CY1123262T1 - Αναστολεας metaφopea aλatoς natpioy oypikoy oξeoς kai kpyσtaλλikh mopφh aytoy - Google Patents
Αναστολεας metaφopea aλatoς natpioy oypikoy oξeoς kai kpyσtaλλikh mopφh aytoyInfo
- Publication number
- CY1123262T1 CY1123262T1 CY20201100720T CY201100720T CY1123262T1 CY 1123262 T1 CY1123262 T1 CY 1123262T1 CY 20201100720 T CY20201100720 T CY 20201100720T CY 201100720 T CY201100720 T CY 201100720T CY 1123262 T1 CY1123262 T1 CY 1123262T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitor
- oypikoy
- natpioy
- mopfh
- metafopea
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά ένα άλας νατρίου του αναστολέα μεταφορέα ουρικού οξέος και την κρυσταλλική μορφή αυτού. Συγκεκριμένα, η παρούσα εφεύρεση αφορά το άλας νατρίου ενός αναστολέα μεταφορέα ουρικού οξέος (URAT1) και τον κρύσταλλο τύπου Ι και τη μέθοδο παρασκευής αυτού. Η παρούσα εφεύρεση αφορά μυρμηκικό 1-((6-βρωμο-κινολιν-4-υλ)θειο)κυκλοβουτυλονάτριο (την ένωση του τύπου (Ι)), και τον κρύσταλλο τύπου Ι και τη μέθοδο παρασκευής αυτού. Ο κρύσταλλος τύπου Ι της ένωσης του τύπου (Ι) που λαμβάνεται στην παρούσα εφεύρεση έχει μία καλή σταθερότητα κρυσταλλικής μορφής και χημική σταθερότητα, και ο διαλύτης κρυστάλλωσης που χρησιμοποιείται έχει μία χαμηλή τοξικότητα και χαμηλό υπόλοιπο, και μπορεί να χρησιμοποιείται καλύτερα στην κλινική αγωγή.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510280720 | 2015-05-27 | ||
| PCT/CN2016/083423 WO2016188444A1 (zh) | 2015-05-27 | 2016-05-26 | 一种尿酸转运蛋白抑制剂的钠盐及其结晶形式 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123262T1 true CY1123262T1 (el) | 2021-12-31 |
Family
ID=57393793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100720T CY1123262T1 (el) | 2015-05-27 | 2020-08-04 | Αναστολεας metaφopea aλatoς natpioy oypikoy oξeoς kai kpyσtaλλikh mopφh aytoy |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10196361B2 (el) |
| EP (1) | EP3305768B1 (el) |
| JP (1) | JP6738350B2 (el) |
| KR (1) | KR20180006441A (el) |
| CN (1) | CN107001276B (el) |
| AU (1) | AU2016269359B2 (el) |
| BR (1) | BR112017022505A2 (el) |
| CA (1) | CA2984961C (el) |
| CY (1) | CY1123262T1 (el) |
| DK (1) | DK3305768T3 (el) |
| ES (1) | ES2811325T3 (el) |
| HR (1) | HRP20201178T1 (el) |
| HU (1) | HUE051640T2 (el) |
| LT (1) | LT3305768T (el) |
| MX (1) | MX2017014319A (el) |
| PL (1) | PL3305768T3 (el) |
| PT (1) | PT3305768T (el) |
| RS (1) | RS60749B1 (el) |
| RU (1) | RU2719484C2 (el) |
| SI (1) | SI3305768T1 (el) |
| WO (1) | WO2016188444A1 (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2811325T3 (es) * | 2015-05-27 | 2021-03-11 | Jiangsu Hengrui Medicine Co | Sal de sodio del inhibidor del transportador de ácido úrico y de su forma cristalina |
| CN108201529B (zh) * | 2016-12-16 | 2021-10-08 | 江苏恒瑞医药股份有限公司 | 一种含有尿酸转运蛋白抑制剂的药物组合物及其制备方法 |
| CN110467571B (zh) * | 2018-05-11 | 2021-02-26 | 江苏恒瑞医药股份有限公司 | 一种制备环烷基甲酸类衍生物或其可药用盐的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| BR112015027303B1 (pt) * | 2013-05-13 | 2023-04-25 | Jiangsu Hengrui Medicine Co.,Ltd. | Derivado de ácido de cicloalquila, método de preparação do mesmo, e aplicação farmacêutica do mesmo |
| ES2811325T3 (es) * | 2015-05-27 | 2021-03-11 | Jiangsu Hengrui Medicine Co | Sal de sodio del inhibidor del transportador de ácido úrico y de su forma cristalina |
-
2016
- 2016-05-26 ES ES16799331T patent/ES2811325T3/es active Active
- 2016-05-26 DK DK16799331.0T patent/DK3305768T3/da active
- 2016-05-26 PT PT167993310T patent/PT3305768T/pt unknown
- 2016-05-26 BR BR112017022505-0A patent/BR112017022505A2/pt not_active Application Discontinuation
- 2016-05-26 LT LTEP16799331.0T patent/LT3305768T/lt unknown
- 2016-05-26 KR KR1020177035949A patent/KR20180006441A/ko not_active Application Discontinuation
- 2016-05-26 EP EP16799331.0A patent/EP3305768B1/en active Active
- 2016-05-26 HU HUE16799331A patent/HUE051640T2/hu unknown
- 2016-05-26 US US15/574,328 patent/US10196361B2/en active Active
- 2016-05-26 CA CA2984961A patent/CA2984961C/en active Active
- 2016-05-26 AU AU2016269359A patent/AU2016269359B2/en active Active
- 2016-05-26 SI SI201630871T patent/SI3305768T1/sl unknown
- 2016-05-26 JP JP2017555478A patent/JP6738350B2/ja active Active
- 2016-05-26 CN CN201680003846.8A patent/CN107001276B/zh active Active
- 2016-05-26 RU RU2017142996A patent/RU2719484C2/ru active
- 2016-05-26 WO PCT/CN2016/083423 patent/WO2016188444A1/zh active Application Filing
- 2016-05-26 PL PL16799331T patent/PL3305768T3/pl unknown
- 2016-05-26 MX MX2017014319A patent/MX2017014319A/es unknown
- 2016-05-26 RS RS20200924A patent/RS60749B1/sr unknown
-
2018
- 2018-10-11 US US16/157,696 patent/US10358424B2/en active Active
-
2020
- 2020-07-28 HR HRP20201178TT patent/HRP20201178T1/hr unknown
- 2020-08-04 CY CY20201100720T patent/CY1123262T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN107001276A (zh) | 2017-08-01 |
| BR112017022505A2 (pt) | 2018-07-17 |
| RU2719484C2 (ru) | 2020-04-17 |
| JP6738350B2 (ja) | 2020-08-12 |
| AU2016269359A1 (en) | 2017-11-23 |
| CA2984961C (en) | 2023-08-01 |
| RU2017142996A (ru) | 2019-06-27 |
| DK3305768T3 (da) | 2020-08-10 |
| US10358424B2 (en) | 2019-07-23 |
| WO2016188444A1 (zh) | 2016-12-01 |
| ES2811325T3 (es) | 2021-03-11 |
| US20190040015A1 (en) | 2019-02-07 |
| MX2017014319A (es) | 2018-03-07 |
| SI3305768T1 (sl) | 2020-10-30 |
| RS60749B1 (sr) | 2020-10-30 |
| RU2017142996A3 (el) | 2019-11-20 |
| CA2984961A1 (en) | 2016-12-01 |
| JP2018515454A (ja) | 2018-06-14 |
| EP3305768B1 (en) | 2020-07-01 |
| HUE051640T2 (hu) | 2021-03-01 |
| AU2016269359B2 (en) | 2020-02-06 |
| EP3305768A1 (en) | 2018-04-11 |
| US20180134663A1 (en) | 2018-05-17 |
| CN107001276B (zh) | 2020-03-13 |
| US10196361B2 (en) | 2019-02-05 |
| HRP20201178T1 (hr) | 2020-11-13 |
| PL3305768T3 (pl) | 2020-12-28 |
| EP3305768A4 (en) | 2019-02-13 |
| PT3305768T (pt) | 2020-08-03 |
| LT3305768T (lt) | 2020-08-25 |
| KR20180006441A (ko) | 2018-01-17 |
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