CY1112740T1 - ΧΡΗΣΗ ΔΕΝΔΡΙΤΙΚΩΝ ΚΥΤΤΑΡΩΝ (DCs) ΕΚΦΡΑΖΟΝΤΑΣ ΙΝΤΕΡΛΕΥΚΙΝΗ 12 (IL-12) - Google Patents

ΧΡΗΣΗ ΔΕΝΔΡΙΤΙΚΩΝ ΚΥΤΤΑΡΩΝ (DCs) ΕΚΦΡΑΖΟΝΤΑΣ ΙΝΤΕΡΛΕΥΚΙΝΗ 12 (IL-12)

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Publication number
CY1112740T1
CY1112740T1 CY20121100427T CY121100427T CY1112740T1 CY 1112740 T1 CY1112740 T1 CY 1112740T1 CY 20121100427 T CY20121100427 T CY 20121100427T CY 121100427 T CY121100427 T CY 121100427T CY 1112740 T1 CY1112740 T1 CY 1112740T1
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CY
Cyprus
Prior art keywords
dcs
interleykin
expressing
treatment
specific
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Application number
CY20121100427T
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English (en)
Inventor
Thomas Felzmann
Original Assignee
Forschungsinstitut Für Krebskranke Kinder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Forschungsinstitut Für Krebskranke Kinder filed Critical Forschungsinstitut Für Krebskranke Kinder
Publication of CY1112740T1 publication Critical patent/CY1112740T1/el

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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Η παρούσα εφεύρεση αποκαλύπτει την χρήση ενεργών δενδριτικών κυττάρων (DCs) που αποδεσμεύουν ιντερλευκίνη 12 (IL-12) τα οποία φορτώνονται με ένα αντιγόνο έναντι ειδικού παθογόνου ή ειδικού όγκου και, λόγω της κατεργασίας με λιποπολυσακχαρίδιο (LPS) και ιντερφερόνη-γάμμα (IFN-y), αποδεσμεύουν IL-12, για την παρασκευή φαρμάκου για την αγωγή ασθενούς έχοντας λοίμωξη με το εν λόγω ειδικό παθογόνο ή για την αγωγή ασθενούς έχοντας τον εν λόγω ειδικό όγκο.
CY20121100427T 2002-09-13 2012-05-08 ΧΡΗΣΗ ΔΕΝΔΡΙΤΙΚΩΝ ΚΥΤΤΑΡΩΝ (DCs) ΕΚΦΡΑΖΟΝΤΑΣ ΙΝΤΕΡΛΕΥΚΙΝΗ 12 (IL-12) CY1112740T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0137502A AT412145B (de) 2002-09-13 2002-09-13 Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen
EP03794972A EP1537203B1 (en) 2002-09-13 2003-08-29 USE OF DENDRITIC CELLS (DCs) EXPRESSING INTERLEUKIN 12 (IL-12)

Publications (1)

Publication Number Publication Date
CY1112740T1 true CY1112740T1 (el) 2016-02-10

Family

ID=31892564

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100427T CY1112740T1 (el) 2002-09-13 2012-05-08 ΧΡΗΣΗ ΔΕΝΔΡΙΤΙΚΩΝ ΚΥΤΤΑΡΩΝ (DCs) ΕΚΦΡΑΖΟΝΤΑΣ ΙΝΤΕΡΛΕΥΚΙΝΗ 12 (IL-12)

Country Status (12)

Country Link
US (1) US7867488B2 (el)
EP (1) EP1537203B1 (el)
JP (1) JP2005538167A (el)
AT (2) AT412145B (el)
AU (1) AU2003260473B2 (el)
CA (1) CA2494216C (el)
CY (1) CY1112740T1 (el)
DK (1) DK1537203T3 (el)
ES (1) ES2381870T3 (el)
PT (1) PT1537203E (el)
SI (1) SI1537203T1 (el)
WO (1) WO2004024900A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005108554A1 (ja) 2004-05-11 2005-11-17 Shukokai Incorporated 腫瘍ワクチンなどへの養子免疫細胞
US20080254537A1 (en) * 2005-12-08 2008-10-16 Northwest Biotherapeutics, Inc. Compositions and Methods for Inducing the Activation of Immature Monocytic Dendritic Cells
AU2013206016B2 (en) * 2005-12-08 2016-08-11 Northwest Biotherapeutics, Inc. Compositions and methods for inducing the activation of immature monocytic dendritic cells
EP2072617A1 (en) * 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
US20130183343A1 (en) * 2010-03-15 2013-07-18 The Trustees Of The University Of Pennsylvania System and Method of Preparing and Storing Activated Mature Dendritic Cells
GB2534478A (en) * 2012-06-27 2016-07-27 Hasumi Int Res Found Therapy and method for intratumorally introducing cytotoxic T lymphocyte and/or NKT cell with anti-TNF and/or anti-IL-10
WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
EP2787005A1 (en) 2013-04-02 2014-10-08 Activartis Biotech GmbH Targeted cancer immune therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479254B2 (en) * 1996-03-22 2002-11-12 Human Genome Sciences, Inc. Apoptosis inducing molecule II
FR2796961B1 (fr) * 1999-07-29 2003-05-02 Chu Montpellier Procede d'obtention de cellules dentritiques, les cellules dentritiques ainsi obtenues et leurs utilisations a des fins cliniques
WO2001039600A1 (en) * 1999-12-03 2001-06-07 University Of Massachusetts Use of hsp27 as an anti-inflammatory agent
AU2000227285A1 (en) * 2000-01-14 2001-07-24 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods of regulating il-12 production by administering ccr5 agonists and antagonists
WO2002034887A2 (en) * 2000-10-24 2002-05-02 Schering Corporation Maturation of dendritic cells
JP2005505270A (ja) * 2001-09-06 2005-02-24 ノースウエスト バイオセラピューティクス，インコーポレイティド 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法

Also Published As

Publication number Publication date
EP1537203B1 (en) 2012-02-08
US20060177420A1 (en) 2006-08-10
AT412145B (de) 2004-10-25
PT1537203E (pt) 2012-05-21
US7867488B2 (en) 2011-01-11
AU2003260473B2 (en) 2008-08-07
ATE544847T1 (de) 2012-02-15
SI1537203T1 (sl) 2012-06-29
AU2003260473A1 (en) 2004-04-30
CA2494216C (en) 2013-07-09
JP2005538167A (ja) 2005-12-15
CA2494216A1 (en) 2004-03-25
WO2004024900A1 (en) 2004-03-25
EP1537203A1 (en) 2005-06-08
ES2381870T3 (es) 2012-06-01
ATA13752002A (de) 2004-03-15
DK1537203T3 (da) 2012-05-14

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