CY1114686T1 - Χρηση toy ck2 αναστολεα για την θεραπεια και χημειοευαισθητοποιηση των ανθεκτικων σε αντικαρκινικα φαρμακα ογκων - Google Patents
Χρηση toy ck2 αναστολεα για την θεραπεια και χημειοευαισθητοποιηση των ανθεκτικων σε αντικαρκινικα φαρμακα ογκωνInfo
- Publication number
- CY1114686T1 CY1114686T1 CY20131100142T CY131100142T CY1114686T1 CY 1114686 T1 CY1114686 T1 CY 1114686T1 CY 20131100142 T CY20131100142 T CY 20131100142T CY 131100142 T CY131100142 T CY 131100142T CY 1114686 T1 CY1114686 T1 CY 1114686T1
- Authority
- CY
- Cyprus
- Prior art keywords
- peptide
- combination
- treatment
- cancer
- inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Αυτή η εφεύρεση σχετίζεται με έναν φαρμακευτικό συνδυασμό που περιέχει έναν πεπτιδικό αναστολέα (ονομαζόμενο Ρ15) της κινάσης της Καζεϊνης 2 (CK2) μαζί με τα τυπικά χημειοθεραπευτικά φάρμακα που χρησιμοποιούνται στην αντικαρκινική θεραπεία και τα οποία χορηγούνται μαζί, χωριστά ή διαδοχικά. Τα χημειοθεραπευτικά φάρμακα περιλαμβάνουν σισπλατίνη, ταξόλη, αλκαλοειδή της Vinca, 5-φθοριοουρακίλη, δοξορουβικίνη, κυκλοφωσφαμίδη, ετοποσίδη, μιτομυκίνη C, ιματινίμπη, Iressa, και velcade (βορτεζομίμπη). Η συνεργεία ανάμεσα στο Ρ15 πεπτίδιο και στα αντικαρκινικά φάρμακα επιτυγχάνει μία αποτελεσματική συγκέντρωση κάθε κυτταροστατικού φαρμάκου στον συνδυασμό η οποία είναι από 10- έως 100-φορές μικρότερη από αυτήν για κάθε κυτταροστατικό φάρμακο μόνο του. Ο φαρμακευτικός συνδυασμός που περιγράφεται σε αυτή την εφεύρεση δείχνει χαμηλότερη τοξικότητα σε σύγκριση με αυτήν που αναφέρεται για τα αντικαρκινικά θεραπευτικά και επομένως, αντιπροσωπεύει ένα καίριο πλεονέκτημα για την χρήση του στην καρκινική θεραπεία. Ακόμη, η διαδοχική χορήγηση αυτού του φαρμακευτικού συνδυασμού μέσω της προηγούμενης αγωγής με το Ρ15 πεπτίδιο οδηγεί στην χημειοευαισθητοποίηση των ανθεκτικών όγκων προς τα αντικαρκινικά θεραπευτικά.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060049A CU23511B6 (es) | 2006-02-28 | 2006-02-28 | Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas |
EP07711104A EP1997506B8 (en) | 2006-02-28 | 2007-02-28 | Use of ck2 inhibitor for the treatment and chemosensibilization of refractory tumors to anticancer drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114686T1 true CY1114686T1 (el) | 2016-10-05 |
Family
ID=40134932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100142T CY1114686T1 (el) | 2006-02-28 | 2013-02-15 | Χρηση toy ck2 αναστολεα για την θεραπεια και χημειοευαισθητοποιηση των ανθεκτικων σε αντικαρκινικα φαρμακα ογκων |
Country Status (23)
Country | Link |
---|---|
US (3) | US8871725B2 (el) |
EP (1) | EP1997506B8 (el) |
JP (2) | JP5733880B2 (el) |
KR (1) | KR101454866B1 (el) |
CN (1) | CN101432012B (el) |
AR (1) | AR059645A1 (el) |
AU (1) | AU2007219572B2 (el) |
BR (1) | BRPI0708307B1 (el) |
CA (1) | CA2642943C (el) |
CL (1) | CL2015001086A1 (el) |
CU (1) | CU23511B6 (el) |
CY (1) | CY1114686T1 (el) |
DO (1) | DOP2007000040A (el) |
HK (1) | HK1132451A1 (el) |
MX (1) | MX2008011141A (el) |
MY (1) | MY150135A (el) |
NO (1) | NO341904B1 (el) |
PE (1) | PE20081191A1 (el) |
PL (1) | PL1997506T3 (el) |
RU (1) | RU2396974C2 (el) |
UY (1) | UY30175A1 (el) |
WO (1) | WO2007098719A1 (el) |
ZA (1) | ZA200807323B (el) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU23511B6 (es) * | 2006-02-28 | 2010-04-13 | Biorec B V | Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas |
GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
US20100173013A1 (en) * | 2009-01-08 | 2010-07-08 | Denis Drygin | Treatment of neoplastic disorders using combination therapies |
CN109875998B (zh) * | 2019-01-24 | 2021-09-03 | 武汉大学 | 酰胺类生物碱在制备肿瘤化疗药物增敏剂中的应用及抗肿瘤药物组合物 |
CN110448699B (zh) * | 2019-06-12 | 2022-03-11 | 天津医科大学 | 包含功能性多肽修饰七甲川花菁素类染料的肿瘤细胞核靶向载药纳米粒子及制备方法 |
CU20200103A7 (es) * | 2020-12-18 | 2022-07-08 | Ct Ingenieria Genetica Biotecnologia | Péptido sintético para la inducción de inmunidad antitumoral y antiviral |
CN114712377B (zh) * | 2022-04-26 | 2023-08-15 | 江苏师范大学 | 断血流皂苷a在制造药物中的用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU23225A1 (es) * | 2001-12-20 | 2007-08-30 | Ct Ingenieria Genetica Biotech | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
CA2478338A1 (en) * | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
US20060014987A1 (en) * | 2003-07-07 | 2006-01-19 | Lan Huang | Synthesis of beta-elemene, intermediates thereto, analogues and uses thereof |
AU2004291037A1 (en) * | 2003-11-14 | 2005-06-02 | Pharma Mar, S.A. | Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer |
BRPI0417498A (pt) * | 2003-12-09 | 2007-05-29 | Us Gov Health & Human Serv | método para suprimir uma resposta imune em um indivìduo; método de inibição da proliferação de um célula; método de tratamento de um distúrbio proliferativo em um indivìduo; método para selecionar um agente imunossupressor ou anti-proliferativo; composição farmacêutica e estente vascular |
TW200538149A (en) * | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
CU23511B6 (es) * | 2006-02-28 | 2010-04-13 | Biorec B V | Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas |
-
2006
- 2006-02-28 CU CU20060049A patent/CU23511B6/es active IP Right Grant
-
2007
- 2007-02-23 DO DO2007000040A patent/DOP2007000040A/es unknown
- 2007-02-27 AR ARP070100805A patent/AR059645A1/es not_active Application Discontinuation
- 2007-02-27 UY UY30175A patent/UY30175A1/es not_active Application Discontinuation
- 2007-02-28 BR BRPI0708307-6A patent/BRPI0708307B1/pt active IP Right Grant
- 2007-02-28 JP JP2008556646A patent/JP5733880B2/ja active Active
- 2007-02-28 WO PCT/CU2007/000010 patent/WO2007098719A1/es active Search and Examination
- 2007-02-28 CN CN2007800152341A patent/CN101432012B/zh active Active
- 2007-02-28 KR KR1020087023587A patent/KR101454866B1/ko active IP Right Grant
- 2007-02-28 US US12/280,629 patent/US8871725B2/en active Active
- 2007-02-28 PE PE2007000215A patent/PE20081191A1/es not_active Application Discontinuation
- 2007-02-28 MX MX2008011141A patent/MX2008011141A/es active IP Right Grant
- 2007-02-28 EP EP07711104A patent/EP1997506B8/en active Active
- 2007-02-28 CA CA2642943A patent/CA2642943C/en active Active
- 2007-02-28 RU RU2008138534/15A patent/RU2396974C2/ru active
- 2007-02-28 AU AU2007219572A patent/AU2007219572B2/en active Active
- 2007-02-28 MY MYPI20083318A patent/MY150135A/en unknown
- 2007-02-28 PL PL07711104T patent/PL1997506T3/pl unknown
-
2008
- 2008-08-23 ZA ZA200807323A patent/ZA200807323B/xx unknown
- 2008-09-29 NO NO20084119A patent/NO341904B1/no not_active IP Right Cessation
-
2009
- 2009-10-29 HK HK09110055.2A patent/HK1132451A1/xx not_active IP Right Cessation
-
2013
- 2013-02-15 CY CY20131100142T patent/CY1114686T1/el unknown
- 2013-07-12 JP JP2013146681A patent/JP2013231065A/ja not_active Withdrawn
-
2014
- 2014-09-19 US US14/490,856 patent/US9226946B2/en active Active
- 2014-10-20 US US14/518,242 patent/US9278118B2/en active Active
-
2015
- 2015-04-24 CL CL2015001086A patent/CL2015001086A1/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1114686T1 (el) | Χρηση toy ck2 αναστολεα για την θεραπεια και χημειοευαισθητοποιηση των ανθεκτικων σε αντικαρκινικα φαρμακα ογκων | |
Ruggiero et al. | Platinum compounds in children with cancer: toxicity and clinical management | |
Piperdi et al. | Bortezomib: understanding the mechanism of action | |
ES2964764T3 (es) | Combinación terapéutica que comprende un inhibidor de cdk y oxaliplatino | |
CY1111065T1 (el) | Φαρμακευτικη συνθεση που περιεχει μια ωμεγα-καρβοξυαρυλ υποκατεστημενη διφαινυλ ουρια για τη θεραπευτικη αντιμετωπιση του καρκινου | |
Eriksson | Histology-driven chemotherapy of soft-tissue sarcoma | |
BRPI0607809A2 (pt) | uso de uma composição compreendendo nanopartìculas, composição e kit | |
EA200801671A1 (ru) | Специфическая терапия, использующая интегриновые лиганды для лечения рака | |
ATE469158T1 (de) | Heteroalkylgebundene pyrimidinderivate | |
TW200630105A (en) | Herbal composition PHY906 and its use in chemotherapy | |
JP2009515901A5 (el) | ||
HUP0300590A2 (hu) | Peptidázzal hasítható, célzott antineoplasztikus szerek és terápiás alkalmazásuk | |
Liebner | The indications and efficacy of conventional chemotherapy in primary and recurrent sarcoma | |
EA200602047A1 (ru) | Сульфонилэтилфосфородиамидаты, предназначенные для применения при лечении рака | |
EA201000127A1 (ru) | Специфическая терапия и лекарственное средство на основе интегриновых лигандов для лечения рака | |
SI1824504T1 (sl) | Protitumorske kombinacije, ki vsebujejo vegf-trap in 5fu ali enega od njegovih derivatov | |
JP2005530735A5 (el) | ||
AR049135A1 (es) | Composicion,metodo, kit y tratamiento con oxaliplatino y un inhibidor del egfr,como erlotinib | |
ATE491695T1 (de) | Tricylische 1,2,4-triazinoxide und zusammensetzungen davon zur therapeutischen anwendung bei krebsbehandlungen | |
Georgoulias | Docetaxel (taxotere) in the treatment of non-small cell lung cancer | |
Klautke et al. | Intensified neoadjuvant radiochemotherapy for locally advanced rectal cancer: a review | |
JP2016522826A5 (el) | ||
EA200801670A1 (ru) | Комбинированная противораковая терапия с перфузией изолированного органа | |
DK1694338T3 (da) | Anvendelse af superoxiddismutase- og reductase-glutathion-mimetika i form af anticancerlægemidler | |
BRPI0409870A (pt) | uso de irinotecano para tratamento de cáncer de mama resistente |