CY1121190T1 - Δοσολογικη μορφη ανταγωνιστη υποδοχεα προγεστερονης - Google Patents

Δοσολογικη μορφη ανταγωνιστη υποδοχεα προγεστερονης

Info

Publication number
CY1121190T1
CY1121190T1 CY20191100113T CY191100113T CY1121190T1 CY 1121190 T1 CY1121190 T1 CY 1121190T1 CY 20191100113 T CY20191100113 T CY 20191100113T CY 191100113 T CY191100113 T CY 191100113T CY 1121190 T1 CY1121190 T1 CY 1121190T1
Authority
CY
Cyprus
Prior art keywords
dosage form
progesterone receptors
competitive progesterone
directed
pharmaceutical composition
Prior art date
Application number
CY20191100113T
Other languages
English (en)
Inventor
Barbara SCHÜTT
Marcus-Hillert SCHULTZE-MOSGAU
Andreas Kaiser
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48050601&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1121190(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of CY1121190T1 publication Critical patent/CY1121190T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση κατευθύνεται σε μια φαρμακευτική σύνθεση η οποία περιλαμβάνει έναν ανταγωνιστή υποδοχέα προγεστερόνης και συγκεκριμένα (11 β, 17β)-17-υδροξυ-11-[4-(μεθυλσουλφονυλ)φαινυλ]-17-(πενταφθοροαιθυλ)οιστρα-4,9-διεν-3-όνη σε δοσολογία περίπου 0,5 έως 5 mg και πιο συγκεκριμένα 2 mg. Επιπροσθέτως, η εφεύρεση κατευθύνεται στη χρήση μιας νέας φαρμακευτικής σύνθεσης για θεραπευτική αγωγή και/ή προφύλαξη των γυναικολογικών παθήσεων, όπως τα ινομυώματα της μήτρας (ινομυώματα, λειομύωμα μήτρας), ενδομητρίωση ή υπερβολική έμμηνο-αιμορραγία, και μέθοδος για τη λήψη μιας τέτοιας σύνθεσης και από του στόματος μορφή δοσολογίας.
CY20191100113T 2013-04-11 2019-01-24 Δοσολογικη μορφη ανταγωνιστη υποδοχεα προγεστερονης CY1121190T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13163417 2013-04-11
EP14715933.9A EP2983671B1 (en) 2013-04-11 2014-04-09 Progesterone receptor antagonist dosage form
PCT/EP2014/057101 WO2014166971A1 (en) 2013-04-11 2014-04-09 Progesterone receptor antagonist dosage form

Publications (1)

Publication Number Publication Date
CY1121190T1 true CY1121190T1 (el) 2020-05-29

Family

ID=48050601

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100113T CY1121190T1 (el) 2013-04-11 2019-01-24 Δοσολογικη μορφη ανταγωνιστη υποδοχεα προγεστερονης

Country Status (35)

Country Link
US (2) US20160296534A1 (el)
EP (1) EP2983671B1 (el)
JP (2) JP6486900B2 (el)
KR (1) KR102198059B1 (el)
CN (2) CN105120873A (el)
AP (1) AP2015008778A0 (el)
AR (1) AR095834A1 (el)
AU (1) AU2014253153B2 (el)
BR (1) BR112015025706A2 (el)
CA (1) CA2909121C (el)
CL (1) CL2015003014A1 (el)
CY (1) CY1121190T1 (el)
DK (1) DK2983671T3 (el)
EA (1) EA032481B1 (el)
ES (1) ES2708351T3 (el)
HK (1) HK1218069A1 (el)
HR (1) HRP20190141T1 (el)
HU (1) HUE042368T2 (el)
IL (1) IL241815B (el)
LT (1) LT2983671T (el)
MA (1) MA38465A1 (el)
MX (1) MX363979B (el)
MY (1) MY188267A (el)
PH (1) PH12015502326A1 (el)
PL (1) PL2983671T4 (el)
PT (1) PT2983671T (el)
RS (1) RS58277B1 (el)
SG (1) SG11201507935TA (el)
SI (1) SI2983671T1 (el)
TN (1) TN2015000454A1 (el)
TR (1) TR201900954T4 (el)
TW (2) TWI672142B (el)
UA (1) UA116471C2 (el)
WO (1) WO2014166971A1 (el)
ZA (1) ZA201801736B (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA036237B1 (ru) * 2015-05-18 2020-10-16 Байер Фарма Акциенгезельшафт Режим приема селективного модулятора рецептора прогестерона (sprm)
EP3214092A1 (en) 2016-03-04 2017-09-06 Bayer Pharma Aktiengesellschaft Prodrugs of the selective progesterone receptor modulator (sprm) (11.beta.,17.beta.)-17-hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-one
EP3384913A1 (en) 2017-04-03 2018-10-10 Bayer Pharma Aktiengesellschaft Selective progesterone receptor modulators and stabilized estrogen level in patient

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426601A1 (de) 1994-07-27 1996-02-01 Schering Ag Verwendung eines Kombinationsproduktes enthaltend einen kompetitiven Progesteronantagonisten und ein Gestagen zur Herstellung eines Arzneimittels zur Behandlung der Endometriose oder des Leiomyomata uteri
DE69532894T2 (de) 1994-11-22 2004-09-02 Balance Pharmaceuticals, Inc., Pacific Palisades Verfahren zur empfängnisverhütung
DE19635525A1 (de) 1996-08-20 1998-02-26 Schering Ag 7alpha-(xi-Aminoalkyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha(xi-Aminoalkyl-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
DE19706061A1 (de) 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette
AR015500A1 (es) 1997-12-23 2001-05-02 Schering Ag 11 BETA-HALoGENO-ESTRATRIENOS SUSTITUIDOS EN 7 ALFA, PROCEDIMIENTO PARA ELABORAR PREPARADOS FARMACEUTICOS QUE CONTIENEN TALES 11 BETA-HALOGENO-ESTRATRIENOSSUSTITUIDOS EN 7 ALFA, ASI COMO SU UTILIZACION EN LA ELABORACION DE MEDICAMENTOS.
US6476079B1 (en) 1999-12-23 2002-11-05 Leiras Oy Devices for the delivery of drugs having antiprogestinic properties
DE10159217A1 (de) 2001-11-27 2003-06-05 Schering Ag 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate
US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
US8088758B2 (en) * 2003-11-12 2012-01-03 Abbott Products Gmbh 17β-hydroxysteroid dehydrogenase type I inhibitors
EP1768625B1 (en) 2004-07-09 2011-02-09 The Population Council, Inc. Sustained release compositions containing progesterone receptor modulators
DE102009034362A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) * 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de) * 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) * 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten

Also Published As

Publication number Publication date
HUE042368T2 (hu) 2019-06-28
CL2015003014A1 (es) 2016-04-15
TR201900954T4 (tr) 2019-02-21
PL2983671T3 (pl) 2019-04-30
JP6691193B2 (ja) 2020-04-28
ZA201801736B (en) 2019-07-31
AU2014253153A1 (en) 2015-10-15
MY188267A (en) 2021-11-24
IL241815B (en) 2019-11-28
KR20150143595A (ko) 2015-12-23
EA032481B1 (ru) 2019-06-28
EP2983671B1 (en) 2018-10-24
PH12015502326A1 (en) 2016-02-10
LT2983671T (lt) 2019-02-11
CA2909121C (en) 2021-02-09
SI2983671T1 (sl) 2020-06-30
RS58277B1 (sr) 2019-03-29
TW201517910A (zh) 2015-05-16
AP2015008778A0 (en) 2015-09-30
TN2015000454A1 (en) 2017-04-06
PT2983671T (pt) 2019-02-25
DK2983671T3 (en) 2019-02-18
BR112015025706A2 (pt) 2017-07-18
JP6486900B2 (ja) 2019-03-20
TWI672142B (zh) 2019-09-21
UA116471C2 (uk) 2018-03-26
MX2015014264A (es) 2016-03-01
US20220143045A1 (en) 2022-05-12
AR095834A1 (es) 2015-11-11
SG11201507935TA (en) 2015-10-29
WO2014166971A1 (en) 2014-10-16
TW201932116A (zh) 2019-08-16
EP2983671A1 (en) 2016-02-17
MA38465A1 (fr) 2017-02-28
US20160296534A1 (en) 2016-10-13
HK1218069A1 (zh) 2017-02-03
EA201501011A1 (ru) 2016-08-31
CN105120873A (zh) 2015-12-02
HRP20190141T1 (hr) 2019-03-22
NZ712670A (en) 2020-10-30
JP2019034969A (ja) 2019-03-07
KR102198059B1 (ko) 2021-01-05
JP2016515639A (ja) 2016-05-30
CN110051619A (zh) 2019-07-26
MX363979B (es) 2019-04-08
ES2708351T3 (es) 2019-04-09
CA2909121A1 (en) 2014-10-16
PL2983671T4 (pl) 2019-04-30
AU2014253153B2 (en) 2019-05-30

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