UY33305A - Compuestos heterocíclicos inhibidores de DGAT1 - Google Patents

Compuestos heterocíclicos inhibidores de DGAT1

Info

Publication number
UY33305A
UY33305A UY0001033305A UY33305A UY33305A UY 33305 A UY33305 A UY 33305A UY 0001033305 A UY0001033305 A UY 0001033305A UY 33305 A UY33305 A UY 33305A UY 33305 A UY33305 A UY 33305A
Authority
UY
Uruguay
Prior art keywords
heterocyclic compounds
compounds inhibiting
inhibiting dgat1
dgat1
prodrugs
Prior art date
Application number
UY0001033305A
Other languages
English (en)
Inventor
Alan Martin Birch
Leach Andrew
Frederick Woolf Goldberg
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY33305A publication Critical patent/UY33305A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen compuestos inhibidores de DGAT1 de fórmula (I), sales y profármacos farmacéuticamente aceptables de estos, junto con composiciones farmacéuticas, procedimientos para hacerlos y su uso en el tratamiento por ejemplo de la diabetes y la obesidad.
UY0001033305A 2010-04-01 2011-03-31 Compuestos heterocíclicos inhibidores de DGAT1 UY33305A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31994610P 2010-04-01 2010-04-01
US36804010P 2010-07-27 2010-07-27

Publications (1)

Publication Number Publication Date
UY33305A true UY33305A (es) 2011-10-31

Family

ID=44023074

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033305A UY33305A (es) 2010-04-01 2011-03-31 Compuestos heterocíclicos inhibidores de DGAT1

Country Status (4)

Country Link
US (1) US20110251173A1 (es)
TW (1) TW201136941A (es)
UY (1) UY33305A (es)
WO (1) WO2011121350A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2922551B1 (en) 2012-11-23 2018-10-31 GlaxoSmithKline LLC Novel compounds as diacylglycerol acyltransferase inhibitors
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors
WO2014086704A1 (en) 2012-12-03 2014-06-12 F. Hoffmann-La Roche Ag Substituted isoxazole amide compounds as inhibitors of stearoyl-coa desaturase 1 (scd1)
CN104418866B (zh) * 2013-08-23 2018-10-16 青岛黄海制药有限责任公司 Dgat1抑制剂及其制备方法和用途
KR20190091455A (ko) * 2016-12-15 2019-08-06 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Nrf2 화합물
CA3061650A1 (en) * 2017-05-11 2018-11-15 Astrazeneca Ab Heteroaryl compounds that inhibit g12c mutant ras proteins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0325192D0 (en) 2003-10-29 2003-12-03 Astrazeneca Ab Method of use
MX2007007101A (es) 2004-12-14 2007-08-21 Astrazeneca Ab Derivados de oxadiazol como inhibidores de acil coa:diacilglicerol aciltransferasa.
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
MX2011014018A (es) 2009-06-19 2012-02-22 Astrazeneca Ab Pirazincarboxamidas como inhibidores de dgati.

Also Published As

Publication number Publication date
US20110251173A1 (en) 2011-10-13
TW201136941A (en) 2011-11-01
WO2011121350A1 (en) 2011-10-06

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20191218