CY1125542T1 - Πεπτιδομιμητικα βητα-φουρκετας ως εκλεκτικοι αναστολεις ελαστασης - Google Patents

Πεπτιδομιμητικα βητα-φουρκετας ως εκλεκτικοι αναστολεις ελαστασης

Info

Publication number
CY1125542T1
CY1125542T1 CY20221100582T CY221100582T CY1125542T1 CY 1125542 T1 CY1125542 T1 CY 1125542T1 CY 20221100582 T CY20221100582 T CY 20221100582T CY 221100582 T CY221100582 T CY 221100582T CY 1125542 T1 CY1125542 T1 CY 1125542T1
Authority
CY
Cyprus
Prior art keywords
peptimimetics
hairbrush
inhibitors
beta
elasticity
Prior art date
Application number
CY20221100582T
Other languages
Greek (el)
English (en)
Inventor
Frank Otto Gombert
Daniel Obrecht
Odile Sellier-Kessler
Christian Ludin
Manuella Schmitt-Billet
Alexander Lederer
Steffen Weinbrenner
Original Assignee
Spexis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spexis Ag filed Critical Spexis Ag
Publication of CY1125542T1 publication Critical patent/CY1125542T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CY20221100582T 2013-12-27 2022-08-30 Πεπτιδομιμητικα βητα-φουρκετας ως εκλεκτικοι αναστολεις ελαστασης CY1125542T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/078073 WO2015096873A1 (en) 2013-12-27 2013-12-27 Beta-hairpin peptidomimetics as selective elastase inhibitors

Publications (1)

Publication Number Publication Date
CY1125542T1 true CY1125542T1 (el) 2026-02-25

Family

ID=49911533

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20221100582T CY1125542T1 (el) 2013-12-27 2022-08-30 Πεπτιδομιμητικα βητα-φουρκετας ως εκλεκτικοι αναστολεις ελαστασης

Country Status (26)

Country Link
US (1) US10273267B2 (https=)
EP (1) EP3087094B1 (https=)
JP (1) JP6499183B2 (https=)
KR (1) KR102214694B1 (https=)
CN (1) CN106029689B (https=)
AU (1) AU2013409200B2 (https=)
BR (1) BR112016014916B1 (https=)
CA (1) CA2933660C (https=)
CY (1) CY1125542T1 (https=)
DK (1) DK3087094T3 (https=)
EA (1) EA201691330A1 (https=)
ES (1) ES2925747T3 (https=)
HR (1) HRP20221046T1 (https=)
HU (1) HUE059846T2 (https=)
IL (1) IL246175B (https=)
LT (1) LT3087094T (https=)
MX (1) MX389053B (https=)
NZ (1) NZ722025A (https=)
PL (1) PL3087094T3 (https=)
PT (1) PT3087094T (https=)
RS (1) RS63543B1 (https=)
SG (1) SG11201605122WA (https=)
SI (1) SI3087094T1 (https=)
SM (1) SMT202200393T1 (https=)
WO (1) WO2015096873A1 (https=)
ZA (1) ZA201604821B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2132221T3 (pl) 2007-02-28 2011-04-29 Polyphor Ltd Przyłączone do matrycy peptydomimetyki
JP6499182B2 (ja) * 2013-12-27 2019-04-10 ポリフォー・アクチェンゲゼルシャフトPolyphor Ag 選択的エラスターゼ阻害剤としてのβ−ヘアピンペプチド模倣体
US10676723B2 (en) * 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CA3001065A1 (en) 2015-10-14 2017-04-20 Xiaoxi WEI Compositions and methods for reducing ice crystal formation
CA3024522C (en) 2016-05-31 2024-06-25 Polyphor Ag Beta-hairpin peptidomimetic with elastase inhibitory activity and aerosol dosage forms thereof
JP7672641B2 (ja) 2019-09-17 2025-05-08 メレオ バイオファーマ 4 リミテッド 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
IL297211B2 (en) 2020-04-16 2025-12-01 Mereo Biopharma 4 Ltd Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
CN114573686A (zh) * 2020-11-30 2022-06-03 中国医学科学院药物研究所 含有二硫键且具有抑制丝氨酸蛋白酶活性的多肽及其应用
KR20240090272A (ko) 2021-10-20 2024-06-21 메레오 바이오파마 4 리미티드 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
GB9825854D0 (en) * 1998-11-25 1999-01-20 Univ Bristol Peptide
CN101157924A (zh) * 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
US8658604B2 (en) * 2005-02-17 2014-02-25 Polyphor Ltd Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
JP6499182B2 (ja) * 2013-12-27 2019-04-10 ポリフォー・アクチェンゲゼルシャフトPolyphor Ag 選択的エラスターゼ阻害剤としてのβ−ヘアピンペプチド模倣体

Also Published As

Publication number Publication date
US10273267B2 (en) 2019-04-30
PT3087094T (pt) 2022-09-05
HRP20221046T1 (hr) 2023-01-20
JP2017504620A (ja) 2017-02-09
MX2016008318A (es) 2016-10-13
WO2015096873A1 (en) 2015-07-02
HUE059846T2 (hu) 2023-01-28
IL246175A0 (en) 2016-07-31
IL246175B (en) 2022-04-01
ZA201604821B (en) 2017-09-27
NZ722025A (en) 2019-06-28
EA201691330A1 (ru) 2016-10-31
JP6499183B2 (ja) 2019-04-10
CA2933660A1 (en) 2015-07-02
AU2013409200A1 (en) 2016-07-21
SI3087094T1 (sl) 2022-11-30
LT3087094T (lt) 2022-09-26
US20160333053A1 (en) 2016-11-17
CN106029689A (zh) 2016-10-12
CA2933660C (en) 2023-05-09
MX389053B (es) 2025-03-20
EP3087094A1 (en) 2016-11-02
EP3087094B1 (en) 2022-06-01
RS63543B1 (sr) 2022-09-30
SG11201605122WA (en) 2016-07-28
BR112016014916A2 (https=) 2017-08-08
ES2925747T3 (es) 2022-10-19
BR112016014916B1 (pt) 2022-10-04
DK3087094T3 (da) 2022-08-29
KR20160102313A (ko) 2016-08-29
SMT202200393T1 (it) 2022-11-18
AU2013409200B2 (en) 2019-08-15
KR102214694B1 (ko) 2021-02-10
PL3087094T3 (pl) 2022-09-26
CN106029689B (zh) 2021-09-28

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