CY1118495T1 - Συνθεσεις συνδυασμου αγωνιστων α1 αδενοσινης και αναστολεων ανθρακικης ανυδρασης για μειωση της ενδοφθαλμιας πιεσης - Google Patents

Συνθεσεις συνδυασμου αγωνιστων α1 αδενοσινης και αναστολεων ανθρακικης ανυδρασης για μειωση της ενδοφθαλμιας πιεσης

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Publication number
CY1118495T1
CY1118495T1 CY20171100110T CY171100110T CY1118495T1 CY 1118495 T1 CY1118495 T1 CY 1118495T1 CY 20171100110 T CY20171100110 T CY 20171100110T CY 171100110 T CY171100110 T CY 171100110T CY 1118495 T1 CY1118495 T1 CY 1118495T1
Authority
CY
Cyprus
Prior art keywords
adenosine
intraocular pressure
carbonic acid
acid reaction
combination
Prior art date
Application number
CY20171100110T
Other languages
English (en)
Inventor
Norman N Kim
William K Mcvicar
Thomas G Mccauley
Original Assignee
Inotek Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corporation filed Critical Inotek Pharmaceuticals Corporation
Publication of CY1118495T1 publication Critical patent/CY1118495T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Παρέχεται στο παρόν μια φαρμακευτική σύνθεση ή ένα κυτίο το οποίο περιλαμβάνει έναν συνδυασμό ενός αναλόγου αναστολέα ανθρακικής ανυδράσης και ενός αγωνιστή υποδοχέα Α1 αδενοσίνης. Επίσης παρέχεται στο παρόν μία μέθοδος μείωσης της ενδοφθάλμιας πίεσης (ΙΟΡ) σε ένα υποκείμενο χρησιμοποιώντας έναν τέτοιο συνδυασμό ή κυτίο. Σε μία συγκεκριμένη υλοποίηση, παρέχεται στο παρόν ένας συνδυασμός δορζολαμίδης που κυκλοφορεί στην αγορά με το σήμα Trusopt™ και Ένωσης Α.
CY20171100110T 2010-03-19 2017-01-25 Συνθεσεις συνδυασμου αγωνιστων α1 αδενοσινης και αναστολεων ανθρακικης ανυδρασης για μειωση της ενδοφθαλμιας πιεσης CY1118495T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31572110P 2010-03-19 2010-03-19
PCT/US2011/029010 WO2011116290A1 (en) 2010-03-19 2011-03-18 Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure

Publications (1)

Publication Number Publication Date
CY1118495T1 true CY1118495T1 (el) 2017-07-12

Family

ID=44649619

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100110T CY1118495T1 (el) 2010-03-19 2017-01-25 Συνθεσεις συνδυασμου αγωνιστων α1 αδενοσινης και αναστολεων ανθρακικης ανυδρασης για μειωση της ενδοφθαλμιας πιεσης

Country Status (17)

Country Link
US (1) US8440639B2 (el)
EP (1) EP2555775B1 (el)
JP (1) JP2013522322A (el)
CN (1) CN102933220A (el)
CY (1) CY1118495T1 (el)
DK (1) DK2555775T3 (el)
ES (1) ES2613254T3 (el)
HR (1) HRP20170008T1 (el)
HU (1) HUE031529T2 (el)
LT (1) LT2555775T (el)
ME (1) ME02593B (el)
PL (1) PL2555775T3 (el)
PT (1) PT2555775T (el)
RS (1) RS55617B1 (el)
SI (1) SI2555775T1 (el)
SM (1) SMT201700019B (el)
WO (1) WO2011116290A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102413832B (zh) * 2009-05-01 2015-11-25 伊诺泰克制药公司 降低人眼内压的方法
CN102711771B (zh) 2010-01-11 2016-05-18 伊诺泰克制药公司 降低眼压的组合、试剂盒和方法
CN102933593A (zh) * 2010-03-26 2013-02-13 伊诺泰克制药公司 使用n6-环戊基腺苷（cpa）、cpa衍生物或其前药降低人眼内压的方法
EA027109B1 (ru) * 2012-01-26 2017-06-30 Инотек Фармасьютикалс Корпорейшн Безводные полиморфы [(2r,3s,4r,5r)-5-(6-(циклопентиламино)-9h-пурин-9-ил)-3,4-дигидрокситетрагидрофуран-2-ил]метилнитрата и способы их получения
MX2015013234A (es) 2013-03-15 2016-04-15 Inotek Pharmaceuticals Corp Formulaciones oftalmicas.
EA201790851A1 (ru) * 2014-12-03 2017-11-30 Инотек Фармасьютикалз Корпорейшн Способы предотвращения, уменьшения и лечения макулодистрофии

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7423144B2 (en) * 2004-05-26 2008-09-09 Inotek Pharmaceuticals Corporation Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
CN101010085B (zh) 2004-05-26 2012-12-26 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
AU2006320578B2 (en) * 2005-11-30 2013-01-31 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
CN102413832B (zh) * 2009-05-01 2015-11-25 伊诺泰克制药公司 降低人眼内压的方法

Also Published As

Publication number Publication date
ES2613254T3 (es) 2017-05-23
SMT201700019B (it) 2017-03-08
EP2555775B1 (en) 2016-12-07
SI2555775T1 (sl) 2017-05-31
US8440639B2 (en) 2013-05-14
PL2555775T3 (pl) 2017-08-31
HUE031529T2 (en) 2017-07-28
HRP20170008T1 (hr) 2017-03-10
CN102933220A (zh) 2013-02-13
EP2555775A1 (en) 2013-02-13
RS55617B1 (sr) 2017-06-30
US20110245193A1 (en) 2011-10-06
WO2011116290A1 (en) 2011-09-22
EP2555775A4 (en) 2013-08-28
JP2013522322A (ja) 2013-06-13
DK2555775T3 (en) 2017-02-06
ME02593B (me) 2017-06-20
LT2555775T (lt) 2017-04-25
PT2555775T (pt) 2017-02-01

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