CY1115902T1 - Συνδυαστικη θεραπεια καρκινου με ανασταλτικες ενωσεις hps90 - Google Patents

Συνδυαστικη θεραπεια καρκινου με ανασταλτικες ενωσεις hps90

Info

Publication number
CY1115902T1
CY1115902T1 CY20141101097T CY141101097T CY1115902T1 CY 1115902 T1 CY1115902 T1 CY 1115902T1 CY 20141101097 T CY20141101097 T CY 20141101097T CY 141101097 T CY141101097 T CY 141101097T CY 1115902 T1 CY1115902 T1 CY 1115902T1
Authority
CY
Cyprus
Prior art keywords
hps90
copper
compounds
cancer therapy
effective amount
Prior art date
Application number
CY20141101097T
Other languages
Greek (el)
English (en)
Inventor
Ronald K Blackman
Kevin Paul Foley
David Proia
Original Assignee
Synta Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corporation filed Critical Synta Pharmaceuticals Corporation
Publication of CY1115902T1 publication Critical patent/CY1115902T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY20141101097T 2009-10-19 2014-12-31 Συνδυαστικη θεραπεια καρκινου με ανασταλτικες ενωσεις hps90 CY1115902T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27933009P 2009-10-19 2009-10-19
US33577810P 2010-01-11 2010-01-11
EP10768357.5A EP2490688B1 (en) 2009-10-19 2010-10-19 Combination cancer therapy with hsp90 inhibitory compounds

Publications (1)

Publication Number Publication Date
CY1115902T1 true CY1115902T1 (el) 2017-01-25

Family

ID=43218142

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141101097T CY1115902T1 (el) 2009-10-19 2014-12-31 Συνδυαστικη θεραπεια καρκινου με ανασταλτικες ενωσεις hps90

Country Status (21)

Country Link
US (1) US20120245186A1 (enrdf_load_stackoverflow)
EP (1) EP2490688B1 (enrdf_load_stackoverflow)
JP (2) JP2013508378A (enrdf_load_stackoverflow)
KR (1) KR20120093970A (enrdf_load_stackoverflow)
CN (1) CN102695504A (enrdf_load_stackoverflow)
AU (1) AU2010308306A1 (enrdf_load_stackoverflow)
BR (1) BR112012009215A2 (enrdf_load_stackoverflow)
CA (1) CA2779233A1 (enrdf_load_stackoverflow)
CY (1) CY1115902T1 (enrdf_load_stackoverflow)
DK (1) DK2490688T3 (enrdf_load_stackoverflow)
EA (1) EA022119B1 (enrdf_load_stackoverflow)
ES (1) ES2526566T3 (enrdf_load_stackoverflow)
HR (1) HRP20141150T1 (enrdf_load_stackoverflow)
MX (1) MX2012004577A (enrdf_load_stackoverflow)
NZ (2) NZ599445A (enrdf_load_stackoverflow)
PH (1) PH12012500748A1 (enrdf_load_stackoverflow)
PL (1) PL2490688T3 (enrdf_load_stackoverflow)
PT (1) PT2490688E (enrdf_load_stackoverflow)
RS (1) RS53716B1 (enrdf_load_stackoverflow)
SI (1) SI2490688T1 (enrdf_load_stackoverflow)
WO (1) WO2011049946A1 (enrdf_load_stackoverflow)

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CA2653329C (en) 2006-05-25 2018-01-16 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
CA2653217A1 (en) 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with protooncogene products
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
US8450500B2 (en) 2008-06-04 2013-05-28 Synta Pharmaceuticals Corp. Pyrrole compounds that modulate HSP90 activity
PL2328893T3 (pl) * 2008-08-08 2013-09-30 Synta Pharmaceuticals Corp Związki triazolowe modulujące aktywność Hsp90
WO2010017545A2 (en) 2008-08-08 2010-02-11 Synta Pharamceuticals Corp. Triazole compounds that modulate hsp90 activity
AU2011210765A1 (en) 2010-01-28 2012-09-13 President And Fellows Of Harvard College Compositions and methods for enhancing proteasome activity
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
WO2011146801A1 (en) * 2010-05-20 2011-11-24 Synta Pharmaceuticals Corp. Formulation and dosing of hsp90 inhibitory compounds
WO2011146803A1 (en) * 2010-05-20 2011-11-24 Synta Pharmaceuticals Corp. Method of treating lung adenocarcinoma with hsp90 inhibitory compounds
EP2575810A1 (en) * 2010-05-24 2013-04-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compound and a topoisomerase ii inhibitor
AU2011302344B2 (en) * 2010-09-13 2015-01-15 Synta Pharmaceuticals Corp. HSP90 inhibitors for treating non-small cell lung cancers in wild-type EGFR and/or KRAS patients
WO2012154967A1 (en) 2011-05-12 2012-11-15 Proteostasis Therapeutics, Inc. Proteostasis regulators
WO2012162293A1 (en) * 2011-05-23 2012-11-29 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitory compounds with mek inhibitors
WO2012162372A1 (en) * 2011-05-24 2012-11-29 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitory compounds with mtor/p13k inhibitors
US20140194388A1 (en) * 2011-05-26 2014-07-10 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitory compounds with chk inhibitors
JP2014520808A (ja) * 2011-07-07 2014-08-25 シンタ ファーマシューティカルズ コーポレーション Hsp90阻害化合物を用いた癌の治療
JP2014532712A (ja) * 2011-11-02 2014-12-08 シンタ ファーマシューティカルズ コーポレーション トポイソメラーゼi阻害剤とhsp90阻害剤の組合せを使用する癌療法
JP2014534228A (ja) * 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とhsp90阻害剤の組合せ療法
AU2012339679A1 (en) 2011-11-14 2014-06-12 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with BRAF inhibitors
US9849135B2 (en) 2013-01-25 2017-12-26 President And Fellows Of Harvard College USP14 inhibitors for treating or preventing viral infections
US9993460B2 (en) 2013-07-26 2018-06-12 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
MY194204A (en) 2014-08-04 2022-11-21 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
BR112018002399A2 (pt) 2015-08-06 2018-09-25 Chimerix, Inc. nucleosídeos de pirrolopirimidina e análogos dos mesmos, úteis como agentes antivirais
CN105237533B (zh) * 2015-10-26 2017-03-22 中国药科大学 四氢吡啶并[4,3‑d]嘧啶类Hsp90抑制剂及其医药用途
US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof
CA3160522A1 (en) 2019-12-20 2021-06-24 Sanne Schroder Glad Compounds active towards nuclear receptors
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Also Published As

Publication number Publication date
CA2779233A1 (en) 2011-04-28
JP2013508378A (ja) 2013-03-07
EA022119B1 (ru) 2015-11-30
NZ622713A (en) 2015-07-31
HK1175112A1 (en) 2013-06-28
WO2011049946A1 (en) 2011-04-28
JP2016041715A (ja) 2016-03-31
AU2010308306A1 (en) 2012-05-10
KR20120093970A (ko) 2012-08-23
RS53716B1 (en) 2015-04-30
PH12012500748A1 (en) 2012-10-29
SI2490688T1 (sl) 2015-01-30
PL2490688T3 (pl) 2015-03-31
NZ599445A (en) 2014-04-30
EP2490688A1 (en) 2012-08-29
CN102695504A (zh) 2012-09-26
MX2012004577A (es) 2012-06-13
EA201270570A1 (ru) 2012-09-28
EP2490688B1 (en) 2014-10-08
HRP20141150T1 (hr) 2015-01-30
PT2490688E (pt) 2014-12-29
DK2490688T3 (en) 2014-12-08
US20120245186A1 (en) 2012-09-27
BR112012009215A2 (pt) 2019-09-24
ES2526566T3 (es) 2015-01-13

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