CY1121753T1 - Μεθοδοι για την παραγωγη εγκαψυλιωμενου κοκκωδους υλικου, μεθοδοι για την ξηρανση υλικων επικαλυψης και ξηραντηρια ρευστοποιημενης κλινης - Google Patents

Μεθοδοι για την παραγωγη εγκαψυλιωμενου κοκκωδους υλικου, μεθοδοι για την ξηρανση υλικων επικαλυψης και ξηραντηρια ρευστοποιημενης κλινης

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Publication number
CY1121753T1
CY1121753T1 CY20191100469T CY191100469T CY1121753T1 CY 1121753 T1 CY1121753 T1 CY 1121753T1 CY 20191100469 T CY20191100469 T CY 20191100469T CY 191100469 T CY191100469 T CY 191100469T CY 1121753 T1 CY1121753 T1 CY 1121753T1
Authority
CY
Cyprus
Prior art keywords
methods
fluidized bed
coating
drying
water content
Prior art date
Application number
CY20191100469T
Other languages
English (en)
Inventor
Naoji SAWAGUCHI
Yuji Amano
Yuichiro Sakurai
Original Assignee
R.P. Scherer Technologies, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R.P. Scherer Technologies, Llc filed Critical R.P. Scherer Technologies, Llc
Publication of CY1121753T1 publication Critical patent/CY1121753T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/18—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles
    • B01J8/24—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles according to "fluidised-bed" technique
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/06—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried
    • F26B3/08—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried so as to loosen them, e.g. to form a fluidised bed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Combustion & Propulsion (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
  • Glanulating (AREA)

Abstract

Αποκαλύπτεται μία μέθοδος για τη μείωση του χρόνου ξήρανσης για την ξήρανση ενός εγκαψυλιωμένου υλικού όπου συμπεριλαμβάνεται ένα υλικό επικάλυψης το οποίο περιέχει νερό χωρίς να προκαλείται παραμόρφωση της επικάλυψης κατά την ξήρανση. Η μέθοδος χρησιμοποιεί ένα ξηραντήριο ρευστοποιημένης κλίνης, για την ξήρανση υλικών επικάλυψης που περιέχουν νερό και που σχηματίζουν μία επικάλυψη όταν το νερό εξατμίζεται. Ένα πρώτο βήμα ξήρανσης περιλαμβάνει επίπλευση και ρευστοποίηση του εγκαψυλιωμένου υλικού και περιορισμό μίας θεωρητικής περιεκτικότητας νερού που εξατμίζεται ΔW ούτως ώστε να μην δημιουργούνται εσοχές ή παραμορφώσεις στην επικάλυψη του εγκαψυλιωμένου κοκκώδους υλικού, ενώ μετράται μία περιεκτικότητα νερού ή θερμοκρασία του εξερχόμενου αερίου από το ξηραντήριο ρευστοποιημένης κλίνης• και ένα δεύτερο βήμα ξήρανσης που εκτελείται μετά τη μείωση της μετρηθείσας περιεκτικότητας νερού κάτω από μία προδιαγεγραμμένη ποσότητα ή την αύξηση της μετρηθείσας θερμοκρασίας, του αερίου εμφύσησης στο ξηραντήριο ρευστοποιημένης κλίνης έτσι ώστε η θεωρητική περιεκτικότητα νερού που εξατμίζεται ΔW να αυξάνεται πάνω από αυτήν κατά τη διάρκεια του πρώτου βήματος ξήρανσης.
CY20191100469T 2014-06-26 2019-05-03 Μεθοδοι για την παραγωγη εγκαψυλιωμενου κοκκωδους υλικου, μεθοδοι για την ξηρανση υλικων επικαλυψης και ξηραντηρια ρευστοποιημενης κλινης CY1121753T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2014/044319 WO2015199696A1 (en) 2014-06-26 2014-06-26 Methods for manufacturing encapsulated granular material, methods for drying coating materials, and fluidized bed dryers

Publications (1)

Publication Number Publication Date
CY1121753T1 true CY1121753T1 (el) 2020-07-31

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ID=54938607

Family Applications (1)

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CY20191100469T CY1121753T1 (el) 2014-06-26 2019-05-03 Μεθοδοι για την παραγωγη εγκαψυλιωμενου κοκκωδους υλικου, μεθοδοι για την ξηρανση υλικων επικαλυψης και ξηραντηρια ρευστοποιημενης κλινης

Country Status (13)

Country Link
US (1) US10278898B2 (el)
EP (1) EP3160420B1 (el)
CN (1) CN106659636B (el)
AU (1) AU2014398634B2 (el)
BR (1) BR112016030274B1 (el)
CA (1) CA2953660C (el)
CY (1) CY1121753T1 (el)
DK (1) DK3160420T3 (el)
ES (1) ES2726902T3 (el)
HU (1) HUE043071T2 (el)
PT (1) PT3160420T (el)
SI (1) SI3160420T1 (el)
WO (1) WO2015199696A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11718901B2 (en) * 2016-05-30 2023-08-08 Sumitomo Electric Industries, Ltd. Method for producing coated magnetic powder, method for producing dust core, and method for producing electromagnetic component
CN111780496B (zh) * 2020-05-29 2022-02-15 浙江工业大学 一种维生素d3微胶囊生产中的喷雾造粒干燥联用装置
CN111780495B (zh) * 2020-05-29 2022-03-25 浙江工业大学 一种连续生产维生素d3微胶囊粉的闭路循环工艺
DE102020208204B3 (de) * 2020-07-01 2021-06-24 Glatt Gesellschaft Mit Beschränkter Haftung Verfahren und Fluidisierungsapparateeinheit zur Behandlung einer Vielzahl an Chargen eines eine Feuchte aufweisenden Gutes
WO2024028346A1 (en) * 2022-08-01 2024-02-08 Franz Dietrich Oeste A photocatalytic aerosol, its production and usage thereof

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US4051075A (en) 1974-05-10 1977-09-27 Raychem Corporation Coated particles and conductive compositions therefrom
EP0573978B1 (en) * 1992-06-12 1999-04-21 Kao Corporation Bath additive composition comprising surfactant-containing seamless capsules and method for producing the capsules.
DE10164110A1 (de) * 2001-12-24 2003-07-10 Dragoco Gerberding Co Ag Mononuklear gefüllte Mikrokapseln
JP2004262774A (ja) * 2003-02-20 2004-09-24 Freunt Ind Co Ltd シームレスカプセル
EP1690518A4 (en) 2003-11-07 2008-12-31 Freund Corp METHOD OF PRODUCING A SEAMLESS CAPSULE, MANUFACTURING DEVICE FOR A SEAMLESS CAPSULE AND SEAMLESS CAPSULE
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US8621764B2 (en) * 2011-03-16 2014-01-07 John PUCKETT Gelatin capsule formulation and drying system
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Also Published As

Publication number Publication date
ES2726902T3 (es) 2019-10-10
AU2014398634B2 (en) 2019-08-22
PT3160420T (pt) 2019-05-31
CA2953660C (en) 2021-05-04
US10278898B2 (en) 2019-05-07
EP3160420B1 (en) 2019-04-03
SI3160420T1 (sl) 2019-06-28
CA2953660A1 (en) 2015-12-30
WO2015199696A1 (en) 2015-12-30
HUE043071T2 (hu) 2019-08-28
US20170151130A1 (en) 2017-06-01
BR112016030274A2 (pt) 2017-08-22
AU2014398634A1 (en) 2017-01-12
CN106659636A (zh) 2017-05-10
BR112016030274B1 (pt) 2021-01-26
EP3160420A4 (en) 2018-03-07
DK3160420T3 (da) 2019-05-06
EP3160420A1 (en) 2017-05-03
CN106659636B (zh) 2019-10-08

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