CZ218798A3 - Disinfectants - Google Patents

Abstract

The present invention relates to disinfecting compositions comprising a peroxygen bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or an active thereof, and to a process for disinfecting surfaces.

Description

(57) Annotation:

The invention relates to disinfectants comprising a peroxide bleaching agent, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or its active ingredient, and to a method for disinfecting surfaces.

CZ 2187-98 A3

Disinfectants

Field of technology

The present invention relates to antimicrobial compositions that are used to disinfect and clean various surfaces including living surfaces (e.g., human skin, mouth, and the like) and non-living surfaces including, but not limited to, solid surfaces such as walls, tiles, table tops, glass, bathroom surfaces, kitchen surfaces, dishes, fabrics, dresses, carpets, and the like.

Prior art

Antimicrobial / antibacterial agents include substances capable of disinfecting. It is generally known that a disinfectant substantially reduces or even destroys microorganisms, such as bacteria, present on the surface. For disinfection purposes, compositions based on halogen-containing compounds such as hypochlorite or on quaternary compounds have been widely described in the art. Compositions containing a peroxide bleaching agent are also known as disinfectants.

However, compositions based on peroxide bleach as the sole antimicrobial compound (typically 7% of the total weight of the composition) are not fully effective, especially when used at high dilutions, e.g. 1:50 dilution (composition: water) in disinfecting soiled surfaces, e.g. surfaces requiring both washing and disinfection. The presence of organic and / or inorganic stains reduces the bactericidal activity of many antimicrobial agents, such as peroxide bleach, and leads to a reduction in the bactericidal activity / disinfectant efficacy of compositions containing these antimicrobial agents.

The subject of the present invention is compositions which lead to a complete disinfection of contaminated surfaces, in particular heavily soiled surfaces, even when used in large dilutions.

It has been shown that this is achieved by combinations of different antimicrobial compounds, i. a combination of a peroxide bleaching agent, an amphoteric surfactant or mixtures thereof, glutaraldehyde and an antimicrobial essential oil or an active ingredient thereof or mixtures thereof. In particular, a composition containing a peroxide bleaching agent, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or an active ingredient thereof has been found to provide perfect disinfection of soiled surfaces, including heavily soiled surfaces, even at high dilutions, i. up to a dilution of 1: 100 (composition: water).

An advantage of the present invention is the complete anti-contamination disinfection of a wide range of bacterial strains, including Gram-positive and Gram-negative bacterial strains, as well as more resistant microorganisms such as fungi.

Another advantage of the compositions according to the present invention is, in addition to the disinfecting properties, also good cleaning effects.

The compositions of the present invention are suitable for use on all types of surfaces, including living surfaces (e.g., human skin and / or mouth when used as an oral preparation or toothpaste) and non-living surfaces. This technology is suitable for applications especially on solid surfaces as well as on laundry, eg as a detergent or additive in the so-called "soaking mode", "washing mode" or for prewashing laundry in the "prewash mode". The compositions of the present invention are particularly suitable for use on delicate surfaces, including surfaces in safe contact with food and / or children. The use of the diluted compositions of the present invention reduces the amount of chemical compounds remaining on the disinfected surface. For example, after application of the diluted compositions of the present invention, it is not necessary to rinse solid surfaces.

Another advantage of the compositions of the present invention is that they may be in various forms, e.g., as a liquid packaged in a conventional detergent bottle or spray or foam packaged in a spray / foam nebulizer, or as wipes containing the composition of the invention, or in a non-liquid state.

EP-B-288 689 discloses a solid surface fluid comprising an effective amount of an antimicrobial pine essential oil and at least one soluble oleic organic acid. No other antimicrobial compounds are mentioned, let alone the peroxide bleaching agent.

EP-241390 describes the disinfection of textiles contaminated with bacteria by first applying detergents and then a peroxide bleach in a water bath at pH 9-13 in the presence of uncomplexed calcium. No other antimicrobial compounds are described.

U.S. Pat. No. 4,404,191 describes the bactericidal, fungicidal and antiviral effects of peroxy compounds such as monoperoxosulfate. U.S. Pat. No. 4,404,191 discloses the use of dilute compositions containing monoperoxosulfate on solid surfaces. However, no other antimicrobial compounds are described.

EP-A-667 392 discloses solid surface cleaning compositions comprising hydrogen peroxide and a surfactant / hardening component comprising an alkyl ether sulfate surfactant together with an amine oxide or betaine. The compositions have a pH of 7 to 10. No other antimicrobial compounds are described, let alone essential oils or their active ingredients or glutaraldehyde.

US-5,403,587 discloses aqueous antimicrobial compositions used for cleaning, sanitizing and disinfecting solid surfaces. U.S. Pat. No. 5,403,587 discloses, in particular, aqueous compositions (pH 1 to 12) containing essential oils (0.02% to 5%) which exhibit effective antimicrobial properties, such as thymic essential oil, eucalyptus essential oil, clove essential oil and the like, and a solubilizing or dispersing agent. sufficient to form an aqueous solution or dispersion of the essential oils in an aqueous medium. These compositions may additionally contain other antimicrobial additives such as phenolic compounds, quaternary ammonium compounds, but no amphoteric surfactants or peroxide bleaching agents are described.

US-5,368,749 discloses compositions for inhibiting the growth of aerobic microorganisms, including bacteria and fungi, comprising an oxidant and glutaraldehyde. The oxidants are from the group of chlorine, bromine, monoperoxosulfate, perborate, hydrogen peroxide, peracetic acid and percarbonate. The oxidant has a synergistic effect when added to glutaraldehyde. No other antimicrobial compounds such as essential oils or their active ingredients or amphoteric surfactants are described.

U.S. Pat. No. 3,852,210 describes aqueous oxygen-releasing compositions suitable for a wide range of industrial and household uses, for example as laundry detergents or as hard surface cleaners. Due to their germicidal and bactericidal activity, the compositions are suitable for medical use. The compositions (pH 2 to 10) contain an active oxygen delivery compound, e.g. hydrogen peroxide (0.1% to 50%), betaine or sulfobetaine (0.5% to 50%) such as cetylbetaine or laurylsulfobetaine and non-ionic polyoxyethylene polyoxypropylene block copolymer surfactants with a solubility of at least 1 g per 100 ml of water and a molecular weight in the range of 1 000 to 15 000.

No other antimicrobial compounds are described, let alone essential oils or their active ingredients or glutaraldehyde.

J-60038497 discloses a foaming detergent two-component composition comprising a) an aqueous solution of hydrogen peroxide (0.5% to 50%), b) an alkaline compound containing an alkaline substance with an alkalinity of 0.1% to 50% expressed by NaOH, such as NaOH, KOH, Na? CO3. At least one of the two components of the detergent compositions a) and b) comprises a surfactant, e.g. amphoteric surfactants, and / or at least one compound from the group of terpene alcohols, cyclic terpene alcohols and their esters, such as geraniol. The compositions according to J-60038497 clean stains on solid materials such as plastics, joints and particularly difficult to clean recesses or corners. Glutaraldehyde is not reported. Disinfectant use is not mentioned either.

The essence of the invention

The present invention includes a disinfectant composition comprising a peroxide bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or an active ingredient thereof.

The present invention further includes a method of disinfecting a surface with a composition comprising a peroxide bleaching agent, an amphoteric surfactant, glutaraldehyde, and an antimicrobial essential oil or active ingredient thereof.

Detailed description of the invention.

The disinfectants of the present invention comprise a peroxide bleaching agent, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or active ingredient thereof.

The compositions of the present invention are either liquid or non-liquid (e.g., gel, paste, or in solid form as a powder or granules). The compositions are solidly mixed with a suitable solvent, usually water, before use. Liquid compositions are preferably, but not necessarily, aqueous compositions. Liquid compositions are preferred for convenient use.

As an essential element, the compositions of the present invention contain a peroxide bleaching agent or a mixture thereof. The preferred peroxide bleaching agent is hydrogen peroxide or a water-soluble source thereof or a mixture thereof. Most preferably, hydrogen peroxide is used in the compositions of the present invention.

The presence of a peroxide bleaching agent, especially hydrogen peroxide, persulfate, and the like, contributes to the disinfecting properties of the compositions of the present invention. A peroxide bleaching agent can attack the vital functions of microorganism cells, for example, it can inhibit the arrangement of ribosomal units in the cytoplasm of microorganism cells. A peroxide bleaching agent such as hydrogen peroxide is a strong oxidizing agent that generates free hydroxyl radicals that attack proteins and nucleic acids. In addition, the presence of a peroxide bleaching agent, in particular hydrogen peroxide, has a strong stain removal effect, which is noticeable, for example, in applications on laundry and hard surfaces.

A source of hydrogen peroxide is used herein to refer to any compound that, upon contact with water, provides hydrogen peroxide. Suitable water-soluble sources of hydrogen peroxide as used herein include percarbonates, persilicates, persulfates such as monoperoxosulfate, perborates and peracids such as diperoxododecanedioic acid (DPDA), magnesium salt of peroxophthalic acid, and mixtures thereof.

Other classes of peroxides are used as an alternative to hydrogen peroxide and its sources or in combination with hydrogen peroxide and its sources. Suitable classes include dialkyl peroxides, diacyl peroxides, preformed peroxocarboxylic acids, organic and inorganic peroxides and / or hydroperoxides.

The compositions typically contain at least 0.01% peroxide bleach or mixtures thereof by total weight of the composition, preferably 0.1% to 15% and more preferably 1% to 10%.

As a second essential component, the compositions of the present invention comprise an amphoteric surfactant or mixtures thereof. These amphoteric surfactants have a double effect. They aid disinfection by increasing the permeability of the bacterial cell wall and allow other active ingredients to enter the cell. Surfactants also contribute to the cleaning properties of the compositions of the invention.

In addition, the compositions according to the present invention are, due to the mild activity of the amphoteric surfactants contained therein, in particular betaine and / or sulfobetaine surfactants, particularly suitable for cleaning delicate surfaces, for example delicate laundry or surfaces in contact with food and / or children, especially when used in the diluted state. E.g. betaine and / or sulfobetaine surfactants are also very gentle on the skin and thus contribute to the comfortable use of the compositions of the present invention by the user.

Preferred amphoteric surfactants include betaine and sulfobetaine surfactants, their derivatives and mixtures thereof. Suitable betaine or sulfobetaine surfactants used in the compositions of the present invention are betaine / sulfobetaine and betaine-like detergents, the molecule of which contains both basic and acidic groups which form an inner salt and impart cationic and anionic hydrophilic groups to the molecule over a wide range of pI values. Some common examples of such detergents are described in U.S. Pat. Patentech No. 2,082,275, 2,702,279 and 2,255,082, incorporated herein by reference. Preferred betaine and sulfobetaine surfactants have the general formula I:

J ²

Rv-Ν ~ (0Η ₃ ) η-Υ '(I)

R 5 where R 1 is an alkyl radical containing 1 to 24 carbon atoms, preferably 8 to 18, more preferably 12 to 14, where R 7 and R ₃ contains 1 to 3 carbon atoms, preferably 1 carbon atom, wherein n is an integer from 1 to 10, preferably 1 to 6 and more preferably 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals and wherein the sum of R 1, R 2; and R ₃ radicals is 14 to 24 carbon atoms or mixtures thereof.

Examples of suitable betaine surfactants include, in particular, C 12 -C ₁₈ alkyldimethylbetaine as coconut betaine and C 10 -C ₁₆ alkyldimethylbetaine as laurylbetaine.

Coconut betaine is commercially available from Seppic under the tradename Amonyl 265® and laurylbetaine is commercially available from Albright & Wilson under the tradename Empigen BB / L®.

Other suitable amphoteric surfactants include amine oxides or mixtures thereof. Amine oxides contribute to the disinfecting properties of the compositions of the invention. They aid in disinfection by disrupting the cell wall / membrane of the bacterium, thus allowing other antimicrobial components to enter the cell and, for example, attack the internal cell space.

Suitable amine oxides have the general formula R _{1 R 2 R 3 NO, wherein each R b} R 2 and R 3 is independently a saturated linear or branched hydrocarbon chain containing 1 to 30 carbon atoms. _{Suitable amine oxides of the present invention have the general formula R 1} R 2 R 2 NO, wherein R 1 is a hydrocarbon chain containing 1 to 30 carbon atoms, preferably 6 to 20, more preferably 6 to 14 and most preferably 8 to 10 and wherein R 2 and R 3 are independently unsubstituted or substituted linear or branched hydrocarbon chains containing 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms and more preferably methyl groups. R 1 is a saturated linear or branched hydrocarbon chain.

Preferred amine oxides according to the invention are, for example, a natural mixture of C ₅ -C 11 amine oxides and C 12 -C 11 amine oxides commercially available from Hoechst.

In one embodiment of the present invention, where the compositions are particularly suitable for disinfecting solid surfaces, the surfactant is typically a surfactant system comprising an amine oxide and a betaine or sulfobetaine surfactant, preferably in a weight ratio of amine oxides to betaine or sulfobetaine of 2: 1 to 100: 1. The use of such a surfactant system in compositions suitable for disinfecting solid surfaces provides effective cleaning and gloss of the cleaned surfaces, i. that the amount of surfactant left by coating or spraying the surface cleaned by the compositions of the invention is minimal.

Compositions of the invention typically contain at least 0.005% amphoteric surfactant or mixtures thereof of the total weight of the composition, preferably 0.01% 10% and more preferably 0.1% 5%.

As a third essential component, the compositions of the present invention contain glutaraldehyde. Glutaraldehyde is commercially available from UNION CARBIDE or BASF.

Compositions of the invention typically contain at least 0.003% glutaraldehyde by total weight of the composition, preferably 0.008% to 4% and more preferably 0.2% to 2%.

As a fourth basic component, the compositions of the present invention comprise an antimicrobial essential oil or an active ingredient thereof or mixtures thereof.

Suitable antimicrobial essential oils useful in the compositions of the invention are essential oils having antimicrobial activity. "Active ingredients of antimicrobial essential oils here refer to any ingredient of essential oils that exhibits antimicrobial activity. Antimicrobial essential oils and their active ingredients probably cause protein denaturation. Antimicrobial essential oils and their active ingredients are compounds of natural origin, which contributes to the safe profile of the compositions of the present invention when used to disinfect any surface. Another advantage of antimicrobial essential oils and their active ingredients is the delivery of a pleasant odor to the disinfectants of the present invention without the need to add perfume. The disinfectants of the present invention not only perfectly disinfect contaminated surfaces, but also impart a pleasant odor to them.

Essential oils include, but are not limited to, thymol essential oil, lemon grass, citrus, lemons, oranges, anise, cloves, anise spice, cinnamon, geranium, roses, mint, lavender, lemongrass essential oil, eucalyptus, peppermint, camphor, sandalwood, cedar and mixtures thereof. The active ingredients of the essential oils used include, but are not limited to, thymol (present, for example, in thymus), eugenol (present, for example, in cinnamon), menthol (present, for example, in mint), geraniol (present, for example, in geranium or rose), verbenone ( present, for example, in verbena), eucalyptol (present, for example, in eucalyptus), cedrol (present, for example, in cedar), pinocarvone, carvacrol, anethole (present, for example, in anise spice), hinokitol, berberine, terpineol, limonene, ratanhiae, and their mixtures. Preferred essential oil ingredients are thymol, eugenol, verbenone, eucalyptol, limonene and / or geraniol.

Thymol is commercially available, for example, from Aldrich, and eugenol is commercially available, for example, from Sigma or Bioindustries (SBI) or Manheimer lne.

The compositions of the invention typically contain at least 0.003% of antimicrobial essential oil or its active ingredients or mixtures thereof by total weight of the composition, preferably 0.006% to 10% and more preferably 0.01% to 4%.

The compositions of the present invention have been shown to provide improved disinfection of contaminated surfaces even at high dilutions, i. until the composition is diluted 1: 100 with water.

"Heavily soiled surfaces" here refers to surfaces contaminated with organic and / or inorganic stains in an amount equivalent to an aqueous solution of 0.3 g / l bovine albumin and heavy water (see contamination conditions European Standard prEN 1276, CEN / TC 216 N59 of 11/95).

"Improved disinfection" as used herein refers to the ability of compositions of the present invention comprising peroxide bleach, amphoteric surfactant, glutaraldehyde and antimicrobial essential oil or active ingredient to reduce bacteria on a heavily soiled surface compared to the same compositions without peroxide bleach, amphoteric surfactant and glutaraldehyde. by the same means without antimicrobial essential oil or its active ingredient, especially when used in diluted form. Complete disinfection is achieved with a variety of microorganisms, including Gram-positive bacteria such as Staphylococcus aureus and Gram-negative bacteria such as Pseudomonas aerugirtosa, as well as fungi such as Candida albicans present on heavily soiled surfaces.

The disinfecting properties of the composition are measured by the bactericidal activity of the composition. The test method for determining the bactericidal activity of a composition is described in Europian Standard, prEN 1276, CÉN / TC 216 N 59 of November 1995, issued by the European Commission for Standardization in Brussels. Europian Standard, prEN 1276 specifies the test method and requirements for minimum bactericidal activity of the disinfectant. The test is positive when the bacterial colony forming units (cfu) are reduced from 10 ⁷ cfu (initial state) to 10 ² cfu (final number after contact with the disinfectant product), ie. it is necessary to reduce viability in the order of 10 ⁵ . The compositions of the present invention pass this test on heavily soiled surfaces even at high dilutions.

Another suitable test method for determining the bactericidal activity of the present compositions on heavily soiled surfaces is AFNOR T72-190® and T72301®.

The compositions of the present invention may be applied undiluted or diluted to the disinfected surface, preferably diluted.

"Diluted" as used herein refers to the ability of a user to dilute the liquid or solid compositions of the present invention with a liquid, typically water. The user dilutes the compositions of the invention typically with water up to 100 times the weight, preferably 80 to 40 times and more preferably 60 to 30 times.

The present invention also includes dilute disinfectants obtained by diluting a composition of the present invention with water.

In a preferred embodiment of the present invention, the compositions are aqueous liquid compositions. The aqueous compositions preferably have a pH not exceeding 12, preferably 3.5 to 7, and more preferably 4 to 5. The pH of the compositions is adjusted using organic acids such as citric acid, succinic acid, acetic acid, aspartic acid, lactic acid, and the like, or inorganic acids. or alkalizing agents.

The compositions of the present invention may further comprise any surfactant known to those skilled in the art, including nonionic, anionic, cationic and / or zwitterionic surfactants. Surfactants suitably contribute to the cleaning properties of the compositions of the invention.

The compositions of the present invention typically contain, in addition to the amphoteric surfactant or mixture thereof, up to 50% of the other surfactant or mixture thereof by weight of the composition, preferably 0.3% to 30% and more preferably 0.4% to 25%.

The compositions of the invention also preferably contain an anionic surfactant or mixtures thereof. Suitable anionic surfactants include in particular water-soluble salts or acids of formula ROSO ₃ M, wherein R is preferably a C 8 -C ₂₄ hydrocarbon radical, preferably an alkyl or hydroxyalkyl group with a C 8 -C 20 alkyl moiety, more preferably a C 8 -C 20 alkyl or hydroxyalkyl group, and M is H or a cation, e.g. alkali metal cations (e.g. sodium, potassium, lithium) or ammonium or substituted ammonium cations (e.g. methyl-, dimethyl-, and trimethylammonium cations and quaternary ammonium cations such as tetramethylammonium and dimethylpiperidine cations and quaternary ammonium cations derived from alkylamines such as ethylamine, diethylamine, triethylamine and mixtures thereof, and the like).

Other suitable anionic surfactants include alkyl diphenyl ether sulfonates and alkyl carboxylates. Other anionic surfactants include soap salts (including, for example, sodium, potassium, ammonium and substituted ammonium salts such as mono-, di- and triethanolamine salts), C9-C20 linear alkylbenzenesulfonates, Gg-C ₂ 2 primary or secondary alkanesulfonates, C _x -C ₂₄ olefin sulfonates, sulfonic polycarboxylic acids prepared by combining the pyrolysis product of alkaline earth metal citrates, as described, for example, in British Pat. 1,082,179, C ₈ -C ₂₄ alkyl polyglycol ether sulfates (containing up to 10 moles of ethylene oxide); alkyl sulfonate esters such as C14-C16 methyl sulfonate ester; acyl glycerol sulfonates, fatty oleylglycerolsulfátů, alkyl phenol, paraffin sulfonates, alkyl phosphates, isethionates such as the acyl isethionates, N-acyl taurates, alkylsukcinamátů and sulfosuccinates, monoesters of sulfosuccinates (especially saturated and unsaturated C ₂ -C _Ig monoesters) diesters of sulfosuccinate (especially saturated and unsaturated C6-C14 diesters ), acyl sarcosinates, alkyl polysaccharide sulfates such as alkyl polyglucoside sulfates (nonionic unsulfonated compounds are described below), branched primary alkyl sulfates, alkyl polyethoxycarboxylates of the general formula RO (CH ₂ CH ₂ O) k _{CH 2} COO-M ⁺ , where R is C ₈ -C ₂₂ alkyl the group, k is an integer from 0 to 10 and M is a soluble salt-forming cation. Also suitable are resin acids and hydrogenated resin acids such as rosin, hydrogenated rosin and resin acids and hydrogenated resin acids present in or derived from tall oil. Further examples are given in "Surface Active Agents and Detergents" (Vol. I and II, Schwartz, Perry and Berch). Various surfactants are also generally described in U.S. Patent 3,929,678, issued December 30, 1975 to Laughlin et al., Column 23, line 58 to column 29, line 23.

Preferred anionic surfactants useful in the compositions of the invention are C 8 -C 18, alkyl sulfonates, C 8 -C 6. alkyl sulfates, C 8 -C ₁₆ alkyl alkoxy sulfates (e.g., C ₆ -C 16 alkyl ethoxy sulfates), and mixtures thereof. Such anionic surfactants advantageously contribute to the disinfecting properties of the disinfectants according to the invention. For example, Cg-Gif. alkyl sulfate disrupts the bacterial cell membrane, inhibits enzymatic activities, interrupts cellular transport, and / or denatures cellular proteins. It is believed that improved disinfecting performance associated with the addition of an anionic surfactant, especially a C ₈ -C 6 _{alkylsulfonate},} C ₆ -C ₈ alkyl sulfate and / or C ₈ -Ci6 alkyl alkoxylated sulfate in the composition of the present invention is likely due to multiple mode of attack of said surfactant against the bacteria. Another aspect of the present invention is the use of an anionic surfactant, especially C ₈ -C 18 alkyl sulfonate, C 8 -C 18 alkyl sulfate and / or C 8 -C 16 alkyl alkoxy sulfate in the disinfectant of the present invention to improve the disinfectant properties of Gram negative and / or Gram positive bacteria.

The compositions of the present invention preferably comprise a nonionic surfactant or a mixture thereof. Suitable nonionic surfactants are fatty alcohol ethoxylates and / or propoxylates, which are commercially available with different fatty alcohol chain lengths and different degrees of ethoxylation. The HLB values of these alkoxylated nonionic surfactants depend mainly on the chain length of the fatty alcohol, the type of alkoxylation and the degree of alkoxylation. The amount of surfactants, including non-ionic ones together with their respective HLB values, is given in the surfactant catalogs.

Suitable nonionic surfactants are in particular hydrophobic nonionic surfactants with an HLB (hydrophilic lipophilic balance) value not exceeding 16, preferably not exceeding 15 and more preferably not exceeding 14. These hydrophobic nonionic surfactants penetrate well through grease.

Preferred hydrophobic nonionic surfactants for use in compositions of the present invention are surfactants having an HLB not exceeding 16 with the general formula RO- (C ll4O) _n ((> DLO) "H wherein R is a _Cg-C22 alkyl chain or a C ₆ - C ₂₈ alkylbenzene chain and wherein n + m is 0 to 20 and n is 0 to 15 and m is 0 to 20, preferably n + m is 1 to 15 and n are 0.5 to 15, more preferably n + m is 1 to 10 and n are 0 to 10. Preferred R chains are C ₈ -C ₂₂ alkyl chains Suitable hydrophobic nonionic surfactants are Dobanol ^R 91-2.5 (HBL = 8.1; R is a mixture of C9 and C 11 alkyl chains, n is 2.5 am is 0) or Lutensol ^R TO3 (HBL = 8; R is a C13 alkyl chain, n is 3 and m is 0) or Lutensol ^R AO3 (HBL = 8; R is a mixture of C13 and C5 alkyl chains, n is 3 and m is 0) or Tergitol ^K 25L3 (HBL = 7.7; R is in the range of C 12 -C 18 alkyl chains, n is 3 and m is 0) or Dobanol ”23-3 (HBL = 8.1; R is a mixture of Cl 2 and C 13 alkyl chains, n is 3 and m is 0) or Dobanol ^R 23-2 (HBL = 6.2; R is a mixture of C 12 and C ₁₃ alkyl chains, n is 2 and m is 0 ) or Dobanol ^R 45-7 (HBL = 11.6; R is a mixture of C 14 and C 13 alkyl chains, n is 7 and m is 0), Dobanol ^R 23-6.5 (HBL = 11.9; R is a mixture of C 12 and C 13 alkyl chains, n is 6.5 and m is 0) or Dobanol ^R 25-7 (HBL = 12; R is a mixture of C12 and C15 alkyl chains, n is 7 and m is 0) or Dobanol ^K 91-5 (HBL = 11.6; R is a mixture of C9 and C11 alkyl chains, n is 5 am is 0) or Dobanol ^R 91-6 (HBL = 12.5; R is a mixture of C9 and C11 alkyl chains, n is 6 and m is 0) or Dobanol ¹ * 91-8 (HBL = 13.7; R is a mixture of C9 and C11 alkyl chains, n is 8 and m is 0) or Dobanol ^R 91-10 (HBL = 14.2; R is a mixture of C9 and C11 alkyl chains, n is 10 and m is 0) or mixtures thereof. Preferred are Dobanol ^K 91-2.5 or Lutensol ^R TO3 or Lutensol ^R AO3 or Tergitol ^R 25L3 or Dobanol ^R 23-3 or Dobanol ^R 23-2 or mixtures thereof. Dobanol ^R surfactants are commercially available from SHELL. Lutensol ^R surfactants are commercially available from BASF and Tergitol ^R surfactants are commercially available from UNION CARBIDE.

Other suitable surfactants also include C6- _C20 conventional soaps (C ₆ -C ₂ alkali metal salt of fatty acids, preferably the sodium salt).

The compositions may further comprise a chelating agent as another preferred ingredient. Suitable chelating agents known to those skilled in the art are selected from phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, polyfunctionally substituted aromatic chelating agents; disuccinic acid or mixtures thereof.

Suitable phosphonate chelating agents include etidronic acid (1-hydroxyethylenediphosphonic acid HEDP) and / or alkali metal ethane-1-hydroxydiphosphonates.

Suitable aminophosphonate chelating agents include aminoalkylene polyalkylene phosphonates, nitrilotris (methylene) triphosphonates, ethylenediaminetetrainethylenephosphonates and / or diethylenetriaminepentamethylenephosphonates. Preferred aminophosphonate chelating agents are diethylenetriamine pentamethylenephosphonates.

These phosphonate / aminophosphonate chelating agents are present either in the form of acids or salts of various cations of some or all of the acidic functions. These phosphonate / aminophosphonate chelating agents are commercially available from

Monsanto under the trade name DEQUEST®.

Substituted heteroaromatic chelating agents include hydroxypiperidine-Oxide or its derivatives.

Suitable hydroxypiperidine N-oxides or derivatives thereof useful in the present invention have the general formula II:

(II) wherein X is nitrogen, Y is selected from the group consisting of oxygen, -CHO, -OH, - (CH ₂ ) n -COOH, n is an integer from 0 to 20, preferably 0 to 10, and more preferably 0, and Y is preferably oxygen. An especially preferred hydroxypiperidine N-oxide is 2-hydroxypiperidine N-oxide and its derivatives.

Hydroxypiperidine-N-oxide and its derivatives are commercially available from

Sigma.

Polyfunctionally substituted aromatic chelating agents are also useful in the compositions of the invention. See U.S. Pat. U.S. Patent 3,812,044, issued to Connor et al. May 21, 1974. Preferred compounds of this type in acid form are dihydroxydisulfobenzenes such as 1,2-dihydroxy-3,5-disulfobenzene.

The preferred biodegradable chelating agent is ethylenediamine N, N'-disuccinic acid or its alkali metal, alkaline earth metal, ammonium or substituted ammonium salts or mixtures thereof. Ethylenediamine Ν, Ν'-disuccinic acid, especially the (S, S) -isomer is described in US No. 4,704,233, issued to Hartman and Perkins on November 3, 1987. Ethylenediamine N, N-disuccinic acid is commercially available, for example, from Palmer Research Laboratories under the tradename ssEDDS®. Ethylenediamine N, N'-disuccinic acid is particularly suitable for use in the compositions of the present invention.

Suitable amino carboxylate chelating agents include ethylene diethylcntriaminpentaacetáty, diethylene (DTPA), Nhydroxyethylendiamintriacetáty, nitrilotriacetates, ethylenediamine, tricthylentetraaminhexaacetáty, ethanoldiglycines, propylene diamine tetracetic acid (PDTA) and methyl glycine diacetic acid (MGDA), both in their acid form or as their alkali metal, ammonium, and substituted ammonium salts. Particularly suitable are diethylenetriaminepentaacetic acid (DTPA), propylenediaminetetraacetic acid (PDTA), which is commercially available, for example, from BASF under the trade name Trilon PS®, and methylglycine diacetic acid (MGDA).

Other carboxylate chelating agents include malonic acid, salicylic acid, glycine, aspartic acid, glutamic acid, or mixtures thereof.

The compositions of the present invention typically contain up to 5% chelating agent or mixtures thereof by total weight of the composition, preferably 0.01% to 3% by weight and more preferably 0.01% to 1.5%.

The compositions according to the invention contain radical scavengers as a further preferred component. Suitable radical scavengers include the well-known substituted mono- and dihydroxybenzenes and their derivatives, alkyl and aryl carboxylates, and mixtures thereof. Preferred radical scavengers include di-tert-butylhydroxytoluene (BHT), p-hydroxytoluene, hydroquinone (HQ), di-tert-butylhydroquinone (DTBHQ), mono-tert-butylhydroxyquinone (MTBHQ), tert-butylhydroxyanisole ( BHA), p-hydroxyanisole, benzoic acid, 2,5-dihydroxybenzoic acid, 2,5-dihydroxyterephthalic acid, toluic acid, catechol, t-butylcatechol, 4-allylcatechol, 4-acetylcatechol, 2-methoxyphenol, 2-ethoxyphenol, 2-methoxy -4- (2-propenyl) phenol, 3,4-dihydroxybenzaldehyde, 2,3-dihydroxybenzaldehyde, benzylamine, 1,1,3-tris- (2-methyl-4-hydroxy-5-t-butylphenyl) butane, tert- butylhydroxyaniline, p-hydroxyaniline, and n-propyl gallate. Very preferred is di-tert-butylhydroxytoluene, which is available, for example, from SHELL under the trade name IONOL CP®, and / or tert-butylhydroxyanisole. These radical scavengers further contribute to the stability of the hydrogen peroxide-containing compositions of the invention.

The compositions of the present invention typically contain up to 5% radical scavengers or mixtures thereof of the total weight of the composition, preferably 0.002% to 1.5% by weight and more preferably 0.002% to 1%.

The compositions of the invention comprise as a further preferred component a solvent or solvent mixtures. The solvents used advantageously improve the cleaning properties of the compositions. Suitable solvents included in the compositions of the present invention include propylene glycol derivatives such as n-hutoxypropanol or n-butoxypropoxypropanol, CARBITOL® water-soluble solvents or CELLOSOLVE® water-soluble solvents. CARBITOL® water-soluble solvents are compounds of the 2- (2-alkoxyethoxy) ethanol class, where the alkoxy group is derived from an ethyl, propyl or butyl group. The preferred water-soluble carbitol is 2- (2-butoxyethoxy) ethanol, also known as butyl carbitol. CELLOSOLVE® water-soluble solvents are compounds of class 2alkoxyethoxyethanol, preferably 2-butoxyethoxyethanol. Other suitable solvents are benzyl alcohol, methanol, ethanol, isopropyl alcohol, and diols such as 2-ethyl-1,3-hexanediol and 2,2,4-trimethyl-1,3-pentadiol and mixtures thereof. Preferred solvents are n-butoxypropoxypropanol, Butylcarbitol®, benzyl alcohol, isopropanol and mixtures thereof. The most preferred solvents are Butylcarbitol®, benzyl alcohol and / or isopropanol.

Compositions of the invention typically contain up to 15% of solvents by total weight of the composition, preferably 2% to 7% by weight of the composition.

The compositions of the invention may further comprise various other preferred ingredients such as buffers (e.g. borate buffers), fillers, stabilizers, bleach activators, stain suspenders, dye transfer agents, brighteners, perfumes, dusting agents, enzymes, dispersants, dye transfer inhibitors, pigments, fragrances and dyes.

Packaging of disinfectants.

The compositions of the invention are packaged in a variety of suitable detergent packages known to those skilled in the art. The liquid compositions of the invention are suitably packaged in hand-held nebulizer containers, which are usually made of synthetic organic polymeric plastics, and are preferably dispensed or pumped into the nebulizer.

The nebulizers allow the liquid disinfectant of the present invention to be uniformly applied to a relatively large portion of the disinfected surface, thereby contributing to the disinfecting properties of the compositions. Sprayers are especially suitable for disinfecting vertical surfaces.

Suitable nebulizers useful in the present invention include manually operated foam trigger nebulizers sold, for example, by Specially Packaging Products, Inc. or Continental Sprayers, lne. These types of nebulizers are described, for example, in U.S. Pat. No. 4,701,311 to Dunnining et al. and U.S. 4,646,973 to Focarracei et al

U.S. 4,538,745, Focarracei. Particularly preferred are T 8500® or T 8900® sprayers, commercially available from Continental Spray International or T 8100®, commercially available from Canyon, Northern Ireland. In the paint sprayer, the liquid composition becomes fine liquid droplets in a spray which are sprayed directly onto the surface to be cleaned. The agent contained in the nebulizer container enters through the nebulizer head when the user activates the pumping mechanism. The agent in the atomizer head is pushed over an obstacle, such as a grid or coil, and the shocks help to atomize the liquid agent, i. they help to form liquid droplets.

The compositions according to the present invention are also realized as wipes. "Wipes" as used herein refer to disposable wipes impregnated with a liquid composition of the present invention. The wipes are preferably packaged in a plastic box. The advantage of this design is the faster use of the disinfectant by the user even outside the home, ie. it is not necessary to pour the liquid compositions according to the present invention on the cleaned / disinfected surfaces and to dry them with a cloth. In other words, the wipes allow the disinfection of surfaces in one step.

Disinfection method.

The present invention includes a method of disinfecting a surface with a composition comprising a peroxide bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or an active ingredient thereof.

"Surface" as used herein refers to any surface, including living surfaces such as human skin, mouth, teeth, and inanimate surfaces. Inanimate surfaces include, without limitation, solid surfaces typically found in homes in kitchens, bathrooms, or car interiors, such as tiles, walls, floors, chrome surfaces, glass, smooth vinyl, any plastic, plasticized wood, table tops, sinks, countertops. cookers, dishes, sanitary ware such as sinks, showers, shower curtains, baths, toilets, and the like, as well as fabrics including dresses, curtains, drapes, bed linen, bathroom linen, tablecloths, sleeping bags, tents, upholstered furniture, and so on similarly, and carpets. Inanimate surfaces also include household appliances including, but not limited to, refrigerators, freezers, washing machines, automatic dryers, ovens, microwave ovens, dishwashers, etc.

In the method of disinfecting surfaces according to the present invention, the composition according to the invention is applied undiluted or after dilution with water. Preferably, the composition of the invention is diluted up to 100 times the weight of water before application to the surface, preferably 80 to 40 times and more preferably 60 to 30 times.

In a preferred embodiment of the disinfection according to the present invention, the composition is applied to the disinfected solid surface diluted, after application of the composition it is not necessary to rinse the surface, no visible residues remain on the surface.

The present invention is further illustrated by the following examples.

Examples of embodiments of the invention

The following compositions were prepared by mixing the indicated ingredients in the indicated proportions (by weight unless otherwise indicated). These products have passed the European Commission's soiling test of prEN 1276 standardization (0.03% albumin / heavy water). These products perfectly disinfect heavily soiled surfaces when used in undiluted and diluted form, eg in dilutions of 1,100, 1:25, 1:50, and also provide perfect surface safety.

Resources AND II III IV IN VI Hydrogen peroxide 7.0 6.0 7.0 2.0 7.0 1.0 Betainx 4.5 4.0 3.0 0.1 6.0 0.2 Thymol - 0.5 - - - - Glutaraldehyde 0.8 0.8 0.5 0.05 0.8 0.15 Eugenol 0.5 - - 0.02 0.5 - Geraniol - - 1.0 - - 0.2 Water and minor components make up to 100% H2SO4 to pH 4 Resources VII VIII IX X XI XII Hydrogen peroxide 7.0 6.0 3.5 2.0 7.0 1.0 Betainx 4.5 4.0 3.0 0.1 6.0 0.2 Glutaraldehyde 0.8 0.8 0.5 0.5 0.8 0.15 Thymol / Eugenol / Geraniol 2.0 3.0 1.5 1.0 3.0 1.0 Water and minor components make up to 100% H2SO4 to pH 4

Resources XIII XIV XV XVI XVII XVIII Hydrogen peroxide 7.0 6.0 7.0 2.0 7.0 1.0 Nonionic surfactant ^xx 1.2 2.0 1.1 0.5 1.2 - Nonionic surfactant ^{χ xx} 1.6 - - 0.7 1.5 0.4 Betainx 4.5 4.0 3.0 0.1 6.0 0.2 Thymol - 0.5 - - - - Glutaraldehyde 0.8 0.8 0.5 0.5 0.8 0.15 Eugenol 0.5 - - 0.05 0.5 - Geraniol - - 0.1 - - 0.2 Water and minor components make up to 100% H2SO4 to pH 4 Resources XIX XX XXI XXII XXIII XXIV Hydrogen peroxide 7.0 6.0 7.0 2.0 7.0 1.0 Nonionic surfactant ^xx 1.2 2.0 1.1 0.5 1.2 - Nonionic surfactant ^{χ χ χ} 1.6 - - 0.7 1.5 0.4 Cio Aminoxide 1.0 2.0 - 1.0 - 0.5 C10 Alkyl sulfate - - 4.5 3.0 - 1.5 Betaine ^x 4.5 4.0 3.0 0.1 6.0 0.2 Thymol - 0.5 - - - Glutaraldehyde 0.8 0.8 0.5 0.5 0.8 0.15 Eugenol 0.5 - - 0.05 0.5 - Geraniol __ - 0.1 - - 0.2

Make up to 100% H2SO4 with water and minor components

Resources XXV XXVI XXVII XXVIII XXIX Hydrogen peroxide 7.0 1.0 2.0 2.0 3.5 Cio Aminoxide 4.5 0.2 0.8 0.8 3.0 Glutaraldehyde 0.8 0.15 0.2 0.2 0.5 Thymol - - 0.2 0.01 - Eugenol 0.5 - - - __ Geraniol - 0.2 0.3 0.02 Thymol / Eugenol / Geraniol - - - - 1.5 Water and minor components make up to 100% H2SO4 to pH 4

Betainx is either coconut betaine commercially available from Seppic under the tradename Amonyl 265®, or laurylbetaine commercially available from Albrigbt & Wilson under the tradename Empigen BB / L®, or mixtures thereof.

* * is Dobanol 23-3® xxx is Dobanol 91-10®

Industrial applicability

The antimicrobial compositions of the present invention are used to disinfect and clean a variety of surfaces, including living surfaces (e.g., human skin, mouth) and non-living surfaces (e.g., solid surfaces, fabrics). The disinfectants according to the present invention perfectly disinfect cleaned surfaces even when used in large dilutions and are suitable for delicate fabrics as well as for use on delicate surfaces in safe contact with food and / or children. The disinfectants of the present invention have a perfect effect on Gram-positive and Gram-negative bacterial strains as well as on fungi. The compositions according to the invention are packaged in the form of a liquid in conventional detergent bottles, or as a spray or foam in a spray / foam atomizer, or they are soaked in wipes intended for quick cleaning in one step.

PATENT CLAIMS

Claims (15)

]. A disinfectant comprising a peroxygen bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or an active ingredient thereof. Disinfectant according to claim 1, characterized in that the peroxygen bleach is hydrogen peroxide or a water-soluble source thereof selected from the group consisting of percarbonates, peroxosilicates, persulfates, perborates, peracids, dialkyl peroxides, diacyl peroxides, preformed peroxycarboxylic acids, organic and inorganic acids. , organic and inorganic hydroperoxides and mixtures thereof, and hydrogen peroxide is preferred. Disinfectant according to any one of claims 1 and 2, characterized in that the amphoteric surfactant is a betaine or a sulfobetaine surfactant of the general formula I: R ₂ R - N - (CH ₃ ) n - Y (I) R ₃ wherein R 1 is an alkyl radical of 1 to 24 carbon atoms, preferably 8 to 18, and more preferably 12 to 14, wherein R ₂ and R ₃ contain 1 to 3 carbon atoms and preferably 1 carbon atom, wherein n is an integer of 1 to 10 , preferably 1 to 6 and more preferably 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals and wherein the sum of R _b R ₂ and R ₃ radicals is 14 to 24 carbon atoms, and / or amine oxide of the formula R ₁ R ₂ R ₃ NO, wherein each R 1, R ₂ and R ₃ is independently a saturated linear or branched hydrocarbon chain of 1 to 30 carbon atoms, preferably 6 to 20, and wherein R ₂ and R ₃ are independently unsubstituted or substituted linear or branched hydrocarbon chains of 1 to 4 atoms carbon atoms, preferably 1 to 3 carbon atoms, and more preferably are methyl groups. Disinfectant according to any one of claims 1 to 3, characterized in that the antimicrobial essential oil is obtained from thymol, lemon grass, citrus, lemons, oranges, anise, cloves, anise spices, cinnamon, geranium, roses, lavender, citronella , eucalyptus, peppermint, camphor, sandalwood, cedar and mixtures thereof, and / or the active ingredient of the essential oil is thymol, eugenol, menthol, cedrol, verbena, eucalyptol, anethole, pinocarvone, carvacroi, geraniol, hinokitol, berberin, tinberin, tcr , ratanhiae and mixtures thereof, and eugenol, verbena, geraniol, eucalyptol, limonene and / or thymol are preferred. Disinfectant composition according to any one of the preceding claims 1 to 4, characterized in that the composition comprises at least 0.003% of the antimicrobial essential oil or its active ingredient or mixtures thereof of the total weight of the composition, preferably 0.006% to 10% and more preferably 0.01% to 4%. %. Disinfectant composition according to any one of the preceding claims 1 to 5, characterized in that the composition comprises at least 0.01% of a peroxygen bleach or a mixture thereof of the total weight of the composition, preferably 0.1% to 15% and more preferably 1% up to 10%. Disinfectant composition according to any one of the preceding claims 1 to 6, characterized in that the composition comprises at least 0.005% amphoteric surfactants, derivatives or mixtures thereof, based on the total weight of the composition, preferably 0.01% to 10% and more preferably 0.1% to 10%. 5%. The disinfectant composition according to any one of the preceding claims, wherein the composition comprises at least 0.003% glutaraldehyde of the total weight of the composition, preferably 0.008% to 4%, and more preferably 0.2% to 2%. Disinfectant composition according to any one of claims 1 to 8, characterized in that the composition further comprises a chelating agent selected from the group of phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, polyfunctionally substituted aromatic chelating agents. agents, ethylenediamine Ν, Ν'-disuccinic acid and mixtures thereof. Disinfectant composition according to any one of the preceding claims 1 to 9, characterized in that the composition further comprises a preferred component from the group of surfactants, radical scavengers, solvents, fillers, stabilizers, bleach activators, stain suspensions, color transfer agents, brighteners, dusting agents. , enzymes, dispersants, dye transfer inhibitors, pigments, perfumes, dyes, and mixtures thereof. Disinfectant composition according to any one of the preceding claims 1 to 10, characterized in that the composition is a liquid composition, preferably an aqueous liquid composition with a pH not exceeding preferably 12, more preferably 3.5 to 7. 12. A disinfectant composition according to claim 11, wherein the composition is packaged in a nebulizer. A wipe impregnated with the composition of claim 11. 14. A method of disinfecting a surface, wherein the surface is disinfected with a composition according to any one of the preceding claims 1 to 12. A method for disinfecting a surface according to claim 14, wherein the composition is diluted with water up to 100 times by weight of water, preferably 80 to 40 times by weight, and more preferably 60 to 30 times by weight, before application to the surface.