DE102004023507A1 - Substituierte Cyclohexylessigsäure-Derivate - Google Patents

Substituierte Cyclohexylessigsäure-Derivate Download PDF

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Publication number
DE102004023507A1
DE102004023507A1 DE102004023507A DE102004023507A DE102004023507A1 DE 102004023507 A1 DE102004023507 A1 DE 102004023507A1 DE 102004023507 A DE102004023507 A DE 102004023507A DE 102004023507 A DE102004023507 A DE 102004023507A DE 102004023507 A1 DE102004023507 A1 DE 102004023507A1
Authority
DE
Germany
Prior art keywords
dimethylamino
hydrochloride
acetamide
indol
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102004023507A
Other languages
German (de)
English (en)
Inventor
Claudia Dr. Hinze
Bernd Dr. Sundermann
Hans Prof. Dr. Schick
Birgitta Dr. Henkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE102004023507A priority Critical patent/DE102004023507A1/de
Priority to DK05745355.7T priority patent/DK1751093T3/da
Priority to ES05745355T priority patent/ES2353390T3/es
Priority to SI200531192T priority patent/SI1751093T1/sl
Priority to CA2563017A priority patent/CA2563017C/en
Priority to DE502005010342T priority patent/DE502005010342D1/de
Priority to AT05745355T priority patent/ATE483679T1/de
Priority to JP2007512029A priority patent/JP4852536B2/ja
Priority to PT05745355T priority patent/PT1751093E/pt
Priority to PCT/EP2005/004909 priority patent/WO2005110976A1/de
Priority to EP05745355A priority patent/EP1751093B1/de
Priority to PL05745355T priority patent/PL1751093T3/pl
Publication of DE102004023507A1 publication Critical patent/DE102004023507A1/de
Priority to US11/594,945 priority patent/US8017630B2/en
Priority to CY20101101057T priority patent/CY1111327T1/el
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE102004023507A 2004-05-10 2004-05-10 Substituierte Cyclohexylessigsäure-Derivate Withdrawn DE102004023507A1 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE102004023507A DE102004023507A1 (de) 2004-05-10 2004-05-10 Substituierte Cyclohexylessigsäure-Derivate
JP2007512029A JP4852536B2 (ja) 2004-05-10 2005-05-06 置換されたシクロヘキシル酢酸誘導体
PT05745355T PT1751093E (pt) 2004-05-10 2005-05-06 Derivados de ácido ciclo-hexilacético substituídos
SI200531192T SI1751093T1 (sl) 2004-05-10 2005-05-06 Substituirani derivati cikloheksilocetne kisline
CA2563017A CA2563017C (en) 2004-05-10 2005-05-06 Substituted cyclohexylacetic acid derivatives
DE502005010342T DE502005010342D1 (en) 2004-05-10 2005-05-06 Substituierte cyclohexylessigsäure-derivate
AT05745355T ATE483679T1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexylessigsäure-derivate
DK05745355.7T DK1751093T3 (da) 2004-05-10 2005-05-06 Substituerede cyklohexyleddikesyre-derivater
ES05745355T ES2353390T3 (es) 2004-05-10 2005-05-06 Derivados de ácido ciclohexilacético sustituidos.
PCT/EP2005/004909 WO2005110976A1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexylessigsäure-derivate
EP05745355A EP1751093B1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexylessigsäure-derivate
PL05745355T PL1751093T3 (pl) 2004-05-10 2005-05-06 Podstawione pochodne kwasu cykloheksylooctowego
US11/594,945 US8017630B2 (en) 2004-05-10 2006-11-09 Cyclohexylacetic acid compounds
CY20101101057T CY1111327T1 (el) 2004-05-10 2010-11-24 Υποκατεστημενα παραγωγα κυκλοεξυλοξεικου οξεος

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004023507A DE102004023507A1 (de) 2004-05-10 2004-05-10 Substituierte Cyclohexylessigsäure-Derivate

Publications (1)

Publication Number Publication Date
DE102004023507A1 true DE102004023507A1 (de) 2005-12-01

Family

ID=34968613

Family Applications (2)

Application Number Title Priority Date Filing Date
DE102004023507A Withdrawn DE102004023507A1 (de) 2004-05-10 2004-05-10 Substituierte Cyclohexylessigsäure-Derivate
DE502005010342T Expired - Lifetime DE502005010342D1 (en) 2004-05-10 2005-05-06 Substituierte cyclohexylessigsäure-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE502005010342T Expired - Lifetime DE502005010342D1 (en) 2004-05-10 2005-05-06 Substituierte cyclohexylessigsäure-derivate

Country Status (13)

Country Link
US (1) US8017630B2 (https=)
EP (1) EP1751093B1 (https=)
JP (1) JP4852536B2 (https=)
AT (1) ATE483679T1 (https=)
CA (1) CA2563017C (https=)
CY (1) CY1111327T1 (https=)
DE (2) DE102004023507A1 (https=)
DK (1) DK1751093T3 (https=)
ES (1) ES2353390T3 (https=)
PL (1) PL1751093T3 (https=)
PT (1) PT1751093E (https=)
SI (1) SI1751093T1 (https=)
WO (1) WO2005110976A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090215725A1 (en) * 2008-02-26 2009-08-27 Grunenthal Gmbh Substituted 4-aminocyclohexane derivatives
ES2375543T3 (es) 2008-03-27 2012-03-01 Grünenthal GmbH Derivados de espiro(5.5)undecano.
CN102046591B (zh) 2008-03-27 2014-12-03 格吕伦塔尔有限公司 羟甲基环己胺
AU2009228647B2 (en) 2008-03-27 2013-07-04 Grunenthal Gmbh Substituted spirocyclic cyclohexane derivatives
ES2464102T3 (es) 2008-03-27 2014-05-30 Grünenthal GmbH Derivados de 4-aminociclohexano sustituidos
JP5529843B2 (ja) 2008-03-27 2014-06-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換シクロヘキシルジアミン
EP2280941B1 (de) 2008-03-27 2015-05-06 Grünenthal GmbH (hetero-)aryl-cyclohexan-derivate
US20090298834A1 (en) * 2008-06-02 2009-12-03 Hassan Pajouhesh 4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers
RS55943B1 (sr) 2013-06-24 2017-09-29 Merck Patent Gmbh Ftalazin derivati
CN106535884A (zh) 2014-06-06 2017-03-22 弗雷克萨斯生物科学公司 免疫调节剂
MX2017005462A (es) * 2014-11-05 2017-07-28 Flexus Biosciences Inc Agentes inmunorreguladores.
UY36391A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
CN114340670B (zh) 2019-07-11 2026-02-17 普拉克西斯精密药物股份有限公司 T-型钙通道调节剂的制剂及其使用方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090317A1 (de) * 2001-05-09 2002-11-14 Grünenthal GmbH Substituierte cyclohexan-1,4-diaminderivate
US20030229119A1 (en) * 2002-02-22 2003-12-11 Kym Philip R. Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor
WO2004022535A1 (ja) * 2002-08-28 2004-03-18 Yamanouchi Pharmaceutical Co., Ltd. アクリルアミド誘導体

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
US4366172A (en) * 1977-09-29 1982-12-28 The Upjohn Company 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use
US4212878A (en) * 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
US4346101A (en) * 1980-12-08 1982-08-24 The Upjohn Company Benzamide derivative analgesics
DE3924304A1 (de) * 1989-07-22 1991-01-31 Bayer Ag Neue fluorierte cyclohexanderivate, verfahren und zwischenprodukte zu deren herstellung und die verwendung der neuen fluorierten cyclohexanderivate als fungizide und zwischenprodukte
US5304479A (en) * 1991-12-06 1994-04-19 Diagnostic Reagents, Inc. Phencyclidine compounds and assays for its determination
US5239110A (en) * 1992-12-30 1993-08-24 Sterling Winthrop, Inc. Phenylcyclohexanol derivatives as agents for treating CNS disorders
CA2373855A1 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
DE19939044A1 (de) 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
DE19963175A1 (de) 1999-12-27 2001-07-12 Gruenenthal Gmbh Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
US7138397B2 (en) * 2000-10-06 2006-11-21 Tanabe Seiyaku Co., Ltd. Nitrogenous 5-membered ring compounds
ES2188344B1 (es) * 2000-11-29 2004-09-16 Laboratorios Vita, S.A. Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
EP1458704A1 (en) * 2001-12-21 2004-09-22 H. Lundbeck A/S Aminoindane derivatives as serotonin and norepinephrine uptake inhibitors
AU2003221178B2 (en) * 2002-03-28 2006-06-15 Tanabe Seiyaku Co., Ltd. Benzofuran derivative
JP4329382B2 (ja) * 2002-04-04 2009-09-09 田辺三菱製薬株式会社 医薬組成物
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
DE10252650A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Cyclohexyl-Harnstoff-Derivate
WO2006040646A1 (en) * 2004-10-14 2006-04-20 Pfizer, Inc. Benzimidazole or indole amides as inhibitors of pin1

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090317A1 (de) * 2001-05-09 2002-11-14 Grünenthal GmbH Substituierte cyclohexan-1,4-diaminderivate
US20030229119A1 (en) * 2002-02-22 2003-12-11 Kym Philip R. Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor
WO2004022535A1 (ja) * 2002-08-28 2004-03-18 Yamanouchi Pharmaceutical Co., Ltd. アクリルアミド誘導体

Also Published As

Publication number Publication date
JP2007536319A (ja) 2007-12-13
US20070129347A1 (en) 2007-06-07
ES2353390T3 (es) 2011-03-01
EP1751093B1 (de) 2010-10-06
EP1751093A1 (de) 2007-02-14
US8017630B2 (en) 2011-09-13
WO2005110976A1 (de) 2005-11-24
PT1751093E (pt) 2010-11-29
DE502005010342D1 (en) 2010-11-18
CA2563017A1 (en) 2005-11-24
JP4852536B2 (ja) 2012-01-11
CY1111327T1 (el) 2015-08-05
DK1751093T3 (da) 2010-12-20
SI1751093T1 (sl) 2011-01-31
ATE483679T1 (de) 2010-10-15
CA2563017C (en) 2012-10-02
PL1751093T3 (pl) 2011-04-29

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Effective date: 20110510