ATA863476A - METHOD FOR PRODUCING NEW SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCINE - Google Patents

METHOD FOR PRODUCING NEW SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCINE

Info

Publication number
ATA863476A
ATA863476A AT863476A AT863476A ATA863476A AT A863476 A ATA863476 A AT A863476A AT 863476 A AT863476 A AT 863476A AT 863476 A AT863476 A AT 863476A AT A863476 A ATA863476 A AT A863476A
Authority
AT
Austria
Prior art keywords
thienamycine
producing new
new substituted
methylene derivatives
methylene
Prior art date
Application number
AT863476A
Other languages
German (de)
Other versions
AT358168B (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ATA863476A publication Critical patent/ATA863476A/en
Application granted granted Critical
Publication of AT358168B publication Critical patent/AT358168B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT863476A 1975-11-21 1976-11-19 METHOD FOR PRODUCING NEW SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCINE AT358168B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63429675A 1975-11-21 1975-11-21
US67626176A 1976-04-12 1976-04-12
US73365476A 1976-10-18 1976-10-18

Publications (2)

Publication Number Publication Date
ATA863476A true ATA863476A (en) 1980-01-15
AT358168B AT358168B (en) 1980-08-25

Family

ID=27417545

Family Applications (1)

Application Number Title Priority Date Filing Date
AT863476A AT358168B (en) 1975-11-21 1976-11-19 METHOD FOR PRODUCING NEW SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCINE

Country Status (27)

Country Link
AT (1) AT358168B (en)
AU (1) AU512383B2 (en)
BG (1) BG34037A3 (en)
CA (1) CA1083577A (en)
CH (2) CH632510A5 (en)
DD (1) DD127742A5 (en)
DE (1) DE2652679A1 (en)
DK (1) DK157401C (en)
EG (1) EG12261A (en)
ES (1) ES453501A1 (en)
FI (1) FI62306C (en)
FR (1) FR2332012A1 (en)
GB (1) GB1570990A (en)
GR (1) GR62072B (en)
HK (1) HK29683A (en)
HU (1) HU180865B (en)
IE (1) IE44433B1 (en)
IL (1) IL50911A (en)
KE (1) KE3286A (en)
NL (1) NL189297C (en)
NO (1) NO153298C (en)
NZ (1) NZ182630A (en)
PH (1) PH16714A (en)
PL (1) PL110937B1 (en)
PT (1) PT65865B (en)
SE (1) SE427841B (en)
SG (1) SG10983G (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
SE436569B (en) * 1977-05-05 1985-01-07 Merck & Co Inc ANALOGY PROCEDURE FOR THE PREPARATION OF TIENAMYCIN DERIVATIVES
US4232030A (en) * 1977-09-15 1980-11-04 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
DK153486C (en) * 1978-07-03 1988-11-28 Merck & Co Inc ANALOGY PROCEDURE FOR THE PREPARATION OF CRYSTALLINIC N-FORMIMIDOYL-THIENAMYCINE MONOHYDRATE
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
AU671071B2 (en) * 1990-08-30 1996-08-15 State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University, Portland, Oregon, and The University of Oregon, Eugene, Oregon, Johnson Hall, Substituted amidines having high binding to the sigma receptor and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004670A (en) * 1963-04-23 1965-09-15 Beecham Res Lab Penicillins
GB1348984A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Antibiotics and processes for their production
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
NO153298C (en) 1986-02-19
NL7612939A (en) 1977-05-24
IE44433L (en) 1977-05-21
PT65865B (en) 1978-10-12
PL110937B1 (en) 1980-08-30
AU512383B2 (en) 1980-10-09
NO763958L (en) 1977-05-24
NO153298B (en) 1985-11-11
ES453501A1 (en) 1978-03-01
FR2332012B1 (en) 1978-11-17
IL50911A (en) 1981-01-30
KE3286A (en) 1983-06-17
CH633800A5 (en) 1982-12-31
FI62306B (en) 1982-08-31
IL50911A0 (en) 1977-01-31
NL189297B (en) 1992-10-01
CA1083577A (en) 1980-08-12
BG34037A3 (en) 1983-06-15
DD127742A5 (en) 1977-10-12
PH16714A (en) 1984-01-25
SE7612963L (en) 1977-05-22
DE2652679C2 (en) 1990-03-01
CH632510A5 (en) 1982-10-15
NL189297C (en) 1993-03-01
NZ182630A (en) 1979-07-11
AT358168B (en) 1980-08-25
DK157401C (en) 1990-05-21
FI62306C (en) 1982-12-10
EG12261A (en) 1978-12-31
AU1964776A (en) 1978-05-25
FI763308A (en) 1977-05-22
GR62072B (en) 1979-02-20
DK523576A (en) 1977-05-22
DK157401B (en) 1990-01-02
HU180865B (en) 1983-04-29
HK29683A (en) 1983-08-26
PT65865A (en) 1976-12-01
GB1570990A (en) 1980-07-09
PL193809A1 (en) 1978-01-16
IE44433B1 (en) 1981-12-02
SE427841B (en) 1983-05-09
FR2332012A1 (en) 1977-06-17
DE2652679A1 (en) 1977-06-02
SG10983G (en) 1983-12-16

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Legal Events

Date Code Title Description
ELA Expired due to lapse of time
EZF Grant of a certificate of protection

Free format text: SZ 102/1994, 19941220, EXPIRES:20000824

SZA Application filed for a certificate of protection

Free format text: SZ 102/1994, 19941220