CY1123003T1 - Εκλεκτικα απογλυκοζυλιωμενη πρωτεϊνη δεσμευσης βιταμινης d (gcmaf) και χοληκαλσιφερολη (calciol) καθως επισης μεθοδος παρασκευης - Google Patents

Εκλεκτικα απογλυκοζυλιωμενη πρωτεϊνη δεσμευσης βιταμινης d (gcmaf) και χοληκαλσιφερολη (calciol) καθως επισης μεθοδος παρασκευης

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Publication number
CY1123003T1
CY1123003T1 CY20201100471T CY201100471T CY1123003T1 CY 1123003 T1 CY1123003 T1 CY 1123003T1 CY 20201100471 T CY20201100471 T CY 20201100471T CY 201100471 T CY201100471 T CY 201100471T CY 1123003 T1 CY1123003 T1 CY 1123003T1
Authority
CY
Cyprus
Prior art keywords
calciol
binding protein
gcmaf
cholecalciferol
preparation
Prior art date
Application number
CY20201100471T
Other languages
English (en)
Inventor
Ralf Herwig
Joachim Greilberger
Original Assignee
Hg Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hg Pharma Gmbh filed Critical Hg Pharma Gmbh
Publication of CY1123003T1 publication Critical patent/CY1123003T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1722—Plasma globulins, lactoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση αφορά ένα διμερές σύμπλοκο από εκλεκτικά απογλυκοζυλιωμένη πρωτεΐνη δέσμευσης βιταμίνης D (GcMAF) και χοληκαλσιφερόλη (Calciol). Επιπλέον η εφεύρεση αφορά μία μέθοδο για την παρασκευή ενός τέτοιου συμπλόκου στο οποίο φέρεται σε αντίδραση η πρωτεΐνη δέσμευσης βιταμίνης D με Calciol και προηγουμένως ή ακολούθως διεξάγεται εκλεκτική απογλυκοζυλίωση, όπου τελικά το προκύπτον προϊόν διαχωρίζεται με ένα μοριακό κόσκινο με μία τιμή ορίου διαχωρισμού μεγαλύτερη από 60 kDa από ακαθαρσίες με μεγαλύτερο μοριακό βάρος, ειδικότερα από ένζυμα της εκλεκτικής απογλυκοζυλίωσης.
CY20201100471T 2016-04-21 2020-05-22 Εκλεκτικα απογλυκοζυλιωμενη πρωτεϊνη δεσμευσης βιταμινης d (gcmaf) και χοληκαλσιφερολη (calciol) καθως επισης μεθοδος παρασκευης CY1123003T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA50354/2016A AT518622A1 (de) 2016-04-21 2016-04-21 Dimerer Komplex aus selektiv deglycosyliertem Vitamin D bindenden Protein (GcMAF) und Cholecalciferol (Calciol) und Verfahren zu dessen Herstellung
PCT/AT2017/060104 WO2017181213A1 (de) 2016-04-21 2017-04-21 Selektiv deglycosiliertes vitamin d bindendes protein (gcmaf) und cholecalciferol (calciol) sowie herstellungsverfahren

Publications (1)

Publication Number Publication Date
CY1123003T1 true CY1123003T1 (el) 2021-10-29

Family

ID=58707253

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100471T CY1123003T1 (el) 2016-04-21 2020-05-22 Εκλεκτικα απογλυκοζυλιωμενη πρωτεϊνη δεσμευσης βιταμινης d (gcmaf) και χοληκαλσιφερολη (calciol) καθως επισης μεθοδος παρασκευης

Country Status (13)

Country Link
US (1) US20190134064A1 (el)
EP (1) EP3445777B1 (el)
JP (1) JP6862536B2 (el)
CN (1) CN109415428B (el)
AT (1) AT518622A1 (el)
AU (1) AU2017254728B2 (el)
CA (1) CA3021701A1 (el)
CY (1) CY1123003T1 (el)
ES (1) ES2794791T3 (el)
HU (1) HUE049818T2 (el)
PL (1) PL3445777T3 (el)
PT (1) PT3445777T (el)
WO (1) WO2017181213A1 (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT521556A1 (de) * 2018-07-24 2020-02-15 Hg Pharma Gmbh Vitamin D bindendes Protein

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177001A (en) * 1989-11-20 1993-01-05 Nobuto Yamamoto In vitro enzymatic conversion of glycosylated mammalian vitamin D-binding protein to a potent macrophage activating factor
US6410269B1 (en) * 1995-06-07 2002-06-25 Nobuto Yamamoto Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis
AU2001261378B2 (en) * 2000-05-09 2005-03-17 Children's Medical Center Corporation Method and composition for the treatment of angiogenesis
US7754693B2 (en) * 2006-02-16 2010-07-13 Young Hee Ko Composition and method for the efficacious and safe administration of halopyruvate for the treatment of cancer
CA2832487A1 (en) * 2011-04-07 2012-10-11 Efranat Ltd. Macrophage activating factor for pharmaceutical compositions
WO2014202956A1 (en) * 2013-06-21 2014-12-24 Noakes, David Vitamin d complexes with de-vdbp and an unsaturated fatty acid, and their use in therapy

Also Published As

Publication number Publication date
ES2794791T3 (es) 2020-11-19
PL3445777T3 (pl) 2020-08-10
PT3445777T (pt) 2020-05-29
HUE049818T2 (hu) 2020-10-28
US20190134064A1 (en) 2019-05-09
JP6862536B2 (ja) 2021-04-21
CN109415428A (zh) 2019-03-01
CA3021701A1 (en) 2017-10-26
CN109415428B (zh) 2022-03-29
EP3445777B1 (de) 2020-02-26
AU2017254728B2 (en) 2021-08-26
WO2017181213A1 (de) 2017-10-26
AT518622A1 (de) 2017-11-15
JP2019515953A (ja) 2019-06-13
AU2017254728A1 (en) 2018-12-06
EP3445777A1 (de) 2019-02-27

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CY1123003T1 (el) Εκλεκτικα απογλυκοζυλιωμενη πρωτεϊνη δεσμευσης βιταμινης d (gcmaf) και χοληκαλσιφερολη (calciol) καθως επισης μεθοδος παρασκευης