CY1110866T1 - Μακρολιδια με αντι-φλεγμονωδη δραστηριοτητα - Google Patents
Μακρολιδια με αντι-φλεγμονωδη δραστηριοτηταInfo
- Publication number
- CY1110866T1 CY1110866T1 CY20101100961T CY101100961T CY1110866T1 CY 1110866 T1 CY1110866 T1 CY 1110866T1 CY 20101100961 T CY20101100961 T CY 20101100961T CY 101100961 T CY101100961 T CY 101100961T CY 1110866 T1 CY1110866 T1 CY 1110866T1
- Authority
- CY
- Cyprus
- Prior art keywords
- activity
- macrolides
- inflammative
- extensive
- relates
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 3
- 229940041033 macrolides Drugs 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- 108010002352 Interleukin-1 Proteins 0.000 abstract 1
- 102000000589 Interleukin-1 Human genes 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 102000000743 Interleukin-5 Human genes 0.000 abstract 1
- 108010002616 Interleukin-5 Proteins 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 102000004890 Interleukin-8 Human genes 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 210000003714 granulocyte Anatomy 0.000 abstract 1
- 206010020718 hyperplasia Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64384105P | 2005-01-13 | 2005-01-13 | |
| US71582805P | 2005-09-09 | 2005-09-09 | |
| EP06727595A EP1851236B1 (en) | 2005-01-13 | 2006-01-13 | Macrolides with anti-inflammatory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110866T1 true CY1110866T1 (el) | 2015-06-10 |
Family
ID=36916830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100961T CY1110866T1 (el) | 2005-01-13 | 2010-10-26 | Μακρολιδια με αντι-φλεγμονωδη δραστηριοτητα |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8080529B2 (enExample) |
| EP (1) | EP1851236B1 (enExample) |
| JP (1) | JP5036558B2 (enExample) |
| KR (1) | KR20070105993A (enExample) |
| CN (1) | CN101142225B (enExample) |
| AT (1) | ATE476438T1 (enExample) |
| AU (1) | AU2006215315B2 (enExample) |
| CA (1) | CA2594820A1 (enExample) |
| CY (1) | CY1110866T1 (enExample) |
| DE (1) | DE602006015919D1 (enExample) |
| DK (1) | DK1851236T3 (enExample) |
| HR (1) | HRP20100549T1 (enExample) |
| IL (1) | IL184438A (enExample) |
| NO (1) | NO20074162L (enExample) |
| PL (1) | PL1851236T3 (enExample) |
| PT (1) | PT1851236E (enExample) |
| RS (1) | RS51479B (enExample) |
| WO (1) | WO2006087644A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110039795A1 (en) * | 2008-04-23 | 2011-02-17 | Mirjana Bukvic-Krajacic | 2'-o,3'-n-bridged macrolides |
| CN101423539B (zh) * | 2008-12-09 | 2011-04-27 | 山东大学 | 4″,11-二氨基甲酸酯阿奇霉素衍生物、制备方法及其药物组合物 |
| EP2384333B1 (en) * | 2009-01-30 | 2013-04-17 | Glaxo Group Limited | Anti-inflammatory macrolide |
| JP5662445B2 (ja) | 2009-08-13 | 2015-01-28 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | 新規マクロライド及びその使用 |
| WO2011131749A1 (en) | 2010-04-23 | 2011-10-27 | Glaxo Group Limited | New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases |
| CN105246334A (zh) | 2013-04-04 | 2016-01-13 | 哈佛大学的校长及成员们 | 大环内酯及其制备和使用方法 |
| CA2908620A1 (en) | 2013-04-10 | 2014-10-16 | Probiotic Pharmaceuticals Aps | Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect |
| HK1242920A1 (zh) * | 2014-10-08 | 2018-07-06 | 哈佛大学的校长及成员们 | 14-元酮内酯及其制备和使用方法 |
| WO2016154591A1 (en) | 2015-03-25 | 2016-09-29 | President And Fellows Of Harvard College | Macrolides with modified desosamine sugars and uses thereof |
| GB201520419D0 (en) | 2015-11-19 | 2016-01-06 | Epi Endo Pharmaceuticals Ehf | Compounds |
| US11771677B2 (en) * | 2020-03-12 | 2023-10-03 | Zoetis Services Llc | Immunomodulating urea azalides |
| WO2022128054A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammatory conditions of human skin (iv) |
| CN114858953B (zh) * | 2022-05-20 | 2023-11-21 | 大连工业大学 | 一种动物源食品中红霉素及降解产物的检测试剂盒及检测方法 |
| GB202404587D0 (en) | 2024-03-28 | 2024-05-15 | Epiendo Pharmaceuticals Ehf | Chemical forms |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0126344A2 (en) | 1983-05-20 | 1984-11-28 | Abbott Laboratories | Tripeptide esters of therapeutic agents |
| SI9011409A (en) * | 1990-07-18 | 1995-10-31 | Pliva Pharm & Chem Works | O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them |
| EP0895999A1 (en) * | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
| HRP980189B1 (en) | 1998-04-06 | 2004-04-30 | Pliva Pharm & Chem Works | Novel 15-membered lactams ketolides |
| NZ537717A (en) * | 2002-07-08 | 2006-04-28 | Pliva Istrazivacki Inst D | New compounds, compositions and methods for treatment of inflammatory diseases and conditions |
| GB0310986D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| JP5036557B2 (ja) | 2005-01-13 | 2012-09-26 | グラクソ グループ リミテッド | 抗炎症活性デクラジノシル−マクロライド |
| WO2006106440A1 (en) | 2005-01-14 | 2006-10-12 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Macrolide compounds containing biotin and photo-affinity group for macrolide target identification |
| EP2384333B1 (en) | 2009-01-30 | 2013-04-17 | Glaxo Group Limited | Anti-inflammatory macrolide |
-
2006
- 2006-01-13 EP EP06727595A patent/EP1851236B1/en active Active
- 2006-01-13 PT PT06727595T patent/PT1851236E/pt unknown
- 2006-01-13 DK DK06727595.8T patent/DK1851236T3/da active
- 2006-01-13 CA CA002594820A patent/CA2594820A1/en not_active Abandoned
- 2006-01-13 DE DE602006015919T patent/DE602006015919D1/de active Active
- 2006-01-13 WO PCT/IB2006/001238 patent/WO2006087644A2/en not_active Ceased
- 2006-01-13 PL PL06727595T patent/PL1851236T3/pl unknown
- 2006-01-13 US US11/813,873 patent/US8080529B2/en not_active Expired - Fee Related
- 2006-01-13 RS RSP-2010/0452A patent/RS51479B/sr unknown
- 2006-01-13 AU AU2006215315A patent/AU2006215315B2/en not_active Ceased
- 2006-01-13 KR KR1020077018362A patent/KR20070105993A/ko not_active Ceased
- 2006-01-13 HR HR20100549T patent/HRP20100549T1/hr unknown
- 2006-01-13 CN CN2006800081835A patent/CN101142225B/zh not_active Expired - Fee Related
- 2006-01-13 JP JP2007550879A patent/JP5036558B2/ja not_active Expired - Fee Related
- 2006-01-13 AT AT06727595T patent/ATE476438T1/de active
-
2007
- 2007-07-05 IL IL184438A patent/IL184438A/en not_active IP Right Cessation
- 2007-08-13 NO NO20074162A patent/NO20074162L/no not_active Application Discontinuation
-
2010
- 2010-10-26 CY CY20101100961T patent/CY1110866T1/el unknown
-
2011
- 2011-11-15 US US13/296,352 patent/US20120058963A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HK1112920A1 (en) | 2008-09-19 |
| CA2594820A1 (en) | 2006-08-24 |
| DE602006015919D1 (de) | 2010-09-16 |
| NO20074162L (no) | 2007-09-18 |
| WO2006087644A2 (en) | 2006-08-24 |
| WO2006087644A3 (en) | 2007-03-15 |
| US20080221046A1 (en) | 2008-09-11 |
| JP2008526950A (ja) | 2008-07-24 |
| CN101142225B (zh) | 2011-09-07 |
| AU2006215315A1 (en) | 2006-08-24 |
| KR20070105993A (ko) | 2007-10-31 |
| HRP20100549T1 (hr) | 2010-11-30 |
| US8080529B2 (en) | 2011-12-20 |
| IL184438A0 (en) | 2008-12-29 |
| US20120058963A1 (en) | 2012-03-08 |
| IL184438A (en) | 2011-12-29 |
| RS51479B (sr) | 2011-04-30 |
| ATE476438T1 (de) | 2010-08-15 |
| DK1851236T3 (da) | 2010-11-22 |
| AU2006215315B2 (en) | 2012-02-16 |
| PL1851236T3 (pl) | 2011-05-31 |
| JP5036558B2 (ja) | 2012-09-26 |
| PT1851236E (pt) | 2010-10-25 |
| EP1851236B1 (en) | 2010-08-04 |
| EP1851236A2 (en) | 2007-11-07 |
| CN101142225A (zh) | 2008-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1110866T1 (el) | Μακρολιδια με αντι-φλεγμονωδη δραστηριοτητα | |
| DE602005027707D1 (de) | Isoindolin-verbindungen und deren verwendungen | |
| BR0313733A (pt) | Uso da proteìna n beta cinase | |
| EA200800100A1 (ru) | Соединения азаиндазола и способы применения | |
| EA200870391A1 (ru) | Тетрагидропирролопиримидиндионы и их применение в качестве ингибиторов эластазы нейтрофилов человека | |
| MXPA05009595A (es) | Compuestos 7-amino-isoindolilo y sus usos farmaceuticos. | |
| EA200701808A1 (ru) | Производные тетрагидроиндолона и тетрагидроиндазолона | |
| ATE452129T1 (de) | N-phenyl-2-pyrimidine-amine derivatives | |
| EA200701113A1 (ru) | Макролиды | |
| CY1109187T1 (el) | Νεα μακρολιδια | |
| EA201101139A1 (ru) | Противовоспалительный макролид | |
| BRPI0410490A (pt) | composto de macrolìdeo, composição farmacêutica e método de tratamento compreendendo o mesmo | |
| EP1594435A4 (en) | INHIBITION OF HIV-1 REPLICATION BY TREATMENT OF THE PROCESSING OF THE VIRAL CAPSID-SPACER PEPTIDE 1 PROTEIN | |
| DOP2006000024A (es) | Tiazolidinonas, su preparación y su uso como medicamento | |
| DE602006004555D1 (de) | Decladinosyl-macrolide mit entzündungshemmender wirkung | |
| NO20054723L (no) | Behandling av proliferative sykdommer med epofilonderivater og straling | |
| EP1841420A4 (en) | TREATMENT OF REMEDIENT-RESISTANT PROLIFERATIVE DISEASES | |
| ATE471318T1 (de) | Neue indol-pyrrol-derivate zur behandlung proliferativer und inflammatorischer krankheiten | |
| CY1110192T1 (el) | Κρυσταλλικες μορφες ενωσεων μακρολιδων με αντιφλεγμονωδη δραση | |
| DE602004028113D1 (de) | Verwendung von 2,3-Dehydronaringenin-Derivaten zur Behandlung von Entzündungsprozessen und diese Derivate enthaltende pharmazeutische Zusammensetzung | |
| CR9323A (es) | TIAZOLIDINONAS COMO INHIBIDORAS DE LAS POLOQUINASAS (Plk) COMO MEDICAMENTO | |
| CU23596A3 (es) | Derivados de pirazol-quinazolina y proceso para su preparación |