SK288402B6 - Baby and child complementary food to increase oral tolerance of lactoproteins - Google Patents

Abstract

Cereal-dairy or dairy-cereal complementary food with optimized of milk component consist of goat's milk and goat's proteins excluding cow proteins, use of which on the end of the 4th month of life infants increased oral tolerance of lactoproteins. The protein profile of milk component is treated with a goat alpha-sl-casein value in the range of 10 mg to 200 mg of alpha-sl-casein in 100 mL of served complementary food.

Description

The invention relates to cereal-milk and milk-cereal infant and baby foods with an optimized milk component of infant infant milk and follow-on milk consisting of goat's milk and goat proteins with the exclusion of cow proteins aimed at increasing the oral tolerance of milk proteins.

BACKGROUND OF THE INVENTION

The protein components of cow's milk are responsible for the vast majority of intolerances or allergies manifesting in infants, young children and, in some cases, persistent into adulthood. The incidence of allergy or intolerance of cow protein varies between 0.36 - 7.5% of the population in different countries, depending on monitoring methods.

Symptoms caused by cow's milk protein intolerance are manifested in affected individuals of varying intensity, the most common being gastrointestinal disorders observed in 55 to 80%, skin reactions in 20 to 40% or respiratory symptoms in 5 to 20% of people with cow protein allergy or intolerance .

As a preventive solution to the risk of developing symptoms due to allergy or intolerance of cow's proteins, so-called "bovine proteins" were developed and used at the end of last century. hypoallergenic baby foods using either heat-treated proteins or protein hydrolysates with varying degrees of degradation of protein molecules. However, infant formulas based on protein hydrolysates do not provide 100% protection against the emergence and development of allergy to cow proteins. In cases where a hypersensitive child is unable to take normal hypoallergenic infant milk with cow's milk hydrolyzates without health problems, it is necessary to provide nutrition either with a preparation of extensively hydrolysed cow's protein or soy replacement nutrition or even only with an amino acid complex. Soy protein-based replacement nutrition for infants and young children may not be a safe way to substitute nutrition, as this type of plant protein has also been shown to be at risk of developing an allergic reaction.

Despite the massive long-term application of infant formulas and follow-on formulas based on cow protein hydrolysates bearing the HA designation, the incidence of allergies or intolerances to this type of protein does not decrease but increases.

Goat's milk is the second most commonly consumed milk in terms of worldwide production. The chemical, physical and nutritional properties of goat's milk justify its application in infant and young child nutrition, provided that some nutritional parameters are fortified or modeled.

The main triggers of cow's milk allergies and intolerances are demonstrably both casein, especially alpha-sl-casein, and the whey protein fraction called beta-lactoglobulin.

Numerous research studies have shown a lower allergenicity of goat's milk and a higher oral tolerance to patients with a proven allergy to cow proteins. In the case of goat's milk, the casein fraction referred to as alpha-sl-casein has been shown to be significantly lower than that of cow's milk in the case of goat's milk. There was no study of allergenicity in goat's milk whey protein. Alpha-sl-casein content in goat milk is associated with genotypic polymorphism ranging from 0.9 g to 4.1 g in 1 liter of milk, with low levels of alpha-sl-casein found in the San, Alpine and Toggennburg breeds. High alpha-sl-casein values are characteristic of the Nubian and La Mancha breeds. Cow's milk contains between 5.9 and 17.5 g of alpha-slkazein per liter of milk.

SUMMARY OF THE INVENTION

Improvement of the present state and thus a reduction in the number of manifested intolerances or allergies to cows' milk proteins is achieved by the timely start of administration of cereal-milk or milk-baby foods with optimized milk component of infant milk and follow-on milk consisting of goat's milk and goat's proteins in the period from the 4th to the 7th month, respectively. 12 months of life, and gradual induction of oral milk protein tolerance.

Ideally, the gradual introduction of baby foods with goat's milk during breastfeeding, which is a natural physiological method of feeding during the infant period, seems ideal. Cereal-milk or milk-cell foods with an optimized milk component of infant seed and follow-on milk consisting of goat's milk and goat proteins with the exclusion of cow proteins according to the invention should also be given as first food to children receiving HA - Initial or follow-on milk cow proteins. Exceptions are individuals whose basic nutrition is based on extensively hydrolysed proteins or mixtures of amino acids.

The highest efficacy for enhancing oral milk protein intolerance is shown by cereal-milk or milk-cereal-based foods with an optimized milk component consisting of goat's milk and goat proteins with the exclusion of cow proteins meeting the infant's initial or follow-on milk parameters that have a milk profile. alpha-sl-casein ranged from 10 mg to 200 mg alpha-sl-casein in 100 ml of the feed.

Based on the determination of alpha-sl-casein in goat milk, the protein profile modeling results in an optimal composition of the resultant milk component of the baby food such that the total protein content required by the baby food legislation is achieved by adding goat whey protein. At the same time, contamination of all recipe ingredients used with cow proteins must be avoided.

The resulting content of vitamins, minerals and trace elements shall be adjusted to the values laid down by the applicable rules for infant cereal-milk or milk-cereal-based foods in the country. Advantageously, cereal-lactic or milk-cereal-based baby foods with optimized baby milk based on goat's milk and goat proteins can be enriched with prebiotics, probiotic microorganisms, nucleotides, polyunsaturated fatty acids, carbohydrates and other nutritionally important components either singly or in mixtures.

Processed cereal-milk or milk-cereal baby foods with optimized baby milk based on goat's milk and goat proteins may be prepared in the form of instant powdered mixtures prepared for consumption by adding water or as pasteurized or otherwise stabilized baby foods for direct use .

DETAILED DESCRIPTION OF THE INVENTION

Example 1

Rice cereal-milk food for children from the end of the fourth month of life in the form of instant powder

Ingredient g per 100 g powder g per 100 ml baby food - 18.7 g powder + 90 ml water

instant rice flour 45.0 8.4 Initial milk nutrition (based on goat 's milk excluding cow protein) 38.0 7.1 carbohydrates (lactose, dextrose) 10.0 1.9 prebiotic fiber 2.0 0.4 lyophilized probiotic microorganisms 0.3 0.06

other ingredients:

vitamins, minerals, trace elements, unsaturated fatty acids in the amounts recommended by the applicable milk formula and baby foods protein profile:

total protein content 12,5 2,3 alpha-sl-casein content 53,5 mg 10 mg

Example 2

Oatmeal cereal for children from the end of 6 months of life in the form of instant powder

Component_g per 100 g of powder

instant oat flour 43.0 continued milk nutrition (based on goat 's milk excluding cow protein) 34.0 carbohydrates (lactose, dextrose) 12.2 prebiotic fiber 2.0 lyophilized probiotic microorganisms 0.3 dried fruit powders such as natural seasonings 2.8

g per 100 ml baby food - 18.7 g powder + 90 ml water

8.0

6.4

2.3

0.4

0.06

0,52 other ingredients:

vitamins, minerals, trace elements, unsaturated fatty acids in the amounts recommended by the applicable milk formula and baby foods protein profile:

total protein content 12.6 2.4 alpha-sl-casein content 192.5 mg 36 mg

Example 3

Multi-grain cereal-milk food for children from the end of the 6th month of life in the form of a finished heat-treated (pasteurized) food

Ingredient_g per 100 ml of ready-made food instant multigrain flour 9.1 continued milk nutrition (goat's milk-based exclusion of cow's protein) 8.0 carbohydrates (lactose, dextrose) 2.1 prebiotic fiber 2.0 fruit pulp as natural flavorings 7.1 other ingredients:

vitamins, minerals, trace elements, unsaturated fatty acids in the amounts recommended by the applicable milk formula and baby foods protein profile:

total protein content 3.0 alpha-sl-casein content 78.3 mg

Example 4

Milk-grain corn meal for children from the end of the 5th month of life in the form of instant powder

Component_g per 100 g of powder

instant corn flour 28.7 continued milk nutrition (based on goat 's milk excluding cow protein) 50.3 carbohydrates (lactose, dextrose) 7.2 prebiotic fiber 2.0 lyophilized probiotic microorganisms 0.9 dried fruit powders such as natural seasonings 3.0

g per 100 ml baby food - 35 g powder + 90 ml water

10.0

17.6

1

0.4

0.06

0,52 other ingredients:

vitamins, minerals, trace elements, unsaturated fatty acids in the amounts recommended by the applicable milk formula and baby foods protein profile:

total protein content 18.6 6.5 alpha-sl-casein content 568 mg 199 mg

Industrial use

Cereal-milk or milk-cereal-based baby foods with an optimized milk component consisting of goat's milk and goat proteins with a modified protein profile that ensures goat alpha-sl-casein content in the range of 10 mg to 200 mg alpha-sl-casein per 100 ml administered may be produced in the form of instant mixtures renewable for consumption by the addition of water, or as ready-to-cook heat-treated baby foods for direct consumption. The use of baby foods from the end of the fourth month of life of infants can be used to target physiologically induced desirable oral milk protein tolerance, which is an integral part of the prevention of allergies and intolerances of milk and milk products in childhood and adulthood.

PATENT CLAIMS

Claims (2)

1. Processed cereal-milk foods with a predominant cereal content and an optimized milk component consisting of goat's milk and goat proteins, excluding cow proteins, fortified either individually or in mixtures with vitamins, minerals, trace elements, prebiotics, probiotic 10 microorganisms, nucleotides, polyunsaturated fatty acids, vegetable oils, carbohydrates, natural flavoring and flavoring, intended for infants from the age of 4 months onwards to increase oral tolerance to milk proteins, characterized in that said milk component has an alpha- sl-casein 10 mg to 200 mg in 100 ml of the feed. 2. Dairy-based foods with a predominantly optimized milk component consisting of: 15 from goat's milk and goat proteins with the exclusion of cow proteins and cereal content, fortified either individually or in mixtures with vitamins, minerals, trace elements, prebiotics, probiotic microorganisms, nucleotides, polyunsaturated fatty acids, vegetable oils, carbohydrates, natural flavorings, carbohydrates substances intended for use in children from the age of 4 months onwards to increase the oral tolerance of milk proteins, characterized in that The 20 milk component has an alpha-sl-casein content of 10 mg to 200 mg per 100 ml of the feed. 25 _