HRP20170532T4 - Derivati kromanila za liječenje mitohondrijske bolesti - Google Patents

Derivati kromanila za liječenje mitohondrijske bolesti Download PDF

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Publication number
HRP20170532T4
HRP20170532T4 HRP20170532TT HRP20170532T HRP20170532T4 HR P20170532 T4 HRP20170532 T4 HR P20170532T4 HR P20170532T T HRP20170532T T HR P20170532TT HR P20170532 T HRP20170532 T HR P20170532T HR P20170532 T4 HRP20170532 T4 HR P20170532T4
Authority
HR
Croatia
Prior art keywords
compound
levels
cancer
alkyl
none
Prior art date
Application number
HRP20170532TT
Other languages
English (en)
Croatian (hr)
Inventor
Richard Hendrik Blaauw
Ruben Gerardus George Leenders
Jan Geert Sterk
Pedro Harold Han Hermkens
Original Assignee
Khondrion Ip B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Khondrion Ip B.V. filed Critical Khondrion Ip B.V.
Priority claimed from PCT/NL2013/050528 external-priority patent/WO2014011047A1/en
Publication of HRP20170532T1 publication Critical patent/HRP20170532T1/hr
Publication of HRP20170532T4 publication Critical patent/HRP20170532T4/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HRP20170532TT 2012-07-12 2013-07-12 Derivati kromanila za liječenje mitohondrijske bolesti HRP20170532T4 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261670644P 2012-07-12 2012-07-12
EP12176128 2012-07-12
PCT/NL2013/050528 WO2014011047A1 (en) 2012-07-12 2013-07-12 Chromanyl derivatives for treating mitochondrial disease
EP13759838.9A EP2872497B2 (en) 2012-07-12 2013-07-12 Chromanyl derivatives for treating mitochondrial disease

Publications (2)

Publication Number Publication Date
HRP20170532T1 HRP20170532T1 (hr) 2017-06-16
HRP20170532T4 true HRP20170532T4 (hr) 2019-12-27

Family

ID=53577992

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20170532TT HRP20170532T4 (hr) 2012-07-12 2013-07-12 Derivati kromanila za liječenje mitohondrijske bolesti

Country Status (5)

Country Link
US (1) US9388156B2 (enExample)
CY (1) CY1119384T1 (enExample)
HR (1) HRP20170532T4 (enExample)
IN (1) IN2015MN00114A (enExample)
MX (1) MX364547B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11285130B2 (en) * 2017-04-05 2022-03-29 Khondrion Ip B.V. Treatment of mitochondrial diseases
EP3713563B1 (en) * 2017-11-22 2025-02-19 Khondrion Ip B.V. Amide derivatives of chromanyl or chromanyl quinones for use in treating depression and migraine
CA3079483A1 (en) * 2017-11-22 2019-05-31 Khondrion Ip B.V. Compounds as mpges-1 inhibitors
CA3127590A1 (en) 2019-01-28 2020-08-06 Mitochondria Emotion, Inc. Mitofusin activators and methods of use thereof
EP3917509A4 (en) 2019-01-28 2022-11-09 Mitochondria Emotion, Inc. TRANS-4-HYDROXYCYCLOHEXYLPHENYLAMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR019190A1 (es) 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
WO2001081324A1 (de) 2000-04-25 2001-11-01 Schering Aktiengesellschaft Benzoxazin- und benzothiazin-derivate mit nos-inhibitorischen und antioxidativen eigenschaften
JP2002047272A (ja) 2000-07-26 2002-02-12 Dai Ichi Seiyaku Co Ltd ポリアミンアミド誘導体
PL2220030T3 (pl) 2007-11-06 2016-07-29 Bioelectron Tech Corp Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych

Also Published As

Publication number Publication date
IN2015MN00114A (enExample) 2015-10-16
US20150166501A1 (en) 2015-06-18
MX2015000488A (es) 2015-04-08
US9388156B2 (en) 2016-07-12
HK1209425A1 (en) 2016-04-01
MX364547B (es) 2019-04-30
HRP20170532T1 (hr) 2017-06-16
CY1119384T1 (el) 2018-02-14

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