DD283609A5 - Verfahren zur herstellung von chinolinderivaten - Google Patents
Verfahren zur herstellung von chinolinderivaten Download PDFInfo
- Publication number
- DD283609A5 DD283609A5 DD89325878A DD32587889A DD283609A5 DD 283609 A5 DD283609 A5 DD 283609A5 DD 89325878 A DD89325878 A DD 89325878A DD 32587889 A DD32587889 A DD 32587889A DD 283609 A5 DD283609 A5 DD 283609A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- mixture
- formula
- added
- dichloromethane
- stirred
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888804016A GB8804016D0 (en) | 1988-02-22 | 1988-02-22 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD283609A5 true DD283609A5 (de) | 1990-10-17 |
Family
ID=10632104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD89325878A DD283609A5 (de) | 1988-02-22 | 1989-02-20 | Verfahren zur herstellung von chinolinderivaten |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4997840A (da) |
| EP (1) | EP0330340A1 (da) |
| JP (1) | JPH02503320A (da) |
| KR (1) | KR900700455A (da) |
| CN (1) | CN1049659A (da) |
| AU (1) | AU3187489A (da) |
| DD (1) | DD283609A5 (da) |
| DK (1) | DK497489A (da) |
| FI (1) | FI894321A0 (da) |
| GB (1) | GB8804016D0 (da) |
| HU (1) | HU891560D0 (da) |
| IE (1) | IE890293L (da) |
| IL (1) | IL89286A0 (da) |
| NO (1) | NO894187L (da) |
| NZ (1) | NZ228035A (da) |
| PL (1) | PL277819A1 (da) |
| PT (1) | PT89794A (da) |
| WO (1) | WO1989007593A1 (da) |
| ZA (1) | ZA89923B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
| SE9103745D0 (sv) * | 1991-12-18 | 1991-12-18 | Wikstroem Haakan | Aryl-triflates and related compounds |
| AU5509099A (en) * | 1998-08-03 | 2000-02-28 | Basf Corporation | Pyridinones for the treatment of sexual dysfunction |
| US6458804B1 (en) | 2001-01-26 | 2002-10-01 | R.T. Alamo Venturesi, Llc | Methods for the treatment of central nervous system disorders in certain patient groups |
| US6562838B2 (en) | 2001-01-26 | 2003-05-13 | R. T. Alamo Ventures I, L.L.C. | Treatment of cardiovascular disease with quinolinone enantiomers |
| US6451813B1 (en) | 2001-01-26 | 2002-09-17 | R. T. Alamo Ventures I, Llc | Treatment of gastroparesis in certain patient groups |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3718653A (en) * | 1970-02-26 | 1973-02-27 | Int Minerals & Chem Corp | Quinoyl alkanesulfonates and toluenesulfonates |
| US4192873A (en) * | 1976-11-25 | 1980-03-11 | Ciba-Geigy Corporation | Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones |
| NZ193167A (en) * | 1979-03-27 | 1984-08-24 | Boots Co Plc | Quinoline derivatives and pharmaceutical compositions |
| GB2085441B (en) * | 1980-09-26 | 1984-10-17 | Boots The Co Ltd | Therapeutic agents |
| IE51542B1 (en) * | 1980-09-26 | 1987-01-07 | Boots Co Ltd | Therapeutic agents |
| US4510290A (en) * | 1982-01-11 | 1985-04-09 | Ciba Geigy Corporation | Acid-curable composition containing a masked curing catalyst, and a process for the curing thereof |
| DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| FR2543140B1 (fr) * | 1983-03-24 | 1985-06-21 | Cortial | Nouveaux acides flavone-carboxyliques-4', leur methode de preparation et leur application en therapeutique |
| FR2543550B1 (fr) * | 1983-04-01 | 1985-08-09 | Cortial | Nouveaux derives de la tetrahydroxy-3', 4',5,7 flavone, leur methode de preparation et leur emploi therapeutique |
| DE3324115A1 (de) * | 1983-07-05 | 1985-01-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| PT79031B (en) * | 1983-08-20 | 1986-08-22 | Boots Co Plc | Therapeutic agents |
| US4515796A (en) * | 1983-09-08 | 1985-05-07 | Eli Lilly And Company | Certain naphthalenyl imidazo compounds and their pharmaceutical use |
| DE3346640A1 (de) * | 1983-12-23 | 1985-07-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, deren herstellung und diese verbindungen enthaltende arzneimittel |
| EP0149519B1 (en) * | 1984-01-13 | 1990-06-27 | The Boots Company PLC | Use of quinolones for the manufacture of a composition for the treatment of heart failure. |
| GR850426B (da) * | 1984-02-24 | 1985-06-18 | Lilly Co Eli | |
| US4578387A (en) * | 1984-03-05 | 1986-03-25 | Eli Lilly And Company | Inotropic agents |
| US4670445A (en) * | 1984-03-05 | 1987-06-02 | Eli Lilly And Company | Inotropic agents |
| DE3576686D1 (de) * | 1984-08-15 | 1990-04-26 | Boots Co Ltd | Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate. |
| DE3446812A1 (de) * | 1984-12-21 | 1986-06-26 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| GB8515209D0 (en) * | 1985-06-15 | 1985-07-17 | Boots Co Plc | Therapeutic agents |
| DE3522230A1 (de) * | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB8726950D0 (en) * | 1987-11-18 | 1987-12-23 | Boots Co Plc | Chemical process |
| GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
-
1988
- 1988-02-22 GB GB888804016A patent/GB8804016D0/en active Pending
-
1989
- 1989-01-30 IE IE890293A patent/IE890293L/xx unknown
- 1989-02-07 ZA ZA89923A patent/ZA89923B/xx unknown
- 1989-02-09 AU AU31874/89A patent/AU3187489A/en not_active Abandoned
- 1989-02-09 WO PCT/GB1989/000126 patent/WO1989007593A1/en active Application Filing
- 1989-02-09 JP JP1502593A patent/JPH02503320A/ja active Pending
- 1989-02-09 HU HU891560A patent/HU891560D0/hu unknown
- 1989-02-09 EP EP89301229A patent/EP0330340A1/en not_active Withdrawn
- 1989-02-09 US US07/399,459 patent/US4997840A/en not_active Expired - Fee Related
- 1989-02-14 IL IL89286A patent/IL89286A0/xx unknown
- 1989-02-17 NZ NZ228035A patent/NZ228035A/en unknown
- 1989-02-20 DD DD89325878A patent/DD283609A5/de not_active IP Right Cessation
- 1989-02-20 PL PL27781989A patent/PL277819A1/xx unknown
- 1989-02-22 PT PT89794A patent/PT89794A/pt not_active Application Discontinuation
- 1989-08-21 CN CN89106439A patent/CN1049659A/zh active Pending
- 1989-09-13 FI FI894321A patent/FI894321A0/fi not_active Application Discontinuation
- 1989-10-09 DK DK497489A patent/DK497489A/da not_active Application Discontinuation
- 1989-10-20 KR KR1019890701922A patent/KR900700455A/ko not_active Application Discontinuation
- 1989-10-20 NO NO89894187A patent/NO894187L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR900700455A (ko) | 1990-08-13 |
| GB8804016D0 (en) | 1988-03-23 |
| ZA89923B (en) | 1989-10-25 |
| AU3187489A (en) | 1989-09-06 |
| CN1049659A (zh) | 1991-03-06 |
| EP0330340A1 (en) | 1989-08-30 |
| DK497489D0 (da) | 1989-10-09 |
| US4997840A (en) | 1991-03-05 |
| DK497489A (da) | 1989-11-16 |
| PT89794A (pt) | 1989-10-04 |
| IL89286A0 (en) | 1989-09-10 |
| NO894187D0 (no) | 1989-10-20 |
| NO894187L (no) | 1989-10-20 |
| JPH02503320A (ja) | 1990-10-11 |
| FI894321A0 (fi) | 1989-09-13 |
| NZ228035A (en) | 1990-11-27 |
| WO1989007593A1 (en) | 1989-08-24 |
| PL277819A1 (en) | 1990-01-08 |
| IE890293L (en) | 1989-08-22 |
| HU891560D0 (en) | 1990-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |