CY2522B1 - 2-Substituted nucleosides and oligonucleotide derivatives - Google Patents

2-Substituted nucleosides and oligonucleotide derivatives

Info

Publication number
CY2522B1
CY2522B1 CY0500020A CY0500020A CY2522B1 CY 2522 B1 CY2522 B1 CY 2522B1 CY 0500020 A CY0500020 A CY 0500020A CY 0500020 A CY0500020 A CY 0500020A CY 2522 B1 CY2522 B1 CY 2522B1
Authority
CY
Cyprus
Prior art keywords
oligonucleotide derivatives
substituted nucleosides
nucleoside building
building blocks
oligonucleotide
Prior art date
Application number
CY0500020A
Other languages
English (en)
Inventor
Bernard Cuenoud
Karl-Heinz Altmann
Pierre Martin
Heinz Ernst Moser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY2522B1 publication Critical patent/CY2522B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
CY0500020A 1996-06-06 2005-04-04 2-Substituted nucleosides and oligonucleotide derivatives CY2522B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH143296 1996-06-06

Publications (1)

Publication Number Publication Date
CY2522B1 true CY2522B1 (en) 2006-02-08

Family

ID=4210329

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0500020A CY2522B1 (en) 1996-06-06 2005-04-04 2-Substituted nucleosides and oligonucleotide derivatives

Country Status (11)

Country Link
US (2) US6670468B1 (ja)
EP (1) EP0906329B1 (ja)
JP (1) JP2000512630A (ja)
AT (1) ATE251638T1 (ja)
AU (1) AU3029797A (ja)
CA (1) CA2256765A1 (ja)
CY (1) CY2522B1 (ja)
DE (1) DE69725440T2 (ja)
DK (1) DK0906329T3 (ja)
WO (1) WO1997046569A2 (ja)
ZA (1) ZA974952B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000512630A (ja) * 1996-06-06 2000-09-26 ノバルティス アクチエンゲゼルシャフト ２’―置換ヌクレオシドおよびオリゴヌクレオチド誘導体
US6277967B1 (en) * 1998-07-14 2001-08-21 Isis Pharmaceuticals, Inc. Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
US6043352A (en) 1998-08-07 2000-03-28 Isis Pharmaceuticals, Inc. 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
US6673912B1 (en) 1998-08-07 2004-01-06 Isis Pharmaceuticals, Inc. 2′-O-aminoethyloxyethyl-modified oligonucleotides
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
WO2006124897A2 (en) * 2005-05-13 2006-11-23 Lexicon Genetics Incorporated Methods and compositions for improving cognition
US8648085B2 (en) 2007-11-30 2014-02-11 Boehringer Ingelheim International Gmbh 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
PE20110383A1 (es) 2008-09-08 2011-07-15 Boehringer Ingelheim Int Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)
EP2669290A1 (en) * 2009-03-02 2013-12-04 Alnylam Pharmaceuticals Inc. Nucleic Acid Chemical Modifications
JP5542196B2 (ja) 2009-03-31 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １−複素環−１，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｐｄｅ９ａモジュレーターとしてのそれらの使用
PL2603511T3 (pl) 2010-08-12 2017-08-31 Boehringer Ingelheim Int Pochodne 6-cykloalkilo-1,5-dihydropirazolo[3,4-d]pirymidyn-4-onu i ich zastosowanie jako inhibitorów PDE9A
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
AU2016301188A1 (en) 2015-08-06 2018-02-15 Chimerix, Inc. Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents
US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0942000B1 (en) * 1989-10-24 2004-06-23 Isis Pharmaceuticals, Inc. 2'-Modified oligonucleotides
US5514786A (en) * 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
WO1995006659A1 (en) 1992-07-01 1995-03-09 Isis Pharmaceuticals, Inc. Amine-derivatized nucleosides and oligonucleosides
DE4037363A1 (de) 1990-04-09 1991-10-10 Europ Lab Molekularbiolog 2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
BR9106826A (pt) 1990-08-13 1994-01-25 Isis Pharmaceuticals Inc Oligonucleotideo ou analogo de oligonucleotideo,processo para modular a producao de uma proteina por um organismo,para tratar um organismo e processos para sintetizar:9(2'-desoxi-2'-substituido-beta-d-ribofuranosil)-guanina e g('-desoxi-2'-fluor-beta-d-ribofuranosil)-guanina
DE4110085A1 (de) 1991-03-27 1992-10-01 Boehringer Ingelheim Int 2'-o-alkyl-oligoribonukleotide, verfahren zu deren herstellung und deren verwendung als antisense-oligonukleotide
ATE239484T1 (de) * 1991-10-24 2003-05-15 Isis Pharmaceuticals Inc Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen
ATE204879T1 (de) 1991-12-24 2001-09-15 Isis Pharmaceuticals Inc Antisense oligonukleotide
US5485592A (en) 1992-04-07 1996-01-16 Video Technology Computers, Ltd. Write back cache controller method and apparatus for use in a system having a CPU with internal cache memory
CA2140428C (en) * 1992-07-23 2003-07-08 Daniel Peter Claude Mcgee Novel 2'-o-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof
EP0626387B1 (de) 1993-05-12 1999-03-10 Novartis AG Nukleoside und Oligonukleotide mit 2'-Ethergruppen
US5571902A (en) * 1993-07-29 1996-11-05 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
DE59510742D1 (de) 1994-04-27 2003-08-14 Novartis Ag Nukleoside und Oligonukleotide mit 2'-Ethergruppen
US5744362A (en) * 1994-05-31 1998-04-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
JP2000512630A (ja) * 1996-06-06 2000-09-26 ノバルティス アクチエンゲゼルシャフト ２’―置換ヌクレオシドおよびオリゴヌクレオチド誘導体

Also Published As

Publication number Publication date
DE69725440D1 (de) 2003-11-13
US20050159374A1 (en) 2005-07-21
WO1997046569A2 (en) 1997-12-11
DE69725440T2 (de) 2004-07-22
AU3029797A (en) 1998-01-05
DK0906329T3 (da) 2004-02-09
EP0906329B1 (en) 2003-10-08
EP0906329A2 (en) 1999-04-07
ZA974952B (en) 1997-12-08
ATE251638T1 (de) 2003-10-15
CA2256765A1 (en) 1997-12-11
WO1997046569A3 (en) 1998-02-19
JP2000512630A (ja) 2000-09-26
US6670468B1 (en) 2003-12-30

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