DE102005028268B4 - Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums - Google Patents

Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums Download PDF

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Publication number
DE102005028268B4
DE102005028268B4 DE102005028268A DE102005028268A DE102005028268B4 DE 102005028268 B4 DE102005028268 B4 DE 102005028268B4 DE 102005028268 A DE102005028268 A DE 102005028268A DE 102005028268 A DE102005028268 A DE 102005028268A DE 102005028268 B4 DE102005028268 B4 DE 102005028268B4
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Germany
Prior art keywords
laser diode
medium
examined
excitation
radiation
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Expired - Fee Related
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DE102005028268A
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German (de)
English (en)
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DE102005028268A1 (de
Inventor
Dr. Klehr Andreas
Bernd Sumpf
Martin Maiwald
Dr. Schmidt Heinar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Berlin De
Ferdinand Braun Institut GgmbH Leibniz Institut fuer Hoechstfrequenztechnik
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Technische Universitaet Berlin
Forschungsverbund Berlin FVB eV
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Application filed by Technische Universitaet Berlin, Forschungsverbund Berlin FVB eV filed Critical Technische Universitaet Berlin
Priority to DE102005028268A priority Critical patent/DE102005028268B4/de
Priority to US11/916,997 priority patent/US7864311B2/en
Priority to EP06763667.0A priority patent/EP1891408B1/de
Priority to PCT/EP2006/063141 priority patent/WO2006134103A1/de
Priority to JP2008516301A priority patent/JP2008544238A/ja
Publication of DE102005028268A1 publication Critical patent/DE102005028268A1/de
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J2003/4424—Fluorescence correction for Raman spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Spectrometry And Color Measurement (AREA)
DE102005028268A 2005-06-14 2005-06-14 Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums Expired - Fee Related DE102005028268B4 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE102005028268A DE102005028268B4 (de) 2005-06-14 2005-06-14 Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums
US11/916,997 US7864311B2 (en) 2005-06-14 2006-06-13 Method and device for producing and detecting a Raman spectrum
EP06763667.0A EP1891408B1 (de) 2005-06-14 2006-06-13 Verfahren und vorrichtung zur erzeugung und detektion eines raman-spektrums
PCT/EP2006/063141 WO2006134103A1 (de) 2005-06-14 2006-06-13 Verfahren und vorrichtung zur erzeugung und detektion eines raman-spektrums
JP2008516301A JP2008544238A (ja) 2005-06-14 2006-06-13 ラマン・スペクトルを発生および検出する方法とその装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005028268A DE102005028268B4 (de) 2005-06-14 2005-06-14 Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums

Publications (2)

Publication Number Publication Date
DE102005028268A1 DE102005028268A1 (de) 2006-12-28
DE102005028268B4 true DE102005028268B4 (de) 2013-12-12

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DE102005028268A Expired - Fee Related DE102005028268B4 (de) 2005-06-14 2005-06-14 Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums

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Country Link
US (1) US7864311B2 (enExample)
EP (1) EP1891408B1 (enExample)
JP (1) JP2008544238A (enExample)
DE (1) DE102005028268B4 (enExample)
WO (1) WO2006134103A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016003334A1 (de) 2016-03-14 2017-09-14 Universität Stuttgart (Körperschaft Des Öffentlichen Rechts) Anordnung und Verfahren zur Raman-Spektroskopie, insbesondere auch zur Tumorgewebe- und Aorta-Diagnostik
DE102018130582A1 (de) * 2018-11-30 2020-06-04 Forschungsverbund Berlin E.V. Vorrichtung und Verfahren zur Raman-Spektroskopie

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US7558619B2 (en) * 2005-10-04 2009-07-07 Nu Skin International, Inc. Raman instrument for measuring weak signals in the presence of strong background fluorescence
US8553221B2 (en) * 2006-10-24 2013-10-08 Pd-Ld, Inc. Compact, low cost Raman monitor for single substances
GB0810761D0 (en) * 2008-06-12 2008-07-23 Avacta Ltd Apparatus and method for raman signal detection
JP5208825B2 (ja) * 2008-09-12 2013-06-12 オリンパス株式会社 光学顕微鏡
DE102009029648B3 (de) 2009-09-21 2011-03-24 Forschungsverbund Berlin E.V. Verfahren zur Erzeugung und zur Detektion eines Raman-Spektrums
US11754488B2 (en) 2009-12-11 2023-09-12 Washington University Opto-mechanical system and method having chaos induced stochastic resonance and opto-mechanically mediated chaos transfer
US20150285728A1 (en) 2009-12-11 2015-10-08 Washington University Detection of nano-scale particles with a self-referenced and self-heterodyned raman micro-laser
JP5903719B2 (ja) * 2010-08-31 2016-04-13 シクパ ホルディング ソシエテ アノニムＳｉｃｐａ Ｈｏｌｄｉｎｇ Ｓａ インライン分光リーダおよび方法
JP5539421B2 (ja) * 2012-02-24 2014-07-02 三菱電機株式会社 プラスチックの識別装置とその方法
US8570507B1 (en) 2012-09-06 2013-10-29 Bruker Optics, Inc. Method and apparatus for acquiring Raman spectra without background interferences
JP2015059800A (ja) * 2013-09-18 2015-03-30 コニカミノルタ株式会社 ラマン分光測定方法及びラマン分光測定装置
JP6248666B2 (ja) * 2014-02-07 2017-12-20 コニカミノルタ株式会社 ラマン散乱光測定方法及びラマン散乱光測定装置
US9905990B1 (en) * 2014-04-17 2018-02-27 Alakai Defense Systems, Inc. Background removal from Raman spectra by an intracavity active-tuning element for a laser
KR101640202B1 (ko) * 2016-04-04 2016-07-21 스페클립스 주식회사 레이저 조사 장치를 이용한 질병 진단 장치 및 질병 진단용 탈부착 핸드피스
EP3803293A4 (en) * 2018-05-30 2022-06-15 Pendar Technologies, LLC METHODS AND DEVICES FOR GAP DIFFERENTIAL RAMAN SPECTROSCOPY WITH INCREASED OCULAR SAFETY AND REDUCED RISK OF EXPLOSION
WO2019231512A1 (en) * 2018-05-30 2019-12-05 Pendar Technologies, Llc Methods and devices for standoff differential raman spectroscopy with increased eye safety and decreased risk of explosion
GB2572662B (en) * 2018-10-05 2020-06-03 Res & Innovation Uk Raman spectrometer
KR102375159B1 (ko) 2019-03-22 2022-03-16 스페클립스 주식회사 레이저 유도 붕괴 스펙트럼 분석을 이용하는 진단 방법 및 이를 수행하는 진단 장치
US11193827B2 (en) 2019-05-06 2021-12-07 Cytoveris, Inc. Method and apparatus for identifying background fluorescence using spread spectrum excitation-source broadening in Raman spectroscopy
US12320682B2 (en) 2023-06-23 2025-06-03 Washington University High-Q whispering gallery mode (WGM) resonators encapsulated in polydimethylsilozane (PDMS) for highly sensitive displacement detection
WO2025174366A1 (en) * 2024-02-14 2025-08-21 Thermo Electron Scientific Instruments Llc Method and system for raman spectroscopy
CN119845419B (zh) * 2025-03-24 2025-11-25 武汉长进光子技术股份有限公司 一种监测受激布里渊散射效应的光学系统及监测方法

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WO2002021087A1 (en) * 2000-09-08 2002-03-14 New Chromex, Inc. Method for adjusting spectral measurements to produce a standard raman spectrum
WO2004008121A2 (en) * 2002-07-16 2004-01-22 East Carolina University Laser tweezers and raman spectroscopy systems and methods for studying microscopic particles

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JP2001185806A (ja) * 1999-12-27 2001-07-06 Yokogawa Electric Corp 波長切換半導体レーザ
US7196786B2 (en) * 2003-05-06 2007-03-27 Baker Hughes Incorporated Method and apparatus for a tunable diode laser spectrometer for analysis of hydrocarbon samples
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EP1700100A1 (en) * 2003-12-22 2006-09-13 Koninklijke Philips Electronics N.V. Optical analysis system, blood analysis system and method of determining an amplitude of a principal component

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DE69231614T2 (de) * 1991-02-26 2001-05-03 Massachusetts Institute Of Technology, Cambridge Molekularspektroskopieverfahren und -einrichtungen zur gewebediagnose
WO2002021087A1 (en) * 2000-09-08 2002-03-14 New Chromex, Inc. Method for adjusting spectral measurements to produce a standard raman spectrum
WO2004008121A2 (en) * 2002-07-16 2004-01-22 East Carolina University Laser tweezers and raman spectroscopy systems and methods for studying microscopic particles

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016003334A1 (de) 2016-03-14 2017-09-14 Universität Stuttgart (Körperschaft Des Öffentlichen Rechts) Anordnung und Verfahren zur Raman-Spektroskopie, insbesondere auch zur Tumorgewebe- und Aorta-Diagnostik
WO2017157514A1 (de) 2016-03-14 2017-09-21 Universität Stuttgart Anordnung und verfahren zur raman-spektroskopie
DE102018130582A1 (de) * 2018-11-30 2020-06-04 Forschungsverbund Berlin E.V. Vorrichtung und Verfahren zur Raman-Spektroskopie

Also Published As

Publication number Publication date
US20080204715A1 (en) 2008-08-28
WO2006134103A1 (de) 2006-12-21
EP1891408A1 (de) 2008-02-27
US7864311B2 (en) 2011-01-04
DE102005028268A1 (de) 2006-12-28
EP1891408B1 (de) 2017-03-15
WO2006134103A8 (de) 2007-03-15
JP2008544238A (ja) 2008-12-04

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OP8 Request for examination as to paragraph 44 patent law
8181 Inventor (new situation)

Inventor name: SUMPF, BERND, DR., 12527 BERLIN, DE

Inventor name: SCHMIDT, HEINAR, DR., 14129 BERLIN, DE

Inventor name: MAIWALD, MARTIN, 14197 BERLIN, DE

Inventor name: KLEHR, ANDREAS, DR., 13156 BERLIN, DE

8181 Inventor (new situation)

Inventor name: MAIWALD, MARTIN, DR., 12045 BERLIN, DE

Inventor name: KLEHR, ANDREAS, DR., 13156 BERLIN, DE

Inventor name: SCHMIDT, HEINAR, DR., 14129 BERLIN, DE

Inventor name: SUMPF, BERND, DR., 12527 BERLIN, DE

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