CZ20033379A3 - Nová léčba obsedantně kompulzivních poruch (OCD) a OCD-příbuzných poruch s použitím GVB - Google Patents
Nová léčba obsedantně kompulzivních poruch (OCD) a OCD-příbuzných poruch s použitím GVB Download PDFInfo
- Publication number
- CZ20033379A3 CZ20033379A3 CZ20033379A CZ20033379A CZ20033379A3 CZ 20033379 A3 CZ20033379 A3 CZ 20033379A3 CZ 20033379 A CZ20033379 A CZ 20033379A CZ 20033379 A CZ20033379 A CZ 20033379A CZ 20033379 A3 CZ20033379 A3 CZ 20033379A3
- Authority
- CZ
- Czechia
- Prior art keywords
- day
- mammal
- ocd
- amount
- human
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 64
- 238000011282 treatment Methods 0.000 title claims description 9
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 title abstract description 11
- PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 claims abstract description 35
- 208000035475 disorder Diseases 0.000 claims description 61
- 241000124008 Mammalia Species 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 41
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 25
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims description 24
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 17
- 206010034158 Pathological gambling Diseases 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- 210000003169 central nervous system Anatomy 0.000 claims description 14
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 13
- 229960001918 tiagabine Drugs 0.000 claims description 12
- PBJUNZJWGZTSKL-MRXNPFEDSA-N tiagabine Chemical compound C1=CSC(C(=CCCN2C[C@@H](CCC2)C(O)=O)C2=C(C=CS2)C)=C1C PBJUNZJWGZTSKL-MRXNPFEDSA-N 0.000 claims description 12
- 208000011688 Generalised anxiety disease Diseases 0.000 claims description 11
- 229960004047 acamprosate Drugs 0.000 claims description 11
- AFCGFAGUEYAMAO-UHFFFAOYSA-N acamprosate Chemical compound CC(=O)NCCCS(O)(=O)=O AFCGFAGUEYAMAO-UHFFFAOYSA-N 0.000 claims description 11
- 208000029364 generalized anxiety disease Diseases 0.000 claims description 11
- 208000026331 Disruptive, Impulse Control, and Conduct disease Diseases 0.000 claims description 10
- 230000001575 pathological effect Effects 0.000 claims description 10
- 208000001613 Gambling Diseases 0.000 claims description 9
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims description 9
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims description 8
- 208000001836 Firesetting Behavior Diseases 0.000 claims description 8
- 229960002870 gabapentin Drugs 0.000 claims description 8
- 206010023461 kleptomania Diseases 0.000 claims description 8
- 201000004645 pyromania Diseases 0.000 claims description 8
- 229960004394 topiramate Drugs 0.000 claims description 8
- 229960000604 valproic acid Drugs 0.000 claims description 8
- 201000001916 Hypochondriasis Diseases 0.000 claims description 6
- ZGLIFVFRIOKQLE-LVZFUZTISA-N chembl2104573 Chemical compound C=1C(Cl)=CC=C(O)C=1C(=N/CCCC)/C1=CC=CC=C1Cl ZGLIFVFRIOKQLE-LVZFUZTISA-N 0.000 claims description 6
- 229950004395 fengabine Drugs 0.000 claims description 6
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 5
- 206010020710 Hyperphagia Diseases 0.000 claims description 5
- 206010021567 Impulsive behaviour Diseases 0.000 claims description 5
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 5
- 235000020830 overeating Nutrition 0.000 claims description 5
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 206010004716 Binge eating Diseases 0.000 claims description 2
- 208000032841 Bulimia Diseases 0.000 claims description 2
- 208000014679 binge eating disease Diseases 0.000 claims description 2
- 208000030459 obsessive-compulsive personality disease Diseases 0.000 claims 12
- 208000007656 osteochondritis dissecans Diseases 0.000 claims 12
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 4
- 230000006735 deficit Effects 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 230000006399 behavior Effects 0.000 abstract description 24
- 239000003445 gaba agent Substances 0.000 abstract description 2
- 239000000126 substance Substances 0.000 description 9
- 210000004556 brain Anatomy 0.000 description 8
- 108010060511 4-Aminobutyrate Transaminase Proteins 0.000 description 6
- 102100035923 4-aminobutyrate aminotransferase, mitochondrial Human genes 0.000 description 6
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 6
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 6
- -1 GVG compound Chemical class 0.000 description 5
- 230000003291 dopaminomimetic effect Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000000737 periodic effect Effects 0.000 description 5
- 231100000867 compulsive behavior Toxicity 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 210000001009 nucleus accumben Anatomy 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
- 229960002752 progabide Drugs 0.000 description 4
- IBALRBWGSVJPAP-HEHNFIMWSA-N progabide Chemical compound C=1C(F)=CC=C(O)C=1C(=N/CCCC(=O)N)/C1=CC=C(Cl)C=C1 IBALRBWGSVJPAP-HEHNFIMWSA-N 0.000 description 4
- 239000003772 serotonin uptake inhibitor Substances 0.000 description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229960003638 dopamine Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940002612 prodrug Drugs 0.000 description 3
- 239000000651 prodrug Substances 0.000 description 3
- 229940076279 serotonin Drugs 0.000 description 3
- PJDFLNIOAUIZSL-YFKPBYRVSA-N (4r)-4-azaniumylhex-5-enoate Chemical compound C=C[C@H](N)CCC(O)=O PJDFLNIOAUIZSL-YFKPBYRVSA-N 0.000 description 2
- PJDFLNIOAUIZSL-RXMQYKEDSA-N (4s)-4-azaniumylhex-5-enoate Chemical compound C=C[C@@H](N)CCC(O)=O PJDFLNIOAUIZSL-RXMQYKEDSA-N 0.000 description 2
- 239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 description 2
- 206010000117 Abnormal behaviour Diseases 0.000 description 2
- 206010010219 Compulsions Diseases 0.000 description 2
- 208000027534 Emotional disease Diseases 0.000 description 2
- 230000009508 GABAergic inhibition Effects 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- 206010057342 Onychophagia Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 230000003371 gabaergic effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 208000015046 intermittent explosive disease Diseases 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 239000013038 irreversible inhibitor Substances 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- 229960005318 vigabatrin Drugs 0.000 description 2
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 1
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000005915 GABA Receptors Human genes 0.000 description 1
- 108010005551 GABA Receptors Proteins 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010029216 Nervousness Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010029897 Obsessive thoughts Diseases 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 201000001880 Sexual dysfunction Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 208000021017 Weight Gain Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- BUVGWDNTAWHSKI-UHFFFAOYSA-L acamprosate calcium Chemical compound [Ca+2].CC(=O)NCCCS([O-])(=O)=O.CC(=O)NCCCS([O-])(=O)=O BUVGWDNTAWHSKI-UHFFFAOYSA-L 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 229940058898 campral Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960001653 citalopram Drugs 0.000 description 1
- 229960004606 clomipramine Drugs 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 229940089052 depakene Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000003821 enantio-separation Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229960002464 fluoxetine Drugs 0.000 description 1
- 229960004038 fluvoxamine Drugs 0.000 description 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 210000001652 frontal lobe Anatomy 0.000 description 1
- 239000002843 gaba uptake inhibitor Substances 0.000 description 1
- 230000028579 gamma-aminobutyric acid uptake involved in synaptic transmission Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000037041 intracellular level Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 208000015001 muscle soreness Diseases 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000001722 neurochemical effect Effects 0.000 description 1
- 229940072228 neurontin Drugs 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229960002296 paroxetine Drugs 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000013406 repetitive behavior Diseases 0.000 description 1
- 230000003989 repetitive behavior Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000862 serotonergic effect Effects 0.000 description 1
- 229960002073 sertraline Drugs 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940035305 topamax Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/853,392 US6462084B1 (en) | 2001-05-14 | 2001-05-14 | Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ20033379A3 true CZ20033379A3 (cs) | 2004-12-15 |
Family
ID=25315916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20033379A CZ20033379A3 (cs) | 2001-05-14 | 2002-05-08 | Nová léčba obsedantně kompulzivních poruch (OCD) a OCD-příbuzných poruch s použitím GVB |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6462084B1 (https=) |
| EP (1) | EP1392273A4 (https=) |
| JP (1) | JP2004533445A (https=) |
| KR (1) | KR20040028758A (https=) |
| CN (1) | CN1509168A (https=) |
| BR (1) | BR0209614A (https=) |
| CA (1) | CA2446641A1 (https=) |
| CZ (1) | CZ20033379A3 (https=) |
| HR (1) | HRP20030894A2 (https=) |
| HU (1) | HUP0400032A3 (https=) |
| IL (1) | IL158761A0 (https=) |
| MX (1) | MXPA03010406A (https=) |
| NO (1) | NO20035037L (https=) |
| NZ (1) | NZ529613A (https=) |
| PL (1) | PL367362A1 (https=) |
| TW (1) | TWI313599B (https=) |
| WO (1) | WO2002092071A1 (https=) |
| YU (1) | YU89103A (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1345602B1 (en) | 2000-11-30 | 2010-07-21 | Novodermix International Limited | Wound healing |
| WO2004002462A2 (en) * | 2002-06-27 | 2004-01-08 | Warner-Lambert Company Llc | Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder |
| EP1617862B1 (en) * | 2003-04-25 | 2012-12-05 | Allergan, Inc. | Botulinum neurotoxin for treating obsessive compulsive behavior symptoms |
| US7393537B2 (en) | 2003-04-25 | 2008-07-01 | Allergan, Inc. | Botulinum toxin for treatment of obsessive compulsive finger biting disorder |
| US20110275664A1 (en) * | 2005-09-26 | 2011-11-10 | The Regents Of The University Of Colorado,A Body Corporate | Method for treating drug and behavioral addictions |
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| CA2790820A1 (en) * | 2010-02-25 | 2011-09-01 | Northwestern University | Use (1s,3s)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid as a gaba aminotransferse inhibitor |
| US8293790B2 (en) | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| WO2014197744A1 (en) * | 2013-06-05 | 2014-12-11 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| CN104306736A (zh) * | 2014-10-31 | 2015-01-28 | 哈尔滨市海江科技开发有限公司 | 一种治疗疑病症的膏药及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5189064A (en) | 1985-07-22 | 1993-02-23 | Matrix Technologies, Inc. | Treatment of cocaine addiction |
| US4761429A (en) | 1985-07-22 | 1988-08-02 | Kenneth Blum | Enkephalinase and endorphinase inhibitors as anti-craving compositions |
| US4786647A (en) | 1986-06-30 | 1988-11-22 | University Of Florida | Method for eliciting anxiolysis |
| US4980168A (en) | 1989-10-13 | 1990-12-25 | Natrol, Inc. | Dietary supplement for children |
| EP0543780A3 (en) | 1991-11-21 | 1993-09-01 | Ciba-Geigy Ag | Novel aminoalkanephosphinic acids and their salts |
| HU222776B1 (hu) * | 1992-05-20 | 2003-10-28 | Northwestern University | (S)-(+)-4-amino-3-(2-metil-propil)-butánsav előállításának új hexánsav- és butándisav-származék köztitermékei és ezek előállítása |
| US5792796A (en) * | 1994-07-27 | 1998-08-11 | Warner-Lambert Company | Methods for treating anxiety and panic |
| RU2214241C2 (ru) | 1996-06-28 | 2003-10-20 | Орто-Макнейл Фармасьютикал, Инк. | Способ лечения ожирения и способ индуцирования потери веса у млекопитающих |
| US5776956A (en) | 1996-07-30 | 1998-07-07 | Lectec Corporation | Use of cotinine in treating psychiatric disorders |
| US6117855A (en) * | 1996-10-07 | 2000-09-12 | Merck Sharp & Dohme Ltd. | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent |
| IL135659A0 (en) | 1997-10-28 | 2001-05-20 | Schering Corp | Method of reducing craving in mammals |
| US6391922B1 (en) * | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
| US6541520B1 (en) * | 1998-08-05 | 2003-04-01 | Brookhaven Science Associates | Treatment of addiction and addiction-related behavior |
| MXPA01004015A (es) * | 1998-10-20 | 2003-03-10 | Johnson & Johnson | Derivados anticonvulsivos utiles para el tratamiento de la dependencia, adiccion y abuso del alcohol. |
| DE60007078T2 (de) | 1999-02-01 | 2004-12-16 | Ortho-Mcneil Pharmaceutical, Inc. | Verwendung von antikonvulsiven derivaten zur behandlung von bulimia nervosa |
| ATE294577T1 (de) | 1999-02-24 | 2005-05-15 | Univ Cincinnati | Verwendung von sulfamat derivaten zur behandlung von impulsiven störungen |
| WO2000061140A1 (en) | 1999-04-08 | 2000-10-19 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in maintaining weight loss |
| EP1345602B1 (en) * | 2000-11-30 | 2010-07-21 | Novodermix International Limited | Wound healing |
-
2001
- 2001-05-14 US US09/853,392 patent/US6462084B1/en not_active Expired - Fee Related
-
2002
- 2002-05-08 NZ NZ529613A patent/NZ529613A/en unknown
- 2002-05-08 YU YU89103A patent/YU89103A/sh unknown
- 2002-05-08 PL PL02367362A patent/PL367362A1/xx not_active Application Discontinuation
- 2002-05-08 HR HR20030894A patent/HRP20030894A2/hr not_active Application Discontinuation
- 2002-05-08 WO PCT/US2002/014344 patent/WO2002092071A1/en not_active Ceased
- 2002-05-08 EP EP02729142A patent/EP1392273A4/en not_active Withdrawn
- 2002-05-08 CN CNA028098269A patent/CN1509168A/zh active Pending
- 2002-05-08 CZ CZ20033379A patent/CZ20033379A3/cs unknown
- 2002-05-08 JP JP2002588988A patent/JP2004533445A/ja active Pending
- 2002-05-08 CA CA002446641A patent/CA2446641A1/en not_active Abandoned
- 2002-05-08 IL IL15876102A patent/IL158761A0/xx unknown
- 2002-05-08 BR BR0209614-5A patent/BR0209614A/pt not_active IP Right Cessation
- 2002-05-08 MX MXPA03010406A patent/MXPA03010406A/es active IP Right Grant
- 2002-05-08 KR KR10-2003-7014792A patent/KR20040028758A/ko not_active Withdrawn
- 2002-05-08 HU HU0400032A patent/HUP0400032A3/hu unknown
- 2002-05-13 TW TW091109922A patent/TWI313599B/zh not_active IP Right Cessation
- 2002-06-20 US US10/175,576 patent/US20020169103A1/en not_active Abandoned
-
2003
- 2003-11-13 NO NO20035037A patent/NO20035037L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20020169103A1 (en) | 2002-11-14 |
| TWI313599B (en) | 2009-08-21 |
| EP1392273A1 (en) | 2004-03-03 |
| NO20035037L (no) | 2004-01-07 |
| HUP0400032A3 (en) | 2012-09-28 |
| PL367362A1 (en) | 2005-02-21 |
| YU89103A (sh) | 2006-08-17 |
| MXPA03010406A (es) | 2004-05-05 |
| WO2002092071A1 (en) | 2002-11-21 |
| NZ529613A (en) | 2006-09-29 |
| KR20040028758A (ko) | 2004-04-03 |
| HUP0400032A2 (hu) | 2004-04-28 |
| CA2446641A1 (en) | 2002-11-21 |
| CN1509168A (zh) | 2004-06-30 |
| EP1392273A4 (en) | 2004-11-24 |
| IL158761A0 (en) | 2004-05-12 |
| BR0209614A (pt) | 2004-12-07 |
| US6462084B1 (en) | 2002-10-08 |
| HRP20030894A2 (en) | 2004-06-30 |
| JP2004533445A (ja) | 2004-11-04 |
| NO20035037D0 (no) | 2003-11-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Papa et al. | Levodopa‐induced dyskinesias improved by a glutamate antagonist in parkinsonia monkeys | |
| Klockgether et al. | The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine‐depleted rats and MPTP‐treated monkeys | |
| JP4154237B2 (ja) | 異痛症および他の種々のタイプの慢性疼痛または幻肢痛を治療するための化合物のペプチドクラスの新規使用 | |
| CZ20033379A3 (cs) | Nová léčba obsedantně kompulzivních poruch (OCD) a OCD-příbuzných poruch s použitím GVB | |
| CZ20021904A3 (cs) | Pyrrolidinacetamidový derivát samotný nebo v kombinaci pro léčení poruch CNS | |
| Essig | Clinical and experimental aspects of barbiturate withdrawal convulsions | |
| EP1071422B1 (fr) | Associations de riluzole et de levodopa pour le traitement de la maladie de parkinson | |
| JP2010523475A (ja) | 医薬組成物およびその調製方法 | |
| EP1464330A1 (fr) | Utilisation par voie topique ou par inhalation d'une composition comprenant des oligosaccharides et une saponine ou un acide aminé basique | |
| EP1154795A1 (en) | Method of treating and diagnosing restless legs syndrome and corresponding means | |
| Wilker | Theories related to physical dependence | |
| US12220389B2 (en) | Combination therapy for the treatment of tinnitus and other medical conditions | |
| MXPA00012808A (es) | El uso de analogo de acido valproico para tratamiento y prevencion de migrana y enfermedad afectiva. | |
| BOSHES | Sinemet and the treatment of parkinsonism | |
| Heikkila et al. | Potentiation by deprenil of l-dopa induced circling in nigral-lesioned rats | |
| KR20050084236A (ko) | 섬유근육통 및 기타 관련 질환의 치료를 위한 프레가발린및 그의 유도체 | |
| WO2005041966A1 (en) | Treatment of parkinson's disease using apomorphine in combination with an apomorphine prodrug | |
| PT626851E (pt) | Utilizacao de 3,5-diamino-6-(2,3-diclorofenil)-1,2,4-triazina para a preparacao de um medicamento para o tratamento de certos tipos de dor e edema | |
| AU2002259153B2 (en) | Novel treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG | |
| FR2781671A1 (fr) | Compositions pharmaceutiques contenant un inhibiteur de la recapture de la serotonine et leur application en therapeutique | |
| DE60035162T2 (de) | Ein ZNS-penetrierender NK-1-Rezeptor-Antagonist in Kombination mit einem antidepressiven oder einem anxiolytischen Wirkstoff zur Behandlung von Depression und Angst | |
| ES2207550T3 (es) | Composicion que comprende un extracto de perna canaliculus, metilsulfonilmetano y glucosamina, y utilizacion de la misma. | |
| JPH05506842A (ja) | 神経変性状態の処置方法 | |
| AU2002259153A1 (en) | Novel treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG | |
| JP2008506630A (ja) | ゾルピデムの更なる治療的使用 |