CY1118226T1 - Συγχωνευμενες τρικυκλικες ενωσεις ως αναστολεις κινασης raf - Google Patents

Συγχωνευμενες τρικυκλικες ενωσεις ως αναστολεις κινασης raf

Info

Publication number
CY1118226T1
CY1118226T1 CY20161100869T CY161100869T CY1118226T1 CY 1118226 T1 CY1118226 T1 CY 1118226T1 CY 20161100869 T CY20161100869 T CY 20161100869T CY 161100869 T CY161100869 T CY 161100869T CY 1118226 T1 CY1118226 T1 CY 1118226T1
Authority
CY
Cyprus
Prior art keywords
raf
models
compounds
tricycle
tricycle compounds
Prior art date
Application number
CY20161100869T
Other languages
Greek (el)
English (en)
Inventor
Changyou Zhou
Shaohui Wang
Guoliang Zhang
Original Assignee
Beigene, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beigene, Ltd. filed Critical Beigene, Ltd.
Publication of CY1118226T1 publication Critical patent/CY1118226T1/el

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28Oxygen atom
    • C07D473/30Oxygen atom attached in position 6, e.g. hypoxanthine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02Ergot alkaloids of the cyclic peptide type

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CY20161100869T 2011-12-31 2016-09-05 Συγχωνευμενες τρικυκλικες ενωσεις ως αναστολεις κινασης raf CY1118226T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2011/085146 WO2013097224A1 (en) 2011-12-31 2011-12-31 Fused tricyclic compounds as raf kinase inhibitors

Publications (1)

Publication Number Publication Date
CY1118226T1 true CY1118226T1 (el) 2017-06-28

Family

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Family Applications (1)

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CY20161100869T CY1118226T1 (el) 2011-12-31 2016-09-05 Συγχωνευμενες τρικυκλικες ενωσεις ως αναστολεις κινασης raf

Country Status (28)

Country Link
US (3) US9273046B2 (cg-RX-API-DMAC7.html)
EP (2) EP3124472B1 (cg-RX-API-DMAC7.html)
JP (1) JP5868521B2 (cg-RX-API-DMAC7.html)
KR (1) KR101713391B1 (cg-RX-API-DMAC7.html)
CN (1) CN103596926B (cg-RX-API-DMAC7.html)
AU (1) AU2011384857B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014013108B1 (cg-RX-API-DMAC7.html)
CA (1) CA2856347C (cg-RX-API-DMAC7.html)
CY (1) CY1118226T1 (cg-RX-API-DMAC7.html)
DK (1) DK2797888T3 (cg-RX-API-DMAC7.html)
EA (1) EA025597B1 (cg-RX-API-DMAC7.html)
ES (1) ES2588775T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20160641T1 (cg-RX-API-DMAC7.html)
HU (1) HUE029656T2 (cg-RX-API-DMAC7.html)
IL (1) IL233364A (cg-RX-API-DMAC7.html)
IN (1) IN2014DN06166A (cg-RX-API-DMAC7.html)
LT (1) LT2797888T (cg-RX-API-DMAC7.html)
ME (1) ME02529B (cg-RX-API-DMAC7.html)
MX (1) MX352617B (cg-RX-API-DMAC7.html)
NZ (1) NZ624068A (cg-RX-API-DMAC7.html)
PL (1) PL2797888T3 (cg-RX-API-DMAC7.html)
PT (1) PT2797888T (cg-RX-API-DMAC7.html)
RS (1) RS55196B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201401725SA (cg-RX-API-DMAC7.html)
SI (1) SI2797888T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201600302B (cg-RX-API-DMAC7.html)
WO (1) WO2013097224A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201405555B (cg-RX-API-DMAC7.html)

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US9670203B2 (en) * 2013-06-28 2017-06-06 Beigene, Ltd. Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors
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WO2015176267A1 (en) * 2014-05-22 2015-11-26 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
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JP6175519B2 (ja) * 2016-01-04 2017-08-09 ベイジーン リミテッド Rafキナーゼ阻害剤としての縮合三環式化合物
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TWI876835B (zh) 2015-04-15 2025-03-11 英屬開曼群島商百濟神州有限公司 B-raf激酶抑制劑的馬來酸鹽、其結晶形式及用途

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EP3124472B1 (en) 2018-07-25
EP2797888A4 (en) 2015-09-02
SMT201600302B (it) 2016-11-10
NZ624068A (en) 2016-09-30
ZA201405555B (en) 2015-10-28
PL2797888T3 (pl) 2016-12-30
BR112014013108B1 (pt) 2020-11-24
MX2014007829A (es) 2014-08-01
CA2856347C (en) 2017-05-30
HUE029656T2 (en) 2017-03-28
EA201491305A1 (ru) 2015-04-30
ME02529B (me) 2017-02-20
PT2797888T (pt) 2016-09-09
CN103596926B (zh) 2015-11-25
WO2013097224A1 (en) 2013-07-04
AU2011384857A1 (en) 2014-05-29
BR112014013108A2 (pt) 2017-06-13
SG11201401725SA (en) 2014-09-26
IL233364A0 (en) 2014-08-31
SI2797888T1 (sl) 2017-01-31
KR20140108541A (ko) 2014-09-11
HRP20160641T1 (hr) 2016-09-23
MX352617B (es) 2017-12-01
EP2797888B1 (en) 2016-06-08
CA2856347A1 (en) 2013-07-04
KR101713391B1 (ko) 2017-03-07
HK1192232A1 (zh) 2014-08-15
AU2011384857B2 (en) 2016-03-03
JP2015506353A (ja) 2015-03-02
ES2588775T3 (es) 2016-11-04
EP3124472A1 (en) 2017-02-01
EA025597B1 (ru) 2017-01-30
DK2797888T3 (en) 2016-09-19
LT2797888T (lt) 2016-10-10
EP2797888A1 (en) 2014-11-05
US9895376B2 (en) 2018-02-20
US20190000857A1 (en) 2019-01-03
HK1221222A1 (zh) 2017-05-26
US20150045355A1 (en) 2015-02-12
IN2014DN06166A (cg-RX-API-DMAC7.html) 2015-08-21
RS55196B1 (sr) 2017-01-31
US9273046B2 (en) 2016-03-01
US20160206621A1 (en) 2016-07-21
IL233364A (en) 2017-06-29
CN103596926A (zh) 2014-02-19
JP5868521B2 (ja) 2016-02-24
US10576087B2 (en) 2020-03-03

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