CY1123496T1 - Μεθοδοι για την ανιχνευση συμμετρικης διμεθυλαργινινης - Google Patents
Μεθοδοι για την ανιχνευση συμμετρικης διμεθυλαργινινηςInfo
- Publication number
- CY1123496T1 CY1123496T1 CY20201101033T CY201101033T CY1123496T1 CY 1123496 T1 CY1123496 T1 CY 1123496T1 CY 20201101033 T CY20201101033 T CY 20201101033T CY 201101033 T CY201101033 T CY 201101033T CY 1123496 T1 CY1123496 T1 CY 1123496T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sdma
- detection
- dimethylarginine
- methods
- analogs
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Stereophonic System (AREA)
- Superheterodyne Receivers (AREA)
Abstract
Μέθοδος ανίχνευσης συμμετρικής διμεθυλαργινίνης (SDMA) σε βιολογικά δείγματα. Ανάλογα SDMA για τη δημιουργία αντι-SDMA αντισωμάτων που έχουν μικρή ή καθόλου διασταυρούμενη αντιδραστικότητα με την ασύμμετρη διμεθυλαργινίνη, την αργινίνη και τη μονομεθυλαργινίνη. Τα ανάλογα έχουν μία προστατευμένη ή ελεύθερη ομάδα θειόλης (-SH) ή ομάδα υδροξυλίου (-ΟΗ) που επιτρέπει σε αυτά να συνδέονται σε έναν κατάλληλο στόχο σύζευξης που μπορεί, για παράδειγμα, να είναι ένα μόριο που περιέχει μία πρωτεΐνη μίας επισήμανσης. Τα αντι-SDMA αντισώματα μπορεί να χρησιμοποιηθούν σε διαγνωστική ανοσοανίχνευση για τη διάγνωση διαταραχών και/ή νόσων σχετιζόμενων με SDMA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8687008P | 2008-08-07 | 2008-08-07 | |
PCT/US2009/052239 WO2010017089A1 (en) | 2008-08-07 | 2009-07-30 | Methods for detecting symmetrical demethylarginine |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1123496T1 true CY1123496T1 (el) | 2022-03-24 |
Family
ID=41016514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201101033T CY1123496T1 (el) | 2008-08-07 | 2020-11-02 | Μεθοδοι για την ανιχνευση συμμετρικης διμεθυλαργινινης |
Country Status (12)
Country | Link |
---|---|
US (5) | US8481690B2 (el) |
EP (2) | EP2313364B1 (el) |
CY (1) | CY1123496T1 (el) |
DK (1) | DK2313364T3 (el) |
ES (1) | ES2828097T3 (el) |
HR (1) | HRP20201734T1 (el) |
HU (1) | HUE051130T2 (el) |
LT (1) | LT2313364T (el) |
PL (1) | PL2313364T3 (el) |
PT (1) | PT2313364T (el) |
SI (1) | SI2313364T1 (el) |
WO (1) | WO2010017089A1 (el) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2828097T3 (es) * | 2008-08-07 | 2021-05-25 | Idexx Lab Inc | Métodos para detectar dimetilarginina simétrica |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
CN102628868B (zh) * | 2011-12-30 | 2014-09-17 | 北京九强生物技术股份有限公司 | 检测非对称二甲基精氨酸含量的胶乳增强免疫比浊法试剂盒 |
WO2015035155A1 (en) * | 2013-09-05 | 2015-03-12 | Idexx Laboratories, Inc. | Methods for detecting renal disease |
CA2977062A1 (en) * | 2015-02-20 | 2016-08-25 | Idexx Laboratories, Inc. | Homogenous immunoassay with compensation for background signal |
KR20200013721A (ko) | 2017-05-31 | 2020-02-07 | 마아즈, 인코오포레이티드 | 만성 신장병을 진단하고 치료하는 방법 |
TWI831753B (zh) * | 2017-10-19 | 2024-02-11 | 美商英代斯實驗公司 | 對稱性二甲基精胺酸之檢測 |
WO2020184660A1 (ja) * | 2019-03-13 | 2020-09-17 | 味の素株式会社 | サルコペニアの評価方法、算出方法、評価装置、算出装置、評価プログラム、算出プログラム、記録媒体、評価システム、及び端末装置 |
US10745492B1 (en) * | 2019-04-03 | 2020-08-18 | Ark Diagnostics, Inc. | Antibodies to symmetrically dimethylated arginine analytes and use thereof |
EP4025301A4 (en) | 2019-09-05 | 2023-07-19 | The Regents of the University of California | NON-INVASIVE METHOD FOR QUANTIFYING KIDNEY FUNCTION AND FUNCTIONAL DECLINE |
AU2021257257A1 (en) * | 2020-04-17 | 2022-10-20 | Idexx Laboratories, Inc. | Fluorescence quenching immunossay |
EP4302087A1 (en) * | 2021-03-02 | 2024-01-10 | IDEXX Laboratories, Inc. | Biochemical probes attached to epoxy-based resins |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0356160A3 (en) | 1988-08-24 | 1991-09-11 | The Board Of Trustees Of The Leland Stanford Junior University | Capillary device |
US5726010A (en) | 1991-07-31 | 1998-03-10 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
AU7269098A (en) | 1997-05-01 | 1998-11-24 | Cooke Pharma, Inc. | Cardiovascular disease risk assessment |
US6736957B1 (en) | 1997-10-16 | 2004-05-18 | Abbott Laboratories | Biosensor electrode mediators for regeneration of cofactors and process for using |
US6358699B1 (en) | 1999-02-05 | 2002-03-19 | Cooke Pharma | Assay for asymmetrical NG, NG dimethyl-l-arginine |
WO2001046221A1 (en) * | 1999-12-22 | 2001-06-28 | The Research Foundation Of State University Of New York | Protein methylarginine-specific antibodies |
JP2004502948A (ja) | 2000-07-06 | 2004-01-29 | ファル ダイアグノスティクス | アルギニン化合物の検出のための方法及びキット |
DE10040904A1 (de) | 2000-08-18 | 2002-02-28 | Boeger Rainer H | Verfahren und Mittel zum Nachweis einer Wahrscheinlichkeit zukünftigen Fortschreitens von Gefässerkrankungen |
US7501053B2 (en) | 2002-10-23 | 2009-03-10 | Abbott Laboratories | Biosensor having improved hematocrit and oxygen biases |
WO2004046314A2 (en) * | 2002-11-15 | 2004-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for detecting asymmetric dimethylarginine in a biological sample |
ES2332218T3 (es) * | 2004-11-04 | 2010-01-29 | Germediq Forschungs- Und Entwicklungsgesellschaft Mbh | Metodo para la determinacion de arginina, argininas metiladas y sus derivados. |
WO2006078813A2 (en) | 2005-01-21 | 2006-07-27 | Biosite Incorporated | Arginine analogs, and methods for their synthesis and use |
DE102005060057A1 (de) | 2005-12-15 | 2007-06-28 | Kellner, Karl-Heinz, Dr. | Sandwich-Immunoassay für kleine Haptenmoleküle |
JP2007176872A (ja) | 2005-12-28 | 2007-07-12 | Sentan Seimei Kagaku Kenkyusho:Kk | アシンメトリックジメチルアルギニンを認識する抗体及びその製造方法並びに翻訳後修飾アミノ酸含有タンパク質の検出方法 |
ES2828097T3 (es) * | 2008-08-07 | 2021-05-25 | Idexx Lab Inc | Métodos para detectar dimetilarginina simétrica |
-
2009
- 2009-07-30 ES ES09790996T patent/ES2828097T3/es active Active
- 2009-07-30 EP EP09790996.4A patent/EP2313364B1/en active Active
- 2009-07-30 US US12/512,479 patent/US8481690B2/en active Active
- 2009-07-30 WO PCT/US2009/052239 patent/WO2010017089A1/en active Application Filing
- 2009-07-30 LT LTEP09790996.4T patent/LT2313364T/lt unknown
- 2009-07-30 DK DK09790996.4T patent/DK2313364T3/da active
- 2009-07-30 HU HUE09790996A patent/HUE051130T2/hu unknown
- 2009-07-30 SI SI200932093T patent/SI2313364T1/sl unknown
- 2009-07-30 PT PT97909964T patent/PT2313364T/pt unknown
- 2009-07-30 EP EP20193595.4A patent/EP3808733A1/en active Pending
- 2009-07-30 PL PL09790996T patent/PL2313364T3/pl unknown
-
2013
- 2013-06-14 US US13/918,531 patent/US9091684B2/en active Active
-
2014
- 2014-02-28 US US14/192,956 patent/US9970927B2/en active Active
-
2018
- 2018-05-11 US US15/977,284 patent/US20180335423A1/en not_active Abandoned
-
2020
- 2020-10-28 HR HRP20201734TT patent/HRP20201734T1/hr unknown
- 2020-11-02 CY CY20201101033T patent/CY1123496T1/el unknown
-
2022
- 2022-03-28 US US17/705,924 patent/US20220221446A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20100035274A1 (en) | 2010-02-11 |
US9970927B2 (en) | 2018-05-15 |
LT2313364T (lt) | 2021-01-25 |
EP2313364B1 (en) | 2020-09-02 |
HRP20201734T1 (hr) | 2021-03-19 |
WO2010017089A1 (en) | 2010-02-11 |
PL2313364T3 (pl) | 2021-03-08 |
HUE051130T2 (hu) | 2021-03-01 |
US9091684B2 (en) | 2015-07-28 |
US20180335423A1 (en) | 2018-11-22 |
SI2313364T1 (sl) | 2021-01-29 |
US8481690B2 (en) | 2013-07-09 |
PT2313364T (pt) | 2020-11-10 |
EP2313364A1 (en) | 2011-04-27 |
ES2828097T3 (es) | 2021-05-25 |
US20140242723A1 (en) | 2014-08-28 |
EP3808733A1 (en) | 2021-04-21 |
US20220221446A1 (en) | 2022-07-14 |
DK2313364T3 (da) | 2020-11-02 |
US20130280740A1 (en) | 2013-10-24 |
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