DE10012824A1 - Arzneimittel gegen virale Erkrankungen - Google Patents

Arzneimittel gegen virale Erkrankungen

Info

Publication number
DE10012824A1
DE10012824A1 DE10012824A DE10012824A DE10012824A1 DE 10012824 A1 DE10012824 A1 DE 10012824A1 DE 10012824 A DE10012824 A DE 10012824A DE 10012824 A DE10012824 A DE 10012824A DE 10012824 A1 DE10012824 A1 DE 10012824A1
Authority
DE
Germany
Prior art keywords
alkyl
substituted
phenyl
alkoxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10012824A
Other languages
German (de)
English (en)
Inventor
Siegfried Goldmann
Juergen Stoltefus
Ulrich Niewoehner
Karl-Heinz Schlemmer
Thomas Kraemer
Arnold Paessens
Erwin Graef
Olaf Weber
Karl Deres
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE10012824A priority Critical patent/DE10012824A1/de
Priority to PCT/EP2001/002444 priority patent/WO2001068642A1/fr
Priority to AU56185/01A priority patent/AU5618501A/en
Publication of DE10012824A1 publication Critical patent/DE10012824A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE10012824A 2000-03-16 2000-03-16 Arzneimittel gegen virale Erkrankungen Withdrawn DE10012824A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE10012824A DE10012824A1 (de) 2000-03-16 2000-03-16 Arzneimittel gegen virale Erkrankungen
PCT/EP2001/002444 WO2001068642A1 (fr) 2000-03-16 2001-03-05 Dihydropirimidines et leur utilisation en tant qu'agents pharmaceutiques destines au traitement de l'hepatite b
AU56185/01A AU5618501A (en) 2000-03-16 2001-03-05 Dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10012824A DE10012824A1 (de) 2000-03-16 2000-03-16 Arzneimittel gegen virale Erkrankungen

Publications (1)

Publication Number Publication Date
DE10012824A1 true DE10012824A1 (de) 2001-09-20

Family

ID=7634954

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10012824A Withdrawn DE10012824A1 (de) 2000-03-16 2000-03-16 Arzneimittel gegen virale Erkrankungen

Country Status (3)

Country Link
AU (1) AU5618501A (fr)
DE (1) DE10012824A1 (fr)
WO (1) WO2001068642A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2135866A1 (fr) * 2007-01-16 2009-12-23 Beijing Molecule Science and Technology Co., Ltd. Nouveaux composés de dihydropyrimidine et leurs utilisations dans la préparation de médicaments pharmaceutiques destinés au traitement et à la prévention des viroses

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101225083A (zh) * 2007-01-16 2008-07-23 北京摩力克科技有限公司 四氢喹唑啉酮类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
WO2008154819A1 (fr) * 2007-06-18 2008-12-24 Zhang, Zhongneng Thiazolyl-dihydropyrimidines à substitution carbéthoxy
CN101328170B (zh) * 2007-06-18 2011-09-14 张中能 一种氟苯基-取代噻唑二氢嘧啶
WO2008154820A1 (fr) * 2007-06-18 2008-12-24 Zhang, Zhongneng Thiazolyl-dihydropyrimidines à substitution carbéthoxy
KR101173892B1 (ko) 2007-06-18 2012-08-16 선샤인 레이크 파르마 컴퍼니 리미티드 브로모-페닐 치환된 티아졸릴 디하이드로피리미딘
WO2013102655A1 (fr) 2012-01-06 2013-07-11 Janssen R&D Ireland 1,4-dihydropyrimidines 4,4-disubstituées et leur utilisation en tant que médicaments pour le traitement de l'hépatite b
CN104144924B (zh) * 2012-03-31 2016-02-24 弗·哈夫曼-拉罗切有限公司 用于治疗和预防乙型肝炎病毒感染的4-甲基-二氢嘧啶类
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
HUE034919T2 (en) * 2012-08-24 2018-03-28 Sunshine Lake Pharma Co Ltd 2,4,5,6-substituted 3,6-dihydropyrimidine derivatives such as hepatitis B virus (HBV) polymerase inhibitors, for example, for the treatment of chronic hepatitis
CN103664897B (zh) * 2012-09-01 2018-04-03 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
WO2014037480A1 (fr) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag Hétéroaryldihydropyrimidines d'acide 6-aminé pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b
WO2015074546A1 (fr) 2013-11-19 2015-05-28 Sunshine Lake Pharma Co., Ltd. Composés dihydropyrimidine et leur application dans des produits pharmaceutiques
RU2688193C1 (ru) 2013-11-27 2019-05-21 Саншайн Лейк Фарма Ко., Лтд. Процессы приготовления производных дигидропиримидина и их промежуточных соединений
CA2935811C (fr) 2014-03-07 2018-09-18 F. Hoffmann-La Roche Ag Nouvelles heteroaryldihydropyrimidines condensees en position 6 pour le traitement et la prophylaxie d'une infection a virus de l'hepatite b
MY196243A (en) 2014-03-28 2023-03-24 Sunshine Lake Pharma Co Ltd Dihydropyrimidine Compounds and Their Application In Pharmaceuticals
CN105859709B (zh) 2015-02-07 2018-12-04 广东东阳光药业有限公司 二氢嘧啶衍生物的复合物及其在药物中的应用
PT3270915T (pt) 2015-03-16 2020-06-17 H Hoffnabb La Roche Ag Tratamento combinado com um agonista do tlr7 e um inibidor da montagem da cápside do vhb
ES2894605T3 (es) 2016-09-13 2022-02-15 Hoffmann La Roche Tratamiento combinado con un agonista de TLR7 y un inhibidor del ensamblaje de la cápside del VHB
RU2745431C1 (ru) 2017-07-27 2021-03-25 Цзянсу Хэнжуй Медицин Ко., Лтд. Гетероарильное производное пиперазина, способ его получения и применение в медицине
CN113614088A (zh) 2019-03-25 2021-11-05 豪夫迈·罗氏有限公司 Hbv核心蛋白变构修饰剂化合物的固体形式

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702564D0 (sv) * 1997-07-02 1997-07-02 Astra Ab New compounds
DE19817265A1 (de) * 1998-04-18 1999-10-21 Bayer Ag Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe
DE19817262A1 (de) * 1998-04-18 1999-10-21 Bayer Ag Neue 2-heterocyclisch substituierte Dihydropyrimidine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2135866A1 (fr) * 2007-01-16 2009-12-23 Beijing Molecule Science and Technology Co., Ltd. Nouveaux composés de dihydropyrimidine et leurs utilisations dans la préparation de médicaments pharmaceutiques destinés au traitement et à la prévention des viroses
EP2135866A4 (fr) * 2007-01-16 2012-02-15 Beijing Molecule Science And Technology Co Ltd Nouveaux composés de dihydropyrimidine et leurs utilisations dans la préparation de médicaments pharmaceutiques destinés au traitement et à la prévention des viroses

Also Published As

Publication number Publication date
WO2001068642A1 (fr) 2001-09-20
AU5618501A (en) 2001-09-24

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee