CY1115278T1 - Παραγωγα 2-αρυλιμιδαζολης ως αναστολεις του ενζυμου ρdε10α - Google Patents

Παραγωγα 2-αρυλιμιδαζολης ως αναστολεις του ενζυμου ρdε10α

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Publication number
CY1115278T1
CY1115278T1 CY20141100539T CY141100539T CY1115278T1 CY 1115278 T1 CY1115278 T1 CY 1115278T1 CY 20141100539 T CY20141100539 T CY 20141100539T CY 141100539 T CY141100539 T CY 141100539T CY 1115278 T1 CY1115278 T1 CY 1115278T1
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CY
Cyprus
Prior art keywords
subject
compound
formula
effective amount
therapeutically effective
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Application number
CY20141100539T
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English (en)
Inventor
Ask Püschl
Jacob Nielsen
Jan Kehler
John Paul Kilburn
Mauro Marigo
Morten Langgård
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H. Lundbeck A/S
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Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1115278T1 publication Critical patent/CY1115278T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Αυτή η εφεύρεση απευθύνεται σε ενώσεις, οι οποίες είναι αναστολείς του ενζύμου ΡDE10A. Η εφεύρεση παρέχει μια φαρμακευτική σύνθεση περιλαμβάνοντας μια θεραπευτικώς αποτελεσματική ποσότητα μιας ένωσης της εφεύρεσης και μια φαρμακευτικώς αποδεκτή ουσία-φορέας. Η παρούσα εφεύρεση παρέχει επίσης και διεργασίες για την παρασκευή των ενώσεων του χημικού τύπου (Ι). Η παρούσα εφεύρεση παρέχει περαιτέρω μια μέθοδο αγωγής ενός υποκειμένου υποφέροντας από μία νευροεκφυλιστική διαταραχή περιλαμβάνοντας την χορήγηση στο υποκείμενο μίας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του χημικού τύπου (Ι). Η παρούσα εφεύρεση παρέχει επίσης και μία μέθοδο αγωγής ενός υποκειμένου υποφέροντας από έναν εθισμό σε φάρμακα περιλαμβάνοντας την χορήγηση στο υποκείμενο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του χημικού τύπου (Ι). Η παρούσα εφεύρεση παρέχει περαιτέρω μια μέθοδο αγωγής ενός υποκειμένου υποφέροντας από μία ψυχιατρική διαταραχή περιλαμβάνοντας την χορήγηση στο υποκείμενο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του χημικού τύπου (Ι).
CY20141100539T 2009-12-17 2014-07-18 Παραγωγα 2-αρυλιμιδαζολης ως αναστολεις του ενζυμου ρdε10α CY1115278T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28732409A 2009-12-17 2009-12-17
DKPA200901341 2009-12-17
EP10797990.8A EP2513105B1 (en) 2009-12-17 2010-12-15 2-arylimidazole derivatives as pde10a enzyme inhibitors

Publications (1)

Publication Number Publication Date
CY1115278T1 true CY1115278T1 (el) 2017-01-04

Family

ID=44246810

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100539T CY1115278T1 (el) 2009-12-17 2014-07-18 Παραγωγα 2-αρυλιμιδαζολης ως αναστολεις του ενζυμου ρdε10α

Country Status (34)

Country Link
US (2) US8501797B2 (el)
EP (1) EP2513105B1 (el)
JP (1) JP5698761B2 (el)
KR (1) KR101777889B1 (el)
CN (1) CN102753551B (el)
AR (1) AR079498A1 (el)
AU (1) AU2010333437B2 (el)
CA (1) CA2783727C (el)
CO (1) CO6612246A2 (el)
CR (1) CR20120317A (el)
CY (1) CY1115278T1 (el)
DK (1) DK2513105T3 (el)
DO (1) DOP2012000168A (el)
EA (1) EA021415B1 (el)
ES (1) ES2484692T3 (el)
GE (1) GEP20156242B (el)
GT (1) GT201200180A (el)
HK (1) HK1177739A1 (el)
HR (1) HRP20140632T1 (el)
MA (1) MA33924B1 (el)
MX (1) MX2012007144A (el)
MY (1) MY158202A (el)
NZ (1) NZ600416A (el)
PL (1) PL2513105T3 (el)
PT (1) PT2513105E (el)
RS (1) RS53413B (el)
SG (1) SG181536A1 (el)
SI (1) SI2513105T1 (el)
SM (1) SMT201400114B (el)
TN (1) TN2012000287A1 (el)
TW (1) TWI481607B (el)
UA (1) UA107817C2 (el)
WO (1) WO2011072696A1 (el)
ZA (1) ZA201204418B (el)

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TWI481607B (zh) * 2009-12-17 2015-04-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI487705B (zh) 2009-12-17 2015-06-11 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
JO3089B1 (ar) * 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
LT2651902T (lt) 2010-12-17 2018-01-10 Reata Pharmaceuticals, Inc. Tricikliniai pirazolil- ir pirimidinilenonai, kaip antioksidantų uždegimo moduliatoriai
JP5916752B2 (ja) 2010-12-17 2016-05-11 ノバルティス アーゲー ５−クロロ−ｎ２−（２−イソプロポキシ−５−メチル−４−ピペリジン−４−イル−フェニル）−ｎ４［２−（プロパン−２−スルホニル）−フェニル］−ピリミジン−２，４−ジアミンの結晶形
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US9938269B2 (en) * 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
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AR089361A1 (es) 2011-12-21 2014-08-20 Lundbeck & Co As H Derivados de quinolina como inhibidores de la enzima pde10a
WO2013107856A1 (en) * 2012-01-20 2013-07-25 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2013127817A1 (en) 2012-02-27 2013-09-06 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
JP7076441B2 (ja) * 2016-11-02 2022-05-27 ヤンセン ファーマシューティカ エヌ．ベー． ＰＤＥ２阻害剤としての［１，２，４］トリアゾロ［１，５－ａ］ピリミジン誘導体
GB202002926D0 (en) * 2020-02-28 2020-04-15 Benevolentai Tech Limited Compositions and uses thereof

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TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI487705B (zh) * 2009-12-17 2015-06-11 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
TWI481607B (zh) 2009-12-17 2015-04-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物

Also Published As

Publication number Publication date
KR20120123276A (ko) 2012-11-08
US8501797B2 (en) 2013-08-06
AU2010333437A1 (en) 2012-06-21
MY158202A (en) 2016-09-15
NZ600416A (en) 2013-08-30
JP2013514285A (ja) 2013-04-25
CA2783727A1 (en) 2011-06-23
EA021415B1 (ru) 2015-06-30
KR101777889B1 (ko) 2017-09-12
TWI481607B (zh) 2015-04-21
EP2513105B1 (en) 2014-05-14
EP2513105A1 (en) 2012-10-24
EA201290518A1 (ru) 2013-01-30
SG181536A1 (en) 2012-07-30
TW201127831A (en) 2011-08-16
MA33924B1 (fr) 2013-01-02
US20120302548A1 (en) 2012-11-29
PT2513105E (pt) 2014-07-31
HK1177739A1 (en) 2013-08-30
AU2010333437B2 (en) 2016-09-01
PL2513105T3 (pl) 2014-09-30
RS53413B (en) 2014-12-31
HRP20140632T1 (hr) 2014-09-26
ZA201204418B (en) 2013-08-28
ES2484692T3 (es) 2014-08-12
CA2783727C (en) 2018-02-20
US20130289038A1 (en) 2013-10-31
GEP20156242B (en) 2015-02-10
CN102753551A (zh) 2012-10-24
CN102753551B (zh) 2014-10-22
WO2011072696A1 (en) 2011-06-23
JP5698761B2 (ja) 2015-04-08
DK2513105T3 (da) 2014-07-14
CR20120317A (es) 2012-08-16
DOP2012000168A (es) 2012-11-30
TN2012000287A1 (en) 2013-12-12
AR079498A1 (es) 2012-02-01
CO6612246A2 (es) 2013-02-01
SMT201400114B (it) 2014-11-10
UA107817C2 (en) 2015-02-25
SI2513105T1 (sl) 2014-11-28
MX2012007144A (es) 2012-07-03
US8927738B2 (en) 2015-01-06
GT201200180A (es) 2015-01-16

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