SK95198A3 - Disinfecting compositions - Google Patents

Abstract

The present invention relates to disinfecting compositions comprising a peroxygen bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or an active thereof, and to a process for disinfecting surfaces.

Description

Technical field

The present invention relates to antimicrobial compositions which are used to disinfect and clean various surfaces including living surfaces (e.g., human skin, mouth, etc.) and inanimate surfaces including, but not limited to, solid surfaces such as walls, tiles, table tops, glass, bathroom surfaces, dishes, fabrics, dresses, carpets and the like.

BACKGROUND OF THE INVENTION

Antimicrobial / antibacterial agents include substances capable of disinfecting. It is generally known that a disinfectant substantially reduces or even kills microorganisms, e.g. bacteria on the surface. For disinfection purposes, compositions based on halogen-containing compounds such as hypochlorite or quaternary compounds have been widely described in the art. Peroxide bleaching agents are also known as disinfectants.

However, compositions based on a peroxygen bleaching agent as the only antimicrobial compound (typically 7% of the total weight of the composition) are not fully effective, especially when used in large dilutions, e.g. at a 1:50 dilution (composition: water) for disinfecting contaminated surfaces, e.g. surfaces requiring both washing and disinfection. The presence of organic and / or inorganic stains reduces the bactericidal activity of many antimicrobial agents, such as a peroxygen bleach, and leads to a decrease in the bactericidal activity / disinfectant activity of the compositions comprising these antimicrobial agents.

It is an object of the present invention to provide compositions that completely disinfect contaminated surfaces, especially heavily soiled surfaces even when used in large dilutions.

This has been shown to be achieved by combining various antimicrobial compounds, i. a combination of a peroxygen bleach, an amphoteric surfactant or a mixture thereof, glutaraldehyde and an antimicrobial essential oil, or an active ingredient thereof, or mixtures thereof. In particular, it has been shown that a composition comprising a peroxygen bleaching agent, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or active ingredient thereof provides a perfect disinfection of contaminated surfaces, including contaminated surfaces, even at high dilution rates, i.e.. up to a 1: 100 dilution (composition: water).

An advantage of the present invention is the perfect disinfection against contamination on a wide range of bacterial strains including gram-positive and gram-negative bacterial strains as well as more resistant microorganisms than fungi.

A further advantage of the compositions of the present invention is, besides the disinfecting properties, also good cleaning effects.

The compositions of the present invention are suitable for use on all types of surfaces including living surfaces (e.g., human skin and / or mouth when used as an oral composition or toothpaste) and inanimate surfaces. This technology is suitable for applications mainly on hard surfaces as well as underwear, e.g. as a detergent or additive in a so-called " a soaking module, a washing module, or a pre-wash in the prewash module. The compositions of the present invention are particularly suitable for use on sensitive surfaces, including surfaces in safe contact with food and / or children. By using the diluted compositions of the present invention, the amount of chemical compounds remaining on the disinfected surface is reduced. For example, it is not necessary to rinse solid surfaces after application of the diluted compositions of the present invention.

A further advantage of the compositions of the present invention is that they can be in various forms, e.g. as a liquid packaged in an ordinary detergent bottle or spray or foam packaged in a spray / foam dispenser, or as wipes containing the composition of the invention, or in a liquid state.

EP-B-288 689 discloses a solid surface liquid comprising an effective amount of an antimicrobial pine oil and at least one soluble oleic organic acid. No other antimicrobial compounds are mentioned, and not a peroxide bleaching agent at all.

EP-241390 discloses disinfecting fabrics contaminated with bacteria by first treating the detergent and then the peroxygen bleach in a water bath at pH 9-13 in the presence of uncomplexed calcium. No other antimicrobial compounds are disclosed.

US 4,4004,191 discloses bactericidal, fungicidal and antiviral effects of peroxy compounds as monoperoxosulfate. US 4,404,191 discloses the use of diluted monoperoxosulfate-containing compositions on solid surfaces. However, no other antimicrobial compounds are disclosed.

EP-A-667 392 discloses solid surface cleaners comprising hydrogen peroxide and a surfactant / hardener component comprising an alkyl ether sulfate surfactant together with an amine oxide or a betaine. The compositions have a pH of 7 to 10. No other antimicrobial compounds, and not essential oils or their active ingredients or glutaraldehyde, are disclosed.

US 5,403,587 discloses aqueous antimicrobial compositions used for cleaning, sanitizing and disinfecting solid surfaces. In particular, US 5,403,587 discloses aqueous compositions (pH 1-12) containing essential oils (0.02-5%) having effective antimicrobial properties such as thymic essential oil, eucalyptic essential oil, clove essential oil and the like, and a solubilizing dispersing agent sufficient to form an aqueous solution or dispersion of essential oils in an aqueous medium. These compositions may additionally contain other antimicrobial additives, such as phenolic compounds, quaternary ammonium compounds, but no amphoteric surfactants or peroxide bleaching agents are disclosed.

US 5,368,749 discloses compositions for inhibiting the growth of aerobic microorganisms, including bacteria and fungi, comprising an oxidant and glutaraldehyde. The oxidants are from the group of chlorine, bromine, monoperoxosulfate, perborate, peracetic and percarbonate. glutaraldehyde synergistic effect, antimicrobial compounds such as strengths or amphoteric surfactants.

hydrogen peroxide, acid Oxidant has no added e or active ingredients thereof when added to

US 3,852,210 discloses aqueous oxygen-releasing compositions suitable for widespread use in industry and households, e.g. as laundry detergents or as hard surface cleaners. Due to their germicidal and bactericidal activity, the compositions are suitable for medical use. The compositions (pH 2-10) contain an active oxygen-providing compound, e.g. hydrogen peroxide (0.1 to 50%), betaine or sulfobetaine (0.5 to 50%) such as cetylbetaine or laurylsulfobetaine and nonionic polyoxyethylene polyoxypropylene block copolymer surfactants with a solubility of at least 1 g per 100 ml of water and a molecular weight ranging from 1000 to 15 No other antimicrobial compounds, not essential oils or active ingredients or glutaraldehyde, are disclosed.

J-60038497 discloses a foaming detergent two-component composition comprising a) an aqueous solution of hydrogen peroxide (0.5 to 50%), b) an alkaline compound containing an alkaline substance with an alkalinity of 0.1 to 50% expressed as NaOH, such as NaOH, KOH, Na 2 CO 3. At least one of the two components of detergent compositions a) and b) comprises a surfactant, e.g. amphoteric surfactants, and / or at least one compound from the group of alcohols, cyclic terpene alcohols and esters thereof, such as geraniol. The compositions of J-60038497 clean stains on solid materials such as plastics, joints, and particularly difficult to clean niches or corners. Glutaraldehyde is not mentioned. Neither is it used for disinfection.

SUMMARY OF THE INVENTION

The present invention includes a disinfectant comprising a peroxygen bleach, an amphoteric surfactant, glutaraldehyde, and an antimicrobial essential oil or an active ingredient thereof.

The present invention further encompasses a method of disinfecting a surface with a composition comprising a peroxygen bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or an active ingredient thereof.

DETAILED DESCRIPTION OF THE INVENTION.

The disinfectants of the present invention comprise a peroxygen bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or an active ingredient thereof.

The compositions of the present invention are either liquid or non-flowable (e.g., gel, paste, or in solid form as a powder or granules). The solid compositions are mixed with a suitable solvent, usually water, before use. Liquid compositions are preferably, but not necessarily, aqueous compositions. Liquid formulations are preferred for convenient use.

As an essential element, the compositions of the present invention comprise a peroxygen bleach or a mixture thereof. A preferred peroxygen bleaching agent is hydrogen peroxide or a water-soluble source thereof, or a mixture thereof. Most preferably, hydrogen peroxide is used in the compositions of the present invention.

The presence of a peroxygen bleach, in particular hydrogen peroxide, persulfate, and the like, contributes to the disinfectant properties of the compositions of the present invention. The peroxygen bleaching agent can attack the vital functions of the microorganism cells, for example, it can inhibit the arrangement of ribosomal units in the cytoplasm of the microorganism cells. A peroxygen bleach such as hydrogen peroxide is a strongly oxidizing agent that generates free hydroxyl radicals that attack proteins and nucleic acids. In addition, the presence of a peroxygen bleaching agent, in particular hydrogen peroxide, has a strong stain removal effect, as is evident, for example, in laundry and hard surface applications.

A source of hydrogen peroxide is used herein to denote any compound which in contact with water provides hydrogen peroxide. Suitable water-soluble hydrogen peroxide sources used herein include percarbonates, persilicates, peroxosulfates such as monoperoxosulfate, perborates and peroxyacids such as diperoxododecanedioic acid (DPDA), magnesium perphthalic acid and mixtures thereof.

As an alternative to hydrogen peroxide and its sources or in combination with hydrogen peroxide and its sources, other classes of peroxides are used. Suitable classes include dialkyl peroxides, diacyl peroxides, preformed peroxocarboxylic acids, organic and inorganic peroxides and / or hydroperoxides.

The compositions typically comprise at least 0.01% of a peroxygen bleach or mixtures thereof, based on the total weight of the composition, preferably 0.1-15%, and more preferably 1-10%.

As a second essential component, the compositions of the present invention comprise an amphoteric surfactant or a mixture thereof. These amphoteric surfactants have a dual effect. They aid in disinfection by increasing the permeability of the bacterial cell wall and allowing other active ingredients to enter the cell. Surfactants also contribute to the cleaning properties of the compositions of the invention.

In addition, the compositions of the present invention, due to the mild activity of the amphoteric surfactants contained therein, especially betaine and / or sulfobetaine surfactants, are particularly suitable for cleaning delicate surfaces, for example delicate laundry or surfaces in contact with food and / or children, especially when used in food. diluted state. E.g. betaine and / or sulfobetaine surfactants are also very skin friendly and thus contribute to the convenient use of the compositions of the present invention by the user.

Preferred amphoteric surfactants include betaine surfactants, derivatives thereof, and mixtures thereof. Suitable betaine or sulfobetaine surfactants used in the compositions of the present invention are betaine / sulfobetaine and betaine-like detergents whose molecule contains both basic and acidic groups that form an internal salt and impart cationic and anionic hydrophilic groups to the molecule over a wide pH range. Some common examples of these detergents are described in U.S. Pat. 2,082,275, 2,702,279 and 2,255,082, incorporated herein by reference. Preferred betaine and sulfobetaine surfactants have the general formula I:

R ²

I

R ¹ - N ⁺ - (CH ₃ ) _n - y - (I) wherein R 1 is an alkyl radical containing 1 to 24 carbon atoms, preferably 8 to 18, more preferably 12 to 14, wherein R and R contain 1 to 3 carbon atoms, preferably 1 carbon atom, wherein n is an integer from 1 to 10, preferably 1 to 6, and more preferably 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals, and wherein the sum of the R 6, R and R radicals is 14 to 24 carbon atoms or mixtures thereof.

Examples of suitable betaine surfactants include, in particular, C 12-18 C 18 alkyldimethylbetaine such as coconut betaine and alkyldimethylbetaine such as laurylbetaine.

Coconut betaine is commercially available from Seppic under the trade name Amonyl 265 ^R and laurylbetaine is commercially available from Albright and Vilson under the trade name Empigen BB / L ^R.

Further suitable amphoteric surfactants include amine oxides or mixtures thereof. Amine oxides contribute to the disinfectant properties of the compositions of the invention. They assist disinfection by disrupting the cell wall / membrane of the bacterium, thereby allowing other antimicrobial components to enter the cell and, for example, attack the interior of the cell space.

Suitable amine oxides have the general formula R ^X R RNO, wherein each R ¹ , R ² and R ³ is independently a saturated linear or branched hydrocarbon chain having 1 to 30 carbon atoms. Suitable amine oxides of the present invention have the general formula R ³ R ² R ³ , wherein R ¹ is a hydrocarbon chain containing 1 to 30 atoms, preferably 6 to 20, more preferably 6 to 14, and most preferably 8 to 10, where R 1 and R ^a are independently unsubstituted or substituted linear or branched hydrocarbon chains containing 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, and more preferably are methyl groups. R ³ is a saturated linear or branched hydrocarbon chain.

Preferably, the amine oxides of the invention are, for example, a natural mixture of C8-C8 Q2 amine oxides and amine oxides commercially available from

Hoechst.

In one embodiment of the present invention, where the compositions are particularly suitable for disinfecting solid surfaces, the surfactant is typically a surfactant system comprising an amine oxide and a betaine or sulfobetaine surfactant, preferably in a weight ratio of amine oxide to betaine or sulfobetaine of 2: 1 to 100: 1. The use of such a surfactant system in compositions suitable for disinfecting solid surfaces provides effective cleaning and shine of the surfaces to be cleaned, i.e.. The amount of surfactant left by coating or spraying the surface cleaned with the compositions of the invention is minimal.

The compositions of the invention typically comprise at least 0.005% amphoteric surfactant or mixtures thereof based on the total weight of the composition, preferably 0.01 to 10%, and more preferably 0.1 to 5%.

As a third essential component, the compositions of the present invention comprise glutaraldehyde. Glutaraldehyde is commercially available from UNION CARBIDE or BAST.

The compositions of the invention typically comprise at least 0.003% glutaraldehyde of the total weight of the composition, preferably 0.008 to 4%, and more preferably 0.2 to 2%.

As a fourth essential component, the compositions of the present invention comprise antimicrobial essential oils or active ingredients thereof or mixtures thereof.

Suitable antimicrobial essential oils useful in the compositions are those exhibiting antimicrobial antimicrobial essential oils herein to indicate which essential oil activity, whichever denaturation of the component is to be safe using antimicrobial pleasant fragrance

It exhibits antimicrobial and their active ingredients. Antimicrobial natural components of essential oil of origin, activity, mainly and active, which contributes according to the invention. Active components of essential oil component, antimicrobial proteins. profile compounds of the compositions of the present invention for disinfecting any surface. A further advantage of the essential oils and their active ingredients is the delivery of the disinfectants of the present invention without the need for perfumes. The disinfectants of the present invention not only perfectly disinfect contaminated surfaces, but also give them a pleasant fragrance.

Essential oils include, but are not limited to, thymol, lemon grass, citrus, lemons, oranges, anise, cloves, anise spices, cinnamon, geranium, roses, mint, lavender, lemon essential oil, eucalyptus, peppermint, camphor, sandalwood. cedar and mixtures thereof. The active ingredients used include, but are not limited to, thymol (present, for example, in the team), eugenol (present, for example, cinnamon), menthol (present, for example, in mint), geraniol (present, for example, geranium or roses), verbenone (present, for example) verbene), eucalyptol (present for example in eucalyptus), cedrol (present for example in cedar), pinocarvone, carvacrol, anethole (present for example in anise pepper), hinokitol, berberine, terpineol, limonene, ratanhiae and mixtures thereof. Preferred active ingredients of the essential oils are thymol, eugenol, verbenone, eucalyptol, limonene and / or geraniol.

Thymol is commercially available from, for example, Aldrich and eugenol is commercially available from, for example, Sigma or Bioindustries (SBI) or Manheimer Inc.

The compositions of the invention typically comprise at least 0.003% of the antimicrobial essential oil or active ingredient thereof, or mixtures thereof, based on the total weight of the composition, preferably 0.006 to 10%, and more preferably 0.01 to 4%.

It has been shown that the compositions of the present invention provide improved disinfection of contaminated surfaces even at high dilution, i.e., high dilution rates, i.e., high dilution rates. until the composition is diluted 1: 100 with water.

Heavily soiled surfaces here means surfaces contaminated with organic and / or inorganic stains in an equivalent equivalent to an aqueous solution of 0.3 g / l bovine albumin and heavy water (see contamination conditions European Standard prEN 1276, CEN / TC 216 N59 of 11/95).

Improved disinfection herein refers to the ability of compositions of the present invention comprising a peroxygen bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or active ingredient thereof to reduce the amount of bacteria on a heavily contaminated surface compared to the same compositions without peroxide bleach, amphoteric surfactant or glutaraldehyde without an antimicrobial essential oil or an active ingredient thereof, especially when used in diluted form. Perfect disinfection is achieved in various microorganisms including Gram positive bacteria such as Staphylococcus aureus and Gram negative bacteria such as Pseudomonas aeruginosa as well as fungi such as Candida albicans present on heavily soiled surfaces.

The disinfectant properties of the compositions are measured by the bactericidal activity of the compositions. The test method for determining the bactericidal activity of the formulation is described in the European Standard, prEN 1276, CEN / TC 216 N 59 of November 1995, issued by the European Commission for Standardization in Brussels. Europian

The standard, prEN 1276, specifies the test method and the requirements for the minimum bactericidal activity of the disinfectant. The test is positive, where the bacterial colony forming units (cfu) are reduced from 10 'cfu (baseline) to 10 cfu (final count after contact with the disinfectant product), ie. it is necessary to reduce viability in a row. $ 10. The compositions of the present invention pass this test on heavily soiled surfaces even at high dilution.

Another suitable test method for determining bactericidal activity of the present compositions on heavily soiled surfaces is AFNOR T72-190 (R) and T72-301 (R).

The compositions of the present invention may be applied undiluted or diluted to the disinfected surface, preferably diluted.

Diluted herein refers to the ability of the user to dilute the liquid or solid compositions of the present invention with a fluid, typically water. The user dilutes the compositions of the invention typically with water up to 100 times the weight, preferably 80 to 40 times, and more preferably 60 to 30 times.

The present invention also includes dilute disinfectants obtained by diluting the compositions of the present invention with water.

In a preferred embodiment of the present invention, the compositions are aqueous liquid compositions. The aqueous compositions preferably have a pH not exceeding 12, preferably 3.5 to 7, and more preferably 4-5. The pH of the compositions is adjusted using organic acids such as citric acid, succinic acid, acetic acid, aspartic acid, lactic acid, and other or inorganic or alkalinizing acids. agents.

The compositions of the present invention may further comprise any surfactant known to those skilled in the art, including nonionic, anionic, cationic and / or zwitterionic surfactants. Surfactants suitably contribute to the cleaning properties of the compositions of the invention.

The compositions of the present invention typically contain in addition to an amphoteric surfactant or a mixture thereof up to 50% of another surfactant or mixture thereof by weight of the composition, preferably 0.3 to 30%, and more preferably 0.4 to 25%.

The compositions of the invention also preferably contain an anionic surfactant or mixtures thereof. Suitable anionic surfactants include, in particular, water-soluble salts or acids of the formula ROSO 1 M, wherein R is preferably a C 8 -C 24 hydrocarbon radical, preferably an alkyl or hydroxyalkyl group with a C 8 -C 20 alkyl component, more preferably a C 8 -C 18 alkyl or hydroxyalkyl group and M is H or a cation, e.g. an alkali metal cation (e.g. sodium, potassium, lithium) or ammonium or substituted ammonium cations (e.g. methyl, dimethyl, and trimethylammonium cations and quaternary ammonium cations such as tetramethylammonium and dimethylpiperidine cation and quaternary ammonium cations such as ethylamine derived from alkylamine) , triethylamine and mixtures thereof, and the like).

Other suitable anionic surfactants include alkyl diphenyl ether sulfonates and alkyl carboxylates. Other anionic surfactants include alkyl diphenyl ether sulfonates and alkyl carboxylates. Other surfactants can include salts (including, for example, sodium, potassium, ammonium, and substituted ammonium salts such as mono-, di- and triethanolamine salts), 9 ~ ^ ^ 2Q linear alkylbenzenesulfonates, Cg-C22 primary or secondary alkanesulfonates, 8 ^_ ^ ⁽²⁴ ^ olefinsulfonates, sulfonic polycarboxylic acids prepared by sulfonating the pyrolysis product of the alkaline earth metal citrate, as described, for example, in GB Patent No. 1,082,179, ^C 8 ^-C 24 alkyl polyglycol ether sulfates (containing up to 10 moles of ethylene oxide), alkyl ester sulfonates such as ^C 14 ^-C 16 sulfonates, acylglycerol sulfonates, fatty oleyglycerol sulfates, alkylphenolethylene oxide ether sulfates, paraffin sulfonates, alkyl phosphates, isethionates such as acyl isethionates, N-acyl taurates, alkyl succinamates and sulfosuccinates, monoesters of the 18 sulfonates unsaturated diesters), acyl sarcosinates, sulfates of alkylpolysaccharides such as the sulfates of alkylpolyglucoside (the nonionic nonsulfated compounds being described below), branched primary alkyl sulfates, alkyl of the formula R 0 _{(CH2 CH2} 0) KCH ₂ C00-M ⁺ 'wherein R is a _Cg-C22 alkyl, k is an integer from 0 to 10 and M is a cation forming a soluble salt. Resin acids and hydrogenated acid resins such as rosin, hydrogenated rosin and resin acids and hydrogenated resin acids present in or derived from tall oil are also suitable. Further examples are given in Surface Active Agents and Detergents (Vol. I and II, Schwartz, Perry and Berch). Various surfactants are also generally described in U.S. Patent 3,929,678, issued December 30, 1975 to Laughlin et al., Column 23, line 58 to column 29, line 23.

Preferred anionic surfactants useful in the compositions of the invention are C8-C18 alkyl sulfonates, C8-C18 alkyl sulfates, C8-C18 alkyl alkoxy sulfates (e.g., C8-C18 alkyl ethoxy sulfates), and mixtures thereof. Such anionic surfactants preferably contribute to the disinfectant properties of the disinfectant compositions of the invention. For example, C8-C8 alkyl sulfate causes disruption of the bacterial cell membrane, inhibits enzymatic activities, disrupts cellular transport and / or denatures cellular proteins. It is believed that the improved disinfecting performance associated with the addition of an anionic surfactant, especially a Cg-C ^ g alkyl sulphonates, Cg-C ^ g alkyl sulfate and / or ^ 8 ^{_ <16} alkyl alkoxylated sulfate, in a composition of the invention is likely due to multiple mode of attack of said surfactant against bacteria. Another aspect of the invention is the use of an anionic surfactant, especially a Cg-C ^ g alkyl sulfonate,? 8 ^-C 16 alkyl sulfate and / or ^C8 ^ 16 alkyl alkoxylated sulfate, in a disinfecting composition of the present invention to improve the disinfecting properties of said composition on gram negative and / or gram positive bacteria.

The compositions of the present invention preferably comprise a nonionic surfactant or a mixture thereof. Suitable nonionic surfactants are fatty alcohol ethoxylates and / or propoxylates which are commercially available with different fatty alcohol chain lengths and varying degrees of ethoxylation. The HLB values of these alkoxylated nonionic surfactants depend mainly on the chain length of the fatty alcohol, the type of alkoxylation and the degree of alkoxylation. The amounts of surfactants, including nonionic, together with their respective HLB values, are listed in the surfactant catalogs.

Suitable nonionic surfactants are, in particular, hydrophobic nonionic surfactants having an HLB (hydrophilic lipophilic balance) value not exceeding 16, preferably not exceeding 15 and more preferably not exceeding 14. These hydrophobic nonionic surfactants well penetrate the grease.

The preferred hydrophobic nonionic surfactants useful in the compositions of the present invention are surfactants having an HLB not exceeding the formula R0- (C ₂ H? O) _n (CgHgO) _m H, wherein R is -C ₂ -C 2 alkyl chain or a C 3 -C 22 alkyl benzene and wherein n + m is 0 to 20 and n is 0 to 15 and m is 0 to 20, preferably n + m is 1 to 5 and n is 0 to 15, more preferably n + m to 10 and n are 0 to 10. Preferred R chains are C8- _C22 alkyl chains. Suitable hydrophobic nonionic surfactants are Dobanol ^R 91-2.5 (HBL = 8.1, R is a mixture of C8 and alkyl chains, n is 2.5 am is 0) or Lutensol ^R T03 (HBL = 8, R is C-L3 alkyl chain, n is 3 and m is 0) or Lutensol ^R A03 (HBL = 8, R is a mixture of C 1-6 g alkyl chains, n is 3 and m is 0) or Tergitol ^R 25L3 (HBL = 7.7, R is v the range of alkyl chain lengths ^C 15 i2 ^ ⁿ d ^e 3 and m is 0), or Dobanol ^R 23-3 (HLB = 8.1; R is a mixture of C ^ 2 ^and C ^ g alkyl chains, n is 3 and m is 0) or Dobanol ^R 45-7 (HBL = 11.6, R is a mixture of alkyl chains, n is 7 and m is 0), Dobanol ^R 23-6.5 (HBL = 11.9, R is a mixture of C12 and C18) alkyl chains, n is 6.5 am is 0) or Dobanol ^R 25-7 (HBL = 12, R is a mixture of C 1-4 and alkyl chains, n is 7 am is 0) or Dobanol ^R 91-5 (HBL = 11 , 6, R is a mixture of C8 and C11-alkyl chains, n is 5 am is 0) or Dobanol ^R 91-6 (HBL = 12.5, R is a mixture of C8 and alkyl chains, n is 6 am is 0) or Dobanol ^R 91-8 (HLB = 13.7; R is a mixture of Cg and C _{1 L} of alkyl ch chains, n is 8 and m is 0), or Dobanol ^R 91-10 (HLB = 14.2; R is a mixture of C ₉ and C ₁₁ alkyl chains, n is 10 and m is

Or mixtures thereof. Preferred are Dobanol? 91-2.5 or Lutensol? T03 or Lutensol? A03 or Tergitol? 25L3 or Dobanol? 23-3? D or Dobanol 23-2 or mixtures thereof. Dobanol surfactants are commercially available from SHELL. Lutensol surfactants are commercially available from BASF and Tergitol surfactants are commercially available from UNION CARDIDE.

Other suitable surfactants also include ^C 6 ^-C 20 conventional soaps (alkali metal salt of C 3 -C 20 fatty acid, preferably sodium salt).

reagents, reagents, other polyfunctionally

The compositions may further comprise a further chelating agent. Suitable chelating agents known to those skilled in the art are selected from aminophosphonate substituted heteroaromatic aminocarboxylate chelating carboxylate chelating substituted aromatics, biodegradable chelating agents such as ethylenediamine N, N-disuccinic acid, or mixtures thereof.

a preferred component comprising which experts in phosphonate chelating chelating chelating agents, agents, agents,

Suitable phosphonate chelating agents include etidronic acid (1-hydroxyethylenediphosphonic acid HEDP) and / or alkali metal ethane-1-hydroxydiphosphonates.

Suitable aminophosphonate chelating agents include aminoalkylene polyalkylene phosphonates, nitrilotris (methylene) triphosphonates, ethylenediaminetetramethylene phosphonates and / or diethylenetriaminepentamethylene phosphonates. Preferred chelating agents are diethylene triamine pentamethylene phosphonates.

These phosphonate / aminophosphonate chelating agents are present or in the form of acids or salts of various cations of some or all of the acidic functions. These phosphonate / aminophosphonate chelating agents are commercially available from Monsanto under the trade name DEQUEST®.

Substituted heteroaromatic chelating agents include hydroxypiperidine-N-oxide or derivatives thereof.

Suitable hydroxypiperidine-N-oxides or derivatives thereof useful according to the present invention have the general formula II

Y (II) wherein X is nitrogen, Y is selected from oxygen, -CHO, -OH, - (CH _{2) n} -C00H, n is an integer of 0-20, preferably 0-10 and more preferably 0, and Y is preferably oxygen. A particularly preferred hydroxypiperidine-N-oxide is 2-hydroxypiperidine-N-oxide and derivatives thereof.

Hydroxypiperidine N-oxide and derivatives thereof are commercially available from Sigma.

Polyfunctionally-substituted aromatic chelating agents are also useful in the formulations of the invention. See U.S. Patent 3,812,044, issued to Connor et al. May 21, 1974. Preferred compounds of this type in acid form are dihydroxydisulfobenzenes such as 1,2-dihydro-3,5-disulfobenzene.

A preferred biodegradable chelating agent is ethylenediamine N, N-disuccinic acid or its alkali metal, alkaline earth, ammonium or substituted ammonium salts or mixtures thereof. Ethylenediamine N, N-disuccinic acid, especially the (S, S) -isomer is disclosed in U.S. Patent 4,704,233 issued to Hartman and Perkins on November 3, 1987. Ethylenediamine N, N-disuccinic acid is commercially available, for example, from Palmer Research Laboratories under the called ssEDDS ( ^R ). Ethylenediamine N, N-disuccinic acid is particularly suitable for use in the compositions of the present invention.

Suitable amino ethylene diamine tetra acetates, diétyléntriaminpentoacetát N- hydroxyethylethylenediamine, ethylenediamine, ethanoldiglycines, propylene chelating agents include diethylene triamine, (DTPA), nitrilotriacetates, triethylenetetraaminehexacetates acid (PDTA) and methyl glycine acid (MGDA), both in their acid form or as their alkali metal salts , ammonium and substituted ammonium salts. Particularly suitable are diethylenetriaminepentaacetic acid (DPTA), propylenediaminetetraacetic acid (PDTA), which is commercially available, for example, from BASF under the trade name Trilon and methylglycine diacetic acid (MGDA).

Other carboxylate chelating agents include malonic acid, salicylic acid, glycine, aspartic acid, glutamic acid, or mixtures thereof.

The compositions of the present invention typically comprise up to 5% of a chelating agent or mixtures thereof, based on the total weight of the composition, preferably 0.01 to 3% by weight, and more preferably 0.01 to 3% by weight.

1.5%.

The compositions of the invention comprise a radical scavenger as a further component. Suitable radical scavengers include the well-known substituted mono- and dihydroxybenzenes and derivatives thereof, alkyl and aryl carboxylates and mixtures thereof. Preferred radical scavengers include di-tert-butylhydroxytoluene (BHT), p-hydroxytoluene, hydroquinone (HQ), di-tert-butyl hydroquinone (DTBHQ), mono-tert-butyl hydroquinone (MTBHQ), tert-butyl-hydroxyanisole ( BHA), p-hydroxyanisole, benzoic acid, acid

2,5-dihydroxybenzoic acid, 2,5-dihydroxyterephthalic acid, toluylic acid, catechol, t-butylcatechol, 4-alkylcatechol, 4-acetylcatechol, 2-methoxyphenol, 2-ethoxyphenol,

2-methoxy-4- (2-propenyl) phenol, 3,4-dihydroxybenzaldehyde,

2.3- dihydroxybenzaldehyde, benzylamine,

1,1.3-tris- (2-methyl-4-hydroxy-5-t-butylphenyl) butane, tert-butylhydroxyaniline, p-hydroxyaniline, and n-propyl gallate. Highly preferred is di-tert-butylhydroxytoluene, which is available, for example, from SHELL under the tradename IONOL Cp ( ^R ) and / or tert-butyl hydroxyanisole. These radical scavengers further contribute to the stability of the compositions of the invention containing hydrogen peroxide.

The compositions of the present invention typically comprise up to 5% of radical scavengers or mixtures thereof of the total weight of the composition, preferably 0.002 to 1.5% by weight, and more preferably 0.002 to 1%.

The compositions of the invention include as a further preferred component a solvent or solvent mixture. The solvents used preferably improve the cleaning properties of the compositions. Suitable solvents included in the compositions of the present invention include propylene glycol derivatives such as n-butoxypropoxypropanol, water-soluble solvents (CARBITOL ®) or water-soluble solvents (CELLOSOLVE ®). The water-soluble solvents CARBI TOL ® are compounds of the class

2- (2-alkoxyethoxy) ethanol, wherein the alkoxy group is derived from ethyl, propyl soluble carbitol is butylcarbitol. Water or butyl groups. Preferred with water

2- (2-butoxyethoxy) ethanol, also known as soluble solvents (CELLOSOLVE ^) are compounds of the class

2-alkoxyethoxyethanol, preferably

2-butoxyethoxyethanol. Other suitable solvents are benzyl alcohol, methanol, ethanol, isopropyl alcohol, and diols such as 2-ethyl-1,3-hexanediol and 2,2,4-trimethyl-1,3-pentadiol and mixtures thereof. Preferred solvents are n-butoxypropoxypropanol, butylcarbitol, benzyl alcohol, isopropanol and mixtures thereof. Most preferred solvents are butylcarbitol, benzyl alcohol and / or isopropanol.

The compositions of the invention typically contain up to 15% of the solvents by weight of the total composition, preferably 2 to 7% by weight of the composition.

The compositions of the invention may further include various other preferred ingredients such as buffers (e.g., borate buffers), fillers, stabilizers, activators, bleaching agents, stain suspending agents, dye transfer agents, brighteners, perfumes, dusting agents, enzymes, dispersants, dye transfer inhibitors , pigments, fragrances and dyes.

Packaging of disinfectants

The compositions of the invention are packaged in various suitable detergent packs known to those skilled in the art. The liquid formulations of the invention are conveniently packaged in hand-held spray containers, which are usually made of synthetic organic polymeric plastics, and preferably in a trigger or pump sprayer.

The nebulizers will allow uniform application of the liquid disinfectant of the present invention to a relatively large portion of the disinfected surface, thereby contributing to the disinfectant properties of the compositions. Sprayers are particularly suitable for disinfecting vertical surfaces.

Suitable nebulisers useful in the present invention include hand-operated trigger foam nebulisers sold, for example, by Specialty Packing Products, Inc. or Continental Sprayers, Inc. These types of nebulizers are described, for example, in U.S. Patent 4,701,311 to Dunnining et al. and US 4,646,973, Focarraci and US 4,538,745, Focarraci. T 8500 W or T 8900 sprayers commercially available from Continental Spray International or T 8100 commercially available from Canyon, Northern Ireland are particularly preferred. In such a sprayer, the liquid composition becomes fine liquid spray droplets which are sprayed directly onto the surface to be cleaned. The composition contained in the dispenser container is passed out through the dispenser head when the user activates the pumping mechanism. The agent in the sprayer head is pushed over an obstacle, e.g. the grid or coil, and the impacts help to disperse the liquid composition, i. aid in the formation of liquid droplets.

The compositions of the present invention are also provided as wipes. Wipes herein refer to disposable wipes impregnated with the liquid composition of the present invention. The wipes are preferably packaged in a plastic box. The advantage of this embodiment is that the disinfectant is used more quickly by the user, even outside the house; there is no need to pour the liquid compositions of the present invention onto cleaned / disinfected surfaces and dry with a cloth. In other words, wipes allow surface disinfection in one step.

Method of disinfection

The present invention encompasses a method of disinfecting a surface with a composition comprising a peroxygen bleach, amphoteric

The surfactant, glutaraldehyde, and the antimicrobial essential oil or active ingredient thereof.

A surface herein refers to any surface including living surfaces such as human skin, mouth, teeth, and inanimate surfaces. Inanimate surfaces include, without limitation, solid surfaces, typically found in kitchens, bathrooms, or car interiors, e.g. tiles, walls, floors, chrome finishes, glass, plain vinyl, any plastic, plasticized wood, table tops, sinks, cooker tops, dishes, sanitaryware such as • sinks, showers, shower curtains, bathtubs, VC, and so on, as well as fabrics including dresses, curtains, drapes, bed linen, bath linen, tablecloths, sleeping bags, tents, upholstered furniture, and the like, and carpets. Inanimate surfaces also include household appliances including, but not limited to, refrigerators, freezers, washing machines, automatic dryers, ovens, microwave ovens, dishwashers, etc.

In the surface disinfection method of the present invention, the composition of the invention is applied undiluted or diluted with water. Preferably, the composition of the invention is diluted up to 100 times the weight of water, preferably 80 to 40 times, and more preferably 60 to 30 times, before application to the surface.

In a preferred embodiment of the disinfectant of the present invention, the composition is applied to the disinfected surface diluted, there is no need to rinse the surface after application of the composition, no visible residue remains on the surface.

The following examples further illustrate the present invention.

DETAILED DESCRIPTION OF THE INVENTION

The following compositions were prepared by mixing the ingredients in the indicated proportions (by weight unless otherwise indicated). These devices have passed the European Commission's standardization test prEN 1276 (0.03% albumin / heavy water). These compositions perfectly disinfect contaminated surfaces when used in both undiluted and diluted form, e.g. in dilution

1: 100, 1: 2.5, security. 1:50 a also add perfect surface resources I II III IV IN VI Hydrogen peroxide 7.0 6.0 7.0 2.0 7.0 1.0 Betain ^x 4.5 4.0 3.0 0.1 6.0 0.2 thymol - 0.5 - - - - glutaraldehyde 0.8 0.8 0.5 0.05 0.8 0.15 eugenol 0.5 - - 0.02 0.5 - geraniol - - 1.0 - - 0.2 Water and minority ingredients complete to 100 % H2SO4 to the value 1 pH 4 resources VII VIII IX X XI XII Hydrogen peroxide 7.0 6.0 3.5 2.0 7.0 1.0 Betain ^x 4.5 4.0 3.0 0.1 6.0 0.2 glutaraldehyde 0.8 0.8 0.5 0.5 0.8 0.15 Thymol / // Eugenol Geraniol 2.0 3.0 1.5 1.0 3.0 1.0 Water and minority ingredients complete to 100 %

H2SO4 to pH 4

resources XIII XIV XV XVI XVII XVIII Hydrogen peroxide 7.0 6.0 7.0 2.0 7.0 1.0 Nonionic surfactant ^xx 1.2 2.0 1.1 0.5 1.2 - Nonionic surfactant ^xxx 1.6 - - 0.7 1.5 0.4 Betain ^x 4.5 4.0 3.0 0.1 6.0 0.2 thymol - 0.5 - - - - glutaraldehyde 0.8 0.8 0.5 0.5 0.8 0.15 eugenol 0.5 - - 0.05 0.5 - geraniol - - 0.1 - - 0.2 Water and minority ingredients complete to 100 % H2SO4 to the value pH 4 resources XIX XX XXI XXII XXIII XIV Hydrogen peroxide 7.0 6.0 7.0 2.0 7.0 1.0 Nonionic surfactant ^xx 1.2 2.0 1.1 0.5 1.2 - Nonionic surfactant ^xxx 1.6 - - 0.7 1.5 0.4 C-? Q Aminoxide 1.0 2.0 - 1.0 - 0.5 C 1-6 alkylsulfate - - 4.5 3.0 - 1.5 Betain ^x 4.5 4.0 3.0 0.1 6.0 0.2 thymol - 0.5 - - - - glutaraldehyde 0.8 0.8 0.5 0.5 0.8 0.15 eugenol 0.5 - - 0.05 0.5 - geraniol - - 0.1 - - 0.2 Water and minority ingredients dpolniť up to 100% H2SO4 to the value pH 4 resources XXV XXVI XXVII XXVIII XXIX Hydrogen peroxide 7.0 1.0 2.0 2.0 3.5 C-? Q Aminoxide 4.5 0.2 0.8 0.8 3.0 glutaraldehyde 0.8 0.15 0.2 0.2 0.5 thymol - - 0.2 0.01 - eugenol 0.5 - - - - geraniol - 0.2 0.3 0.02 - Thymol / Eugenol / - - - - - 1.5 / geraniol Water and minority ingredients complete to 100 %

H2SO4 to pH 4

Betaine ^x is or coconut betaine commercially available from Seppic after the trade name Amonyl 265 ( ^R 1 or laurylbetaine commercially available from Albright and Vilson under the trade name Empigen BB / I / ^R ), or mixtures thereof.

^xx is Dobanol ^xxx is Dobanol

23-3 ( ^R )

91-1o ( ^R )

Industrial usability

The antimicrobial compositions of the present invention are used to disinfect and clean surfaces, including living surfaces (e.g., human skin, mouth) and inanimate surfaces (e.g., solid surfaces, fabrics). The disinfectants of the present invention perfectly disinfect clean surfaces even when used in large dilutions and are suitable for delicate fabrics and for use on delicate surfaces in safe contact with food and / or children. The disinfectant compositions of the present invention are perfectly effective on Gram-positive and Gram-negative bacterial strains as well as fungi. The compositions of the present invention are packaged in liquid detergent bottles in conventional detergent bottles, or as a spray or foam in a spray / foam dispenser, or impregnated with wipes for rapid cleaning in one step.

Claims (15)

Disinfectant, characterized in that it comprises a peroxygen bleach, an amphoteric surfactant, glutaraldehyde and an antimicrobial essential oil or its active ingredients. Disinfectant according to claim 1, characterized in that the peroxygen bleach-soluble dialkyl peroxides, peroxocarboxylic peroxides, mixtures thereof, are characterized in that; or a source of peracids, preformed and inorganic hydroperoxides, and characterized by hydrogen peroxide in water of the group of percarbonates, diacyl peroxides, acids, organic organic and inorganic, and hydrogen peroxide is preferred. The disinfectant of claims 1 and the surfactant is of formula I 2, according to any of the preceding &lt; _RTI ID = 0.0 &gt; sulfobetaine, &lt; / _RTI &gt; containing 1 to 14, wherein R is carbon, wherein n is whole 1, Y is selected and wherein and / or the amine oxide R is independently a chain of ² and R ³ 1 is a more preferred atom and sulfonyl radicals 14 to 24 carbon atoms, 9 and R contain 1 to 1 to the sum of r 1, 24 carbon atoms wherein each R 1, R ² and a branched hydrocarbon is an alkyl radical of preferably 8 to 18, more preferably 12 3 carbon atoms, preferably 10, preferably 1 to 6, and containing the carboxyl R ² and R ³ radicals is of the general formula: saturated linear or containing 1 to 30 carbon atoms, preferably 6 to 20 and wherein R is independently unsubstituted or substituted linear or branched hydrocarbon chains containing 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, and more preferably methyl groups. Disinfectant according to any one of the preceding claims 1 to 3, characterized in that the antimicrobial silica is obtained from thymol, lemon grass, citrus, lemons, oranges, anise, cloves, anise spice, cinnamon, pelargon, roses, lavender, lemon. , eucalyptus, peppermint, camphor, sandalwood, cedar and mixtures thereof, and / or the active ingredient of the essential oil is thymol, eugenol, menthol, cedrol, verbenone, eucalyptol, anethole, pinocarvone, carvacrol, geraniol, hinokonene, berkine, berinol, , ratanhiae and mixtures thereof, and eugenol, verbenone, geraniol, eucalyptol, limonene and / or thymol are preferred. Disinfectant composition according to any one of the preceding claims 1 to 4, characterized in that the composition comprises at least 0.003% of the antimicrobial essential oil or its active ingredient or a mixture thereof of the total weight of the compositions, preferably 0.006 to 10% and more preferably 0.01 to 4%. . Disinfectant composition according to any one of the preceding claims 1 to 5, characterized in that the composition comprises at least 0.01% of a peroxygen bleaching agent or a mixture thereof, based on the total weight of the composition, preferably 0.1 to 15% and more preferably 1 to 10%. Disinfectant composition according to any one of the preceding claims 1 to 6, characterized in that the composition comprises at least 0.005% amphoteric surfactant, derivatives or mixtures thereof, based on the total weight of the composition, preferably 0.01 to 10% and more preferably 0.1 to 5 %. Disinfectant composition according to any one of the preceding claims 1 to 7, characterized in that the composition comprises at least 0.003% glutaraldehyde of the total weight of the composition, preferably 0.008 to 4% and more preferably 0.2 to 2%. Disinfectant according to any one of claims 1 to 8, characterized in that the composition further comprises a chelating agent selected from the group of phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, polyfunctional chelating agents, polyfunctional chelating agents chelating agents, ethylenediamine N, N-disuccinic acid, and mixtures thereof. Disinfectant composition according to any one of the preceding claims 1 to 9, characterized in that the composition further comprises a preferred ingredient from the group of surfactants, radical scavengers, solvents, fillers, stabilizers, bleach activators, stain suspensions, dye transfer agents, brighteners, brighteners. anti-dusting agents, enzymes, dispersants, dye transfer inhibitors, pigments, perfumes, dyes, and mixtures thereof. Disinfectant composition according to any one of the preceding claims 1 to 10, characterized in that the composition is a liquid composition, preferably an aqueous liquid composition having a pH not exceeding preferably 12, more preferably 3.5 to 7. Disinfectant composition according to claim 11, characterized in that the composition is packaged in a sprayer. A wipe impregnated with the composition of claim 11. Method of disinfecting a surface, characterized in that the surface is disinfected with a composition according to any of the preceding claims 1 to 12. Surface disinfection method according to claim 14, characterized in that the composition is diluted with water up to 100 times by weight of water, preferably 80 to 40 times by weight and more preferably 60 to 30 times by weight, before application to the surface.