CZ2014232A3 - Způsob výroby enzalutamidu - Google Patents

Způsob výroby enzalutamidu Download PDF

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Publication number
CZ2014232A3
CZ2014232A3 CZ2014-232A CZ2014232A CZ2014232A3 CZ 2014232 A3 CZ2014232 A3 CZ 2014232A3 CZ 2014232 A CZ2014232 A CZ 2014232A CZ 2014232 A3 CZ2014232 A3 CZ 2014232A3
Authority
CZ
Czechia
Prior art keywords
formula
alcohol
process according
enzalutamide
roh
Prior art date
Application number
CZ2014-232A
Other languages
Czech (cs)
English (en)
Inventor
Jan Stach
Ondřej Klecán
Petr Lehnert
Jan Rymeš
Original Assignee
Zentiva, K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Priority to CZ2014-232A priority Critical patent/CZ2014232A3/cs
Priority to CN201580015975.4A priority patent/CN106164052A/zh
Priority to ES15720253T priority patent/ES2806458T3/es
Priority to PT157202532T priority patent/PT3129356T/pt
Priority to EP19020441.2A priority patent/EP3587402A1/en
Priority to EP15720253.2A priority patent/EP3129356B1/en
Priority to PCT/CZ2015/000032 priority patent/WO2015154730A1/en
Priority to PL15720253T priority patent/PL3129356T3/pl
Publication of CZ2014232A3 publication Critical patent/CZ2014232A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CZ2014-232A 2014-04-07 2014-04-07 Způsob výroby enzalutamidu CZ2014232A3 (cs)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CZ2014-232A CZ2014232A3 (cs) 2014-04-07 2014-04-07 Způsob výroby enzalutamidu
CN201580015975.4A CN106164052A (zh) 2014-04-07 2015-04-07 用于制备恩杂鲁胺的方法
ES15720253T ES2806458T3 (es) 2014-04-07 2015-04-07 Un procedimiento para producir enzalutamida
PT157202532T PT3129356T (pt) 2014-04-07 2015-04-07 Processo para produção de enzalutamida
EP19020441.2A EP3587402A1 (en) 2014-04-07 2015-04-07 Process for producing enzalutamide
EP15720253.2A EP3129356B1 (en) 2014-04-07 2015-04-07 A process for producing enzalutamide
PCT/CZ2015/000032 WO2015154730A1 (en) 2014-04-07 2015-04-07 A process for producing enzalutamide
PL15720253T PL3129356T3 (pl) 2014-04-07 2015-04-07 Sposób wytwarzania enzalutamidu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2014-232A CZ2014232A3 (cs) 2014-04-07 2014-04-07 Způsob výroby enzalutamidu

Publications (1)

Publication Number Publication Date
CZ2014232A3 true CZ2014232A3 (cs) 2015-10-14

Family

ID=53051699

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2014-232A CZ2014232A3 (cs) 2014-04-07 2014-04-07 Způsob výroby enzalutamidu

Country Status (7)

Country Link
EP (2) EP3129356B1 (zh)
CN (1) CN106164052A (zh)
CZ (1) CZ2014232A3 (zh)
ES (1) ES2806458T3 (zh)
PL (1) PL3129356T3 (zh)
PT (1) PT3129356T (zh)
WO (1) WO2015154730A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI613194B (zh) 2015-06-10 2018-02-01 台灣神隆股份有限公司 用於製備恩雜魯胺的新穎方法
CN106478477A (zh) * 2015-08-26 2017-03-08 四川科伦药物研究院有限公司 恩杂鲁胺中间体化合物及其制备方法
WO2017081702A2 (en) * 2015-11-09 2017-05-18 Sun Pharmaceutical Industries Limited A process for preparation of enzalutamide
CN109422737B (zh) * 2017-08-22 2021-07-30 上海时莱生物技术有限公司 咪唑酮类雄激素受体拮抗剂、其制备方法和用途
CN109503416A (zh) * 2018-12-24 2019-03-22 常州智超化学有限公司 一种恩杂鲁胺中间体合成方法
CA3143111A1 (en) 2019-06-27 2020-12-30 Synthon B.V. Process for preparation of enzalutamide
EP4112603A1 (en) 2021-06-29 2023-01-04 Química Sintética, S.A. Processes for the preparation of non-steroidal antiandrogens
CN115703745A (zh) * 2021-08-10 2023-02-17 中国船舶重工集团公司第七一八研究所 一种恩杂鲁胺的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US8470829B2 (en) * 2004-09-09 2013-06-25 Chugai Seiyaku Kabushiki Kaisha Imidazolidine derivative and use thereof
PT2444085E (pt) 2005-05-13 2015-06-11 Univ California Compostos de diaril-hidantoínas como antagonistas do recetor androgénio para tratamento de cancro
PL2538785T3 (pl) 2010-02-24 2018-08-31 Medivation Prostate Therapeutics Llc Sposoby syntezy zwiazków diarylotiohydantoinowych i diarylohydantoinowych
US20170190670A1 (en) * 2014-07-11 2017-07-06 Shilpa Medicare Limited Improved process for the preparation of enzalutamide

Also Published As

Publication number Publication date
EP3587402A1 (en) 2020-01-01
PL3129356T3 (pl) 2020-11-30
EP3129356A1 (en) 2017-02-15
CN106164052A (zh) 2016-11-23
ES2806458T3 (es) 2021-02-17
PT3129356T (pt) 2020-08-28
EP3129356B1 (en) 2020-06-03
WO2015154730A1 (en) 2015-10-15

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