CY1118858T1 - Νεα παραγωγα πυριμιδινης, παρασκευη αυτων και φαρμακευτικη χρηση αυτων ως αναστολεων φωσφορυλιωσης ακτ(ρκβ) - Google Patents
Νεα παραγωγα πυριμιδινης, παρασκευη αυτων και φαρμακευτικη χρηση αυτων ως αναστολεων φωσφορυλιωσης ακτ(ρκβ)Info
- Publication number
- CY1118858T1 CY1118858T1 CY20171100117T CY171100117T CY1118858T1 CY 1118858 T1 CY1118858 T1 CY 1118858T1 CY 20171100117 T CY20171100117 T CY 20171100117T CY 171100117 T CY171100117 T CY 171100117T CY 1118858 T1 CY1118858 T1 CY 1118858T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- phosphorilylation
- inspectors
- pkb
- producers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η παρούσα εφεύρεση αφορά νέες χημικές ενώσεις που προέρχονται από πυριμιδίνες, τη διαδικασία για την παρασκευή αυτών, τα νέα ενδιάμεσα που λαμβάνονται, τη χρήση αυτών ως φαρμάκων, τις φαρμακευτικές συνθέσεις που τα περιέχουν και τη θεραπευτική χρήση αυτών ως αναστολέων ΑΚΤ.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1061301A FR2969614A1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de pyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
FR1061298A FR2969609B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de 6-oxo-dihydro-pyrimidine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
FR1061297A FR2969608B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (5-halo-6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
FR1061303A FR2969607B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de thiopyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
FR1061300A FR2969610B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-indolinamide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
FR1159316 | 2011-10-14 | ||
FR1159315 | 2011-10-14 | ||
FR1159317 | 2011-10-14 | ||
FR1159313 | 2011-10-14 | ||
PCT/EP2011/073875 WO2012089633A1 (fr) | 2010-12-28 | 2011-12-22 | Nouveaux derives de pyrimidines, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118858T1 true CY1118858T1 (el) | 2018-01-10 |
Family
ID=45464546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100117T CY1118858T1 (el) | 2010-12-28 | 2017-01-26 | Νεα παραγωγα πυριμιδινης, παρασκευη αυτων και φαρμακευτικη χρηση αυτων ως αναστολεων φωσφορυλιωσης ακτ(ρκβ) |
Country Status (12)
Country | Link |
---|---|
US (1) | US9133168B2 (el) |
EP (1) | EP2658844B1 (el) |
CY (1) | CY1118858T1 (el) |
DK (1) | DK2658844T3 (el) |
ES (1) | ES2612492T3 (el) |
HR (1) | HRP20170119T1 (el) |
HU (1) | HUE030393T2 (el) |
LT (1) | LT2658844T (el) |
PL (1) | PL2658844T3 (el) |
PT (1) | PT2658844T (el) |
SI (1) | SI2658844T1 (el) |
WO (1) | WO2012089633A1 (el) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103819422A (zh) * | 2014-03-18 | 2014-05-28 | 南通佰华生物医药研究有限公司 | 一种制备手性n-取代-2-吗啉甲醇类化合物的方法 |
EP3154962B1 (en) | 2014-06-13 | 2019-08-07 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
CA2952037A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
CA2952012A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
EA201692267A1 (ru) | 2014-06-13 | 2017-06-30 | Джилид Сайэнс, Инк. | Ингибиторы фосфатидилинозитол-3-киназы |
EA201692266A1 (ru) | 2014-06-13 | 2017-06-30 | Джилид Сайэнс, Инк. | Ингибиторы фосфатидилинозитол-3-киназы |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
WO2018057808A1 (en) | 2016-09-23 | 2018-03-29 | Gilead Sciences, Inc. | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
CN106966951B (zh) * | 2017-04-21 | 2020-01-31 | 常州佳德医药科技有限公司 | 4-氟-2-甲基吲哚及其制备方法和应用 |
CN115916754A (zh) | 2020-05-05 | 2023-04-04 | 纽威伦特公司 | 杂芳族大环醚化学治疗剂 |
EP4146205A4 (en) | 2020-05-05 | 2024-05-29 | Nuvalent Inc | HETEROAROMATIC MACROCYCLIC ETHER-BASED CHEMOTHERAPY AGENTS |
CN115707685A (zh) * | 2021-08-20 | 2023-02-21 | 中国石油化工股份有限公司 | 一种制备胺-环氧卤丙烷聚合单体的方法及产物和系统 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4416884A (en) | 1978-04-12 | 1983-11-22 | Otsuka Pharmaceutical Co., Ltd. | Piperazinylbenzoheterocyclic compounds |
CA2398163C (en) | 2000-01-24 | 2011-02-22 | Kinacia Pty Ltd. | Therapeutic morpholino-substituted compounds |
GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
NZ538420A (en) | 2002-08-16 | 2007-06-29 | Kinacia Pty Ltd | Inhibition of phosphoinositide 3-kinase beta |
WO2004099189A1 (en) | 2003-05-09 | 2004-11-18 | F. Hoffmann-La Roche Ag | Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists |
US20070083053A1 (en) * | 2003-06-27 | 2007-04-12 | Nissan Chemical Industries, Ltd. | Process for producing indole compound |
BRPI0511834A (pt) | 2004-07-14 | 2008-01-08 | Ptc Therapeutics Inc | métodos por tratar hepatite c |
ITMI20060621A1 (it) | 2006-03-31 | 2007-10-01 | Dac Srl | Nuova classe di inibitori delle istone deacetilasi |
AR054438A1 (es) | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | Inhibidores de adn -pk |
WO2006126010A2 (en) | 2005-05-26 | 2006-11-30 | Kudos Pharmaceuticals Limited | Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies |
US20070072897A1 (en) | 2005-09-29 | 2007-03-29 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
TWI418556B (zh) * | 2006-07-27 | 2013-12-11 | Mitsubishi Tanabe Pharma Corp | 吲哚衍生物 |
WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
WO2008148074A2 (en) | 2007-05-24 | 2008-12-04 | Research Foundation Of State University Of New York | Inhibitors of mtor and methods of treatment using same |
WO2009007751A2 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
AU2008273889B2 (en) | 2007-07-09 | 2012-03-08 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
JP2010533159A (ja) | 2007-07-09 | 2010-10-21 | アストラゼネカ アクチボラグ | 化合物947 |
CN101809002B (zh) | 2007-07-09 | 2013-03-27 | 阿斯利康(瑞典)有限公司 | 用于与mtor激酶和/或pi3k相关的疾病中的吗啉代嘧啶衍生物 |
US7985750B2 (en) | 2007-08-14 | 2011-07-26 | Concert Pharmaceuticals, Inc. | Substituted oxazolidinone derivatives |
EP2062889A1 (de) | 2007-11-22 | 2009-05-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verbindungen |
JP2011510033A (ja) | 2008-01-25 | 2011-03-31 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 化合物 |
JP2012508692A (ja) | 2008-11-12 | 2012-04-12 | シェーリング コーポレイション | 脂肪酸結合タンパク質(fabp)の阻害薬 |
TWI469965B (zh) | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
EP2448927B1 (fr) | 2009-07-02 | 2014-03-12 | Sanofi | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt |
-
2011
- 2011-12-22 DK DK11805849.4T patent/DK2658844T3/en active
- 2011-12-22 HU HUE11805849A patent/HUE030393T2/en unknown
- 2011-12-22 EP EP11805849.4A patent/EP2658844B1/fr active Active
- 2011-12-22 LT LTEP11805849.4T patent/LT2658844T/lt unknown
- 2011-12-22 PL PL11805849T patent/PL2658844T3/pl unknown
- 2011-12-22 ES ES11805849.4T patent/ES2612492T3/es active Active
- 2011-12-22 PT PT118058494T patent/PT2658844T/pt unknown
- 2011-12-22 US US13/977,396 patent/US9133168B2/en active Active
- 2011-12-22 WO PCT/EP2011/073875 patent/WO2012089633A1/fr active Application Filing
- 2011-12-22 SI SI201131075A patent/SI2658844T1/sl unknown
-
2017
- 2017-01-25 HR HRP20170119TT patent/HRP20170119T1/hr unknown
- 2017-01-26 CY CY20171100117T patent/CY1118858T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20130274253A1 (en) | 2013-10-17 |
PL2658844T3 (pl) | 2017-04-28 |
EP2658844B1 (fr) | 2016-10-26 |
PT2658844T (pt) | 2017-01-24 |
LT2658844T (lt) | 2017-02-10 |
SI2658844T1 (sl) | 2017-02-28 |
EP2658844A1 (fr) | 2013-11-06 |
HUE030393T2 (en) | 2017-05-29 |
ES2612492T3 (es) | 2017-05-17 |
HRP20170119T1 (hr) | 2017-03-24 |
WO2012089633A9 (fr) | 2012-08-23 |
DK2658844T3 (en) | 2017-02-06 |
WO2012089633A1 (fr) | 2012-07-05 |
US9133168B2 (en) | 2015-09-15 |
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