CY1121632T1 - Η rv2386c πρωτεϊνη φυματιωσης, συνθεσεις και χρησεις αυτης - Google Patents
Η rv2386c πρωτεϊνη φυματιωσης, συνθεσεις και χρησεις αυτηςInfo
- Publication number
- CY1121632T1 CY1121632T1 CY20181100883T CY181100883T CY1121632T1 CY 1121632 T1 CY1121632 T1 CY 1121632T1 CY 20181100883 T CY20181100883 T CY 20181100883T CY 181100883 T CY181100883 T CY 181100883T CY 1121632 T1 CY1121632 T1 CY 1121632T1
- Authority
- CY
- Cyprus
- Prior art keywords
- rv2386c
- compositions
- tuberculosis protein
- protein sequence
- rv2386c protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1289—Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8369908P | 2008-07-25 | 2008-07-25 | |
| PCT/EP2009/059585 WO2010010179A1 (en) | 2008-07-25 | 2009-07-24 | The tuberculosis rv2386c protein, compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121632T1 true CY1121632T1 (el) | 2020-07-31 |
Family
ID=41227131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100883T CY1121632T1 (el) | 2008-07-25 | 2018-08-24 | Η rv2386c πρωτεϊνη φυματιωσης, συνθεσεις και χρησεις αυτης |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US20110206712A1 (enExample) |
| EP (1) | EP2315834B1 (enExample) |
| JP (2) | JP5981138B2 (enExample) |
| KR (1) | KR20110049834A (enExample) |
| CN (2) | CN102165064B (enExample) |
| AU (1) | AU2009273132B2 (enExample) |
| BR (1) | BRPI0916704A2 (enExample) |
| CA (1) | CA2731547C (enExample) |
| CO (1) | CO6351811A2 (enExample) |
| CY (1) | CY1121632T1 (enExample) |
| DK (1) | DK2315834T3 (enExample) |
| EA (1) | EA201100070A1 (enExample) |
| ES (1) | ES2685498T3 (enExample) |
| HR (1) | HRP20181353T1 (enExample) |
| HU (1) | HUE039159T2 (enExample) |
| IL (1) | IL210589A (enExample) |
| LT (1) | LT2315834T (enExample) |
| MX (1) | MX2011000982A (enExample) |
| PL (1) | PL2315834T3 (enExample) |
| PT (1) | PT2315834T (enExample) |
| SI (1) | SI2315834T1 (enExample) |
| UA (1) | UA107329C2 (enExample) |
| WO (1) | WO2010010179A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2207035B1 (en) * | 2006-03-14 | 2013-10-16 | Oregon Health and Science University | Methods for detecting a mycobacterium tuberculosis infection |
| WO2009158284A2 (en) * | 2008-06-26 | 2009-12-30 | Mayo Foundation For Medical Education And Research | Methods and materials for producing immune responses against polypeptides involved in antibiotic resistance |
| PT2315834T (pt) | 2008-07-25 | 2018-08-10 | Glaxosmithkline Biologicals Sa | A proteína rv2386c de tuberculose, composições e as suas utilizações |
| BRPI0916705A2 (pt) | 2008-07-25 | 2015-11-10 | Glaxo Group Ltd | polipeptídeo isolado, polinucleotídeo isolado, composição farmacêutica, composição imunogênica, método para tratamento ou prevenção de tuberculose, e, usos de um polipeptídeo, e de um polinucleotídeo. |
| GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| WO2013090897A1 (en) * | 2011-12-15 | 2013-06-20 | The Trustees Of The University Of Pennsylvania | Using adaptive immunity to detect drug resistance |
| CN104211787A (zh) * | 2013-05-31 | 2014-12-17 | 中国医学科学院病原生物学研究所 | 用于结核病诊断和预防的蛋白 |
| GB201405921D0 (en) * | 2014-04-02 | 2014-05-14 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| EP3180353B1 (en) | 2014-08-15 | 2021-09-22 | Oxford Immunotec Limited | Mycobacterium tuberculosis proteins |
| CN105572352B (zh) * | 2016-02-17 | 2017-07-28 | 遵义医学院附属医院 | 一组结核潜伏感染诊断标志物及其用途 |
| EP3551222B1 (en) | 2016-12-07 | 2024-08-07 | GlaxoSmithKline Biologicals SA | Process for making a liposome composition comprising a saponin |
| GB201621686D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Biologicals Sa | Novel methods for inducing an immune response |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| GB2600654B (en) | 2017-05-30 | 2022-11-02 | Glaxosmithkline Biologicals Sa | Novel devices |
| WO2019106192A1 (en) | 2017-12-01 | 2019-06-06 | Glaxosmithkline Biologicals Sa | Saponin purification |
| CN108950031A (zh) * | 2018-06-29 | 2018-12-07 | 周琳 | 结核分枝杆菌的利福平耐药性诊断标志物及其应用 |
| CN109234414B (zh) * | 2018-06-29 | 2022-05-17 | 周琳 | 结核分枝杆菌的对氨基水杨酸耐药性诊断标志物及其应用 |
| CN108866213A (zh) * | 2018-06-29 | 2018-11-23 | 周琳 | 结核分枝杆菌利福平耐药性诊断标志物及其应用 |
| JP7640473B2 (ja) | 2019-06-05 | 2025-03-05 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | サポニン精製 |
| EP3983011A1 (en) * | 2019-06-14 | 2022-04-20 | Statens Serum Institut | Fusion proteins for tuberculosis vaccines |
| CN112457410B (zh) * | 2020-11-05 | 2023-04-07 | 迈克生物股份有限公司 | 用于结核分枝杆菌感染检测的抗原组合物 |
| DE202022102137U1 (de) | 2022-04-21 | 2022-04-28 | Damayanthi Dalu | Eine neue Zusammensetzung zur Behandlung von Tuberkulose |
| CN115073612B (zh) * | 2022-06-22 | 2024-09-27 | 宁夏大学 | 一种结核分枝杆菌Zera-71cA蛋白纳米颗粒、制备方法及其用途 |
| CN115725607B (zh) * | 2022-07-14 | 2023-11-28 | 山东第一医科大学附属省立医院(山东省立医院) | 一种鼻疽诺卡菌的致病靶基因及其应用 |
| CN120058854A (zh) * | 2025-03-05 | 2025-05-30 | 北京知筹科技有限公司 | 一种调节低密度脂蛋白受体相关蛋白（lrp）的多肽及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2138997C (en) | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
| US6592877B1 (en) | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6613881B1 (en) | 1997-05-20 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use |
| KR100797876B1 (ko) | 1998-04-07 | 2008-01-24 | 코릭사 코포레이션 | 마이코박테리움 튜베르쿨로시스 항원의 융합 단백질 및이의 용도 |
| AU2001241738A1 (en) | 2000-02-25 | 2001-09-03 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
| DE60139963D1 (de) | 2000-06-20 | 2009-10-29 | Corixa Corp | Fusionsproteine aus mycobakterium tuberculosis |
| US20040121322A9 (en) | 2001-02-22 | 2004-06-24 | Cole Stewart T. | Comparative mycobacterial genomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses |
| US7026465B2 (en) | 2002-02-15 | 2006-04-11 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis |
| US20030236393A1 (en) | 2002-03-22 | 2003-12-25 | United States Of America Dept Of Vetrans Affairs | Virulence genes of M. marinum and M. tuberculosis |
| KR101178776B1 (ko) | 2004-02-06 | 2012-09-07 | 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 | 치료학적 잠재성을 가진 어드헤신 및 어드헤신계 단백질을 동정하기 위한 컴퓨터 장치 |
| SI2457926T1 (sl) * | 2005-04-29 | 2015-01-30 | Glaxosmithkline Biologicals S.A. | Nov postopek za preprečevanje ali zdravljenje infekcije z M. tuberculosis |
| WO2008007942A1 (en) | 2006-07-10 | 2008-01-17 | Het Nederlands Kanker Instituut | Means and methods for manipulating sequential phagolysomal-cytosolic translocation of mycobacteria, and uses thereof |
| CA2679410C (en) | 2007-03-02 | 2017-01-17 | Glaxosmithkline Biologicals S.A. | Novel method and compositions |
| WO2010010178A1 (en) | 2008-07-25 | 2010-01-28 | Glaxosmithkline Biologicals S.A | The tuberculosis rv2707c protein, compositions and uses thereof |
| PT2315834T (pt) | 2008-07-25 | 2018-08-10 | Glaxosmithkline Biologicals Sa | A proteína rv2386c de tuberculose, composições e as suas utilizações |
| BRPI0916705A2 (pt) | 2008-07-25 | 2015-11-10 | Glaxo Group Ltd | polipeptídeo isolado, polinucleotídeo isolado, composição farmacêutica, composição imunogênica, método para tratamento ou prevenção de tuberculose, e, usos de um polipeptídeo, e de um polinucleotídeo. |
| AU2009273130B2 (en) | 2008-07-25 | 2014-10-16 | Glaxo Group Limited | Novel compositions and methods |
| KR20170072366A (ko) | 2009-04-24 | 2017-06-26 | 스태튼스 세룸 인스티튜트 | 재활성화를 예방하기 위한 결핵 백신 |
| WO2010132112A2 (en) | 2009-05-14 | 2010-11-18 | Wisconsin Alumni Research Foundation | Immunogenic compositions against tuberculosis |
| UA110103C2 (uk) | 2010-01-27 | 2015-11-25 | Ґлаксосмітклайн Байолоджікалз С.А. | Модифікований туберкульозний антиген |
-
2009
- 2009-07-24 PT PT97810576T patent/PT2315834T/pt unknown
- 2009-07-24 EP EP09781057.6A patent/EP2315834B1/en active Active
- 2009-07-24 HR HRP20181353TT patent/HRP20181353T1/hr unknown
- 2009-07-24 JP JP2011519186A patent/JP5981138B2/ja not_active Expired - Fee Related
- 2009-07-24 LT LTEP09781057.6T patent/LT2315834T/lt unknown
- 2009-07-24 HU HUE09781057A patent/HUE039159T2/hu unknown
- 2009-07-24 SI SI200931869T patent/SI2315834T1/sl unknown
- 2009-07-24 UA UAA201100300A patent/UA107329C2/uk unknown
- 2009-07-24 DK DK09781057.6T patent/DK2315834T3/en active
- 2009-07-24 WO PCT/EP2009/059585 patent/WO2010010179A1/en not_active Ceased
- 2009-07-24 CN CN200980138405.9A patent/CN102165064B/zh active Active
- 2009-07-24 EA EA201100070A patent/EA201100070A1/ru unknown
- 2009-07-24 ES ES09781057.6T patent/ES2685498T3/es active Active
- 2009-07-24 KR KR1020117004639A patent/KR20110049834A/ko not_active Ceased
- 2009-07-24 US US13/055,787 patent/US20110206712A1/en not_active Abandoned
- 2009-07-24 AU AU2009273132A patent/AU2009273132B2/en not_active Ceased
- 2009-07-24 CA CA2731547A patent/CA2731547C/en active Active
- 2009-07-24 BR BRPI0916704-8A patent/BRPI0916704A2/pt not_active IP Right Cessation
- 2009-07-24 CN CN201710068231.XA patent/CN106866801A/zh active Pending
- 2009-07-24 MX MX2011000982A patent/MX2011000982A/es active IP Right Grant
- 2009-07-24 PL PL09781057T patent/PL2315834T3/pl unknown
-
2011
- 2011-01-12 IL IL210589A patent/IL210589A/en not_active IP Right Cessation
- 2011-01-27 CO CO11009237A patent/CO6351811A2/es not_active Application Discontinuation
-
2013
- 2013-06-27 US US13/929,232 patent/US20140086948A1/en not_active Abandoned
-
2014
- 2014-05-21 US US14/283,727 patent/US9480735B2/en active Active
-
2015
- 2015-07-03 JP JP2015134587A patent/JP6104326B2/ja not_active Expired - Fee Related
-
2016
- 2016-09-15 US US15/266,220 patent/US10286053B2/en active Active
-
2018
- 2018-08-24 CY CY20181100883T patent/CY1121632T1/el unknown
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