluoroalkyl-containing complexes, process for their production as well as their use |
GT200600313A GT200600313A (es) | 2005-07-15 | 2006-07-14 | Complejos metalicos con contenido de perfluoroalquilo, procedimientos para su preparacion, asi como su uso. |
US11/487,604 US7618957B2 (en) | 2005-07-15 | 2006-07-17 | Perfluoroalkyl-containing complexes, process for their production as well as their use |
IL187926A IL187926A0 (en) | 2005-07-15 | 2007-12-06 | Complexes containing perfluoroalkyl, method for the production and use thereof |
CR9645A CR9645A (es) | 2005-07-15 | 2008-01-08 | Complejos con contenido de perfluoroalquilo, procedimientos para su preparacion asi como su uso |
EC2008008100A ECSP088100A (es) | 2005-07-15 | 2008-01-11 | Complejos con contenido de perfluoroalquilo, procedimientos para su preparación, así como su uso |
TNP2008000016A TNSN08016A1 (en) | 2005-07-15 | 2008-01-14 | Complexes containing perfluoroalkyl, method for the production and use thereof |
ZA200801523A ZA200801523B (en) | 2005-07-15 | 2008-02-14 | Complexes containing perfluoroalkyl, method for the production and use thereof |
NO20080813A NO20080813L (no) | 2005-07-15 | 2008-02-14 | Komplekser inneholdende perfluoralkyl, fremgangsmate for fremstilling og anvendelse derav |
US12/469,234 US20090297454A1 (en) | 2005-07-15 | 2009-05-20 | Perfluoroalkyl-Containing Complexes, Process For Their Production As Well As Their Use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005033902A DE102005033902B3 (de) | 2005-07-15 | 2005-07-15 | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DE102005033902B3 true DE102005033902B3 (de) | 2007-04-05 |
Family
ID=37057146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE102005033902A Expired - Fee Related DE102005033902B3 (de) | 2005-07-15 | 2005-07-15 | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1904463A2 (ru) |
JP (1) | JP2009501174A (ru) |
KR (1) | KR20080043762A (ru) |
CN (1) | CN101223148A (ru) |
AR (1) | AR054865A1 (ru) |
AU (1) | AU2006272025A1 (ru) |
BR (1) | BRPI0613407A2 (ru) |
CA (1) | CA2615443A1 (ru) |
CR (1) | CR9645A (ru) |
DE (1) | DE102005033902B3 (ru) |
DO (1) | DOP2006000167A (ru) |
EC (1) | ECSP088100A (ru) |
GT (1) | GT200600313A (ru) |
IL (1) | IL187926A0 (ru) |
NO (1) | NO20080813L (ru) |
PE (1) | PE20070376A1 (ru) |
RU (1) | RU2008105356A (ru) |
TN (1) | TNSN08016A1 (ru) |
TW (1) | TW200706538A (ru) |
UY (1) | UY29664A1 (ru) |
WO (1) | WO2007009638A2 (ru) |
ZA (1) | ZA200801523B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007015598A1 (de) * | 2007-03-29 | 2008-10-02 | Heinrich-Heine-Universität Düsseldorf | Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren |
CN103965128B (zh) | 2008-01-08 | 2018-04-03 | 兰休斯医疗成像公司 | 作为显像剂的n‑烷氧基酰胺共轭物 |
CA3153519A1 (en) * | 2019-10-04 | 2021-04-08 | Bryan J. Traughber | Development of imaging and therapeutic glucose analogues for sodium dependent glucose transporters |
EP4059925A1 (en) | 2021-03-15 | 2022-09-21 | Bayer Aktiengesellschaft | New contrast agent for use in magnetic resonance imaging |
CN114181164A (zh) * | 2021-12-13 | 2022-03-15 | 武汉大学中南医院 | 基于Fe(Ⅱ)特异性MRI对比剂的合成方法及其应用 |
EP4335840A1 (en) | 2022-09-09 | 2024-03-13 | Bayer Aktiengesellschaft | New contrast agents for use in diagnostic imaging |
EP4335462A1 (en) | 2022-09-09 | 2024-03-13 | Bayer AG | Contrast agents for use in diagnostic computed tomography imaging |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4317588A1 (de) * | 1993-05-24 | 1994-12-01 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe |
DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
DE19744003A1 (de) * | 1997-09-26 | 1999-07-15 | Schering Ag | Kontrastmittel für das Infarkt- und Nekroseimaging |
DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
DE19914101C1 (de) * | 1999-03-22 | 2000-10-12 | Schering Ag | Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik |
DE10040858A1 (de) * | 2000-08-11 | 2002-03-28 | Schering Ag | Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung |
-
2005
- 2005-07-15 DE DE102005033902A patent/DE102005033902B3/de not_active Expired - Fee Related
-
2006
- 2006-07-11 KR KR1020087001084A patent/KR20080043762A/ko not_active Application Discontinuation
- 2006-07-11 BR BRPI0613407-6A patent/BRPI0613407A2/pt not_active Application Discontinuation
- 2006-07-11 WO PCT/EP2006/006777 patent/WO2007009638A2/de active Application Filing
- 2006-07-11 UY UY29664A patent/UY29664A1/es not_active Application Discontinuation
- 2006-07-11 CA CA002615443A patent/CA2615443A1/en not_active Abandoned
- 2006-07-11 RU RU2008105356/04A patent/RU2008105356A/ru not_active Application Discontinuation
- 2006-07-11 CN CNA2006800258905A patent/CN101223148A/zh active Pending
- 2006-07-11 EP EP06791535A patent/EP1904463A2/de not_active Withdrawn
- 2006-07-11 AU AU2006272025A patent/AU2006272025A1/en not_active Abandoned
- 2006-07-11 JP JP2008520780A patent/JP2009501174A/ja not_active Withdrawn
- 2006-07-13 DO DO2006000167A patent/DOP2006000167A/es unknown
- 2006-07-14 GT GT200600313A patent/GT200600313A/es unknown
- 2006-07-14 TW TW095125755A patent/TW200706538A/zh unknown
- 2006-07-14 PE PE2006000844A patent/PE20070376A1/es not_active Application Discontinuation
- 2006-07-14 AR ARP060103020A patent/AR054865A1/es unknown
-
2007
- 2007-12-06 IL IL187926A patent/IL187926A0/en unknown
-
2008
- 2008-01-08 CR CR9645A patent/CR9645A/es unknown
- 2008-01-11 EC EC2008008100A patent/ECSP088100A/es unknown
- 2008-01-14 TN TNP2008000016A patent/TNSN08016A1/en unknown
- 2008-02-14 ZA ZA200801523A patent/ZA200801523B/xx unknown
- 2008-02-14 NO NO20080813A patent/NO20080813L/no not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4317588A1 (de) * | 1993-05-24 | 1994-12-01 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe |
DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
DE19744003A1 (de) * | 1997-09-26 | 1999-07-15 | Schering Ag | Kontrastmittel für das Infarkt- und Nekroseimaging |
DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
DE19914101C1 (de) * | 1999-03-22 | 2000-10-12 | Schering Ag | Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik |
DE10040858A1 (de) * | 2000-08-11 | 2002-03-28 | Schering Ag | Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung |
Also Published As
Publication number | Publication date |
---|---|
CN101223148A (zh) | 2008-07-16 |
AR054865A1 (es) | 2007-07-25 |
ZA200801523B (en) | 2008-11-26 |
RU2008105356A (ru) | 2009-08-20 |
DOP2006000167A (es) | 2007-02-28 |
GT200600313A (es) | 2007-04-23 |
JP2009501174A (ja) | 2009-01-15 |
NO20080813L (no) | 2008-04-09 |
EP1904463A2 (de) | 2008-04-02 |
IL187926A0 (en) | 2008-03-20 |
WO2007009638A2 (de) | 2007-01-25 |
BRPI0613407A2 (pt) | 2011-01-11 |
CA2615443A1 (en) | 2007-01-25 |
CR9645A (es) | 2008-05-21 |
KR20080043762A (ko) | 2008-05-19 |
AU2006272025A1 (en) | 2007-01-25 |
ECSP088100A (es) | 2008-05-30 |
UY29664A1 (es) | 2007-02-28 |
TW200706538A (en) | 2007-02-16 |
TNSN08016A1 (en) | 2009-07-14 |
PE20070376A1 (es) | 2007-04-20 |
WO2007009638A3 (de) | 2007-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8100 | Publication of patent without earlier publication of application | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE Owner name: EPIX PHARMACEUTICALS INC., CAMBRIDGE, MASS., US |
|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: EPIX PHARMACEUTICALS INC., CAMBRIDGE, MASS., US Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, 1335, DE |
|
R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |
Effective date: 20120201 |