CY1119384T1 - Παραγωγα χρωμανυλιου για αντιμετωπιση μιτοχονδριακης νοσου - Google Patents
Παραγωγα χρωμανυλιου για αντιμετωπιση μιτοχονδριακης νοσουInfo
- Publication number
- CY1119384T1 CY1119384T1 CY20171100415T CY171100415T CY1119384T1 CY 1119384 T1 CY1119384 T1 CY 1119384T1 CY 20171100415 T CY20171100415 T CY 20171100415T CY 171100415 T CY171100415 T CY 171100415T CY 1119384 T1 CY1119384 T1 CY 1119384T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- relates
- mitochondrial
- nitrogen atom
- derivatives
- Prior art date
Links
- 208000012268 mitochondrial disease Diseases 0.000 title abstract 2
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003368 amide group Chemical group 0.000 abstract 2
- 239000002537 cosmetic Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical compound O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000857 drug effect Effects 0.000 abstract 1
- 230000004065 mitochondrial dysfunction Effects 0.000 abstract 1
- 230000002438 mitochondrial effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000009759 skin aging Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261670644P | 2012-07-12 | 2012-07-12 | |
| EP12176128 | 2012-07-12 | ||
| PCT/NL2013/050528 WO2014011047A1 (en) | 2012-07-12 | 2013-07-12 | Chromanyl derivatives for treating mitochondrial disease |
| EP13759838.9A EP2872497B2 (en) | 2012-07-12 | 2013-07-12 | Chromanyl derivatives for treating mitochondrial disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119384T1 true CY1119384T1 (el) | 2018-02-14 |
Family
ID=53577992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100415T CY1119384T1 (el) | 2012-07-12 | 2017-04-07 | Παραγωγα χρωμανυλιου για αντιμετωπιση μιτοχονδριακης νοσου |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9388156B2 (enExample) |
| CY (1) | CY1119384T1 (enExample) |
| HR (1) | HRP20170532T4 (enExample) |
| IN (1) | IN2015MN00114A (enExample) |
| MX (1) | MX364547B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11285130B2 (en) * | 2017-04-05 | 2022-03-29 | Khondrion Ip B.V. | Treatment of mitochondrial diseases |
| EP3713563B1 (en) * | 2017-11-22 | 2025-02-19 | Khondrion Ip B.V. | Amide derivatives of chromanyl or chromanyl quinones for use in treating depression and migraine |
| CA3079483A1 (en) * | 2017-11-22 | 2019-05-31 | Khondrion Ip B.V. | Compounds as mpges-1 inhibitors |
| CA3127590A1 (en) | 2019-01-28 | 2020-08-06 | Mitochondria Emotion, Inc. | Mitofusin activators and methods of use thereof |
| EP3917509A4 (en) | 2019-01-28 | 2022-11-09 | Mitochondria Emotion, Inc. | TRANS-4-HYDROXYCYCLOHEXYLPHENYLAMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR019190A1 (es) | 1998-07-08 | 2001-12-26 | Sod Conseils Rech Applic | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
| WO2001081324A1 (de) | 2000-04-25 | 2001-11-01 | Schering Aktiengesellschaft | Benzoxazin- und benzothiazin-derivate mit nos-inhibitorischen und antioxidativen eigenschaften |
| JP2002047272A (ja) | 2000-07-26 | 2002-02-12 | Dai Ichi Seiyaku Co Ltd | ポリアミンアミド誘導体 |
| PL2220030T3 (pl) | 2007-11-06 | 2016-07-29 | Bioelectron Tech Corp | Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych |
-
2013
- 2013-07-12 IN IN114MUN2015 patent/IN2015MN00114A/en unknown
- 2013-07-12 HR HRP20170532TT patent/HRP20170532T4/hr unknown
- 2013-07-12 MX MX2015000488A patent/MX364547B/es active IP Right Grant
- 2013-07-12 US US14/414,055 patent/US9388156B2/en active Active
-
2017
- 2017-04-07 CY CY20171100415T patent/CY1119384T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN2015MN00114A (enExample) | 2015-10-16 |
| US20150166501A1 (en) | 2015-06-18 |
| MX2015000488A (es) | 2015-04-08 |
| US9388156B2 (en) | 2016-07-12 |
| HK1209425A1 (en) | 2016-04-01 |
| MX364547B (es) | 2019-04-30 |
| HRP20170532T1 (hr) | 2017-06-16 |
| HRP20170532T4 (hr) | 2019-12-27 |
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