ATE544847T1 - Verwendung von dendritischen zellen, die interleukin 12 (il-12) exprimieren - Google Patents
Verwendung von dendritischen zellen, die interleukin 12 (il-12) exprimierenInfo
- Publication number
- ATE544847T1 ATE544847T1 AT03794972T AT03794972T ATE544847T1 AT E544847 T1 ATE544847 T1 AT E544847T1 AT 03794972 T AT03794972 T AT 03794972T AT 03794972 T AT03794972 T AT 03794972T AT E544847 T1 ATE544847 T1 AT E544847T1
- Authority
- AT
- Austria
- Prior art keywords
- cells expressing
- dendritic cells
- expressing interleukin
- interleukin
- dendritic
- Prior art date
Links
- 102000013462 Interleukin-12 Human genes 0.000 title 2
- 108010065805 Interleukin-12 Proteins 0.000 title 2
- 229940117681 interleukin-12 Drugs 0.000 title 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4634—Antigenic peptides; polypeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/53—Liver
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/56—Kidney
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/052—Lipopolysaccharides [LPS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0137502A AT412145B (de) | 2002-09-13 | 2002-09-13 | Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen |
PCT/EP2003/009591 WO2004024900A1 (en) | 2002-09-13 | 2003-08-29 | USE OF DENDRITIC CELLS (DCs) EXPRESSING INTERLEUKIN 12 (IL-12) |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE544847T1 true ATE544847T1 (de) | 2012-02-15 |
Family
ID=31892564
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0137502A AT412145B (de) | 2002-09-13 | 2002-09-13 | Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen |
AT03794972T ATE544847T1 (de) | 2002-09-13 | 2003-08-29 | Verwendung von dendritischen zellen, die interleukin 12 (il-12) exprimieren |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0137502A AT412145B (de) | 2002-09-13 | 2002-09-13 | Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen |
Country Status (12)
Country | Link |
---|---|
US (1) | US7867488B2 (de) |
EP (1) | EP1537203B1 (de) |
JP (1) | JP2005538167A (de) |
AT (2) | AT412145B (de) |
AU (1) | AU2003260473B2 (de) |
CA (1) | CA2494216C (de) |
CY (1) | CY1112740T1 (de) |
DK (1) | DK1537203T3 (de) |
ES (1) | ES2381870T3 (de) |
PT (1) | PT1537203E (de) |
SI (1) | SI1537203T1 (de) |
WO (1) | WO2004024900A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1757680B1 (de) * | 2004-05-11 | 2009-09-16 | Shukokai Incorporated | Methoden zur Kultivierung von Antigen presentierenden Immunzellen |
AU2013206016B2 (en) * | 2005-12-08 | 2016-08-11 | Northwest Biotherapeutics, Inc. | Compositions and methods for inducing the activation of immature monocytic dendritic cells |
KR20150082688A (ko) * | 2005-12-08 | 2015-07-15 | 노쓰웨스트 바이오써라퓨틱스, 인크. | 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법 |
EP2072617A1 (de) * | 2007-12-12 | 2009-06-24 | Trimed Biotech GmbH | Verfahren zur Herstellung dendritischer Zellen |
JP2013522309A (ja) * | 2010-03-15 | 2013-06-13 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 活性化した成熟樹状細胞を調製し保存するシステムおよび方法 |
SG11201510552WA (en) * | 2012-06-27 | 2016-01-28 | Hasumi Internat Res Foundation | Therapy and method for intratumorally introducing cytotoxic t lymphocyte and/or nkt cell with anti-tnf and/or anti-il-10 |
WO2014149871A1 (en) | 2013-03-14 | 2014-09-25 | Icahn School Of Medicine At Mount Sinai | Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer |
EP2787005A1 (de) | 2013-04-02 | 2014-10-08 | Activartis Biotech GmbH | Gezielte Krebs-Immuntherapie |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6479254B2 (en) * | 1996-03-22 | 2002-11-12 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II |
FR2796961B1 (fr) * | 1999-07-29 | 2003-05-02 | Chu Montpellier | Procede d'obtention de cellules dentritiques, les cellules dentritiques ainsi obtenues et leurs utilisations a des fins cliniques |
AU2575201A (en) * | 1999-12-03 | 2001-06-12 | University Of Massachusetts | Use of hsp27 as an anti-inflammatory agent |
AU2000227285A1 (en) * | 2000-01-14 | 2001-07-24 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods of regulating il-12 production by administering ccr5 agonists and antagonists |
WO2002034887A2 (en) * | 2000-10-24 | 2002-05-02 | Schering Corporation | Maturation of dendritic cells |
WO2003022215A2 (en) * | 2001-09-06 | 2003-03-20 | Northwest Biotherapeutics, Inc. | Compositions and methods for priming monocytic dendritic cells and t cells for th-1 response |
-
2002
- 2002-09-13 AT AT0137502A patent/AT412145B/de not_active IP Right Cessation
-
2003
- 2003-08-29 SI SI200332142T patent/SI1537203T1/sl unknown
- 2003-08-29 AT AT03794972T patent/ATE544847T1/de active
- 2003-08-29 EP EP03794972A patent/EP1537203B1/de not_active Expired - Lifetime
- 2003-08-29 PT PT03794972T patent/PT1537203E/pt unknown
- 2003-08-29 ES ES03794972T patent/ES2381870T3/es not_active Expired - Lifetime
- 2003-08-29 DK DK03794972.4T patent/DK1537203T3/da active
- 2003-08-29 US US10/527,679 patent/US7867488B2/en not_active Expired - Lifetime
- 2003-08-29 JP JP2004535211A patent/JP2005538167A/ja active Pending
- 2003-08-29 CA CA2494216A patent/CA2494216C/en not_active Expired - Fee Related
- 2003-08-29 WO PCT/EP2003/009591 patent/WO2004024900A1/en active Application Filing
- 2003-08-29 AU AU2003260473A patent/AU2003260473B2/en not_active Ceased
-
2012
- 2012-05-08 CY CY20121100427T patent/CY1112740T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1112740T1 (el) | 2016-02-10 |
AU2003260473A1 (en) | 2004-04-30 |
CA2494216A1 (en) | 2004-03-25 |
ATA13752002A (de) | 2004-03-15 |
AU2003260473B2 (en) | 2008-08-07 |
WO2004024900A1 (en) | 2004-03-25 |
ES2381870T3 (es) | 2012-06-01 |
EP1537203A1 (de) | 2005-06-08 |
AT412145B (de) | 2004-10-25 |
US7867488B2 (en) | 2011-01-11 |
DK1537203T3 (da) | 2012-05-14 |
SI1537203T1 (sl) | 2012-06-29 |
JP2005538167A (ja) | 2005-12-15 |
CA2494216C (en) | 2013-07-09 |
PT1537203E (pt) | 2012-05-21 |
EP1537203B1 (de) | 2012-02-08 |
US20060177420A1 (en) | 2006-08-10 |
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