CY1122645T1 - Oyρεθανες, ουριες, αμιδινες και σχετικοι αναστολεις του παραγοντα χα - Google Patents
Oyρεθανες, ουριες, αμιδινες και σχετικοι αναστολεις του παραγοντα χαInfo
- Publication number
- CY1122645T1 CY1122645T1 CY20191101032T CY191101032T CY1122645T1 CY 1122645 T1 CY1122645 T1 CY 1122645T1 CY 20191101032 T CY20191101032 T CY 20191101032T CY 191101032 T CY191101032 T CY 191101032T CY 1122645 T1 CY1122645 T1 CY 1122645T1
- Authority
- CY
- Cyprus
- Prior art keywords
- factor
- congestion
- compounds
- pharmaceutically acceptable
- urethans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η εφεύρεση αφορά σε μία νέα κατηγορία ενώσεων, φαρμακευτικώς αποδεκτά άλατα αυτών και φαρμακευτικώς αποδεκτές συνθέσεις που είναι αποτελεσματικές ως εκλεκτικοί αναστολείς του παράγοντα Xa, τόσο στην απομονωθείσα κατάσταση όσο και σε ένα σύμπλοκο με άλλες πρωτεΐνες. Οι ενώσεις της εφεύρεσης μπορεί να χρησιμοποιηθούν για θεραπεία και αποτροπή ασθενειών όπως οξέος στεφανιαίου συνδρόμου, μυοκαρδιακής απόφραξης, ασταθούς στηθάγχης, αθεράπευτης στηθάγχης, θρομβώσεων που προκαλούνται από μεταθρομβολυτική θεραπεία ή αγγειοπλαστική της στεφανιαίας, προκαλούμενο από οξεία ισχαιμία εγκεφαλοαγγειακό σύνδρομο, εμβολική συμφόρηση, θρομβωτική συμφόρηση και άλλες ασθένειες σε ανθρώπους και άλλα θηλαστικά που συνδυάζονται με προβλήματα πήξης αίματος.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EA201000506A EA015918B1 (ru) | 2010-03-03 | 2010-03-03 | УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa |
| PCT/RU2011/000129 WO2011108963A1 (en) | 2010-03-03 | 2011-03-02 | Urethanes, ureas, amidines and related inhibitors of factor xa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122645T1 true CY1122645T1 (el) | 2021-03-12 |
Family
ID=44542428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191101032T CY1122645T1 (el) | 2010-03-03 | 2019-10-03 | Oyρεθανες, ουριες, αμιδινες και σχετικοι αναστολεις του παραγοντα χα |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9708265B2 (el) |
| EP (1) | EP2542529B1 (el) |
| JP (1) | JP6078707B2 (el) |
| KR (1) | KR101771760B1 (el) |
| CN (1) | CN102971294B (el) |
| AU (1) | AU2011221601B2 (el) |
| BR (1) | BR112012021884B8 (el) |
| CA (1) | CA2791875C (el) |
| CY (1) | CY1122645T1 (el) |
| DK (1) | DK2542529T3 (el) |
| EA (1) | EA015918B1 (el) |
| HK (1) | HK1182700A1 (el) |
| HR (1) | HRP20192125T1 (el) |
| HU (1) | HUE047249T2 (el) |
| IL (1) | IL221727A (el) |
| LT (1) | LT2542529T (el) |
| MX (1) | MX2012009976A (el) |
| NZ (1) | NZ602769A (el) |
| PL (1) | PL2542529T3 (el) |
| PT (1) | PT2542529T (el) |
| SI (1) | SI2542529T1 (el) |
| UA (1) | UA107106C2 (el) |
| WO (1) | WO2011108963A1 (el) |
| ZA (1) | ZA201207345B (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014003153A1 (ja) * | 2012-06-28 | 2014-01-03 | 協和発酵キリン株式会社 | 置換アミド化合物 |
| RU2698202C2 (ru) * | 2016-06-01 | 2019-08-23 | Закрытое акционерное общество "ФАРМА ВАМ" | СПОСОБ ПОЛУЧЕНИЯ ПРЯМОГО ИНГИБИТОРА ФАКТОРА Ха |
| EA030138B1 (ru) * | 2016-06-15 | 2018-06-29 | Общество С Ограниченной Ответственностью "Фармадиол" | Фармацевтические композиции, включающие антикоагулянт n-(5-хлорпиридин-2-ил)-2-({4-[этанимидоил(метил)амино]бензоил}амино)-5-метилбензамид |
| RU2659161C1 (ru) | 2017-11-17 | 2018-06-28 | Общество С Ограниченной Ответственностью "Ива Фарм" | Фармацевтическая композиция, включающая дисульфид глутатиона и глутатион дисульфид s-оксид |
| EA032764B1 (ru) * | 2018-01-19 | 2019-07-31 | Общество С Ограниченной Ответственностью "Фармадиол" | НОВЫЕ АМИДИНЫ - ИНГИБИТОРЫ ФАКТОРА Xa |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588587A (en) | 1983-03-01 | 1986-05-13 | Pennsylvania Hospital | Method of treatment to inhibit metastasis |
| US5869501A (en) | 1994-12-02 | 1999-02-09 | Yamanouchi Pharmaceutical Co. Ltd | Amidinonaphthyl derivative or salt thereof |
| US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| ATE443698T1 (de) | 1996-12-23 | 2009-10-15 | Bristol Myers Squibb Pharma Co | Stickstoffhaltige heterocyclen als faktor xa- hemmer |
| AU8747598A (en) | 1997-08-27 | 1999-03-16 | Kissei Pharmaceutical Co. Ltd. | 3-amidinoaniline derivatives, activated blood coagulation factor x inhibitors, and intermediates for producing both |
| AU780787B2 (en) * | 1999-09-17 | 2005-04-14 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| AU2108601A (en) * | 1999-12-15 | 2001-06-25 | Axys Pharmaceuticals, Inc. | Salicylamides as serine protease inhibitors |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DK1259485T3 (da) | 2000-02-29 | 2006-04-10 | Millennium Pharm Inc | Benzamider og beslægtede inhibitorer for faktor Xa |
| DE10063008A1 (de) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
| TWI331526B (en) | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
| AU2002350217A1 (en) * | 2001-12-04 | 2003-06-17 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
| JPWO2006070878A1 (ja) * | 2004-12-28 | 2008-06-12 | アステラス製薬株式会社 | カルボン酸誘導体またはその塩 |
| DE102005042583A1 (de) * | 2005-09-08 | 2007-03-15 | Bayer Healthcare Ag | Iminooxazolidin-Derivate und ihre Verwendung |
| US7598276B2 (en) * | 2005-11-08 | 2009-10-06 | Millenium Pharmaceuticals, Inc. | Pharmaceutical salts and polymorphs of a factor Xa inhibitor |
| WO2008073670A2 (en) * | 2006-12-08 | 2008-06-19 | Millennium Pharmaceuticals, Inc. | Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor |
-
2010
- 2010-03-03 EA EA201000506A patent/EA015918B1/ru unknown
-
2011
- 2011-02-03 UA UAA201211358A patent/UA107106C2/ru unknown
- 2011-03-02 NZ NZ602769A patent/NZ602769A/en unknown
- 2011-03-02 SI SI201131816T patent/SI2542529T1/sl unknown
- 2011-03-02 CN CN201180011928.4A patent/CN102971294B/zh active Active
- 2011-03-02 CA CA2791875A patent/CA2791875C/en active Active
- 2011-03-02 PT PT117509828T patent/PT2542529T/pt unknown
- 2011-03-02 EP EP11750982.8A patent/EP2542529B1/en active Active
- 2011-03-02 BR BR112012021884A patent/BR112012021884B8/pt active IP Right Grant
- 2011-03-02 DK DK11750982.8T patent/DK2542529T3/da active
- 2011-03-02 MX MX2012009976A patent/MX2012009976A/es active IP Right Grant
- 2011-03-02 LT LT11750982T patent/LT2542529T/lt unknown
- 2011-03-02 KR KR1020127025881A patent/KR101771760B1/ko active IP Right Grant
- 2011-03-02 WO PCT/RU2011/000129 patent/WO2011108963A1/en active Application Filing
- 2011-03-02 AU AU2011221601A patent/AU2011221601B2/en active Active
- 2011-03-02 JP JP2012556036A patent/JP6078707B2/ja active Active
- 2011-03-02 HU HUE11750982A patent/HUE047249T2/hu unknown
- 2011-03-02 PL PL11750982T patent/PL2542529T3/pl unknown
-
2012
- 2012-08-30 IL IL221727A patent/IL221727A/en active IP Right Grant
- 2012-08-30 US US13/599,038 patent/US9708265B2/en active Active
- 2012-10-01 ZA ZA2012/07345A patent/ZA201207345B/en unknown
-
2013
- 2013-08-26 HK HK13109973.7A patent/HK1182700A1/xx unknown
-
2019
- 2019-10-03 CY CY20191101032T patent/CY1122645T1/el unknown
- 2019-11-26 HR HRP20192125TT patent/HRP20192125T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1122645T1 (el) | Oyρεθανες, ουριες, αμιδινες και σχετικοι αναστολεις του παραγοντα χα | |
| CY1123504T1 (el) | Αντιδοτα για τους αναστολεις του παραγοντα χα και μεθοδοι χρησεως αυτων | |
| CY1121695T1 (el) | Ενωσεις και συνθεσεις ως αναστολεις κινασης c-kit | |
| CY1125436T1 (el) | Αναστολεις dna-pk | |
| CY1122740T1 (el) | Ευτηκτικα σκευασματα υδροχλωρικης κυκλοβενζαπρινης και μαννιτολης | |
| CY1124959T1 (el) | Αναστολεις λυσινης ειδικης απομεθυλασης-1 | |
| CY1108087T1 (el) | ΠΑΡΑΓΩΓΑ ΙΜΙΔΑΖΟΛΙΟΥ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΟΥ TAFIa | |
| CY1119167T1 (el) | Αναστολεις toy nkcc για τη θεραπεια του αυτισμου | |
| CY1119004T1 (el) | Διϋδροπυριδονη p1 ως αναστολεις τελεστη χια | |
| CY1122895T1 (el) | Στερεες μορφες 3-(6-(1-(2,2-διφθοροβενζο[d][1,3]διοξολ-5-υλο)-κυκλοπροπανοκαρβοξαμιδο)-3-μεθυλοπυριδιν-3-υλο)-βενζοϊκου οξεος | |
| CY1124407T1 (el) | Ενωσεις αναστολεα αυτοταξινης | |
| CY1124858T1 (el) | Σαλικυλαμιδια σπειροεπτανιου και σχετικες ενωσεις ως αναστολεις του rock | |
| CY1121040T1 (el) | Aντιικη θεραπεια | |
| CY1123811T1 (el) | Κρυσταλλικη μορφη αναστολεα pde4 | |
| CY1119546T1 (el) | Συνδυαστικη θεραπεια υποκατεστημενης οξαζολιδινονης | |
| CY1117678T1 (el) | Ενωσεις αναστολεων μεταλλοενζυμου | |
| CY1117204T1 (el) | ΕΝΩΣΕΙΣ ΤΡΙΑΖΟΛΟΝΗΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ mPGES-1 | |
| CY1118125T1 (el) | Αναστολεις ιβατ για τη θεραπεια ηπατικων νοσων | |
| CY1120751T1 (el) | Αναστολεις ετεροδικυκλοαρυλιου του rorc2 και μεθοδοι χρησης αυτων | |
| BR112015000704A2 (pt) | imidazotriazinacarbonitrilas úteis como inibidores de quinase | |
| CY1119489T1 (el) | Υποκατεστημενη πιπεριδυλο-αιθυλο-πυριμιδινη ως αναστολεας της ο-ακυλο τρανσφερασης της γκρελινης | |
| CY1122670T1 (el) | Παρασκευη παρασκευασματος και παρασκευασμα που περιλαμβανει αναστολεα μεκ | |
| BR112018001478A2 (pt) | anticorpos do inibidor da via do fator de tecidos e uso dos mesmos | |
| CY1117654T1 (el) | Πολυαιθυλενογλυκολιωμενη απελινη και χρησεις αυτης | |
| CY1119599T1 (el) | Μορια αντισωματων δεσμευσης-θρομβινης και χρησεις εξ’ αυτων |