DD127742A5 - METHOD FOR THE PRODUCTION OF SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCIN - Google Patents

METHOD FOR THE PRODUCTION OF SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCIN

Info

Publication number
DD127742A5
DD127742A5 DD7600195868A DD19586876A DD127742A5 DD 127742 A5 DD127742 A5 DD 127742A5 DD 7600195868 A DD7600195868 A DD 7600195868A DD 19586876 A DD19586876 A DD 19586876A DD 127742 A5 DD127742 A5 DD 127742A5
Authority
DD
German Democratic Republic
Prior art keywords
thienamycin
substituted
production
methylene derivatives
methylene
Prior art date
Application number
DD7600195868A
Other languages
German (de)
Inventor
Burton G Christensen
William J Leanza
Kenneth J Wildonger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DD127742A5 publication Critical patent/DD127742A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DD7600195868A 1975-11-21 1976-11-19 METHOD FOR THE PRODUCTION OF SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCIN DD127742A5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63429675A 1975-11-21 1975-11-21
US67626176A 1976-04-12 1976-04-12
US73365476A 1976-10-18 1976-10-18

Publications (1)

Publication Number Publication Date
DD127742A5 true DD127742A5 (en) 1977-10-12

Family

ID=27417545

Family Applications (1)

Application Number Title Priority Date Filing Date
DD7600195868A DD127742A5 (en) 1975-11-21 1976-11-19 METHOD FOR THE PRODUCTION OF SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCIN

Country Status (27)

Country Link
AT (1) AT358168B (en)
AU (1) AU512383B2 (en)
BG (1) BG34037A3 (en)
CA (1) CA1083577A (en)
CH (2) CH632510A5 (en)
DD (1) DD127742A5 (en)
DE (1) DE2652679A1 (en)
DK (1) DK157401C (en)
EG (1) EG12261A (en)
ES (1) ES453501A1 (en)
FI (1) FI62306C (en)
FR (1) FR2332012A1 (en)
GB (1) GB1570990A (en)
GR (1) GR62072B (en)
HK (1) HK29683A (en)
HU (1) HU180865B (en)
IE (1) IE44433B1 (en)
IL (1) IL50911A (en)
KE (1) KE3286A (en)
NL (1) NL189297C (en)
NO (1) NO153298C (en)
NZ (1) NZ182630A (en)
PH (1) PH16714A (en)
PL (1) PL110937B1 (en)
PT (1) PT65865B (en)
SE (1) SE427841B (en)
SG (1) SG10983G (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
SE436569B (en) * 1977-05-05 1985-01-07 Merck & Co Inc ANALOGY PROCEDURE FOR THE PREPARATION OF TIENAMYCIN DERIVATIVES
US4232030A (en) * 1977-09-15 1980-11-04 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
DK153486C (en) * 1978-07-03 1988-11-28 Merck & Co Inc ANALOGY PROCEDURE FOR THE PREPARATION OF CRYSTALLINIC N-FORMIMIDOYL-THIENAMYCINE MONOHYDRATE
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
AU671071B2 (en) * 1990-08-30 1996-08-15 State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University, Portland, Oregon, and The University of Oregon, Eugene, Oregon, Johnson Hall, Substituted amidines having high binding to the sigma receptor and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004670A (en) * 1963-04-23 1965-09-15 Beecham Res Lab Penicillins
GB1348984A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Antibiotics and processes for their production
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
NO153298C (en) 1986-02-19
NL7612939A (en) 1977-05-24
IE44433L (en) 1977-05-21
PT65865B (en) 1978-10-12
PL110937B1 (en) 1980-08-30
AU512383B2 (en) 1980-10-09
NO763958L (en) 1977-05-24
NO153298B (en) 1985-11-11
ATA863476A (en) 1980-01-15
ES453501A1 (en) 1978-03-01
FR2332012B1 (en) 1978-11-17
IL50911A (en) 1981-01-30
KE3286A (en) 1983-06-17
CH633800A5 (en) 1982-12-31
FI62306B (en) 1982-08-31
IL50911A0 (en) 1977-01-31
NL189297B (en) 1992-10-01
CA1083577A (en) 1980-08-12
BG34037A3 (en) 1983-06-15
PH16714A (en) 1984-01-25
SE7612963L (en) 1977-05-22
DE2652679C2 (en) 1990-03-01
CH632510A5 (en) 1982-10-15
NL189297C (en) 1993-03-01
NZ182630A (en) 1979-07-11
AT358168B (en) 1980-08-25
DK157401C (en) 1990-05-21
FI62306C (en) 1982-12-10
EG12261A (en) 1978-12-31
AU1964776A (en) 1978-05-25
FI763308A (en) 1977-05-22
GR62072B (en) 1979-02-20
DK523576A (en) 1977-05-22
DK157401B (en) 1990-01-02
HU180865B (en) 1983-04-29
HK29683A (en) 1983-08-26
PT65865A (en) 1976-12-01
GB1570990A (en) 1980-07-09
PL193809A1 (en) 1978-01-16
IE44433B1 (en) 1981-12-02
SE427841B (en) 1983-05-09
FR2332012A1 (en) 1977-06-17
DE2652679A1 (en) 1977-06-02
SG10983G (en) 1983-12-16

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