DD202804A5 - Verfahren zur herstellung eines mittels zur vorbeugung und behandlung von leber- und nierenerkrankungen - Google Patents
Verfahren zur herstellung eines mittels zur vorbeugung und behandlung von leber- und nierenerkrankungen Download PDFInfo
- Publication number
- DD202804A5 DD202804A5 DD82242397A DD24239782A DD202804A5 DD 202804 A5 DD202804 A5 DD 202804A5 DD 82242397 A DD82242397 A DD 82242397A DD 24239782 A DD24239782 A DD 24239782A DD 202804 A5 DD202804 A5 DD 202804A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- liver
- item
- treatment
- enzyme
- pronase
- Prior art date
Links
- 210000004185 liver Anatomy 0.000 title claims abstract description 22
- 208000019423 liver disease Diseases 0.000 title claims abstract description 11
- 208000017169 kidney disease Diseases 0.000 title claims abstract description 8
- 230000002265 prevention Effects 0.000 title claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 title description 2
- 102000004190 Enzymes Human genes 0.000 claims abstract description 17
- 108090000790 Enzymes Proteins 0.000 claims abstract description 17
- 108091005804 Peptidases Proteins 0.000 claims abstract description 13
- 102000035195 Peptidases Human genes 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 5
- 239000005017 polysaccharide Substances 0.000 claims abstract description 5
- 150000004676 glycans Chemical class 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 21
- 108010059712 Pronase Proteins 0.000 claims description 17
- 239000004480 active ingredient Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 4
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 3
- 230000002934 lysing effect Effects 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 12
- 210000003734 kidney Anatomy 0.000 abstract description 12
- 210000002700 urine Anatomy 0.000 description 16
- 229940088598 enzyme Drugs 0.000 description 14
- 230000002159 abnormal effect Effects 0.000 description 12
- 239000003826 tablet Substances 0.000 description 12
- 201000010099 disease Diseases 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 239000013049 sediment Substances 0.000 description 9
- 208000006454 hepatitis Diseases 0.000 description 8
- 230000036772 blood pressure Effects 0.000 description 7
- 208000019425 cirrhosis of liver Diseases 0.000 description 7
- 206010008909 Chronic Hepatitis Diseases 0.000 description 6
- 230000003908 liver function Effects 0.000 description 6
- 208000022531 anorexia Diseases 0.000 description 5
- 206010061428 decreased appetite Diseases 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 4
- 239000004365 Protease Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- -1 ci-chymotrypsin Proteins 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 210000004276 hyalin Anatomy 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 4
- 230000002485 urinary effect Effects 0.000 description 4
- 206010020880 Hypertrophy Diseases 0.000 description 3
- 206010029164 Nephrotic syndrome Diseases 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000000496 pancreas Anatomy 0.000 description 3
- 150000004804 polysaccharides Chemical class 0.000 description 3
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 2
- 108010004032 Bromelains Proteins 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- 108010023197 Streptokinase Proteins 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 235000019835 bromelain Nutrition 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 201000001883 cholelithiasis Diseases 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000002497 edematous effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 208000011318 facial edema Diseases 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 208000001130 gallstones Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 201000008383 nephritis Diseases 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 229960005202 streptokinase Drugs 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 244000144725 Amygdalus communis Species 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010088842 Fibrinolysin Proteins 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 241001662043 Icterus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 108010038346 Seaprose S Proteins 0.000 description 1
- 241000187392 Streptomyces griseus Species 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 229920001284 acidic polysaccharide Polymers 0.000 description 1
- 150000004805 acidic polysaccharides Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940034982 antineoplastic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940001501 fibrinolysin Drugs 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21081—Streptogrisin B (3.4.21.81)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56125002A JPS5826822A (ja) | 1981-08-10 | 1981-08-10 | 慢性腎炎治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD202804A5 true DD202804A5 (de) | 1983-10-05 |
Family
ID=14899442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD82242397A DD202804A5 (de) | 1981-08-10 | 1982-08-10 | Verfahren zur herstellung eines mittels zur vorbeugung und behandlung von leber- und nierenerkrankungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4485095A (enExample) |
| EP (1) | EP0072947B2 (enExample) |
| JP (1) | JPS5826822A (enExample) |
| AT (1) | ATE20185T1 (enExample) |
| AU (1) | AU558711B2 (enExample) |
| DD (1) | DD202804A5 (enExample) |
| DE (1) | DE3271549D1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3941324A1 (de) * | 1989-05-08 | 1990-11-15 | Shigemi Fujisaki | Aktivator fuer verletzte neurozyten zur verhuetung und behandlung von krankheiten |
| DE19726253A1 (de) * | 1997-06-20 | 1998-12-24 | Mucos Pharma Gmbh & Co | Verwendung von mindestens einem proteolytischen Enzym zur Behandlung von Glomerulonephritis |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4844897A (en) * | 1985-09-13 | 1989-07-04 | Hiroshi Maeda | Anti-tumor protease preparations |
| JPS62215533A (ja) * | 1986-03-17 | 1987-09-22 | Shigemi Fujisaki | 膠原病又は関節リウマチの予防治療剤 |
| JPS61293928A (ja) * | 1986-06-18 | 1986-12-24 | Kaken Pharmaceut Co Ltd | 腎ネフロ−ゼ治療剤 |
| EP0309602B1 (de) * | 1987-09-30 | 1993-03-24 | MUCOS EMULSIONSGESELLSCHAFT m.b.H. | Verwendung katabolischer Enzyme zur Herstellung eines Medikaments zum Bekämpfen der erworbenen Immunschwäche (AIDS) und deren Vorstadien (LAS, ARC) |
| US5116615A (en) * | 1989-01-27 | 1992-05-26 | Immunolytics, Inc. | Method for treating benign prostatic hypertrophy |
| ES2072424T3 (es) | 1989-01-27 | 1995-07-16 | Immunolytics Inc | Formula y metodo para el tratamiento de hipertrofias prostaticas benignas. |
| NL9201842A (nl) * | 1992-10-23 | 1994-05-16 | Teng Hian Khoe | Toepassing van een papaine bevattend voedingssupplement voor therapeutische behandeling van AIDS aandoeningen. |
| US5639934A (en) * | 1993-04-01 | 1997-06-17 | Nakamichi Yamasaki | Process for the desulfurization of sulfur-containing compositions by hydrothermal reaction |
| JP2673417B2 (ja) * | 1994-08-03 | 1997-11-05 | 茂巳 藤崎 | Ｂ型肝炎又はｃ型肝炎のウイルス性疾患の予防治療剤 |
| US5814328A (en) | 1997-01-13 | 1998-09-29 | Gunasekaran; Subramanian | Preparation of collagen using papain and a reducing agent |
| US20020102253A1 (en) | 1997-02-25 | 2002-08-01 | Mynott Tracey Lehanne | Component of bromelain |
| GB9713667D0 (en) * | 1997-06-27 | 1997-09-03 | Cortecs Ltd | Enhancement of intestinal permeability |
| JP2002087990A (ja) * | 2000-09-18 | 2002-03-27 | Shigemi Fujisaki | エイズ、ｂ型肝炎、ｃ型肝炎、インフルエンザなどのウイルス性疾患予防治療剤 |
| AU2003212195A1 (en) * | 2002-02-06 | 2003-09-02 | N-Zyme Biotec Gmbh | Protease screening and novel use of proteases |
| AUPS242702A0 (en) * | 2002-05-21 | 2002-06-13 | Colltech Australia Limited | Improved method for the extraction and purification of collagen |
| WO2006130034A1 (fr) * | 2005-04-25 | 2006-12-07 | Dmitry Dmitrievich Genkin | Procede pour prolonger la duree de vie d'animaux ou de l'humain |
| US8431123B2 (en) | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| US9248166B2 (en) | 2003-07-14 | 2016-02-02 | Cls Therapeutics Limited | Method for treating oncological diseases |
| US8710012B2 (en) * | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| ES2421538T3 (es) * | 2003-10-29 | 2013-09-03 | Cystic Fibrosis Foundation Therapeutics Inc | Proteasas no pancreáticas para controlar la concentración de colecistocinina (CCK) en plasma y para tratar el dolor |
| EP2095825B8 (en) * | 2006-11-28 | 2012-03-28 | CLS Therapeutics Limited | Method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and a medicinal preparation for carrying out said method |
| UA28103U (uk) * | 2007-07-12 | 2007-11-26 | Ольга Олександрівна Біляєва | Комплексний сорбційно-протеолітичний препарат сертасил для лікування гнійних ран, трофічних виразок, опіків |
| WO2010079209A2 (en) * | 2009-01-08 | 2010-07-15 | Golub Alexandr A | Compositions for treating wounds and skin conditions |
| ITTO20121050A1 (it) * | 2012-12-06 | 2014-06-07 | Giuseppe Carpignoli | Sostanze vegetali ad effetto curativo |
| US10086053B2 (en) | 2012-12-06 | 2018-10-02 | Giuseppe CARPIGNOLI | Therapeutic vegetable substances |
| US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
| RU2726131C2 (ru) | 2015-05-22 | 2020-07-09 | Дмитрий Дмитриевич Генкин | Внеклеточная днк в качестве терапевтической мишени при нейродегенерации |
| EP3740581A4 (en) | 2018-01-16 | 2021-10-27 | CLS Therapeutics Limited | TREATMENT OF DISEASES BY LIVER EXPRESSION OF AN ENZYME WITH DESOXYRIBONUCLEASE (DNASE) ACTIVITY |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2073659A (en) * | 1933-12-13 | 1937-03-16 | Ernest K Stratton | Medicinal compounds |
| US3004893A (en) * | 1959-10-21 | 1961-10-17 | Richardson Merrell Inc | Enteric coated trypsin and chymotrypsin anti-inflammatory compositions |
| FR2603M (fr) * | 1962-01-22 | 1964-06-22 | Roussel Uclaf | Nouveau médicament notamment pour le traitement des dégénérescences hépatiques d'origine chimique, bactérienne, toxique ou sénile. |
| US3324002A (en) * | 1962-09-17 | 1967-06-06 | Armour Pharma | Anti-inflammatory preparations containing proteolytic enzymes and adrenal glucocorticoids |
| FR3536M (enExample) * | 1964-06-16 | 1965-09-13 | Mauvernay Roland Yves | |
| BE684147A (enExample) * | 1965-07-22 | 1966-12-16 | ||
| LU59502A1 (enExample) * | 1969-09-24 | 1970-02-26 | ||
| US3819830A (en) * | 1971-07-01 | 1974-06-25 | Dainippon Pharmaceutical Co | Method for treating diseases by coenzyme a and adenosine triphosphate and composition therefor |
| FR2448903A1 (fr) * | 1979-02-19 | 1980-09-12 | Martin Henri | Medicament nouveau a base d'agents antimicrobiens, d'enzymes, d'anti-inflammatoires, d'anesthesique local, d'agents keratolytiques, d'agents mucolytiques et d'au moins un emulsionnant |
-
1981
- 1981-08-10 JP JP56125002A patent/JPS5826822A/ja active Granted
-
1982
- 1982-07-09 AU AU85792/82A patent/AU558711B2/en not_active Ceased
- 1982-08-05 DE DE8282107092T patent/DE3271549D1/de not_active Expired
- 1982-08-05 AT AT82107092T patent/ATE20185T1/de active
- 1982-08-05 EP EP82107092A patent/EP0072947B2/en not_active Expired - Lifetime
- 1982-08-06 US US06/405,770 patent/US4485095A/en not_active Expired - Fee Related
- 1982-08-10 DD DD82242397A patent/DD202804A5/de not_active IP Right Cessation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3941324A1 (de) * | 1989-05-08 | 1990-11-15 | Shigemi Fujisaki | Aktivator fuer verletzte neurozyten zur verhuetung und behandlung von krankheiten |
| DE3941324C2 (enExample) * | 1989-05-08 | 1992-06-25 | Fujisaki, Shigemi, Nishinomiya, Hyogo, Jp | |
| DE3943649C2 (enExample) * | 1989-05-08 | 1992-10-29 | Fujisaki, Shigemi, Nishinomiya, Hyogo, Jp | |
| DE19726253A1 (de) * | 1997-06-20 | 1998-12-24 | Mucos Pharma Gmbh & Co | Verwendung von mindestens einem proteolytischen Enzym zur Behandlung von Glomerulonephritis |
| DE19726253C2 (de) * | 1997-06-20 | 2000-03-16 | Mucos Pharma Gmbh & Co | Verwendung von mindestens einem proteolytischen Enzym und Rutosid zur Behandlung von Glomerulonephritis |
Also Published As
| Publication number | Publication date |
|---|---|
| AU558711B2 (en) | 1987-02-05 |
| ATE20185T1 (de) | 1986-06-15 |
| EP0072947A2 (en) | 1983-03-02 |
| US4485095A (en) | 1984-11-27 |
| EP0072947A3 (en) | 1983-07-27 |
| DE3271549D1 (en) | 1986-07-10 |
| JPS5826822A (ja) | 1983-02-17 |
| EP0072947B2 (en) | 1994-01-12 |
| JPH0133085B2 (enExample) | 1989-07-11 |
| EP0072947B1 (en) | 1986-06-04 |
| AU8579282A (en) | 1983-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4485095A (en) | Pronase used for the treatment of diseases of the liver and kidneys in humans and animals | |
| DE69431433T2 (de) | Zusammensetzungen und verfahren zur reparatur und vorbeugung fibrotischer verletzungen | |
| Okyar et al. | Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models | |
| DE3437599C2 (de) | Ibuprofen enthaltende Weichgelatinekapseln | |
| DE69010162T2 (de) | Zusammensetzung zur Behandlung von Entzündung. | |
| DE10012095A1 (de) | Arzneimittel zur Behandlung von Diabetes | |
| DE69327642T2 (de) | Verfahren zur behandlung von viralen infectionen | |
| CH640738A5 (de) | Arzneimitteltablette zur peroralen applikation und verfahren zu deren herstellung. | |
| Bhathal et al. | Primary intrahepatic obliterating cholangitis: a possible variant ofsclerosing cholangitis' | |
| DE4332985A1 (de) | Arzneimittel zur Behandlung der Dysfunktion des exokrinen Pankreas | |
| DE69919868T2 (de) | Oregano zur behandlung interner parasiten und protozoen | |
| Diallo et al. | A double-blind comparison of the efficacy and safety of ivermectin and diethylcarbamazine in a placebo controlled study of Senegalese patients with onchocerciasis | |
| Fiese | Treatment of Disseminated Coccidioidomycosis with Amphotericin B—Report of a Case | |
| August et al. | Histological and ultrastructural findings in chloroquine-induced cardiomyopathy | |
| DE69021257T2 (de) | Verwendung von IFN-gamma zur Herstellung einer pharmazeutischen Zusammensetzung für die Behandlung von ATL. | |
| DE3876817T2 (de) | Anwendung des humanblut-koagulationsfaktors-xiii zur behandlung von colitis gravis. | |
| DE69005978T2 (de) | Verwendung von Actinonin zur Herstellung eines Medikamentes zur Inhibierung der Angiogenese. | |
| DE60128793T2 (de) | Verfahren und Zusammensetzung zur Behandlung von Neoplasmen | |
| Schwartz et al. | Pentamidine-associated pancreatitis | |
| Cumming et al. | A multi-centre phase two study of intravesical epirubicin in the treatment of superficial bladder tumour | |
| DE69525306T2 (de) | Nichtabsorbierbare, synthetische, sulfatierte Polysaccharide | |
| DE3204631A1 (de) | Therapeutisches mittel und dessen verwendung | |
| DE19748417A1 (de) | Verwendung von Thiaminen zur Prophylaxe und Therapie der diabetischen Retinopathie und Nephropathie | |
| CN100569277C (zh) | 一种治疗妇女阴道炎的泡腾片及其制备方法和用途 | |
| DE3941324C2 (enExample) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |