CY1123785T1 - Μια διεργασια για την παρασκευη μιας εκ του στοματος χορηγουμενης μορφης δοσολογιας πολλαπλων μοναδων τροποποιημενης αποδεσμευσης της ηλεκτρικης δοξυλαμινης και υδροχλωρικης πυριδοξινης - Google Patents
Μια διεργασια για την παρασκευη μιας εκ του στοματος χορηγουμενης μορφης δοσολογιας πολλαπλων μοναδων τροποποιημενης αποδεσμευσης της ηλεκτρικης δοξυλαμινης και υδροχλωρικης πυριδοξινηςInfo
- Publication number
- CY1123785T1 CY1123785T1 CY20211100065T CY211100065T CY1123785T1 CY 1123785 T1 CY1123785 T1 CY 1123785T1 CY 20211100065 T CY20211100065 T CY 20211100065T CY 211100065 T CY211100065 T CY 211100065T CY 1123785 T1 CY1123785 T1 CY 1123785T1
- Authority
- CY
- Cyprus
- Prior art keywords
- modified release
- doxylamine
- preparation
- dosage form
- electric
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με μια διεργασία για την παρασκευή μιας εκ του στόματος χορηγούμενης μορφής δοσολογίας πολλαπλών μονάδων τροποποιημένης αποδέσμευσης περιλαμβάνοντας μια πλειάδα σβόλων τροποποιημένης αποδέσμευσης της δοξυλαμίνης ή άλατος εξ αυτής και σβόλων τροποποιημένης αποδέσμευσης της πυριδοξίνης ή ενός άλατος εξ αυτής• όπου η διεργασία περιλαμβάνει επικάλυψη των σβόλων της δοξυλαμίνης έχοντας την εσώτερη ενεργή στοιβάδα επικάλυψης και την ενδιάμεση εντερική στοιβάδα επικάλυψης• και των σβόλων πυριδοξίνης έχοντας την εσώτερη ενεργή στοιβάδα επικάλυψης, όπου το βήμα επικάλυψης περιλαμβάνοντας ταυτόχρονο ψεκασμό ενός μείγματος που περιλαμβάνει τους παράγοντες επικάλυψης εντερικής και τροποποιημένης αποδέσμευσης και παράγοντες σχηματισμού-πόρων προσθήκης σε μορφή κόνεων.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18382687.4A EP3628311B1 (en) | 2018-09-27 | 2018-09-27 | A process for the preparation of a modified release multiple unit oral dosage form of doxylamine succinate and pyridoxine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123785T1 true CY1123785T1 (el) | 2022-05-27 |
Family
ID=63722327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100065T CY1123785T1 (el) | 2018-09-27 | 2021-01-27 | Μια διεργασια για την παρασκευη μιας εκ του στοματος χορηγουμενης μορφης δοσολογιας πολλαπλων μοναδων τροποποιημενης αποδεσμευσης της ηλεκτρικης δοξυλαμινης και υδροχλωρικης πυριδοξινης |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP3628311B1 (el) |
| JP (1) | JP7444862B2 (el) |
| KR (1) | KR20210066864A (el) |
| CN (1) | CN112839638B (el) |
| AR (1) | AR116480A1 (el) |
| AU (1) | AU2019348630B2 (el) |
| BR (1) | BR112021005192A8 (el) |
| CL (1) | CL2021000687A1 (el) |
| CO (1) | CO2021005412A2 (el) |
| CR (1) | CR20210208A (el) |
| CY (1) | CY1123785T1 (el) |
| DK (1) | DK3628311T3 (el) |
| DO (1) | DOP2021000052A (el) |
| EA (1) | EA202190700A1 (el) |
| EC (1) | ECSP21029863A (el) |
| ES (1) | ES2847648T3 (el) |
| HR (1) | HRP20210181T1 (el) |
| HU (1) | HUE053082T2 (el) |
| MX (1) | MX2021003357A (el) |
| MY (1) | MY197676A (el) |
| NI (1) | NI202100021A (el) |
| PE (1) | PE20211462A1 (el) |
| PH (1) | PH12021550640A1 (el) |
| PL (1) | PL3628311T3 (el) |
| PT (1) | PT3628311T (el) |
| RS (1) | RS61368B1 (el) |
| SA (1) | SA521421557B1 (el) |
| SI (1) | SI3628311T1 (el) |
| UA (1) | UA127768C2 (el) |
| WO (1) | WO2020064985A1 (el) |
| ZA (1) | ZA202101279B (el) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR121619A1 (es) * | 2020-03-25 | 2022-06-22 | Inibsa Ginecologia S A | Una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina y un procedimiento para su preparación |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE55745B1 (en) * | 1983-04-06 | 1991-01-02 | Elan Corp Plc | Sustained absorption pharmaceutical composition |
| CA2350195C (en) * | 2000-12-20 | 2003-06-10 | Duchesnay Inc. | Rapid onset formulation of pyridoxine hydrochloride and doxylamine succinate |
| US20070141147A1 (en) * | 2005-12-21 | 2007-06-21 | Auriga Laboratories, Inc. | Sequential release pharmaceutical formulations |
| CN101448493A (zh) * | 2006-05-22 | 2009-06-03 | 特瓦制药工业有限公司 | 度洛西汀盐酸盐延迟释放配制剂 |
| ES2376095B1 (es) * | 2008-10-02 | 2013-01-24 | Laboratorios Del Dr. Esteve, S.A. | Pellets entéricos de duloxetina. |
| CA2761212A1 (en) * | 2011-12-07 | 2013-06-07 | Pharmascience Inc. | Disintegrant-free delayed release doxylamine and pyridoxine formulation and process of it manufacturing |
| WO2013123569A1 (en) | 2012-02-22 | 2013-08-29 | Duchesnay Inc. | Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
| SG11201403931YA (en) * | 2012-02-22 | 2014-08-28 | Duchesnay Inc | Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
| CN103142552A (zh) * | 2013-02-22 | 2013-06-12 | 广州科的信医药技术有限公司 | 一种洛伐他汀肠溶缓释微丸胶囊及其制备方法 |
| CN103690506B (zh) * | 2013-11-08 | 2015-05-13 | 舒泰神（北京）生物制药股份有限公司 | 一种曲司氯铵缓释组合物及其制备方法 |
| SG11201701448XA (en) * | 2014-08-29 | 2017-03-30 | Duchesnay Inc | Plurimodal release formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
| JP6695337B2 (ja) * | 2014-11-26 | 2020-05-20 | レーム・ゲーエムベーハーＲｏｅｈｍ ＧｍｂＨ | エタノールの影響に対する耐性を有する医薬品組成物または栄養機能食品組成物 |
| CN106606502B (zh) * | 2015-10-27 | 2019-12-31 | 四川海思科制药有限公司 | 一种琥珀酸多西拉敏盐酸吡哆醇肠溶片药物组合物及其制备方法 |
-
2018
- 2018-09-27 PT PT183826874T patent/PT3628311T/pt unknown
- 2018-09-27 ES ES18382687T patent/ES2847648T3/es active Active
- 2018-09-27 PL PL18382687T patent/PL3628311T3/pl unknown
- 2018-09-27 SI SI201830208T patent/SI3628311T1/sl unknown
- 2018-09-27 HU HUE18382687A patent/HUE053082T2/hu unknown
- 2018-09-27 EP EP18382687.4A patent/EP3628311B1/en active Active
- 2018-09-27 RS RS20210089A patent/RS61368B1/sr unknown
- 2018-09-27 DK DK18382687.4T patent/DK3628311T3/da active
-
2019
- 2019-09-23 AR ARP190102692A patent/AR116480A1/es unknown
- 2019-09-27 MY MYPI2021001522A patent/MY197676A/en unknown
- 2019-09-27 UA UAA202101817A patent/UA127768C2/uk unknown
- 2019-09-27 JP JP2021516918A patent/JP7444862B2/ja active Active
- 2019-09-27 CR CR20210208A patent/CR20210208A/es unknown
- 2019-09-27 KR KR1020217012326A patent/KR20210066864A/ko active Search and Examination
- 2019-09-27 BR BR112021005192A patent/BR112021005192A8/pt unknown
- 2019-09-27 PE PE2021000345A patent/PE20211462A1/es unknown
- 2019-09-27 AU AU2019348630A patent/AU2019348630B2/en active Active
- 2019-09-27 MX MX2021003357A patent/MX2021003357A/es unknown
- 2019-09-27 WO PCT/EP2019/076140 patent/WO2020064985A1/en active Application Filing
- 2019-09-27 EA EA202190700A patent/EA202190700A1/ru unknown
- 2019-09-27 CN CN201980063235.6A patent/CN112839638B/zh active Active
-
2021
- 2021-01-27 CY CY20211100065T patent/CY1123785T1/el unknown
- 2021-02-02 HR HRP20210181TT patent/HRP20210181T1/hr unknown
- 2021-02-25 ZA ZA2021/01279A patent/ZA202101279B/en unknown
- 2021-03-19 PH PH12021550640A patent/PH12021550640A1/en unknown
- 2021-03-19 CL CL2021000687A patent/CL2021000687A1/es unknown
- 2021-03-23 NI NI202100021A patent/NI202100021A/es unknown
- 2021-03-24 SA SA521421557A patent/SA521421557B1/ar unknown
- 2021-03-26 DO DO2021000052A patent/DOP2021000052A/es unknown
- 2021-04-26 EC ECSENADI202129863A patent/ECSP21029863A/es unknown
- 2021-04-26 CO CONC2021/0005412A patent/CO2021005412A2/es unknown
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