CY1118305T1 - Πολυμορφικη μορφη της ν-[4-(τριφθορομεθυλο)βενζυλο]-4-μεθοξυβουτυραμιδης - Google Patents

Πολυμορφικη μορφη της ν-[4-(τριφθορομεθυλο)βενζυλο]-4-μεθοξυβουτυραμιδης

Info

Publication number
CY1118305T1
CY1118305T1 CY20161101190T CY161101190T CY1118305T1 CY 1118305 T1 CY1118305 T1 CY 1118305T1 CY 20161101190 T CY20161101190 T CY 20161101190T CY 161101190 T CY161101190 T CY 161101190T CY 1118305 T1 CY1118305 T1 CY 1118305T1
Authority
CY
Cyprus
Prior art keywords
methoxybutyramide
trifluoromethyl
benzyl
polymorphic form
polymorphic
Prior art date
Application number
CY20161101190T
Other languages
English (en)
Inventor
Roberto Cacciaglia
Massimo Ferrari
Original Assignee
Laboratorio Farmaceutico C.T. S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Farmaceutico C.T. S.R.L. filed Critical Laboratorio Farmaceutico C.T. S.R.L.
Publication of CY1118305T1 publication Critical patent/CY1118305T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Περιγράφονται κρυσταλλικές πολυμορφικές μορφές μίας ένωσης του τύπου Ν-[4-(τριφθορομεθυλο)βενζυλο]-4-μεθοξυβουτυραμίδης. Οι δύο πολυμορφικές μορφές, που ονομάζονται πολυμορφική Μορφή Α και πολυμορφική Μορφή Β, μπορούν να χρησιμοποιηθούν στη θεραπεία του εθισμού στα ναρκωτικά και του αλκοολισμού με πολύ καλή σταθερότητα. Περιγράφονται, επίσης, μέθοδοι για την παρασκευή των πολυμορφικών μορφών.
CY20161101190T 2007-11-13 2016-11-17 Πολυμορφικη μορφη της ν-[4-(τριφθορομεθυλο)βενζυλο]-4-μεθοξυβουτυραμιδης CY1118305T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07120551A EP2062875A1 (en) 2007-11-13 2007-11-13 New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide
PCT/EP2008/065367 WO2009062949A1 (en) 2007-11-13 2008-11-12 New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide
EP08849561.9A EP2220027B1 (en) 2007-11-13 2008-11-12 Polymorphic form of n-[4-(trifluoromethyl)benzyl)-4-methoxybutyramide

Publications (1)

Publication Number Publication Date
CY1118305T1 true CY1118305T1 (el) 2017-06-28

Family

ID=39186150

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161101190T CY1118305T1 (el) 2007-11-13 2016-11-17 Πολυμορφικη μορφη της ν-[4-(τριφθορομεθυλο)βενζυλο]-4-μεθοξυβουτυραμιδης

Country Status (23)

Country Link
US (2) US8742172B2 (el)
EP (3) EP2062875A1 (el)
JP (1) JP5448197B2 (el)
CN (1) CN101855200B (el)
AU (1) AU2008323005B2 (el)
BR (1) BRPI0819370A2 (el)
CA (2) CA2705508C (el)
CY (1) CY1118305T1 (el)
DK (1) DK2220027T3 (el)
EA (1) EA017718B9 (el)
ES (1) ES2602358T3 (el)
HK (1) HK1223606A1 (el)
HR (1) HRP20161485T1 (el)
HU (1) HUE031858T2 (el)
IL (2) IL205661A (el)
LT (1) LT2220027T (el)
NZ (1) NZ586109A (el)
PL (1) PL2220027T3 (el)
PT (1) PT2220027T (el)
RS (1) RS55310B1 (el)
SI (1) SI2220027T1 (el)
UA (1) UA101816C2 (el)
WO (1) WO2009062949A1 (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUA20164040A1 (it) * 2016-06-01 2017-12-01 Laboratorio Farm C T S R L Procedimento per la preparazione di polimorfo a
BR112020008102B1 (pt) * 2017-11-03 2022-09-20 Dow Global Technologies Llc Formulação pesticida

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1283782B1 (it) * 1996-08-09 1998-04-30 Ct Lab Farm Srl Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
JP2000273069A (ja) 1999-03-23 2000-10-03 Central Glass Co Ltd トリフルオロメチルベンジルアミンの製造方法
JP2001294559A (ja) 2000-04-13 2001-10-23 Central Glass Co Ltd トリフルオロメチルベンジルアミンの製造方法

Also Published As

Publication number Publication date
CA2705508C (en) 2017-01-24
USRE47078E1 (en) 2018-10-09
JP5448197B2 (ja) 2014-03-19
US20100261797A1 (en) 2010-10-14
EP2220027A1 (en) 2010-08-25
PT2220027T (pt) 2016-11-24
CA2911120C (en) 2017-10-17
HK1223606A1 (zh) 2017-08-04
CN101855200B (zh) 2014-05-07
CA2911120A1 (en) 2009-05-22
EA017718B9 (ru) 2013-05-30
AU2008323005A1 (en) 2009-05-22
EP2062875A1 (en) 2009-05-27
US8742172B2 (en) 2014-06-03
NZ586109A (en) 2012-05-25
JP2011503037A (ja) 2011-01-27
IL205661A (en) 2016-07-31
IL205661A0 (en) 2011-08-01
ES2602358T3 (es) 2017-02-20
BRPI0819370A2 (pt) 2015-04-22
HRP20161485T1 (hr) 2016-12-30
EP3012246A1 (en) 2016-04-27
EA201000801A1 (ru) 2010-10-29
PL2220027T3 (pl) 2017-03-31
UA101816C2 (en) 2013-05-13
DK2220027T3 (en) 2016-12-12
CA2705508A1 (en) 2009-05-22
AU2008323005B2 (en) 2013-10-24
EP3012246B1 (en) 2020-12-23
HUE031858T2 (en) 2017-08-28
RS55310B1 (sr) 2017-03-31
LT2220027T (lt) 2016-12-12
EP2220027B1 (en) 2016-08-17
SI2220027T1 (sl) 2017-04-26
IL242736B (en) 2018-08-30
EA017718B1 (ru) 2013-02-28
AU2008323005A2 (en) 2010-07-22
WO2009062949A1 (en) 2009-05-22
CN101855200A (zh) 2010-10-06

Similar Documents

Publication Publication Date Title
CY1120107T1 (el) Κρυσταλλικο πολυμορφο των εκλεκτικων τροποποιητων ανδρογονου (r) ή (s)-ν-(4-κυανο-3-(τριφθορομεθυλ)φαινυλ)-3-(4-κυανοφαινοξυ)-2-υδροξυ-2-μεθυλοπροπαναμιδιου
CY1117760T1 (el) Συνδυασμος ενωσεων μορφινανης και αντικαταθλιπτικου για την αγωγη του ψευδοπρομηκικου συναισθηματος
DK2114933T3 (da) Piperidin-GPCR-agonister
EA201200741A1 (ru) Способ получения этексилата дабигатрана
BRPI0615705A2 (pt) processo para preparar um composto, e, composto
ECSP088210A (es) Bencimidazoles sustituidos y métodos de preparación
EA200901039A1 (ru) Способ получения производного бензимидазола
CY1110520T1 (el) Παραγωγα 5-υποκατεστημενης κινολινης και ισοκινολινης· μεθοδος για την παραγωγη τους και η χρηση τους ως αντιφλεγμονωδη
ATE557024T1 (de) Piperidinverbindungen als gpcr-agonisten
AR051754A1 (es) Metodos para preparar compuestos de indazol
EA201000269A1 (ru) Новые гербициды
EA201171062A1 (ru) Алкиламидные соединения и их применение
UA104438C2 (uk) Спосіб одержання дабігатрану і його проміжних сполук
ATE557023T1 (de) Piperidinylverbindungen als gpcr-agonisten
RS52255B (en) NALMEFEN HYDROCHLORIDE DIHYDRATE
EA201100612A1 (ru) Новые производные 2-амидотиадиазола
DE602008005141D1 (de) 1,3-dihydroimidazol-2-thionderivate als inhibitoren von dopamin-beta-hydroxylase
CY1115623T1 (el) Μεθοδος για την συνθεση 7,8-διμεθοξυ-1,3-διϋδρο-2η-3-βενζαζεπιν-2-ονης και εφαρμογη αυτης στη συνθεση της ιβαμπραδινης καθως επισης αλατων προσθηκης αυτης με ενα φαρμακευτικως αποδεκτο οξυ
CY1116391T1 (el) Αιθινυλο παραγωγα ως θετικοι αλλοστερικοι ρυθμιστες του mglur5
CR10540A (es) Derivados ciclopropil amina
EA200801366A1 (ru) Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
NO20064884L (no) Kjemisk fremgangsmate og ny krystallinsk form
EA200800070A1 (ru) Производные 2-(1h-индолилсульфанил)ариламина
DK2763981T3 (da) Fremgangsmåde til fremstilling af 1-(4-(4-(3,4-dichlor-2-fluorphenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-on-hydrochlorid og mellemprodukter anvendt deri
CY1111914T1 (el) Μεθοδος συνθεσης της ιβαβραδινης και των αλατων προσθηκης αυτης με ενα φαρμακευτικως αποδεκτο οξυ