CZ2011870A3 - Suckling and baby additional foods for increasing oral tolerance of milk proteins - Google Patents

Abstract

Milk-based milk-based cereal-based baby foods containing goat's milk and goat protein with the exclusion of cow protein, which have been shown to increase the oral tolerance of milk proteins since the end of month 4 of infant life. Dairy ingredient has a modified protein profile containing goat alpha-s1-casein in the range of 10 mg to 200 mg of alpha-s1-casein in 100 ml of fed food and also complies with infant formula or milk according to the applicable guidelines.

Description

BABY & CHILDREN 'S FEEDINGS TO INCREASE ORAL TOLERANCE OF MILK PROTEINS.

Technical field

BACKGROUND OF THE INVENTION The present invention relates to cereal-milk and milk-cereal infant and baby foods with an optimized milk component of infant infant milk and follow-on milk consisting of goat milk and goat proteins excluding cow proteins aimed at increasing oral tolerance of milk proteins.

BACKGROUND OF THE INVENTION

The protein components of cow's milk are responsible for the vast majority of intolerances or allergies manifesting in infants, young children and in some cases persistent into adulthood. The incidence of allergy or cow protein intolerance varies between 0.36 X 7.5% of the population in different countries depending on monitoring methods.

Symptoms caused by cow's milk protein intolerance manifest in affected individuals of varying intensity, the most common being gastrointestinal disorders observed in 55 to 80%, skin reactions in 20 to 40% or respiratory symptoms in 5 to 20% of people with cow protein allergy or intolerance .

Hypoallergenic infant formulas using either heat-treated proteins or protein hydrolysates with varying degrees of protein molecule degradation have been developed and used at the end of the last century as a preventive solution to the risk of developing symptoms due to allergy or intolerance of cow proteins. However, infant formulas based on protein hydrolysates do not provide 100% protection against the emergence and development of allergy to cow proteins. In cases where a hypersensitive child is unable to accept common hypoallergenic infant milk with cow's milk hydrolyzates without health problems, it is necessary to provide nutrition either using a preparation with extensively hydrolyzed cow proteins or soy replacement nutrition or even only through the amino acid complex. Soy protein-based replacement nutrition for infants and young children may not be a safe substitute solution, as this type of plant protein has also been shown to be at risk of developing an allergic reaction.

Despite massive long-term applications of infant formulas and follow-on formulas based on cow protein hydrolysates bearing the HA designation, the incidence of allergies or intolerances to this type of protein does not decrease but increases.

Goat's milk is the second most consumed milk in terms of worldwide production. The chemical, physical and nutritional properties of goat's milk justify its application in the feeding of infants and young children, provided that some nutritional parameters are fortified or modeled.

The main triggers of cow's milk allergy and protein intolerance are demonstrably both caseins, primarily alpha-sl-casein, and the whey protein fraction called beta-lactoglobulin.

···· ····

Numerous research studies have shown lower goat milk allergenicity and higher oral tolerance to patients with proven cow protein allergy. In the case of goat's milk, the protein component eliciting an immunological response has been shown to be only the casein fraction referred to as alpha-sl-casein, whose content is significantly lower than that of cow's milk. No studies have been shown in allergenicity in goat milk whey proteins. The alpha-sl-casein content of goat milk is associated with polymorphism of genotypes ranging from 0.9 g to 4.1 g in 1 liter of milk, with low levels of alpha-casein found in the San, Alpine and Toggennburg breeds. High alpha-sl-casein values are characteristic of the Nubian and La Mancha breeds. Cow milk contains between 5.9 and 17.5 g of alpha-casein per liter of milk.

SUMMARY OF THE INVENTION

Improvement of the present state and thus reduction in the number of manifested intolerances or allergies to cow's milk proteins is achieved by timely initiation of the feed of cereal milk or milk cereal with optimized milk component of infant milk and goat milk consisting of goat milk and goat proteins the period from the 4th to the 7th month, resp. 12. months of life and gradual induction of oral tolerance of milk proteins.

The gradual introduction of baby foods with goat milk proteins during breastfeeding, which is a natural physiological method of feeding during the infant period, seems ideal. Processed milk-based or milk-based baby foods with an optimized milk component of infant infant and follow-on milk consisting of goat's milk and goat proteins excluding cow proteins according to the invention should also be given as first baby foods also in children receiving HA - infant milk or follow-on milk hydrolyzed cow proteins. Exceptions are individuals whose basic nutrition is based on extensively hydrolysed proteins or mixtures of amino acids.

The highest efficacy for enhancing oral milk protein tolerance is shown by the milk-based or milk-cereal-based baby foods with an optimized milk component consisting of goat's milk and goat proteins excluding cow proteins meeting the infant's infant or follow-on milk parameters. sl-casein ranged from 10 mg to 200 mg of alpha-sl-casein in 100 ml of the feed.

By determining the alpha-sl-casein content in goat's milk, the protein profile modeling results in an optimum composition of the resulting milk-based baby food such that the total protein content required by the baby food legislation is achieved by the addition of goat whey proteins. At the same time, contamination of all recipe ingredients used with cow proteins must be avoided.

The resulting content of vitamins, minerals and trace elements shall be adjusted to the values laid down by the legislation in force for infant grain or milk-based baby foods in the country. Advantageously, processed cereal-milk or milk-cereal-based baby foods with optimized baby milk based on goat milk and goat

Proteins enrich for prebiotics, probiotic microorganisms, nucleotides, polyunsaturated fatty acids, carbohydrates and other nutritionally important components, either singly or in mixtures.

Processed baby milk or goat protein baby foods based on goat's milk and goat protein may be prepared in the form of instant powdered mixtures prepared for consumption by the addition of water or as pasteurized or otherwise stabilized baby foods for direct use.

DETAILED DESCRIPTION OF THE INVENTION

Example 1

Rice cereal-based baby food from the end of the fourth month of life in the form of instant powder

Ingredient _______________________ g per 100 g powder g per 100 ml baby food -18.7 g powder + 90 ml water

instant rice flour 45.0 8.4 Initial milk nutrition (based on goat milk) excluding cow proteins) 38.0 7.1 carbohydrates (lactose, dextrose) 10.0 1.9 prebiotic fiber 2,0 0.4 lyophilized probiotic microorganisms 0.3 0.06

other components:

vitamins, mineral substances, trace elements, unsaturated fatty acids in the amounts recommended by the current directive for infant milk and baby foods protein profile:

total protein content 12,5 2,3 alpha-sl-casein content

53.5 mg mg

Example 2

Oatmeal cereal for children from the end of the 6th month of life in the form of instant powder

Ingredient ______________________ g per 100 g powder g per 100 ml baby food -18.7 g powder + 90 ml water

instant oat flour 43.0 8.0 follow - on milk nutrition (based on goat milk) excluding cow proteins) 34.0 6.4 carbohydrates (lactose, dextrose) 12.2 2.3 prebiotic fiber 2,0 0.4 lyophilized probiotic microorganisms 0.3 0.06 dried fruit powders such as natural seasonings 2.8 0.52

other components:

vitamins, minerals, trace elements, unsaturated fatty acids in the amounts recommended by the applicable formula for infant milk formulas and baby foods protein profile:

total protein content 12,6 2,4 a) fa-sl-casein content 192,5 mg 36 mg

Example 3

Multi-grain cereal-based baby food from the end of the 6th month of life in the form of a finished heat-treated (pasteurized) baby food

Ingredient _______________________ g per 100 ml of finished baby food instant multigrain flour 9.1 continued milk nutrition

(based on goat's milk excluding cow proteins) 8,0 carbohydrates (lactose, dextrose) 2,1 prebiotic fiber2,0 fruit pulp as natural flavorings7,1 other ingredients:

vitamins, minerals, trace elements, unsaturated fatty acids in the amounts recommended by the applicable formula for infant milk formulas and baby foods protein profile:

total protein content 3.0 alpha-sl-casein content 78.3 mg

Example 4

Milk cereal baby food for children from the end of the 5th month of life in the form of instant powder

Ingredient ______________________ g per 100 g powder g per 100 ml baby food -35 g powder + 90 ml water

instant corn flour 28.7 10.0 follow - on milk nutrition (based on goat milk) excluding cow proteins) 50.3 17.6 carbohydrates (lactose, dextrose) 7.2 1, prebiotic fiber 2,0 0.4 lyophilized probiotic microorganisms 0.9 0.06 dried fruit powders such as natural seasonings 3.0 0.52

Other ingredients:

vitamins, minerals, trace elements, unsaturated fatty acids in the amounts recommended by the applicable formula for infant milk and baby foods protein profile:

total protein content 18.6 6.5 alpha-sl-casein content

568 mg 199 mg

Industrial use

Processed milk or cereal-based baby foods with an optimized milk component consisting of goat's milk and goat proteins with a modified protein profile that provides a goat alpha-sl-casein content ranging from 10 mg to 200 mg alpha-sl-casein per 100 ml produced in the form of instant mixtures renewable for consumption by the addition of water, or as ready-to-cook heat-treated baby foods for direct consumption. The use of baby food from the end of the fourth month of life of infants can be used to target physiologically induced desirable oral tolerance of milk proteins, which is an integral part of prevention of allergies and intolerances of milk and dairy products in childhood and adulthood.

Claims (2)

1. Processed cereal-based foods with a predominant cereal content and an optimized milk component consisting of goat milk and goat proteins excluding cow proteins, fortified either singly or in mixtures with vitamins, minerals, trace elements, prebiotics, probiotic microorganisms, nucleotides, polyunsaturated fatty acids, vegetable oils, carbohydrates, natural flavoring and flavoring agents, intended for infants from the age of 4 months of age to increase oral milk protein tolerance, characterized in that said milk component has an alpha-sl-casein content of 10 mg to 200 mg in 100 ml of side dish. 2. Dairy-based baby foods with a predominantly optimized milk component consisting of goat's milk and goat proteins excluding cow proteins, fortified either singly or in mixtures with vitamins, minerals, trace elements, prebiotics, probiotic microorganisms, nucleotides, polyunsaturated fatty acids, vegetable oils, carbohydrates, natural flavoring and flavoring agents, intended for infants from the age of four months of age to increase oral milk protein tolerance, characterized in that said milk component has an alpha-sl-casein content of 10 mg to 200 mg per 100 ml administered side dish.