CZ2013621A3 - Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci - Google Patents

Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci Download PDF

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Publication number
CZ2013621A3
CZ2013621A3 CZ2013-621A CZ2013621A CZ2013621A3 CZ 2013621 A3 CZ2013621 A3 CZ 2013621A3 CZ 2013621 A CZ2013621 A CZ 2013621A CZ 2013621 A3 CZ2013621 A3 CZ 2013621A3
Authority
CZ
Czechia
Prior art keywords
agomelatine
solid solution
weight
pharmaceutical composition
extrudate
Prior art date
Application number
CZ2013-621A
Other languages
Czech (cs)
English (en)
Inventor
Jaroslav Řezáč
Anna Hanovská
Daniel Přibyl
Ondřej Dammer
Alena Prokopová
Original Assignee
Zentiva, K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Priority to CZ2013-621A priority Critical patent/CZ2013621A3/cs
Priority to PCT/CZ2014/000088 priority patent/WO2015021949A1/fr
Publication of CZ2013621A3 publication Critical patent/CZ2013621A3/cs

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CZ2013-621A 2013-08-13 2013-08-13 Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci CZ2013621A3 (cs)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CZ2013-621A CZ2013621A3 (cs) 2013-08-13 2013-08-13 Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci
PCT/CZ2014/000088 WO2015021949A1 (fr) 2013-08-13 2014-08-13 Solution d'agomélatine solide et thermodynamiquement stable destinée à être utilisée dans une préparation pharmaceutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2013-621A CZ2013621A3 (cs) 2013-08-13 2013-08-13 Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci

Publications (1)

Publication Number Publication Date
CZ2013621A3 true CZ2013621A3 (cs) 2015-02-25

Family

ID=51589032

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2013-621A CZ2013621A3 (cs) 2013-08-13 2013-08-13 Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci

Country Status (2)

Country Link
CZ (1) CZ2013621A3 (fr)
WO (1) WO2015021949A1 (fr)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866335B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2889522B1 (fr) 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline iv de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2889521B1 (fr) 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2889523B1 (fr) 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2923482B1 (fr) 2007-11-09 2010-01-29 Servier Lab Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
WO2011006387A1 (fr) 2009-07-11 2011-01-20 浙江华海药业股份有限公司 Procédé pour la préparation d'agomélatine, cristaux d'agomélatine et leur procédé de préparation
CN102106807B (zh) * 2009-12-29 2013-03-27 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
EP2705023A4 (fr) * 2011-01-04 2014-11-19 Symed Labs Ltd Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide
WO2012130837A1 (fr) * 2011-03-28 2012-10-04 Ratiopharm Gmbh Agomélatine solide sous une forme non cristalline
CN102670514B (zh) * 2012-04-29 2017-05-10 浙江华海药业股份有限公司 阿戈美拉汀固体制剂

Also Published As

Publication number Publication date
WO2015021949A1 (fr) 2015-02-19

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