CY1116196T1 - Ρευστη συνθεση περιλαμβανουσα βιοσυμβατες συνθεσεις ολιγομερους-πολυμερους - Google Patents
Ρευστη συνθεση περιλαμβανουσα βιοσυμβατες συνθεσεις ολιγομερους-πολυμερουςInfo
- Publication number
- CY1116196T1 CY1116196T1 CY20151100326T CY151100326T CY1116196T1 CY 1116196 T1 CY1116196 T1 CY 1116196T1 CY 20151100326 T CY20151100326 T CY 20151100326T CY 151100326 T CY151100326 T CY 151100326T CY 1116196 T1 CY1116196 T1 CY 1116196T1
- Authority
- CY
- Cyprus
- Prior art keywords
- fluid composition
- metabolite
- prodrug
- bioactive agent
- polymer compositions
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Biological Depolymerization Polymers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε βιοσυμβατές συνθέσεις ολιγομερούς-πολυμερούς για τον in situ σχηματισμό εμφυτευμάτων, όπου τα εμφυτεύματα απελευθερώνουν βιοδραστικό παράγοντα, μεταβολίτη ή προφάρμακο αυτού, με ελεγχόμενο ρυθμό. Το σύστημα παροχής παρατεταμένης απελευθέρωσης περιλαμβάνει ρευστή σύνθεση που περιέχει βιοδραστικό παράγοντα, μεταβολίτη ή προφάρμακο αυτού και εμφύτευμα που περιέχει βιοδραστικό παράγοντα, μεταβολίτη ή προφάρμακο αυτού. Η ρευστή σύνθεση μπορεί να εγχέεται εντός ιστού οπότε πήζει για να συσταθεί το στερεό ή γέλης, μονολιθικό εμφύτευμα. Η ρευστή σύνθεση περιλαμβάνει βιοαποικοδομήσιμο, θερμοπλαστικό πολυμερές, βιοσυμβατό καλυμμένου-άκρου ολιγομερικό υγρό και βιοδραστικό παράγοντα, μεταβολίτη ή προφάρμακο αυτού.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5845808P | 2008-06-03 | 2008-06-03 | |
| EP09758745.5A EP2291174B1 (en) | 2008-06-03 | 2009-06-03 | Flowable composition comprising biocompatible oligomer-polymer compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116196T1 true CY1116196T1 (el) | 2017-02-08 |
Family
ID=41127673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100326T CY1116196T1 (el) | 2008-06-03 | 2015-04-06 | Ρευστη συνθεση περιλαμβανουσα βιοσυμβατες συνθεσεις ολιγομερους-πολυμερους |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9308162B2 (el) |
| EP (1) | EP2291174B1 (el) |
| CY (1) | CY1116196T1 (el) |
| DK (1) | DK2291174T3 (el) |
| ES (1) | ES2535330T3 (el) |
| HR (1) | HRP20150350T1 (el) |
| PL (1) | PL2291174T3 (el) |
| PT (1) | PT2291174E (el) |
| SI (1) | SI2291174T1 (el) |
| WO (1) | WO2009148581A1 (el) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| EP1984009B1 (en) | 2006-01-18 | 2012-10-24 | Qps, Llc | Pharmaceutical compositions with enhanced stability |
| AU2008262545B2 (en) | 2007-05-25 | 2013-12-05 | Indivior Uk Limited | Sustained delivery formulations of risperidone compounds |
| EP2291174B1 (en) | 2008-06-03 | 2015-01-28 | Tolmar Therapeutics, Inc. | Flowable composition comprising biocompatible oligomer-polymer compositions |
| US8822546B2 (en) * | 2008-12-01 | 2014-09-02 | Medtronic, Inc. | Flowable pharmaceutical depot |
| GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| US20160120877A1 (en) * | 2010-07-16 | 2016-05-05 | James S Rowe | Pharmaceutical compositions for sustained delivery of benzodiazepine antagonists |
| BR112013013676A2 (pt) * | 2010-12-15 | 2016-09-06 | 3M Innovative Properties Co | fibra degradáveis |
| FR2973386B1 (fr) * | 2011-03-28 | 2013-04-26 | Valagro Carbone Renouvelable Poitou Charentes | Utilisation d'un oligomere de lactide biodegradable comme plastifiants |
| US10675376B2 (en) | 2012-05-24 | 2020-06-09 | Ethicon Llc | Mechanically strong absorbable polymeric blend compositions of precisely controllable absorption rates, processing methods, and products therefrom |
| US9757330B2 (en) | 2013-10-18 | 2017-09-12 | Industrial Technology Research Institute | Recipe for in-situ gel, and implant, drug delivery system formed thereby |
| KR20160091960A (ko) * | 2013-11-27 | 2016-08-03 | 에티컨, 엘엘씨 | 정밀하게 제어가능한 흡수 속도를 갖는 흡수성 중합체 블렌드 조성물, 가공 방법, 및 그로부터의 치수 안정한 의료 장치 |
| US9669137B2 (en) * | 2014-02-04 | 2017-06-06 | Abbott Cardiovascular Systems Inc. | Modified polylactide polymers |
| GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| EP3554494A4 (en) | 2016-12-19 | 2021-02-17 | Cellixbio Private Limited | COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION |
| US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
| CN111249298B (zh) * | 2020-04-08 | 2021-03-12 | 曲阜师范大学 | 一种含有马杜霉素和顺铂的抗癌药物组合物 |
| CN112812520B (zh) * | 2021-01-07 | 2022-08-23 | 江南大学 | 一种提高聚合物加工流动性能的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2371281A (en) * | 1945-03-13 | Lactyuactic esters and process of | ||
| DE1020324B (de) | 1954-12-17 | 1957-12-05 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von esterartigen Milchsaeurederivaten mit definierter Kettenlaenge und endstaendiger Ester-, Amid- oder Nitrilgruppe |
| US7033608B1 (en) * | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
| US6126919A (en) * | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| US6565874B1 (en) * | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
| DE19908753C2 (de) * | 1999-02-20 | 2003-10-02 | Jenapharm Gmbh | Bioabbaubare, injizierbare Oligomer-Polymer-Zusammensetzung |
| US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP1526835B1 (en) * | 2002-07-31 | 2008-04-23 | ALZA Corporation | Injectable depot compositions and uses thereof |
| US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
| EP2291174B1 (en) | 2008-06-03 | 2015-01-28 | Tolmar Therapeutics, Inc. | Flowable composition comprising biocompatible oligomer-polymer compositions |
-
2009
- 2009-06-03 EP EP09758745.5A patent/EP2291174B1/en active Active
- 2009-06-03 ES ES09758745.5T patent/ES2535330T3/es active Active
- 2009-06-03 DK DK09758745T patent/DK2291174T3/en active
- 2009-06-03 US US12/995,910 patent/US9308162B2/en not_active Expired - Fee Related
- 2009-06-03 PL PL09758745T patent/PL2291174T3/pl unknown
- 2009-06-03 PT PT97587455T patent/PT2291174E/pt unknown
- 2009-06-03 SI SI200931165T patent/SI2291174T1/sl unknown
- 2009-06-03 WO PCT/US2009/003363 patent/WO2009148581A1/en active Application Filing
-
2015
- 2015-03-30 HR HRP20150350TT patent/HRP20150350T1/hr unknown
- 2015-04-06 CY CY20151100326T patent/CY1116196T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2291174B1 (en) | 2015-01-28 |
| PL2291174T3 (pl) | 2015-06-30 |
| SI2291174T1 (sl) | 2015-05-29 |
| PT2291174E (pt) | 2015-05-20 |
| WO2009148581A1 (en) | 2009-12-10 |
| HRP20150350T1 (hr) | 2015-05-08 |
| DK2291174T3 (en) | 2015-03-09 |
| US9308162B2 (en) | 2016-04-12 |
| EP2291174A1 (en) | 2011-03-09 |
| US20110245172A1 (en) | 2011-10-06 |
| ES2535330T3 (es) | 2015-05-08 |
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