DD275874A5 - Verfahren zur herstellung von 2',3'-dideoxy-2'-fluoronucleosiden - Google Patents

Verfahren zur herstellung von 2',3'-dideoxy-2'-fluoronucleosiden Download PDF

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Publication number
DD275874A5
DD275874A5 DD88321728A DD32172888A DD275874A5 DD 275874 A5 DD275874 A5 DD 275874A5 DD 88321728 A DD88321728 A DD 88321728A DD 32172888 A DD32172888 A DD 32172888A DD 275874 A5 DD275874 A5 DD 275874A5
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DD
German Democratic Republic
Prior art keywords
group
hydroxy
deoxy
compound
compounds
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Application number
DD88321728A
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German (de)
English (en)
Inventor
Roman Z Sterzycki
Muzammil M Mansuri
John C Martin
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Publication of DD275874A5 publication Critical patent/DD275874A5/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD88321728A 1987-11-12 1988-11-11 Verfahren zur herstellung von 2',3'-dideoxy-2'-fluoronucleosiden DD275874A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/120,051 US4908440A (en) 1987-11-12 1987-11-12 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides

Publications (1)

Publication Number Publication Date
DD275874A5 true DD275874A5 (de) 1990-02-07

Family

ID=22387985

Family Applications (1)

Application Number Title Priority Date Filing Date
DD88321728A DD275874A5 (de) 1987-11-12 1988-11-11 Verfahren zur herstellung von 2',3'-dideoxy-2'-fluoronucleosiden

Country Status (22)

Country Link
US (4) US4908440A (es)
EP (1) EP0316017B1 (es)
JP (4) JPH01153698A (es)
KR (1) KR920004459B1 (es)
AT (1) ATE100461T1 (es)
AU (1) AU615960B2 (es)
CA (1) CA1340961C (es)
CZ (3) CZ278366B6 (es)
DD (1) DD275874A5 (es)
DE (1) DE3887273T2 (es)
DK (1) DK173971B1 (es)
ES (1) ES2061609T3 (es)
FI (1) FI90244C (es)
HU (1) HU199499B (es)
IE (1) IE62227B1 (es)
IL (1) IL88330A (es)
NO (1) NO169492C (es)
NZ (1) NZ226845A (es)
PT (1) PT88994B (es)
SK (2) SK545290A3 (es)
YU (1) YU47121B (es)
ZA (1) ZA888313B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459256A (en) * 1987-04-17 1995-10-17 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Lipophilic, aminohydrolase-activated prodrugs
US5495010A (en) * 1987-04-17 1996-02-27 The United States Of America As Represented By The Department Of Health And Human Services Acid stable purine dideoxynucleosides
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5644043A (en) * 1988-02-16 1997-07-01 Eli Lilly And Company 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates
US5198539A (en) * 1988-08-19 1993-03-30 Burroughs Wellcome Co. 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
GR1000618B (el) * 1989-03-17 1992-08-31 Oncogen Μεθοδος αναστολης hiv χρησιμοποιωντας συνεργιστικους συνδυασμους νουκλεοσιδικων παραγωγων.
FI95384C (fi) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
ES2253732T3 (es) * 1989-09-15 2006-06-01 Southern Research Institute 2'-deoxi-4'-tioribonucleosidos como agentes antivirales y anticancerosos.
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5420115A (en) * 1990-09-10 1995-05-30 Burroughs Wellcome Co. Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides
AU1254892A (en) * 1990-12-18 1992-07-22 Sloan-Kettering Institute For Cancer Research Novel synthesis of 2'-"up" fluorinated 2''-deoxy-arabinofuranosylpurines
US5712477A (en) * 1996-05-14 1998-01-27 Allen-Bradley Company, Inc. System to provide alignment and troubleshooting aid photoelectric sensors through alternating numeric display
BR9908270A (pt) 1998-02-25 2004-06-29 Univ Emory 2-fluoro-nucleosìdeos, composições farmacêuticas e seus usos
CN101240001B (zh) * 1998-02-25 2013-10-16 埃莫里大学 2'-氟代核苷
CN1646141B (zh) 2000-10-18 2014-06-25 吉利德制药有限责任公司 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
EP1478322A4 (en) 2001-06-22 2007-08-08 Pharmasset Ltd Beta 2'-OR 3'-HALONUCLEOSIDE
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
US20070243798A1 (en) * 2006-04-18 2007-10-18 3M Innovative Properties Company Embossed structured abrasive article and method of making and using the same
KR20160076373A (ko) 2014-12-22 2016-06-30 김기범 양식용 패각 고정을 위한 로프 어셈블리

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE292023C (es) *
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
GB8712115D0 (en) * 1987-05-22 1987-06-24 Hoffmann La Roche Pyrimidine derivatives
JPH01100190A (ja) * 1987-10-12 1989-04-18 Asahi Glass Co Ltd ヌクレオシド類
NZ226672A (en) * 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
JPH0649091A (ja) 1994-02-22
ATE100461T1 (de) 1994-02-15
FI885153A (fi) 1989-05-13
US5218106A (en) 1993-06-08
CZ743188A3 (en) 1993-08-11
SK277919B6 (en) 1995-08-09
SK278017B6 (en) 1995-10-11
NO884995L (no) 1989-05-16
EP0316017A2 (en) 1989-05-17
CZ545190A3 (en) 1993-08-11
CZ278366B6 (en) 1993-12-15
ZA888313B (en) 1989-07-26
CZ278394B6 (en) 1993-12-15
JP2699050B2 (ja) 1998-01-19
FI90244C (fi) 1994-01-10
KR920004459B1 (ko) 1992-06-05
CZ545290A3 (en) 1993-08-11
DK173971B1 (da) 2002-03-18
JP2699049B2 (ja) 1998-01-19
DE3887273T2 (de) 1994-05-19
PT88994A (pt) 1989-09-14
US4908440A (en) 1990-03-13
DE3887273D1 (de) 1994-03-03
PT88994B (pt) 1995-03-31
IL88330A0 (en) 1989-06-30
FI90244B (fi) 1993-09-30
NO884995D0 (no) 1988-11-09
AU615960B2 (en) 1991-10-17
CA1340961C (en) 2000-04-18
IE883406L (en) 1989-05-12
DK631688A (da) 1989-05-13
KR890008161A (ko) 1989-07-10
HU199499B (en) 1990-02-28
JP2811561B2 (ja) 1998-10-15
US4973677A (en) 1990-11-27
NZ226845A (en) 1991-10-25
NO169492C (no) 1993-01-12
JPH0648947A (ja) 1994-02-22
SK545290A3 (en) 1995-10-11
YU47121B (sh) 1994-12-28
CZ278395B6 (en) 1993-12-15
IL88330A (en) 1995-03-15
NO169492B (no) 1992-03-23
FI885153A0 (fi) 1988-11-09
EP0316017B1 (en) 1994-01-19
AU2504288A (en) 1989-05-25
DK631688D0 (da) 1988-11-11
US5126506A (en) 1992-06-30
ES2061609T3 (es) 1994-12-16
JPH09183731A (ja) 1997-07-15
YU204888A (en) 1990-04-30
EP0316017A3 (en) 1990-05-30
SK743188A3 (en) 1995-08-09
IE62227B1 (en) 1995-01-11
HUT48266A (en) 1989-05-29
JPH01153698A (ja) 1989-06-15

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IF04 In force in the year 2004

Expiry date: 20081112