CY2091B1 - Process for separating 2-deoxy-2, 2-difluoro-d-ribofuranosyl alkylsulfonate anomers - Google Patents

Process for separating 2-deoxy-2, 2-difluoro-d-ribofuranosyl alkylsulfonate anomers

Info

Publication number
CY2091B1
CY2091B1 CY9800012A CY9800012A CY2091B1 CY 2091 B1 CY2091 B1 CY 2091B1 CY 9800012 A CY9800012 A CY 9800012A CY 9800012 A CY9800012 A CY 9800012A CY 2091 B1 CY2091 B1 CY 2091B1
Authority
CY
Cyprus
Prior art keywords
ribofuranosyl
deoxy
difluoro
separating
anomers
Prior art date
Application number
CY9800012A
Other languages
English (en)
Inventor
Chou Ta Sen
Timothy James Mccarthy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CY2091B1 publication Critical patent/CY2091B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY9800012A 1992-06-22 1998-06-18 Process for separating 2-deoxy-2, 2-difluoro-d-ribofuranosyl alkylsulfonate anomers CY2091B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
CY2091B1 true CY2091B1 (en) 2002-04-05

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9800012A CY2091B1 (en) 1992-06-22 1998-06-18 Process for separating 2-deoxy-2, 2-difluoro-d-ribofuranosyl alkylsulfonate anomers

Country Status (16)

Country Link
US (1) US5256797A (index.php)
EP (1) EP0576232B1 (index.php)
JP (1) JPH0656867A (index.php)
KR (1) KR100302087B1 (index.php)
AT (1) ATE149505T1 (index.php)
BR (1) BR9302426A (index.php)
CA (1) CA2098888C (index.php)
CY (1) CY2091B1 (index.php)
DE (1) DE69308391T2 (index.php)
DK (1) DK0576232T3 (index.php)
ES (1) ES2100462T3 (index.php)
GR (1) GR3023060T3 (index.php)
HU (1) HU217976B (index.php)
IL (1) IL106074A (index.php)
MX (1) MX9303714A (index.php)
TW (1) TW233300B (index.php)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103433T3 (es) * 1992-06-22 1997-09-16 Lilly Co Eli Procedimiento para preparar derivados de 1-halo-2-desoxi-2,2-difluoro-d-ribofuranosilo enriquecidos en anomero alfa.
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1294735A2 (en) 2000-05-26 2003-03-26 Novirio Pharmaceuticals Limited Methods and compositions for treating flaviviruses and pestiviruses
CA2489552A1 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
KR20050088079A (ko) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
PL377287A1 (pl) 2002-12-12 2006-01-23 Idenix (Cayman) Limited Sposób wytwarzania 2'-rozgałęzionych nukleozydów
EP1912643A2 (en) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
ES2422290T3 (es) 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
WO2007092705A2 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
ATE217009T1 (de) * 1987-08-28 2002-05-15 Lilly Co Eli Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen

Also Published As

Publication number Publication date
HUT64551A (en) 1994-01-28
KR940000473A (ko) 1994-01-03
ATE149505T1 (de) 1997-03-15
HU9301826D0 (en) 1993-09-28
CA2098888C (en) 2003-07-29
HU217976B (hu) 2000-05-28
DK0576232T3 (da) 1997-07-21
MX9303714A (es) 1994-01-31
IL106074A0 (en) 1993-10-20
KR100302087B1 (ko) 2001-10-22
GR3023060T3 (en) 1997-07-30
DE69308391D1 (de) 1997-04-10
JPH0656867A (ja) 1994-03-01
BR9302426A (pt) 1994-01-11
HK1006022A1 (en) 1999-02-05
DE69308391T2 (de) 1997-07-17
ES2100462T3 (es) 1997-06-16
EP0576232B1 (en) 1997-03-05
TW233300B (index.php) 1994-11-01
IL106074A (en) 1998-02-22
CA2098888A1 (en) 1993-12-23
US5256797A (en) 1993-10-26
EP0576232A1 (en) 1993-12-29

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