CY1123496T1 - Μεθοδοι για την ανιχνευση συμμετρικης διμεθυλαργινινης - Google Patents

Μεθοδοι για την ανιχνευση συμμετρικης διμεθυλαργινινης

Info

Publication number
CY1123496T1
CY1123496T1 CY20201101033T CY201101033T CY1123496T1 CY 1123496 T1 CY1123496 T1 CY 1123496T1 CY 20201101033 T CY20201101033 T CY 20201101033T CY 201101033 T CY201101033 T CY 201101033T CY 1123496 T1 CY1123496 T1 CY 1123496T1
Authority
CY
Cyprus
Prior art keywords
sdma
detection
dimethylarginine
methods
analogs
Prior art date
Application number
CY20201101033T
Other languages
English (en)
Inventor
Yerramilli V.S.N. Murthy
Mahalakshmi Padmanabhan
Michael Atkinson
Kwok Kam Yeung
Original Assignee
Idexx Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41016514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1123496(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idexx Laboratories, Inc. filed Critical Idexx Laboratories, Inc.
Publication of CY1123496T1 publication Critical patent/CY1123496T1/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Stereophonic System (AREA)
  • Superheterodyne Receivers (AREA)

Abstract

Μέθοδος ανίχνευσης συμμετρικής διμεθυλαργινίνης (SDMA) σε βιολογικά δείγματα. Ανάλογα SDMA για τη δημιουργία αντι-SDMA αντισωμάτων που έχουν μικρή ή καθόλου διασταυρούμενη αντιδραστικότητα με την ασύμμετρη διμεθυλαργινίνη, την αργινίνη και τη μονομεθυλαργινίνη. Τα ανάλογα έχουν μία προστατευμένη ή ελεύθερη ομάδα θειόλης (-SH) ή ομάδα υδροξυλίου (-ΟΗ) που επιτρέπει σε αυτά να συνδέονται σε έναν κατάλληλο στόχο σύζευξης που μπορεί, για παράδειγμα, να είναι ένα μόριο που περιέχει μία πρωτεΐνη μίας επισήμανσης. Τα αντι-SDMA αντισώματα μπορεί να χρησιμοποιηθούν σε διαγνωστική ανοσοανίχνευση για τη διάγνωση διαταραχών και/ή νόσων σχετιζόμενων με SDMA.
CY20201101033T 2008-08-07 2020-11-02 Μεθοδοι για την ανιχνευση συμμετρικης διμεθυλαργινινης CY1123496T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8687008P 2008-08-07 2008-08-07
PCT/US2009/052239 WO2010017089A1 (en) 2008-08-07 2009-07-30 Methods for detecting symmetrical demethylarginine

Publications (1)

Publication Number Publication Date
CY1123496T1 true CY1123496T1 (el) 2022-03-24

Family

ID=41016514

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201101033T CY1123496T1 (el) 2008-08-07 2020-11-02 Μεθοδοι για την ανιχνευση συμμετρικης διμεθυλαργινινης

Country Status (12)

Country Link
US (5) US8481690B2 (el)
EP (2) EP2313364B1 (el)
CY (1) CY1123496T1 (el)
DK (1) DK2313364T3 (el)
ES (1) ES2828097T3 (el)
HR (1) HRP20201734T1 (el)
HU (1) HUE051130T2 (el)
LT (1) LT2313364T (el)
PL (1) PL2313364T3 (el)
PT (1) PT2313364T (el)
SI (1) SI2313364T1 (el)
WO (1) WO2010017089A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2828097T3 (es) * 2008-08-07 2021-05-25 Idexx Lab Inc Métodos para detectar dimetilarginina simétrica
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
CN102628868B (zh) * 2011-12-30 2014-09-17 北京九强生物技术股份有限公司 检测非对称二甲基精氨酸含量的胶乳增强免疫比浊法试剂盒
WO2015035155A1 (en) * 2013-09-05 2015-03-12 Idexx Laboratories, Inc. Methods for detecting renal disease
CA2977062A1 (en) * 2015-02-20 2016-08-25 Idexx Laboratories, Inc. Homogenous immunoassay with compensation for background signal
KR20200013721A (ko) 2017-05-31 2020-02-07 마아즈, 인코오포레이티드 만성 신장병을 진단하고 치료하는 방법
TWI831753B (zh) * 2017-10-19 2024-02-11 美商英代斯實驗公司 對稱性二甲基精胺酸之檢測
WO2020184660A1 (ja) * 2019-03-13 2020-09-17 味の素株式会社 サルコペニアの評価方法、算出方法、評価装置、算出装置、評価プログラム、算出プログラム、記録媒体、評価システム、及び端末装置
US10745492B1 (en) * 2019-04-03 2020-08-18 Ark Diagnostics, Inc. Antibodies to symmetrically dimethylated arginine analytes and use thereof
EP4025301A4 (en) 2019-09-05 2023-07-19 The Regents of the University of California NON-INVASIVE METHOD FOR QUANTIFYING KIDNEY FUNCTION AND FUNCTIONAL DECLINE
AU2021257257A1 (en) * 2020-04-17 2022-10-20 Idexx Laboratories, Inc. Fluorescence quenching immunossay
EP4302087A1 (en) * 2021-03-02 2024-01-10 IDEXX Laboratories, Inc. Biochemical probes attached to epoxy-based resins

Family Cites Families (15)

* Cited by examiner, † Cited by third party
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EP0356160A3 (en) 1988-08-24 1991-09-11 The Board Of Trustees Of The Leland Stanford Junior University Capillary device
US5726010A (en) 1991-07-31 1998-03-10 Idexx Laboratories, Inc. Reversible flow chromatographic binding assay
AU7269098A (en) 1997-05-01 1998-11-24 Cooke Pharma, Inc. Cardiovascular disease risk assessment
US6736957B1 (en) 1997-10-16 2004-05-18 Abbott Laboratories Biosensor electrode mediators for regeneration of cofactors and process for using
US6358699B1 (en) 1999-02-05 2002-03-19 Cooke Pharma Assay for asymmetrical NG, NG dimethyl-l-arginine
WO2001046221A1 (en) * 1999-12-22 2001-06-28 The Research Foundation Of State University Of New York Protein methylarginine-specific antibodies
JP2004502948A (ja) 2000-07-06 2004-01-29 ファル　ダイアグノスティクス アルギニン化合物の検出のための方法及びキット
DE10040904A1 (de) 2000-08-18 2002-02-28 Boeger Rainer H Verfahren und Mittel zum Nachweis einer Wahrscheinlichkeit zukünftigen Fortschreitens von Gefässerkrankungen
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WO2004046314A2 (en) * 2002-11-15 2004-06-03 The Board Of Trustees Of The Leland Stanford Junior University Methods for detecting asymmetric dimethylarginine in a biological sample
ES2332218T3 (es) * 2004-11-04 2010-01-29 Germediq Forschungs- Und Entwicklungsgesellschaft Mbh Metodo para la determinacion de arginina, argininas metiladas y sus derivados.
WO2006078813A2 (en) 2005-01-21 2006-07-27 Biosite Incorporated Arginine analogs, and methods for their synthesis and use
DE102005060057A1 (de) 2005-12-15 2007-06-28 Kellner, Karl-Heinz, Dr. Sandwich-Immunoassay für kleine Haptenmoleküle
JP2007176872A (ja) 2005-12-28 2007-07-12 Sentan Seimei Kagaku Kenkyusho:Kk アシンメトリックジメチルアルギニンを認識する抗体及びその製造方法並びに翻訳後修飾アミノ酸含有タンパク質の検出方法
ES2828097T3 (es) * 2008-08-07 2021-05-25 Idexx Lab Inc Métodos para detectar dimetilarginina simétrica

Also Published As

Publication number Publication date
US20100035274A1 (en) 2010-02-11
US9970927B2 (en) 2018-05-15
LT2313364T (lt) 2021-01-25
EP2313364B1 (en) 2020-09-02
HRP20201734T1 (hr) 2021-03-19
WO2010017089A1 (en) 2010-02-11
PL2313364T3 (pl) 2021-03-08
HUE051130T2 (hu) 2021-03-01
US9091684B2 (en) 2015-07-28
US20180335423A1 (en) 2018-11-22
SI2313364T1 (sl) 2021-01-29
US8481690B2 (en) 2013-07-09
PT2313364T (pt) 2020-11-10
EP2313364A1 (en) 2011-04-27
ES2828097T3 (es) 2021-05-25
US20140242723A1 (en) 2014-08-28
EP3808733A1 (en) 2021-04-21
US20220221446A1 (en) 2022-07-14
DK2313364T3 (da) 2020-11-02
US20130280740A1 (en) 2013-10-24

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